Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics

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Completion of doctoral theses of the GlyCoCan ESRs

Pubblicazioni

Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation

Autori: Di Wang, Tao Zhang, Katarina Madunić, Antonius A. de Waard, Constantin Blöchl, Oleg A. Mayboroda, Marieke Griffioen, Robbert M. Spaapen, Christian G. Huber, Guinevere S.M. Lageveen-Kammeijer, and Manfred Wuhrer
Pubblicato in: Journal of proteome Research, 2022, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.1c00911

Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines

Autori: Martina Pirro; Yoann Rombouts; Alexandre Stella; Olivier Neyrolles; Odile Burlet-Schiltz; Sandra J. van Vliet; Arnoud H. de Ru; Yassene Mohammed; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Pubblicato in: "Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 2020, 1864 (4), pp.129513. ⟨10.1016/j.bbagen.2020.129513⟩", Numero 7, 2020, ISSN 1872-8006
Editore: Elsevier
DOI: 10.1016/j.bbagen.2020.129513

Serum protein N-glycosylation changes in multiple myeloma

Autori: Zejian Zhang, Marita Westhrin, Albert Bondt, Manfred Wuhrer, Therese Standal, Stephanie Holst
Pubblicato in: Biochimica et Biophysica Acta, 2019, ISSN 0006-3002
Editore: Elsevier
DOI: 10.1016/j.bbagen.2019.03.001

A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases.

Autori: Colin Ruprecht; Colin Ruprecht; Max Peter Bartetzko; Max Peter Bartetzko; Deborah Senf; Deborah Senf; Anna Lakhina; Peter J. Smith; Maria J. Soto; Maria J. Soto; Hyunil Oh; Hyunil Oh; Jeong-Yeh Yang; Digantkumar Chapla; Daniel Varón Silva; Mads Hartvig Clausen; Michael G. Hahn; Kelley W. Moremen; Breeanna R. Urbanowicz; Fabian Pfrengle; Fabian Pfrengle; Fabian Pfrengle
Pubblicato in: Angewandte Chemie, Numero 1, 2020, ISSN 0044-8249
Editore: Weinheim-Wiley-VCH
DOI: 10.1002/ange.202003105

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

Autori: Jelena Simunovic, Marija Vilaj, Irena Trbojevic-Akmacic, Ana Momcilovic, Frano Vuckovic, Ivan Gudelj, Julija Juric, Natali Nakic, Gordan Lauc, Marija Pezer
Pubblicato in: Glycobiology, 2019, ISSN 1460-2423
Editore: Oxford Academic
DOI: 10.1093/glycob/cwz061

OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines

Autori: James Biwi,Charlotte Clarisse,Christophe Biot,Radoslaw Pawel Kozak,Katarina Madunic,Marlène Mortuaire,Manfred Wuhrer,Daniel Ian Richard Spencer,Céline Schulz,Yann Guerardel,Tony Lefebvre,Anne-Sophie Vercoutter-Edouart
Pubblicato in: Proteomics, 2019, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201800452

The Role of Glycosphingolipids in Immune Cell Functions.

Autori: Tao Zhang; Antonius A. de Waard; Antonius A. de Waard; Manfred Wuhrer; Robbert M. Spaapen; Robbert M. Spaapen
Pubblicato in: Frontiers in Immunology, Vol 10 (2019), Numero 1, 2019, ISSN 1664-3224
Editore: Frontiers Editorial Office
DOI: 10.3389/fimmu.2019.00090

Colorectal cancer cell lines show striking diversity of their O- glycome reflecting the cellular differentiation phenotype

Autori: Katarina Madunić; Tao Zhang; Oleg A. Mayboroda; Stephanie Holst; Kathrin Stavenhagen; Chunsheng Jin; Niclas G. Karlsson; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer
Pubblicato in: Cellular and Molecular Life Sciences, Numero 10, 2020, ISSN 0014-4754
Editore: Spinger-Link
DOI: 10.1007/s00018-020-03504-z

