Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

Rezultaty

Website established
Completion of theses

Completion of doctoral theses of the GlyCoCan ESRs

Publikacje

Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation

Autorzy: Di Wang, Tao Zhang, Katarina Madunić, Antonius A. de Waard, Constantin Blöchl, Oleg A. Mayboroda, Marieke Griffioen, Robbert M. Spaapen, Christian G. Huber, Guinevere S.M. Lageveen-Kammeijer, and Manfred Wuhrer
Opublikowane w: Journal of proteome Research, 2022, ISSN 1535-3893
Wydawca: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00911

Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines

Autorzy: Martina Pirro; Yoann Rombouts; Alexandre Stella; Olivier Neyrolles; Odile Burlet-Schiltz; Sandra J. van Vliet; Arnoud H. de Ru; Yassene Mohammed; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Opublikowane w: "Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2020, 1864 (4), pp.129513. ⟨10.1016/j.bbagen.2020.129513⟩", Numer 7, 2020, ISSN 1872-8006
Wydawca: Elsevier
DOI: 10.1016/j.bbagen.2020.129513

Serum protein N-glycosylation changes in multiple myeloma

Autorzy: Zejian Zhang, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Opublikowane w: Biochimica et Biophysica Acta, 2019, ISSN 0006-3002
Wydawca: Elsevier
DOI: 10.1016/j.bbagen.2019.03.001

A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases.

Autorzy: Colin Ruprecht; Colin Ruprecht; Max Peter Bartetzko; Max Peter Bartetzko; Deborah Senf; Deborah Senf; Anna Lakhina; Peter J. Smith; Maria J. Soto; Maria J. Soto; Hyunil Oh; Hyunil Oh; Jeong-Yeh Yang; Digantkumar Chapla; Daniel Varón Silva; Mads Hartvig Clausen; Michael G. Hahn; Kelley W. Moremen; Breeanna R. Urbanowicz; Fabian Pfrengle; Fabian Pfrengle; Fabian Pfrengle
Opublikowane w: Angewandte Chemie, Numer 1, 2020, ISSN 0044-8249
Wydawca: Weinheim-Wiley-VCH
DOI: 10.1002/ange.202003105

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

Autorzy: Jelena Simunovic, Marija Vilaj, Irena Trbojevic-Akmacic, Ana Momcilovic, Frano Vuckovic, Ivan Gudelj, Julija Juric, Natali Nakic, Gordan Lauc, Marija Pezer
Opublikowane w: Glycobiology, 2019, ISSN 1460-2423
Wydawca: Oxford Academic
DOI: 10.1093/glycob/cwz061

OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Autorzy: James Biwi,Charlotte Clarisse,Christophe Biot,Radoslaw Pawel Kozak,Katarina Madunic,Marlène Mortuaire,Manfred Wuhrer,Daniel Ian Richard Spencer,Céline Schulz,Yann Guerardel,Tony Lefebvre,Anne-Sophie Vercoutter-Edouart
Opublikowane w: Proteomics, 2019, ISSN 1615-9853
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800452

The Role of Glycosphingolipids in Immune Cell Functions.

Autorzy: Tao Zhang; Antonius A. de Waard; Antonius A. de Waard; Manfred Wuhrer; Robbert M. Spaapen; Robbert M. Spaapen
Opublikowane w: Frontiers in Immunology, Vol 10 (2019), Numer 1, 2019, ISSN 1664-3224
Wydawca: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.00090

Colorectal cancer cell lines show striking diversity of their O- glycome reflecting the cellular differentiation phenotype

Autorzy: Katarina Madunić; Tao Zhang; Oleg A. Mayboroda; Stephanie Holst; Kathrin Stavenhagen; Chunsheng Jin; Niclas G. Karlsson; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer
Opublikowane w: Cellular and Molecular Life Sciences, Numer 10, 2020, ISSN 0014-4754
Wydawca: Spinger-Link
DOI: 10.1007/s00018-020-03504-z

