A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Strategies for Conditional Regulation of Proteins

Author(s): Karthik Nadendla; Grant G. Simpson; Julie Becher; Toby Journeaux; Mar Cabeza-Cabrerizo; Gonçalo J. L. Bernardes
Published in: Crossref, Issue 1, 2023, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00654

The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer

Author(s): Somovilla, V., Bermejo, I., Albuquerque, I., Martínez-Sáez, N., Castro-López, J., García-Martín, F., Compañón, I., Hinou, H., Nishimura, S., Jiménez-Barbero, J., Asensio, J., Avenoza, A., Busto, Hurtado-Guerrero, R., Peregrina, J., Lopes Bernardes, G., & Corzana, F.
Published in: J. Am. Chem. Soc., 2017, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b09447

Site-selective installation of an electrophilic handle on proteins for bioconjugation

Author(s): Lee, B., Sun, S., Jiménez-Moreno, E., Neves, A. A., & Bernardes, G. J.
Published in: Bioorganic & Medicinal Chemistry, 2018, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.02.028

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation.

Author(s): Gil De Montes, Enrique; Istrate, Alena; Navo, Claudio D; Jiménez-Moreno, Ester; Hoyt, Emily A; Corzana, Francisco; Robina, Inmaculada; Jiménez-Osés, Gonzalo; Moreno-Vargas, Antonio J; Bernardes, Gonçalo JL
Published in: Angewandte Chemie International Edition, Issue 2, 2020, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914529

Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions

Author(s): Zbigniew Zawada; Zijian Guo; Bruno L. Oliveira; Bruno L. Oliveira; Claudio D. Navo; He Li; Pedro M. S. D. Cal; Francisco Corzana; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Published in: Bioconjugate Chemistry, Issue 4, 2021, ISSN 1520-4812
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00276

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

Author(s): Kwan, T. T.-L., Boutureira, O., Frye, E. C., Walsh, S. J., Gupta, M. K., Wallace, S., Wu, Y., Zhang, F., Sore, H. F., Galloway, W. R. J. D., Chin, J. W., Welch, M., Bernardes, G. J. L., Spring, D. R.
Published in: Chemical Science, 2017, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6sc05313k

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.

Author(s): Juraj Konč; Valerio Sabatino; Ester Jiménez-Moreno; Eloah Latocheski; Laura Rodríguez Pérez; Jason Day; Josiel B. Domingos; Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 4, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202113519

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Author(s): Cal, P. M. S. D., Sieglitz, F., Santos, F. M. F., Parente Carvalho, C., Guerreiro, A., Bertoldo, J. B., Pischel, U., Gois, P. M. P., Bernardes, G. J. L.
Published in: Chemical Communications, 2017, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6cc08671c

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides

Author(s): Sun, S., Compañón, I., Martínez‐Sáez, N., Seixas, J. D., Boutureira, O., Corzana, F., & Bernardes, G. J. L.
Published in: ChemBioChem, 2017, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201700586

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

Author(s): Tiago Rodrigues, Florian Sieglitz, Gonçalo J. L. Bernardes
Published in: Chemical Society Reviews, 2016, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/c5cs00916b

Oxidative Activation of C-S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Author(s): Kitowski, A., Jiménez-Moreno, E., Salvadó, M., Mestre, J., Castillón, S., Jiménez-Osés, G., Boutureira, O., & Bernardes, G. J.
Published in: Organic Letters, 2017, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.7b02886

Site-Selective Modification of Proteins with Oxetanes

Author(s): Boutureira, O., Martínez‐Sáez, N., Brindle, K. M., Neves, A. A., Corzana, F., & Bernardes, G. J. L.
Published in: Chemistry – A European Journal, 2017, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700745

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism

Author(s): Zwicker, V. E., Oliveira, B. L., Yeo, J. H., Fraser, S. T., Bernardes, G. J., New, E. J., & Jolliffe, K. A.
Published in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201812489

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Author(s): Cal, P., Matos, M., Bernardes, G.
Published in: Expert Opinion on Therapeutic Patents, 2017, ISSN 1354-3776
Publisher: Ashley Publications Ltd.
DOI: 10.1080/13543776.2017.1259411

Inverse electron demand Diels–Alder reactions in chemical biology

Author(s): B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Published in: Chemical Society Reviews, Issue 46/16, 2017, Page(s) 4895-4950, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cs00184c

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

Author(s): Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Published in: Journal of the American Chemical Society, Issue 139/50, 2017, Page(s) 18365-18375, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b10702

A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells

Author(s): Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 55/47, 2016, Page(s) 14683-14687, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201608438

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Author(s): Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Nature Communications, Issue 7, 2016, Page(s) 13128, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms13128

Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation

Author(s): Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael Compañón, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 58/20, 2019, Page(s) 6640-6644, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201901405

Chemo- and Regioselective Lysine Modification on Native Proteins

Author(s): Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Journal of the American Chemical Society, Issue 140/11, 2018, Page(s) 4004-4017, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b12874

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Author(s): Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Published in: Leukemia, Issue 33/9, 2019, Page(s) 2155-2168, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Author(s): Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L. Oliveira, Claudio D. Navo, Pedro M. S. D. Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J. Moreno-Vargas, Gonçalo J. L. Bernardes
Published in: Chemical Science, Issue 10/16, 2019, Page(s) 4515-4522, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc00125e

Ethynylbenziodoxolone Reactivity in Cysteine Bioconjugation

Author(s): Srinivasa Rao Adusumalli, Gonçalo J.L. Bernardes
Published in: Chem, Issue 5/8, 2019, Page(s) 1932-1934, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2019.07.014

Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice

Author(s): Miguel Chaves-Ferreira, Inês S. Albuquerque, Dijana Matak-Vinkovic, Ana C. Coelho, Sandra M. Carvalho, Lígia M. Saraiva, Carlos C. Romão, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, 2015, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201409344

Chemo- and Regioselective Lysine Modification on Native Proteins.