Plasma N-glycome composition associates with chronic low back pain

Autori: IrenaTrbojević-AkmačićaFranoVučkovićaMarijaVilajaAndreaSkelinakLennart C.KarssenbJasminkaKrištićaJulijaJurićaAnaMomčilovićacJelenaŠimunovićaMassimoManginodeManuelaDe GregorifgMaurizioMarchesinighConcettaDagostinogiJerkoŠtambukaMislavNovokmetaRichardRauckjYurii S.AulchenkobDraganPrimoracklmnoLeonardoKapuraljKlaasBuysepDieterMesottenpFrances M.K.WilliamsdJanvan ZundertpMassimoAllegrigqG
Pubblicato in: Biochimica et Biophysica Acta (BBA), 2018, ISSN 0006-3002
Editore: Science Direct
DOI: 10.1016/j.bbagen.2018.07.003

Site-Specific N-Linked Glycosylation Analysis of Human Carcinoembryonic Antigen by Sheathless Capillary Electrophoresis-Tandem Mass Spectrometry

Autori: Laura Pont; Valeriia Kuzyk; Valeriia Kuzyk; Fernando Benavente; Victoria Sanz-Nebot; Oleg A. Mayboroda; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Pubblicato in: VOLUME=20;ISSUE=3;STARTPAGE=1666;ENDPAGE=1675;ISSN=1535-3893;TITLE=Journal of Proteome Research, Numero 1, 2021, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00875

Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)

Autori: Martina Pirro, Yassene Mohammed, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Katarina Madunić, Manfred Wuhrer, Peter A. van Veelen, Paul J. Hensbergen
Pubblicato in: International Journal of Molecular Sciences, Numero 22/10, 2021, Pagina/e 5369, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22105369

Colon-specific immune microenvironment regulates cancer progression versus rejection

Autori: Giulia Trimaglio; Anne-Françoise Tilkin-Mariamé; Virginie Feliu; Françoise Lauzeral-Vizcaino; Marie Tosolini; Carine Valle; Maha Ayyoub; Maha Ayyoub; Olivier Neyrolles; Nathalie Vergnolle; Yoann Rombouts; Christel Devaud
Pubblicato in: OncoImmunology, Numero 7, 2020, ISSN 2162-4011
Editore: Landes Bioscience
DOI: 10.1101/2020.01.02.892711

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations

Autori: JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang
Pubblicato in: Journal of human hypertention, 2018, ISSN 0950-9240
Editore: Nature Publishing Group
DOI: 10.1038/s41371-018-0071-0

A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy

Autori: Rui P.S.Patrício, Paula A.Videira, Florbela Pereira
Pubblicato in: BIOORGANIC & MEDICINAL CHEMISTRY, 2022, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116530

A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases

Autori: Colin Ruprecht, Max P. Bartetzko, Deborah Senf, Anna Lakhina, Peter J. Smith, Maria J. Soto, Hyunil Oh, Jeong‐Yeh Yang, Digantkumar Chapla, Daniel Varon Silva, Mads H. Clausen, Michael G. Hahn, Kelley W. Moremen, Breeanna R. Urbanowicz, Fabian Pfrengle
Pubblicato in: Angewandte Chemie, Numero 132/30, 2020, Pagina/e 12593-12598, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202003105

Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.

Autori: Pirro, Martina; Schoof, Esmee; van Vliet, Sandra J.; Rombouts, Yoann; Stella, Alexandre; de Ru, Arnoud; Mohammed, Yassene; Wuhrer, Manfred; van Veelen, Peter A.; Hensbergen, Paul J.
Pubblicato in: VOLUME=18;ISSUE=3;STARTPAGE=1125;ENDPAGE=1132;ISSN=1535-3893;TITLE=Journal of Proteome Research, Numero 16, 2018, ISSN 1535-3893
Editore: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00796

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells

Autori: Joost C van der Horst, Henri J van de Vrugt, Hakan Kalay, Daniel I R Spencer, Rad P Kozak, Sandra J van Vliet
Pubblicato in: Glycobiology, 2018, ISSN 0959-6658
Editore: Oxford University Press
DOI: 10.1093/glycob/cwy096

The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition

Autori: Michela Pucci; Inês Gomes Ferreira; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Pubblicato in: Numero 18, Numero 1, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21186558

High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer

Autori: Michela Pucci; Inês Gomes Ferreira; Martina Orlandani; Nadia Malagolini; Manuela Ferracin; Fabio Dall'Olio
Pubblicato in: Cells, Vol 9, Iss 948, p 948 (2020), Numero 2, 2020, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells9040948

Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis.

