Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Informazioni relative al progetto

Tendon Therapy Train

ID dell’accordo di sovvenzione: 676338

DOI

10.3030/676338

Progetto chiuso

Data della firma CE 27 Luglio 2015

Data di avvio 1 Febbraio 2016

Data di completamento 31 Gennaio 2020

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 876 965,65

Contributo UE

€ 3 876 965,64

Coordinato da

UNIVERSITY OF GALWAY
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (2)

IDF and patent filings

To protect intellectual property, three patents strengthening European innovation in cell-based therapy development will be filed: i) methods to differentiate dermal fibroblasts (DFs) and stem cells (BMSCs) towards tenogenic lineage; ii) methods to maintain tendon-specific function in vitro; and iii) the final tendon substitute products.

Digital media dissemination

Led by NUI Galway, digital media dissemination will include the Tendon Therapy website and dedicated project accounts on social media including twitter and linked-in. All press releases will also be issued electronically.

Documents, reports (5)

Supervisory Board of the Network

supervisory agreement

Ethics

provide documents linked to the ethics issues

Progress report

progress report

Draft Periodic Report

periodic report

Mid Term review meeting

mid term review meeting

Pubblicazioni

Peer reviewed articles (23)

Natural Architectures for Tissue Engineering and Regenerative Medicine

Autori: Floris Honig, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer, Lidy E. Fratila-Apachitei
Pubblicato in: Journal of Functional Biomaterials, Numero 11/3, 2020, Pagina/e 47, ISSN 2079-4983
Editore: MDPI
DOI: 10.3390/jfb11030047

Screening as a strategy to drive regenerative medicine research

Autori: Steven Vermeulen, Jan de Boer
Pubblicato in: Methods, 2020, ISSN 1046-2023
Editore: Academic Press
DOI: 10.1016/j.ymeth.2020.04.004

Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells

Autori: Steven Vermeulen, Nadia Roumans, Floris Honig, Aurélie Carlier, Dennie G.A.J. Hebels, Aysegul Dede Eren, Peter ten Dijke, Aliaksei Vasilevich, Jan de Boer
Pubblicato in: Biomaterials, Numero 259, 2020, Pagina/e 120331, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120331

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

Autori: Eugenia Pugliese, João Q. Coentro, Dimitrios I. Zeugolis
Pubblicato in: Advanced Materials, Numero 30/13, 2018, Pagina/e 1704324, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201704324

Biophysics Rules the Cell Culture but Has Yet to Reach the Clinic

Autori: Salomé Guillaumin, Ignacio Sallent, Dimitrios I. Zeugolis
Pubblicato in: Journal of the American Academy of Orthopaedic Surgeons, Numero 25/7, 2017, Pagina/e e144-e147, ISSN 1067-151X
Editore: American Academy of Orthopaedic Surgeons
DOI: 10.5435/JAAOS-D-17-00324

Micro-Topographies Promote Late Chondrogenic Differentiation Markers in the ATDC5 Cell Line

Autori: Bach Q. Le, Aliaksei Vasilevich, Steven Vermeulen, Frits Hulshof, Dimitrios F. Stamatialis, Clemens A. van Blitterswijk, Jan de Boer
Pubblicato in: Tissue Engineering Part A, Numero 23/9-10, 2017, Pagina/e 458-469, ISSN 1937-3341
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.TEA.2016.0421

Identification of topographical architectures supporting the phenotype of rat tenocytes

Autori: Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer
Pubblicato in: Acta Biomaterialia, Numero 83, 2019, Pagina/e 277-290, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2018.10.041

Current and upcoming therapies to modulate skin scarring and fibrosis

Autori: João Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis
Pubblicato in: Advanced Drug Delivery Reviews, Numero Theme issue format, 2018, Pagina/e digital, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2018.08.009

Wound healing and scar wars

Autori: Eugenia Pugliese, João Q. Coentro, Michael Raghunath, Dimitrios I. Zeugolis
Pubblicato in: Advanced Drug Delivery Reviews, Numero 129, 2018, Pagina/e 1-3, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2018.05.010

Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells

Autori: Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Pubblicato in: Tissue Engineering Part B: Reviews, Numero 24/4, 2018, Pagina/e 255-266, ISSN 1937-3368
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.teb.2017.0468

Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs

Autori: Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon
Pubblicato in: Journal of Materials Science: Materials in Medicine, Numero 29/8, 2018, ISSN 0957-4530
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10856-018-6136-3

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Autori: Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis
Pubblicato in: Advanced Materials, Numero 31/1, 2019, Pagina/e 1801651, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201801651

Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells

Autori: Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Pubblicato in: Journal of Tissue Engineering and Regenerative Medicine, Numero 13/12, 2019, Pagina/e 2204-2217, ISSN 1932-6254
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/term.2967

Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype in Vitro and tendon repair in vivo

Autori: Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer
Pubblicato in: Journal of Immunology and Regenerative Medicine, Numero 8, 2020, Pagina/e 100027, ISSN 2468-4988
Editore: Elsevier
DOI: 10.1016/j.regen.2020.100027

The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents

Autori: Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis
Pubblicato in: Biofabrication, Numero 12/2, 2020, Pagina/e 025018, ISSN 1758-5090
Editore: IOP Publishing
DOI: 10.1088/1758-5090/ab6412

Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics

Autori: Dimitrios Tsiapalis, Dimitrios I. Zeugolis
Pubblicato in: Journal of the American Academy of Orthopaedic Surgeons, Numero 27/23, 2019, Pagina/e e1040-e1042, ISSN 1067-151X
Editore: American Academy of Orthopaedic Surgeons
DOI: 10.5435/jaaos-d-19-00044

