Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

Resultado final

Website established
Completion of theses

Completion of doctoral theses of the GlyCoCan ESRs

Publicaciones

Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation

Autores: Di Wang, Tao Zhang, Katarina Madunić, Antonius A. de Waard, Constantin Blöchl, Oleg A. Mayboroda, Marieke Griffioen, Robbert M. Spaapen, Christian G. Huber, Guinevere S.M. Lageveen-Kammeijer, and Manfred Wuhrer
Publicado en: Journal of proteome Research, 2022, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00911

Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines

Autores: Martina Pirro; Yoann Rombouts; Alexandre Stella; Olivier Neyrolles; Odile Burlet-Schiltz; Sandra J. van Vliet; Arnoud H. de Ru; Yassene Mohammed; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Publicado en: "Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2020, 1864 (4), pp.129513. ⟨10.1016/j.bbagen.2020.129513⟩", Edición 7, 2020, ISSN 1872-8006
Editor: Elsevier
DOI: 10.1016/j.bbagen.2020.129513

Serum protein N-glycosylation changes in multiple myeloma

Autores: Zejian Zhang, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Publicado en: Biochimica et Biophysica Acta, 2019, ISSN 0006-3002
Editor: Elsevier
DOI: 10.1016/j.bbagen.2019.03.001

A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases.

Autores: Colin Ruprecht; Colin Ruprecht; Max Peter Bartetzko; Max Peter Bartetzko; Deborah Senf; Deborah Senf; Anna Lakhina; Peter J. Smith; Maria J. Soto; Maria J. Soto; Hyunil Oh; Hyunil Oh; Jeong-Yeh Yang; Digantkumar Chapla; Daniel Varón Silva; Mads Hartvig Clausen; Michael G. Hahn; Kelley W. Moremen; Breeanna R. Urbanowicz; Fabian Pfrengle; Fabian Pfrengle; Fabian Pfrengle
Publicado en: Angewandte Chemie, Edición 1, 2020, ISSN 0044-8249
Editor: Weinheim-Wiley-VCH
DOI: 10.1002/ange.202003105

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

Autores: Jelena Simunovic, Marija Vilaj, Irena Trbojevic-Akmacic, Ana Momcilovic, Frano Vuckovic, Ivan Gudelj, Julija Juric, Natali Nakic, Gordan Lauc, Marija Pezer
Publicado en: Glycobiology, 2019, ISSN 1460-2423
Editor: Oxford Academic
DOI: 10.1093/glycob/cwz061

OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Autores: James Biwi,Charlotte Clarisse,Christophe Biot,Radoslaw Pawel Kozak,Katarina Madunic,Marlène Mortuaire,Manfred Wuhrer,Daniel Ian Richard Spencer,Céline Schulz,Yann Guerardel,Tony Lefebvre,Anne-Sophie Vercoutter-Edouart
Publicado en: Proteomics, 2019, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800452

The Role of Glycosphingolipids in Immune Cell Functions.

Autores: Tao Zhang; Antonius A. de Waard; Antonius A. de Waard; Manfred Wuhrer; Robbert M. Spaapen; Robbert M. Spaapen
Publicado en: Frontiers in Immunology, Vol 10 (2019), Edición 1, 2019, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.00090

Colorectal cancer cell lines show striking diversity of their O- glycome reflecting the cellular differentiation phenotype

Autores: Katarina Madunić; Tao Zhang; Oleg A. Mayboroda; Stephanie Holst; Kathrin Stavenhagen; Chunsheng Jin; Niclas G. Karlsson; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer
Publicado en: Cellular and Molecular Life Sciences, Edición 10, 2020, ISSN 0014-4754
Editor: Spinger-Link
DOI: 10.1007/s00018-020-03504-z

