A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery

Pubblicazioni

Strategies for Conditional Regulation of Proteins

Autori: Karthik Nadendla; Grant G. Simpson; Julie Becher; Toby Journeaux; Mar Cabeza-Cabrerizo; Gonçalo J. L. Bernardes
Pubblicato in: Crossref, Numero 1, 2023, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.2c00654

The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer

Autori: Somovilla, V., Bermejo, I., Albuquerque, I., Martínez-Sáez, N., Castro-López, J., García-Martín, F., Compañón, I., Hinou, H., Nishimura, S., Jiménez-Barbero, J., Asensio, J., Avenoza, A., Busto, Hurtado-Guerrero, R., Peregrina, J., Lopes Bernardes, G., & Corzana, F.
Pubblicato in: J. Am. Chem. Soc., 2017, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b09447

Site-selective installation of an electrophilic handle on proteins for bioconjugation

Autori: Lee, B., Sun, S., Jiménez-Moreno, E., Neves, A. A., & Bernardes, G. J.
Pubblicato in: Bioorganic & Medicinal Chemistry, 2018, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.02.028

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation.

Autori: Gil De Montes, Enrique; Istrate, Alena; Navo, Claudio D; Jiménez-Moreno, Ester; Hoyt, Emily A; Corzana, Francisco; Robina, Inmaculada; Jiménez-Osés, Gonzalo; Moreno-Vargas, Antonio J; Bernardes, Gonçalo JL
Pubblicato in: Angewandte Chemie International Edition, Numero 2, 2020, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914529

Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions

Autori: Zbigniew Zawada; Zijian Guo; Bruno L. Oliveira; Bruno L. Oliveira; Claudio D. Navo; He Li; Pedro M. S. D. Cal; Francisco Corzana; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Pubblicato in: Bioconjugate Chemistry, Numero 4, 2021, ISSN 1520-4812
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00276

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

Autori: Kwan, T. T.-L., Boutureira, O., Frye, E. C., Walsh, S. J., Gupta, M. K., Wallace, S., Wu, Y., Zhang, F., Sore, H. F., Galloway, W. R. J. D., Chin, J. W., Welch, M., Bernardes, G. J. L., Spring, D. R.
Pubblicato in: Chemical Science, 2017, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c6sc05313k

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.

Autori: Juraj Konč; Valerio Sabatino; Ester Jiménez-Moreno; Eloah Latocheski; Laura Rodríguez Pérez; Jason Day; Josiel B. Domingos; Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 4, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202113519

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Autori: Cal, P. M. S. D., Sieglitz, F., Santos, F. M. F., Parente Carvalho, C., Guerreiro, A., Bertoldo, J. B., Pischel, U., Gois, P. M. P., Bernardes, G. J. L.
Pubblicato in: Chemical Communications, 2017, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c6cc08671c

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides

Autori: Sun, S., Compañón, I., Martínez‐Sáez, N., Seixas, J. D., Boutureira, O., Corzana, F., & Bernardes, G. J. L.
Pubblicato in: ChemBioChem, 2017, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201700586

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

Autori: Tiago Rodrigues, Florian Sieglitz, Gonçalo J. L. Bernardes
Pubblicato in: Chemical Society Reviews, 2016, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/c5cs00916b

Oxidative Activation of C-S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Autori: Kitowski, A., Jiménez-Moreno, E., Salvadó, M., Mestre, J., Castillón, S., Jiménez-Osés, G., Boutureira, O., & Bernardes, G. J.
Pubblicato in: Organic Letters, 2017, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.7b02886

Site-Selective Modification of Proteins with Oxetanes

Autori: Boutureira, O., Martínez‐Sáez, N., Brindle, K. M., Neves, A. A., Corzana, F., & Bernardes, G. J. L.
Pubblicato in: Chemistry – A European Journal, 2017, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700745

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism

Autori: Zwicker, V. E., Oliveira, B. L., Yeo, J. H., Fraser, S. T., Bernardes, G. J., New, E. J., & Jolliffe, K. A.
Pubblicato in: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201812489

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Autori: Cal, P., Matos, M., Bernardes, G.
Pubblicato in: Expert Opinion on Therapeutic Patents, 2017, ISSN 1354-3776
Editore: Ashley Publications Ltd.
DOI: 10.1080/13543776.2017.1259411

Inverse electron demand Diels–Alder reactions in chemical biology

Autori: B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Pubblicato in: Chemical Society Reviews, Numero 46/16, 2017, Pagina/e 4895-4950, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/c7cs00184c

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

Autori: Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Pubblicato in: Journal of the American Chemical Society, Numero 139/50, 2017, Pagina/e 18365-18375, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b10702

A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells

Autori: Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 55/47, 2016, Pagina/e 14683-14687, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201608438

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Autori: Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Nature Communications, Numero 7, 2016, Pagina/e 13128, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms13128

Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation

Autori: Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael Compañón, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 58/20, 2019, Pagina/e 6640-6644, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201901405

Chemo- and Regioselective Lysine Modification on Native Proteins

Autori: Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Journal of the American Chemical Society, Numero 140/11, 2018, Pagina/e 4004-4017, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b12874

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Autori: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Pubblicato in: Leukemia, Numero 33/9, 2019, Pagina/e 2155-2168, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Autori: Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L. Oliveira, Claudio D. Navo, Pedro M. S. D. Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J. Moreno-Vargas, Gonçalo J. L. Bernardes
Pubblicato in: Chemical Science, Numero 10/16, 2019, Pagina/e 4515-4522, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c9sc00125e

Ethynylbenziodoxolone Reactivity in Cysteine Bioconjugation

Autori: Srinivasa Rao Adusumalli, Gonçalo J.L. Bernardes
Pubblicato in: Chem, Numero 5/8, 2019, Pagina/e 1932-1934, ISSN 2451-9294
Editore: Cell Press
DOI: 10.1016/j.chempr.2019.07.014

Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice

Autori: Miguel Chaves-Ferreira, Inês S. Albuquerque, Dijana Matak-Vinkovic, Ana C. Coelho, Sandra M. Carvalho, Lígia M. Saraiva, Carlos C. Romão, Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, 2015, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201409344

Chemo- and Regioselective Lysine Modification on Native Proteins.