Autori: Kotsias, Maximilianos; Blanas, Athanasios; van Vliet, Sandra J.; Pirro, Martina; Spencer, Daniel I. R.; Kozak, Radoslaw P.
Pubblicato in: Plos One, Numero 1, 2019, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0223270

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.

Autori: Katarina Madunić; Sander Wagt; Tao Zhang; Manfred Wuhrer; Guinevere S. M. Lageveen-Kammeijer
Pubblicato in: VOLUME=93;ISSUE=18;STARTPAGE=6919;ENDPAGE=6923;TITLE=Analytical Chemistry, Numero 8, 2021, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

O- and N-glycosylation analysis of cell lines by ultrahigh resolution MALDI-FTICR-MS

Autori: Gerda C M Vreeker; Simone Nicolardi; Katarina Madunić; Maximilianos Kotsias; Yuri E. M. van der Burgt; Manfred Wuhrer
Pubblicato in: International Journal of Mass Spectrometry, Numero 1, 2020, ISSN 1873-2798
Editore: Amsterdam Elsevier B>V>
DOI: 10.1016/j.ijms.2019.116267

MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

Autori: Zélia Silva; Tiago Ferro; Danielle Almeida; Helena Soares; José Alexandre Ferreira; Fanny M. Deschepper; Paul J. Hensbergen; Martina Pirro; Sandra J. van Vliet; Sebastian Springer; Paula A. Videira
Pubblicato in: Pharmaceutics, Numero 12, 2020, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12030249

Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis

Autori: Lenneke A.M. Cornelissen,Athanasios Blanas,Joost C. van der Horst,Laura Kruijssen,Anouk Zaal,Tom O'Toole,Lieke Wiercx,Yvette van Kooyk,Sandra J. van Vliet
Pubblicato in: International journal of cancer, 2018, ISSN 1097-0215
Editore: Wiley Online Library
DOI: 10.1002/ijc.32084

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry.

Autori: Tao Zhang; Katarina Madunić; Stephanie Holst; Jing Zhang; Chunsheng Jin; Peter ten Dijke; Niclas G. Karlsson; Kathrin Stavenhagen; Manfred Wuhrer
Pubblicato in: Molecular Omics, Numero 1, 2020, ISSN 2515-4184
Editore: The Royal Society of Chemistry’s
DOI: 10.1039/c9mo00180h

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS

Autori: Maximilianos Kotsias; Katarina Madunić; Simone Nicolardi; Radoslaw P. Kozak; Richard A. Gardner; Bas C. Jansen; Daniel I. R. Spencer; Manfred Wuhrer
Pubblicato in: Glycoconjugate Journal, Numero 15, 2021, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-021-10003-1

Histo-blood group glycans in the context of personalized medicine

Autori: Viktoria Dotz, Manfred Wuhrer
Pubblicato in: Biochimica et Biophysica Acta (BBA) - General Subjects, Numero 1860/8, 2016, Pagina/e 1596-1607, ISSN 0304-4165
Editore: Elsevier BV
DOI: 10.1016/j.bbagen.2015.12.026

IgG Glycome in Colorectal Cancer

Autori: F. Vuckovic, E. Theodoratou, K. Thaci, M. Timofeeva, A. Vojta, J. Stambuk, M. Pucic-Bakovic, P. M. Rudd, L. erek, D. Servis, A. Wennerstro m, S. M. Farrington, M. Perola, Y. Aulchenko, M. G. Dunlop, H. Campbell, G. Lauc
Pubblicato in: Clinical Cancer Research, Numero 22/12, 2016, Pagina/e 3078-3086, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-15-1867

Mechanisms of disease: The human N-glycome

Autori: Gordan Lauc, Marija Pezer, Igor Rudan, Harry Campbell
Pubblicato in: Biochimica et Biophysica Acta (BBA) - General Subjects, Numero 1860/8, 2016, Pagina/e 1574-1582, ISSN 0304-4165
Editore: Elsevier BV
DOI: 10.1016/j.bbagen.2015.10.016

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

Autori: Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira
Pubblicato in: BMC Cancer, Numero 18/1, 2018, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-018-4410-x

Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling

Autori: Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo and Fabio Dall’Olio
Pubblicato in: International Journal of Molecular Sciences, Numero 19/2, 2018, Pagina/e 580, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020580

Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Autori: Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet
Pubblicato in: Frontiers in Oncology, Numero 8, 2018, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00039

Serum sialylation changes in cancer

Autori: Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Pubblicato in: Glycoconjugate Journal, Numero 35/2, 2018, Pagina/e 139-160, ISSN 0282-0080
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10719-018-9820-0

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications

Autori: Ana Momčilović; Noortje de Haan; Agnes L. Hipgrave Ederveen; Albert Bondt; Carolien A. M. Koeleman; David Falck; Louise A. de Neef; Wilma E. Mesker; Rob A. E. M. Tollenaar; Arnoud H. de Ru; Peter A. van Veelen; Manfred Wuhrer; Viktoria Dotz
Pubblicato in: Analytical Chemistry, Numero 1, 2020, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.9b05722

FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State

Autori: Athanasios Blanas, Anouk Zaal , Irene van der Haar Àvila , Maxime Kempers , Laura Kruijssen, Mike de Kok , Marko A. Popovic, Joost C. van der Horst and Sandra J. van Vliet
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092580

N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity

Autori: Martina Pirro; Yassene Mohammed; Sandra J. van Vliet; Yoann Rombouts; Agnese Sciacca; Arnoud H. de Ru; George M.C. Janssen; Rayman T. N. Tjokrodirijo; Manfred Wuhrer; Peter A. van Veelen; Paul J. Hensbergen
Pubblicato in: VOLUME=21;ISSUE=15;STARTPAGE=1;ENDPAGE=13;ISSN=1661-6596;TITLE=International Journal of Molecular Sciences, Numero 1, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155522

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.

Autori: Kotsias, Maximilianos; Kozak, Radoslaw P.; Gardner, Richard A.; Wuhrer, Manfred; Spencer, Daniel I. R.
Pubblicato in: PLoS ONE, Numero 2, 2019, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0210759

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer

Autori: Lenneke A. M. Cornelissen, Athanasios Blanas†, Anouk Zaal†, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk and Sandra J. van Vliet*
Pubblicato in: FRONTIERS IN ONCOLOGY, 2020, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.01622

High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin

Autori: Šimunović, Jelena; Gašperšič, Jernej; Černigoj, Urh; Vidič, Jana; Štrancar, Aleš; Novokmet, Mislav; Razdorov, Genadij; Pezer, Marija; Lauc, Gordan; Trbojević-Akmačić, Irena
Pubblicato in: Biotechnology and Bioengineering, 2022, ISSN 0006-3592
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.28280

L1CAM as an E-selectin Ligand in Colon Cancer

Autori: Fanny M. Deschepper; Roberta Zoppi; Martina Pirro; Paul J. Hensbergen; Fabio Dall'Olio; Maximillianos Kotsias; Richard A. Gardner; Daniel I. R. Spencer; Paula A. Videira
Pubblicato in: International Journal of Molecular Sciences, 21(21). MDPI, Numero 11, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21218286

Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode

Autori: Katarina Madunić, Sander Wagt, Tao Zhang, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Pubblicato in: Analytical Chemistry, Numero 93/18, 2021, Pagina/e 6919-6923, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.1c00023

Impact of sialyltransferase ST6GAL1 overexpression on different colon cancer cell types.

Autori: Venturi, Giulia; Gomes Ferreira, Inês; Pucci, Michela; Ferracin, Manuela; Malagolini, Nadia; Chiricolo, Mariella; Dall’Olio, Fabio
Pubblicato in: Glycobiology, Numero 11, 2019, ISSN 1460-2423
Editore: Oxford Academic
DOI: 10.1093/glycob/cwz053

The Many Ways by Which O -GlcNAcylation May Orchestrate the Diversity of Complex Glycosylations.

Autori: Biwi, James; Biot, Christophe; Guerardel, Yann; Vercoutter-Edouart, Anne-Sophie; Lefebvre, Tony
Pubblicato in: "Molecules, MDPI, 2018, 23 (11), pp.2858. ⟨10.3390/molecules23112858⟩", Numero 1, 2018, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23112858

UNRAVELING MUCIN TYPE OGLYCOSYLATIONSIGNATURESOF COLORECTAL CANCER

Autori: Katarina Madunic
Pubblicato in: 2022, ISBN 978-94-6458-073-0
Editore: Ridderprint

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