Plasma N-glycome composition associates with chronic low back pain

Autores: IrenaTrbojević-AkmačićaFranoVučkovićaMarijaVilajaAndreaSkelinakLennart C.KarssenbJasminkaKrištićaJulijaJurićaAnaMomčilovićacJelenaŠimunovićaMassimoManginodeManuelaDe GregorifgMaurizioMarchesinighConcettaDagostinogiJerkoŠtambukaMislavNovokmetaRichardRauckjYurii S.AulchenkobDraganPrimoracklmnoLeonardoKapuraljKlaasBuysepDieterMesottenpFrances M.K.WilliamsdJanvan ZundertpMassimoAllegrigqG
Publicado en: Biochimica et Biophysica Acta (BBA), 2018, ISSN 0006-3002
Editor: Science Direct
DOI: 10.1016/j.bbagen.2018.07.003

Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry

Autores: Laura Pont; Valeriia Kuzyk; Valeriia Kuzyk; Fernando Benavente; Victoria Sanz-Nebot; Oleg A. Mayboroda; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Publicado en: VOLUME=20;ISSUE=3;STARTPAGE=1666;ENDPAGE=1675;ISSN=1535-3893;TITLE=Journal of Proteome Research, Edición 1, 2021, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00875

Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)

Autores: Martina Pirro, Yassene Mohammed, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Katarina Madunić, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Publicado en: International Journal of Molecular Sciences, Edición 22/10, 2021, Página(s) 5369, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105369

Colon-specific immune microenvironment regulates cancer progression versus rejection

Autores: Giulia Trimaglio; Anne-Françoise Tilkin-Mariamé; Virginie Feliu; Françoise Lauzeral-Vizcaino; Marie Tosolini; Carine Valle; Maha Ayyoub; Maha Ayyoub; Olivier Neyrolles; Nathalie Vergnolle; Yoann Rombouts; Christel Devaud
Publicado en: OncoImmunology, Edición 7, 2020, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.1101/2020.01.02.892711

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autores: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Publicado en: Journal of human hypertention, 2018, ISSN 0950-9240
Editor: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy

Autores: Rui P.S.Patrício, Paula A.Videira, Florbela Pereira
Publicado en: BIOORGANIC & MEDICINAL CHEMISTRY, 2022, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116530

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Autores: Colin Ruprecht, Max P. Bartetzko, Deborah Senf, Anna Lakhina, Peter J. Smith, Maria J. Soto, Hyunil Oh, Jeong‐Yeh Yang, Digantkumar Chapla, Daniel Varon Silva, Mads H. Clausen, Michael G. Hahn, Kelley W. Moremen, Breeanna R. Urbanowicz, Fabian Pfrengle
Publicado en: Angewandte Chemie, Edición 132/30, 2020, Página(s) 12593-12598, ISSN 0044-8249
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202003105

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.

Autores: Pirro, Martina; Schoof, Esmee; van Vliet, Sandra J.; Rombouts, Yoann; Stella, Alexandre; de Ru, Arnoud; Mohammed, Yassene; Wuhrer, Manfred; van Veelen, Peter A.; Hensbergen, Paul J.
Publicado en: VOLUME=18;ISSUE=3;STARTPAGE=1125;ENDPAGE=1132;ISSN=1535-3893;TITLE=Journal of Proteome Research, Edición 16, 2018, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00796

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Autores: Joost C van der Horst, Henri J van de Vrugt, Hakan Kalay, Daniel I R Spencer, Rad P Kozak, Sandra J van Vliet
Publicado en: Glycobiology, 2018, ISSN 0959-6658
Editor: Oxford University Press
DOI: 10.1093/glycob/cwy096

The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition

Autores: Michela Pucci; Inês Gomes Ferreira; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Publicado en: Edición 18, Edición 1, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186558

High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer

Autores: Michela Pucci; Inês Gomes Ferreira; Martina Orlandani; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Publicado en: Cells, Vol 9, Iss 948, p 948 (2020), Edición 2, 2020, ISSN 2073-4409
Editor: Cells
DOI: 10.3390/cells9040948

Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis.

Autores: Kotsias, Maximilianos; Blanas, Athanasios; van Vliet, Sandra J.; Pirro, Martina; Spencer, Daniel I. R.; Kozak, Radoslaw P.
Publicado en: Plos One, Edición 1, 2019, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0223270

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.