Plasma N-glycome composition associates with chronic low back pain

Autorzy: IrenaTrbojević-AkmačićaFranoVučkovićaMarijaVilajaAndreaSkelinakLennart C.KarssenbJasminkaKrištićaJulijaJurićaAnaMomčilovićacJelenaŠimunovićaMassimoManginodeManuelaDe GregorifgMaurizioMarchesinighConcettaDagostinogiJerkoŠtambukaMislavNovokmetaRichardRauckjYurii S.AulchenkobDraganPrimoracklmnoLeonardoKapuraljKlaasBuysepDieterMesottenpFrances M.K.WilliamsdJanvan ZundertpMassimoAllegrigqG
Opublikowane w: Biochimica et Biophysica Acta (BBA), 2018, ISSN 0006-3002
Wydawca: Science Direct
DOI: 10.1016/j.bbagen.2018.07.003

Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry

Autorzy: Laura Pont; Valeriia Kuzyk; Valeriia Kuzyk; Fernando Benavente; Victoria Sanz-Nebot; Oleg A. Mayboroda; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Opublikowane w: VOLUME=20;ISSUE=3;STARTPAGE=1666;ENDPAGE=1675;ISSN=1535-3893;TITLE=Journal of Proteome Research, Numer 1, 2021, ISSN 1535-3893
Wydawca: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00875

Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)

Autorzy: Martina Pirro, Yassene Mohammed, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Katarina Madunić, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Opublikowane w: International Journal of Molecular Sciences, Numer 22/10, 2021, Strona(/y) 5369, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105369

Colon-specific immune microenvironment regulates cancer progression versus rejection

Autorzy: Giulia Trimaglio; Anne-Françoise Tilkin-Mariamé; Virginie Feliu; Françoise Lauzeral-Vizcaino; Marie Tosolini; Carine Valle; Maha Ayyoub; Maha Ayyoub; Olivier Neyrolles; Nathalie Vergnolle; Yoann Rombouts; Christel Devaud
Opublikowane w: OncoImmunology, Numer 7, 2020, ISSN 2162-4011
Wydawca: Landes Bioscience
DOI: 10.1101/2020.01.02.892711

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autorzy: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Opublikowane w: Journal of human hypertention, 2018, ISSN 0950-9240
Wydawca: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy

Autorzy: Rui P.S.Patrício, Paula A.Videira, Florbela Pereira
Opublikowane w: BIOORGANIC & MEDICINAL CHEMISTRY, 2022, ISSN 0968-0896
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116530

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Autorzy: Colin Ruprecht, Max P. Bartetzko, Deborah Senf, Anna Lakhina, Peter J. Smith, Maria J. Soto, Hyunil Oh, Jeong‐Yeh Yang, Digantkumar Chapla, Daniel Varon Silva, Mads H. Clausen, Michael G. Hahn, Kelley W. Moremen, Breeanna R. Urbanowicz, Fabian Pfrengle
Opublikowane w: Angewandte Chemie, Numer 132/30, 2020, Strona(/y) 12593-12598, ISSN 0044-8249
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202003105

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.

Autorzy: Pirro, Martina; Schoof, Esmee; van Vliet, Sandra J.; Rombouts, Yoann; Stella, Alexandre; de Ru, Arnoud; Mohammed, Yassene; Wuhrer, Manfred; van Veelen, Peter A.; Hensbergen, Paul J.
Opublikowane w: VOLUME=18;ISSUE=3;STARTPAGE=1125;ENDPAGE=1132;ISSN=1535-3893;TITLE=Journal of Proteome Research, Numer 16, 2018, ISSN 1535-3893
Wydawca: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00796

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Autorzy: Joost C van der Horst, Henri J van de Vrugt, Hakan Kalay, Daniel I R Spencer, Rad P Kozak, Sandra J van Vliet
Opublikowane w: Glycobiology, 2018, ISSN 0959-6658
Wydawca: Oxford University Press
DOI: 10.1093/glycob/cwy096

The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition

Autorzy: Michela Pucci; Inês Gomes Ferreira; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Opublikowane w: Numer 18, Numer 1, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186558

High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer

Autorzy: Michela Pucci; Inês Gomes Ferreira; Martina Orlandani; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Opublikowane w: Cells, Vol 9, Iss 948, p 948 (2020), Numer 2, 2020, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells9040948

Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis.