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment

Autori: Daniëlle G. Leuning, Nick R. M. Beijer, Nadia A. du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer
Pubblicato in: Scientific Reports, Numero 8/1, 2018, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-018-25700-5

Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation

Autori: João Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon
Pubblicato in: Journal of Materials Science: Materials in Medicine, Numero 30/12, 2019, ISSN 0957-4530
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6339-2

ISEV2018 abstract book

Autori: Clotilde Théry, Kenneth Witwer
Pubblicato in: Journal of Extracellular Vesicles, Numero 7/sup1, 2018, Pagina/e 1461450, ISSN 2001-3078
Editore: US
DOI: 10.1080/20013078.2018.1461450

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs

Autori: Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath
Pubblicato in: Advanced Drug Delivery Reviews, Numero 146, 2019, Pagina/e 126-154, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2019.06.002

British Society for Matrix Biology Spring 2019 Meeting: “Stroma, Niche, Repair”

Autori: Gifford. V., et. at.,
Pubblicato in: International Journal of Experimental Pathology, Numero 100/4, 2019, ISSN 0959-9673
Editore: Blackwell Publishing Inc.
DOI: 10.1111/iep.12332

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation

Autori: Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aurélie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.
Pubblicato in: Advanced Science, 2020, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.201903392

Seaweed polysaccharides as macromolecular crowding agents

Autori: Andrea De Pieri, Shubhasmin Rana, Stefanie Korntner, Dimitrios I. Zeugolis
Pubblicato in: International Journal of Biological Macromolecules, Numero 164, 2020, Pagina/e 434-446, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2020.07.087

Book chapters (6)

Bioreactors for Tendon Tissue Engineering

Autori: Ana I. Gonçalves
Pubblicato in: Bioreactors for Stem Cell Expansion and Differentiation, 2018, Pagina/e 269-300, ISBN 9780-429453144
Editore: CRC Press
DOI: 10.1201/9780429453144-10

Preparation and Characterization of Tissue Surrogates Rich in Extracellular Matrix Using the Principles of Macromolecular Crowding

Autori: Adrian Djalali-Cuevas, Sergio Garnica-Galvez, Andrea Rampin, Diana Gaspar, Ioannis Skoufos, Athina Tzora, Nikitas Prassinos, Nikolaos Diakakis, Dimitrios I. Zeugolis
Pubblicato in: The Extracellular Matrix - Methods and Protocols, Numero 1952, 2019, Pagina/e 245-259, ISBN 978-1-4939-9132-7
Editore: Springer New York
DOI: 10.1007/978-1-4939-9133-4_20

Designing Microenvironments for Optimal Outcomes in Tissue Engineering and Regenerative Medicine: From Biopolymers to Culturing Conditions

Autori: Dimitrios Tsiapalis, Sofia Ribeiro, Andrea De Pieri, Ignacio Sallent, Salomé Guillaumin, Diana Gaspar, Stefanie Korntner, Yves Bayon, Manuela E. Gomes, Rui L. Reis, Dimitrios I. Zeugolis
Pubblicato in: Reference Module in Biomedical Sciences, 2019, ISBN 9780-128012383
Editore: Elsevier
DOI: 10.1016/b978-0-12-801238-3.11140-7

Scaffolds for tendon tissue engineering

Autori: Héctor Capella-Monsonís, Salomé Guillaumin, Sofia Ribeiro, Stefanie Korntner, Yves Bayon, Dimitrios I. Zeugolis
Pubblicato in: Handbook of Tissue Engineering Scaffolds: Volume One, 2019, Pagina/e 259-298, ISBN 9780-081025635
Editore: Elsevier
DOI: 10.1016/b978-0-08-102563-5.00013-7

The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture

Autori: Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis
Pubblicato in: Methods in Cell Biology, 2019
Editore: Elsevier
DOI: 10.1016/bs.mcb.2019.11.003

Production and Characterization of Chemically Cross-Linked Collagen Scaffolds

Autori: Ignacio Sallent, Héctor Capella-Monsonís, Dimitrios I. Zeugolis
Pubblicato in: Collagen - Methods and Protocols, Numero 1944, 2019, Pagina/e 23-38, ISBN 978-1-4939-9094-8
Editore: Springer New York
DOI: 10.1007/978-1-4939-9095-5_3

Conference proceedings (3)

Concept Design of a New Portable Medical Device for Lymphedema Monitoring: A EIT Health ClinMed Summer School Project

Autori: Jordi Tisaire, Elena Rodrigo, Sofia Ribeiro, Mariachiara Ricci, Juan Cuellar, Dimitrios Zeugolis, Yves Bayon, Isabel Rocha
Pubblicato in: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Pagina/e 611-620, ISBN 978-989-758-353-7
Editore: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696706110620

Design and Characterization of Synthetic Biodegradable Films for Soft Tissue Engineering

Autori: Ribeiro, S.; Fernandes, E.; Gomes, M.; Reis, R.; Bayon, Y. and Zeugolis, D.
Pubblicato in: Doctoral Consortium - Volume 1: DCBIOSTEC, 2019, Pagina/e 28-32
Editore: DCBIOSTEC

Empowering Translation of New Ideas - A EIT Health ClinMed Summer School Overview

Autori: Sofia Ribeiro, Mariachiara Ricci, Albert Von Der Lieth, Yves Bayon, Dimitrios Zeugolis, Sylvia Pelayo, Isabelle Marque, Lionel Pazart
Pubblicato in: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies, 2019, Pagina/e 603-610, ISBN 978-989-758-353-7
Editore: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0007696606030610