Author(s): Matos, Maria J; Oliveira, Bruno L; Martínez-Sáez, Nuria; Guerreiro, Ana; Cal, Pedro MSD; Bertoldo, Jean; Maneiro, María; Perkins, Elizabeth; Howard, Julie; Deery, Michael J; Chalker, Justin M; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo JL
Published in: Journal of the American Chemical Society, Issue 12, 2018, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.17863/cam.22987

A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis

Author(s): Kymberley R. Scroggie, Lisa J. Alcock, Maria J. Matos, Gonçalo J. L. Bernardes, Michael V. Perkins, Justin M. Chalker
Published in: Peptide Science, 2018, Page(s) e24069, ISSN 2475-8817
Publisher: John Wiley & Sons, Inc
DOI: 10.1002/pep2.24069

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Author(s): Jean B. Bertoldo; Jean B. Bertoldo; Tiago Rodrigues; Lavinia Dunsmore; Francesco A. Aprile; Marta C. Marques; Leonardo Astolfi Rosado; Omar Boutureira; Thomas Steinbrecher; Woody Sherman; Francisco Corzana; Hernán Terenzi; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Published in: Chem, Issue 10, 2017, ISSN 2451-9294
Publisher: Elsevier
DOI: 10.1016/j.chempr.2017.07.009

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

Author(s): Lavinia Dunsmore, Claudio D. Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R. Ruivo, Tiago Rodrigues, Filipa P. da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Nature Chemistry, 2022, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-022-00964-7

Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells.

Author(s): Shuang Sun; Bruno L. Oliveira; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 5, 2018, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811338

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Author(s): Carvalho, S. B., Freire, J. M., Moleirinho, M. G., Monteiro, F., Gaspar, D., Castanho, M. A. R. B., Carrondo, M. J. T., Alves, P. M., Bernardes, G. J. L., & Peixoto, C.
Published in: Bioconjugate Chemistry, 2016, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00372

Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo

Author(s): Martínez‐Sáez, N., Sun, S., Oldrini, D., Sormanni, P., Boutureira, O., Carboni, F., Compañón, I., Deery, M. J., Vendruscolo, M., Corzana, F., Adamo, R., & Bernardes, G. J. L.
Published in: Angewandte Chemie International Edition, 2017, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708847

Norbornene probes for the study of cysteine oxidation

Author(s): Alcock, L. J., Farrell, K. D., Akol, M. T., Jones, G. H., Tierney, M. M., Kramer, H. B., Pukala, T. L., Bernardes, G. J. L., Perkins, M. V., & Chalker, J. M.
Published in: ACS Chemical Biology, 2019, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.8b01104

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Author(s): Jiménez‐Moreno, E., Guo, Z., Oliveira, B. L., Albuquerque, I. S., Kitowski, A., Guerreiro, A., Boutureira, O., Rodrigues, T., Jiménez‐Osés, G., & Bernardes, G. J. L.
Published in: Angewandte Chemie, 2016, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201609607

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Author(s): Worthington, M. J. H., Kucera, R. L., Albuquerque, I. S., Gibson, C. T., Sibley, A., Slattery, A. D., Campbell, J. A., Alboaiji, S. F. K., Muller, K. A., Young, J., Adamson, N., Gascooke, J. R., Jampaiah, D., Sabri, Y. M., Bhargava, S. K., Ippolito, S. J., Lewis, D. A., Quinton, J. S., Ellis, A. V., Johs, A., Bernardes, G. J. L., Chalker, J. M.
Published in: Chemistry — A European Journal, 2017, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702871

De novo design of potent and selective mimics of IL-2 and IL-15

Author(s): Daniel-Adriano Silva; Shawn Yu; Umut Ulge; Jamie B. Spangler; Jamie B. Spangler; Kevin Jude; Carlos Labão-Almeida; Lestat R. Ali; Alfredo Quijano-Rubio; Mikel Ruterbusch; Isabel Leung; Tamara Biary; Stephanie J. Crowley; Enrique Marcos; Carl Walkey; Brian D. Weitzner; Fátima Pardo-Avila; Javier Castellanos; Lauren Carter; Lance Stewart; Stanley R. Riddell; Marion Pepper; Gonçalo J. L. Bernardes
Published in: Nature, Issue 10, 2019, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0830-7

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides

Author(s): Juraj Konč; Libby Brown; Daniel R. Whiten; Yukun Zuo; Peter Ravn; Peter Ravn; David Klenerman; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 1, 2021, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202109713

Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation

Author(s): Bruno L. Oliveira; Bruno L. Oliveira; Benjamin J Stenton; V B Unnikrishnan; Cátia Rebelo de Almeida; João Conde; Magda Negrão; Felipe S. S. Schneider; Carlos Cordeiro; Miguel Godinho Ferreira; Giovanni F. Caramori; Josiel B. Domingos; Rita Fior; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Published in: Journal of the American Chemical Society, Issue 15, 2020, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c01622

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