Autorzy: Kotsias, Maximilianos; Blanas, Athanasios; van Vliet, Sandra J.; Pirro, Martina; Spencer, Daniel I. R.; Kozak, Radoslaw P.
Opublikowane w: Plos One, Numer 1, 2019, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0223270

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.

Autorzy: Katarina Madunić; Sander Wagt; Tao Zhang; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Opublikowane w: VOLUME=93;ISSUE=18;STARTPAGE=6919;ENDPAGE=6923;TITLE=Analytical Chemistry, Numer 8, 2021, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

O- and N-glycosylation analysis of cell lines by ultrahigh resolution MALDI-FTICR-MS

Autorzy: Gerda C M Vreeker; Simone Nicolardi; Katarina Madunić; Maximilianos Kotsias; Yuri E. M. van der Burgt; Manfred Wuhrer
Opublikowane w: International Journal of Mass Spectrometry, Numer 1, 2020, ISSN 1873-2798
Wydawca: Amsterdam Elsevier B>V>
DOI: 10.1016/j.ijms.2019.116267

MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

Autorzy: Zélia Silva; Tiago Ferro; Danielle Almeida; Helena Soares; José Alexandre Ferreira; Fanny M. Deschepper; Paul J. Hensbergen; Martina Pirro; Sandra J. van Vliet; Sebastian Springer; Paula A. Videira
Opublikowane w: Pharmaceutics, Numer 12, 2020, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12030249

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

Autorzy: Lenneke A.M. Cornelissen,Athanasios Blanas,Joost C. van der Horst,Laura Kruijssen,Anouk Zaal,Tom O'Toole,Lieke Wiercx,Yvette van Kooyk,Sandra J. van Vliet
Opublikowane w: International journal of cancer, 2018, ISSN 1097-0215
Wydawca: Wiley Online Library
DOI: 10.1002/ijc.32084

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry.

Autorzy: Tao Zhang; Katarina Madunić; Stephanie Holst; Jing Zhang; Chunsheng Jin; Peter ten Dijke; Niclas G. Karlsson; Kathrin Stavenhagen; Manfred Wuhrer
Opublikowane w: Molecular Omics, Numer 1, 2020, ISSN 2515-4184
Wydawca: The Royal Society of Chemistry’s
DOI: 10.1039/c9mo00180h

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS

Autorzy: Maximilianos Kotsias; Katarina Madunić; Simone Nicolardi; Radoslaw P. Kozak; Richard A. Gardner; Bas C. Jansen; Daniel I. R. Spencer; Manfred Wuhrer
Opublikowane w: Glycoconjugate Journal, Numer 15, 2021, ISSN 0282-0080
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-10003-1

Histo-blood group glycans in the context of personalized medicine

Autorzy: Viktoria Dotz, Manfred Wuhrer
Opublikowane w: Biochimica et Biophysica Acta (BBA) - General Subjects, Numer 1860/8, 2016, Strona(/y) 1596-1607, ISSN 0304-4165
Wydawca: Elsevier BV
DOI: 10.1016/j.bbagen.2015.12.026

IgG Glycome in Colorectal Cancer

Autorzy: F. Vuckovic, E. Theodoratou, K. Thaci, M. Timofeeva, A. Vojta, J. Stambuk, M. Pucic-Bakovic, P. M. Rudd, L. erek, D. Servis, A. Wennerstro m, S. M. Farrington, M. Perola, Y. Aulchenko, M. G. Dunlop, H. Campbell, G. Lauc
Opublikowane w: Clinical Cancer Research, Numer 22/12, 2016, Strona(/y) 3078-3086, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1867

Mechanisms of disease: The human N-glycome

Autorzy: Gordan Lauc, Marija Pezer, Igor Rudan, Harry Campbell
Opublikowane w: Biochimica et Biophysica Acta (BBA) - General Subjects, Numer 1860/8, 2016, Strona(/y) 1574-1582, ISSN 0304-4165
Wydawca: Elsevier BV
DOI: 10.1016/j.bbagen.2015.10.016

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

Autorzy: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira
Opublikowane w: BMC Cancer, Numer 18/1, 2018, ISSN 1471-2407
Wydawca: BioMed Central
DOI: 10.1186/s12885-018-4410-x

Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling

Autorzy: Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dall’Olio
Opublikowane w: International Journal of Molecular Sciences, Numer 19/2, 2018, Strona(/y) 580, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020580