Autores: Katarina Madunić; Sander Wagt; Tao Zhang; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Publicado en: VOLUME=93;ISSUE=18;STARTPAGE=6919;ENDPAGE=6923;TITLE=Analytical Chemistry, Edición 8, 2021, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

O- and N-glycosylation analysis of cell lines by ultrahigh resolution MALDI-FTICR-MS

Autores: Gerda C M Vreeker; Simone Nicolardi; Katarina Madunić; Maximilianos Kotsias; Yuri E. M. van der Burgt; Manfred Wuhrer
Publicado en: International Journal of Mass Spectrometry, Edición 1, 2020, ISSN 1873-2798
Editor: Amsterdam Elsevier B>V>
DOI: 10.1016/j.ijms.2019.116267

MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

Autores: Zélia Silva; Tiago Ferro; Danielle Almeida; Helena Soares; José Alexandre Ferreira; Fanny M. Deschepper; Paul J. Hensbergen; Martina Pirro; Sandra J. van Vliet; Sebastian Springer; Paula A. Videira
Publicado en: Pharmaceutics, Edición 12, 2020, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12030249

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

Autores: Lenneke A.M. Cornelissen,Athanasios Blanas,Joost C. van der Horst,Laura Kruijssen,Anouk Zaal,Tom O'Toole,Lieke Wiercx,Yvette van Kooyk,Sandra J. van Vliet
Publicado en: International journal of cancer, 2018, ISSN 1097-0215
Editor: Wiley Online Library
DOI: 10.1002/ijc.32084

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry.

Autores: Tao Zhang; Katarina Madunić; Stephanie Holst; Jing Zhang; Chunsheng Jin; Peter ten Dijke; Niclas G. Karlsson; Kathrin Stavenhagen; Manfred Wuhrer
Publicado en: Molecular Omics, Edición 1, 2020, ISSN 2515-4184
Editor: The Royal Society of Chemistry’s
DOI: 10.1039/c9mo00180h

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS

Autores: Maximilianos Kotsias; Katarina Madunić; Simone Nicolardi; Radoslaw P. Kozak; Richard A. Gardner; Bas C. Jansen; Daniel I. R. Spencer; Manfred Wuhrer
Publicado en: Glycoconjugate Journal, Edición 15, 2021, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-10003-1

Histo-blood group glycans in the context of personalized medicine

Autores: Viktoria Dotz, Manfred Wuhrer
Publicado en: Biochimica et Biophysica Acta (BBA) - General Subjects, Edición 1860/8, 2016, Página(s) 1596-1607, ISSN 0304-4165
Editor: Elsevier BV
DOI: 10.1016/j.bbagen.2015.12.026

IgG Glycome in Colorectal Cancer

Autores: F. Vuckovic, E. Theodoratou, K. Thaci, M. Timofeeva, A. Vojta, J. Stambuk, M. Pucic-Bakovic, P. M. Rudd, L. erek, D. Servis, A. Wennerstro m, S. M. Farrington, M. Perola, Y. Aulchenko, M. G. Dunlop, H. Campbell, G. Lauc
Publicado en: Clinical Cancer Research, Edición 22/12, 2016, Página(s) 3078-3086, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1867

Mechanisms of disease: The human N-glycome

Autores: Gordan Lauc, Marija Pezer, Igor Rudan, Harry Campbell
Publicado en: Biochimica et Biophysica Acta (BBA) - General Subjects, Edición 1860/8, 2016, Página(s) 1574-1582, ISSN 0304-4165
Editor: Elsevier BV
DOI: 10.1016/j.bbagen.2015.10.016

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

Autores: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira
Publicado en: BMC Cancer, Edición 18/1, 2018, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-018-4410-x

Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling

Autores: Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dall’Olio
Publicado en: International Journal of Molecular Sciences, Edición 19/2, 2018, Página(s) 580, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020580