Autori: Matos, Maria J; Oliveira, Bruno L; Martínez-Sáez, Nuria; Guerreiro, Ana; Cal, Pedro MSD; Bertoldo, Jean; Maneiro, María; Perkins, Elizabeth; Howard, Julie; Deery, Michael J; Chalker, Justin M; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo JL
Pubblicato in: Journal of the American Chemical Society, Numero 12, 2018, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.17863/cam.22987

A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis

Autori: Kymberley R. Scroggie, Lisa J. Alcock, Maria J. Matos, Gonçalo J. L. Bernardes, Michael V. Perkins, Justin M. Chalker
Pubblicato in: Peptide Science, 2018, Pagina/e e24069, ISSN 2475-8817
Editore: John Wiley & Sons, Inc
DOI: 10.1002/pep2.24069

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Autori: Jean B. Bertoldo; Jean B. Bertoldo; Tiago Rodrigues; Lavinia Dunsmore; Francesco A. Aprile; Marta C. Marques; Leonardo Astolfi Rosado; Omar Boutureira; Thomas Steinbrecher; Woody Sherman; Francisco Corzana; Hernán Terenzi; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Pubblicato in: Chem, Numero 10, 2017, ISSN 2451-9294
Editore: Elsevier
DOI: 10.1016/j.chempr.2017.07.009

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

Autori: Lavinia Dunsmore, Claudio D. Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R. Ruivo, Tiago Rodrigues, Filipa P. da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Nature Chemistry, 2022, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-022-00964-7

Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells.

Autori: Shuang Sun; Bruno L. Oliveira; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 5, 2018, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811338

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Autori: Carvalho, S. B., Freire, J. M., Moleirinho, M. G., Monteiro, F., Gaspar, D., Castanho, M. A. R. B., Carrondo, M. J. T., Alves, P. M., Bernardes, G. J. L., & Peixoto, C.
Pubblicato in: Bioconjugate Chemistry, 2016, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00372

Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo

Autori: Martínez‐Sáez, N., Sun, S., Oldrini, D., Sormanni, P., Boutureira, O., Carboni, F., Compañón, I., Deery, M. J., Vendruscolo, M., Corzana, F., Adamo, R., & Bernardes, G. J. L.
Pubblicato in: Angewandte Chemie International Edition, 2017, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708847

Norbornene probes for the study of cysteine oxidation

Autori: Alcock, L. J., Farrell, K. D., Akol, M. T., Jones, G. H., Tierney, M. M., Kramer, H. B., Pukala, T. L., Bernardes, G. J. L., Perkins, M. V., & Chalker, J. M.
Pubblicato in: ACS Chemical Biology, 2019, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b01104

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Autori: Jiménez‐Moreno, E., Guo, Z., Oliveira, B. L., Albuquerque, I. S., Kitowski, A., Guerreiro, A., Boutureira, O., Rodrigues, T., Jiménez‐Osés, G., & Bernardes, G. J. L.
Pubblicato in: Angewandte Chemie, 2016, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201609607

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Autori: Worthington, M. J. H., Kucera, R. L., Albuquerque, I. S., Gibson, C. T., Sibley, A., Slattery, A. D., Campbell, J. A., Alboaiji, S. F. K., Muller, K. A., Young, J., Adamson, N., Gascooke, J. R., Jampaiah, D., Sabri, Y. M., Bhargava, S. K., Ippolito, S. J., Lewis, D. A., Quinton, J. S., Ellis, A. V., Johs, A., Bernardes, G. J. L., Chalker, J. M.
Pubblicato in: Chemistry — A European Journal, 2017, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702871

De novo design of potent and selective mimics of IL-2 and IL-15

Autori: Daniel-Adriano Silva; Shawn Yu; Umut Ulge; Jamie B. Spangler; Jamie B. Spangler; Kevin Jude; Carlos Labão-Almeida; Lestat R. Ali; Alfredo Quijano-Rubio; Mikel Ruterbusch; Isabel Leung; Tamara Biary; Stephanie J. Crowley; Enrique Marcos; Carl Walkey; Brian D. Weitzner; Fátima Pardo-Avila; Javier Castellanos; Lauren Carter; Lance Stewart; Stanley R. Riddell; Marion Pepper; Gonçalo J. L. Bernardes
Pubblicato in: Nature, Numero 10, 2019, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0830-7

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides

Autori: Juraj Konč; Libby Brown; Daniel R. Whiten; Yukun Zuo; Peter Ravn; Peter Ravn; David Klenerman; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 1, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202109713

Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation

Autori: Bruno L. Oliveira; Bruno L. Oliveira; Benjamin J Stenton; V B Unnikrishnan; Cátia Rebelo de Almeida; João Conde; Magda Negrão; Felipe S. S. Schneider; Carlos Cordeiro; Miguel Godinho Ferreira; Giovanni F. Caramori; Josiel B. Domingos; Rita Fior; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Pubblicato in: Journal of the American Chemical Society, Numero 15, 2020, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c01622

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