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autorzy: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Opublikowane w: Frontiers in Oncology, Numer 8, 2018, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Serum sialylation changes in cancer

Autorzy: Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Opublikowane w: Glycoconjugate Journal, Numer 35/2, 2018, Strona(/y) 139-160, ISSN 0282-0080
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications

Autorzy: Ana Momčilović; Noortje de Haan; Agnes L. Hipgrave Ederveen; Albert Bondt; Carolien A. M. Koeleman; David Falck; Louise A. de Neef; Wilma E. Mesker; Rob A. E. M. Tollenaar; Arnoud H. de Ru; Peter A. van Veelen; Manfred Wuhrer; Viktoria Dotz
Opublikowane w: Analytical Chemistry, Numer 1, 2020, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.9b05722

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State

Autorzy: Athanasios Blanas, Anouk Zaal , Irene van der Haar Àvila , Maxime Kempers , Laura Kruijssen, Mike de Kok , Marko A. Popovic, Joost C. van der Horst and Sandra J. van Vliet
Opublikowane w: Cancers, 2020, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092580

N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity

Autorzy: Martina Pirro; Yassene Mohammed; Sandra J. van Vliet; Yoann Rombouts; Agnese Sciacca; Arnoud H. de Ru; George M.C. Janssen; Rayman T. N. Tjokrodirijo; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Opublikowane w: VOLUME=21;ISSUE=15;STARTPAGE=1;ENDPAGE=13;ISSN=1661-6596;TITLE=International Journal of Molecular Sciences, Numer 1, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155522

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.

Autorzy: Kotsias, Maximilianos; Kozak, Radoslaw P.; Gardner, Richard A.; Wuhrer, Manfred; Spencer, Daniel I. R.
Opublikowane w: PLoS ONE, Numer 2, 2019, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0210759

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Autorzy: Lenneke A. M. Cornelissen, Athanasios Blanas†, Anouk Zaal†, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk and Sandra J. van Vliet*
Opublikowane w: FRONTIERS IN ONCOLOGY, 2020, ISSN 2234-943X
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01622

High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin

Autorzy: Šimunović, Jelena; Gašperšič, Jernej; Černigoj, Urh; Vidič, Jana; Štrancar, Aleš; Novokmet, Mislav; Razdorov, Genadij; Pezer, Marija; Lauc, Gordan; Trbojević-Akmačić, Irena
Opublikowane w: Biotechnology and Bioengineering, 2022, ISSN 0006-3592
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28280

L1CAM as an E-selectin Ligand in Colon Cancer

Autorzy: Fanny M. Deschepper; Roberta Zoppi; Martina Pirro; Paul J. Hensbergen; Fabio Dall'Olio; Maximillianos Kotsias; Richard A. Gardner; Daniel I. R. Spencer; Paula A. Videira
Opublikowane w: International Journal of Molecular Sciences, 21(21). MDPI, Numer 11, 2020, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218286

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode

Autorzy: Katarina Madunić, Sander Wagt, Tao Zhang, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Opublikowane w: Analytical Chemistry, Numer 93/18, 2021, Strona(/y) 6919-6923, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.

Autorzy: Venturi, Giulia; Gomes Ferreira, Inês; Pucci, Michela; Ferracin, Manuela; Malagolini, Nadia; Chiricolo, Mariella; Dall’Olio, Fabio
Opublikowane w: Glycobiology, Numer 11, 2019, ISSN 1460-2423
Wydawca: Oxford Academic
DOI: 10.1093/glycob/cwz053

The Many Ways by Which O -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations.

Autorzy: Biwi, James; Biot, Christophe; Guerardel, Yann; Vercoutter-Edouart, Anne-Sophie; Lefebvre, Tony
Opublikowane w: "Molecules, MDPI, 2018, 23 (11), pp.2858. ⟨10.3390/molecules23112858⟩", Numer 1, 2018, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23112858

UNRAVELING MUCIN TYPE OGLYCOSYLATIONSIGNATURESOF COLORECTAL CANCER

Autorzy: Katarina Madunic
Opublikowane w: 2022, ISBN 978-94-6458-073-0
Wydawca: Ridderprint

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