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autores: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Serum sialylation changes in cancer

Autores: Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Publicado en: Glycoconjugate Journal, Edición 35/2, 2018, Página(s) 139-160, ISSN 0282-0080
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications

Autores: Ana Momčilović; Noortje de Haan; Agnes L. Hipgrave Ederveen; Albert Bondt; Carolien A. M. Koeleman; David Falck; Louise A. de Neef; Wilma E. Mesker; Rob A. E. M. Tollenaar; Arnoud H. de Ru; Peter A. van Veelen; Manfred Wuhrer; Viktoria Dotz
Publicado en: Analytical Chemistry, Edición 1, 2020, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.9b05722

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State

Autores: Athanasios Blanas, Anouk Zaal , Irene van der Haar Àvila , Maxime Kempers , Laura Kruijssen, Mike de Kok , Marko A. Popovic, Joost C. van der Horst and Sandra J. van Vliet
Publicado en: Cancers, 2020, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092580

N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity

Autores: Martina Pirro; Yassene Mohammed; Sandra J. van Vliet; Yoann Rombouts; Agnese Sciacca; Arnoud H. de Ru; George M.C. Janssen; Rayman T. N. Tjokrodirijo; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Publicado en: VOLUME=21;ISSUE=15;STARTPAGE=1;ENDPAGE=13;ISSN=1661-6596;TITLE=International Journal of Molecular Sciences, Edición 1, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155522

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.

Autores: Kotsias, Maximilianos; Kozak, Radoslaw P.; Gardner, Richard A.; Wuhrer, Manfred; Spencer, Daniel I. R.
Publicado en: PLoS ONE, Edición 2, 2019, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0210759

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Autores: Lenneke A. M. Cornelissen, Athanasios Blanas†, Anouk Zaal†, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk and Sandra J. van Vliet*
Publicado en: FRONTIERS IN ONCOLOGY, 2020, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01622

High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin

Autores: Šimunović, Jelena; Gašperšič, Jernej; Černigoj, Urh; Vidič, Jana; Štrancar, Aleš; Novokmet, Mislav; Razdorov, Genadij; Pezer, Marija; Lauc, Gordan; Trbojević-Akmačić, Irena
Publicado en: Biotechnology and Bioengineering, 2022, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28280

L1CAM as an E-selectin Ligand in Colon Cancer

Autores: Fanny M. Deschepper; Roberta Zoppi; Martina Pirro; Paul J. Hensbergen; Fabio Dall'Olio; Maximillianos Kotsias; Richard A. Gardner; Daniel I. R. Spencer; Paula A. Videira
Publicado en: International Journal of Molecular Sciences, 21(21). MDPI, Edición 11, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218286

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode

Autores: Katarina Madunić, Sander Wagt, Tao Zhang, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Publicado en: Analytical Chemistry, Edición 93/18, 2021, Página(s) 6919-6923, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.

Autores: Venturi, Giulia; Gomes Ferreira, Inês; Pucci, Michela; Ferracin, Manuela; Malagolini, Nadia; Chiricolo, Mariella; Dall’Olio, Fabio
Publicado en: Glycobiology, Edición 11, 2019, ISSN 1460-2423
Editor: Oxford Academic
DOI: 10.1093/glycob/cwz053

The Many Ways by Which O -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations.

Autores: Biwi, James; Biot, Christophe; Guerardel, Yann; Vercoutter-Edouart, Anne-Sophie; Lefebvre, Tony
Publicado en: "Molecules, MDPI, 2018, 23 (11), pp.2858. ⟨10.3390/molecules23112858⟩", Edición 1, 2018, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23112858

UNRAVELING MUCIN TYPE OGLYCOSYLATIONSIGNATURESOF COLORECTAL CANCER

Autores: Katarina Madunic
Publicado en: 2022, ISBN 978-94-6458-073-0
Editor: Ridderprint

Buscando datos de OpenAIRE...

Resultado final

Publicaciones

Compartir esta página

Descargar