A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery

Publicaciones

Strategies for Conditional Regulation of Proteins

Autores: Karthik Nadendla; Grant G. Simpson; Julie Becher; Toby Journeaux; Mar Cabeza-Cabrerizo; Gonçalo J. L. Bernardes
Publicado en: Crossref, Edición 1, 2023, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacsau.2c00654

The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer

Autores: Somovilla, V., Bermejo, I., Albuquerque, I., Martínez-Sáez, N., Castro-López, J., García-Martín, F., Compañón, I., Hinou, H., Nishimura, S., Jiménez-Barbero, J., Asensio, J., Avenoza, A., Busto, Hurtado-Guerrero, R., Peregrina, J., Lopes Bernardes, G., & Corzana, F.
Publicado en: J. Am. Chem. Soc., 2017, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b09447

Site-selective installation of an electrophilic handle on proteins for bioconjugation

Autores: Lee, B., Sun, S., Jiménez-Moreno, E., Neves, A. A., & Bernardes, G. J.
Publicado en: Bioorganic & Medicinal Chemistry, 2018, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.02.028

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation.

Autores: Gil De Montes, Enrique; Istrate, Alena; Navo, Claudio D; Jiménez-Moreno, Ester; Hoyt, Emily A; Corzana, Francisco; Robina, Inmaculada; Jiménez-Osés, Gonzalo; Moreno-Vargas, Antonio J; Bernardes, Gonçalo JL
Publicado en: Angewandte Chemie International Edition, Edición 2, 2020, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201914529

Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions

Autores: Zbigniew Zawada; Zijian Guo; Bruno L. Oliveira; Bruno L. Oliveira; Claudio D. Navo; He Li; Pedro M. S. D. Cal; Francisco Corzana; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Publicado en: Bioconjugate Chemistry, Edición 4, 2021, ISSN 1520-4812
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00276

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

Autores: Kwan, T. T.-L., Boutureira, O., Frye, E. C., Walsh, S. J., Gupta, M. K., Wallace, S., Wu, Y., Zhang, F., Sore, H. F., Galloway, W. R. J. D., Chin, J. W., Welch, M., Bernardes, G. J. L., Spring, D. R.
Publicado en: Chemical Science, 2017, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c6sc05313k

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.

Autores: Juraj Konč; Valerio Sabatino; Ester Jiménez-Moreno; Eloah Latocheski; Laura Rodríguez Pérez; Jason Day; Josiel B. Domingos; Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 4, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202113519

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Autores: Cal, P. M. S. D., Sieglitz, F., Santos, F. M. F., Parente Carvalho, C., Guerreiro, A., Bertoldo, J. B., Pischel, U., Gois, P. M. P., Bernardes, G. J. L.
Publicado en: Chemical Communications, 2017, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c6cc08671c

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides

Autores: Sun, S., Compañón, I., Martínez‐Sáez, N., Seixas, J. D., Boutureira, O., Corzana, F., & Bernardes, G. J. L.
Publicado en: ChemBioChem, 2017, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201700586

Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents

Autores: Tiago Rodrigues, Florian Sieglitz, Gonçalo J. L. Bernardes
Publicado en: Chemical Society Reviews, 2016, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/c5cs00916b

Oxidative Activation of C-S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Autores: Kitowski, A., Jiménez-Moreno, E., Salvadó, M., Mestre, J., Castillón, S., Jiménez-Osés, G., Boutureira, O., & Bernardes, G. J.
Publicado en: Organic Letters, 2017, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.7b02886

Site-Selective Modification of Proteins with Oxetanes

Autores: Boutureira, O., Martínez‐Sáez, N., Brindle, K. M., Neves, A. A., Corzana, F., & Bernardes, G. J. L.
Publicado en: Chemistry – A European Journal, 2017, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700745

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism

Autores: Zwicker, V. E., Oliveira, B. L., Yeo, J. H., Fraser, S. T., Bernardes, G. J., New, E. J., & Jolliffe, K. A.
Publicado en: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201812489

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Autores: Cal, P., Matos, M., Bernardes, G.
Publicado en: Expert Opinion on Therapeutic Patents, 2017, ISSN 1354-3776
Editor: Ashley Publications Ltd.
DOI: 10.1080/13543776.2017.1259411

Inverse electron demand Diels–Alder reactions in chemical biology

Autores: B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Publicado en: Chemical Society Reviews, Edición 46/16, 2017, Página(s) 4895-4950, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/c7cs00184c

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

Autores: Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Publicado en: Journal of the American Chemical Society, Edición 139/50, 2017, Página(s) 18365-18375, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b10702

A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells

Autores: Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 55/47, 2016, Página(s) 14683-14687, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201608438

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Autores: Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Nature Communications, Edición 7, 2016, Página(s) 13128, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms13128

Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation

Autores: Maria J. Matos, Claudio D. Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L. Saar, Ismael Compañón, Francisco Corzana, Tuomas P. J. Knowles, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 58/20, 2019, Página(s) 6640-6644, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201901405

Chemo- and Regioselective Lysine Modification on Native Proteins

Autores: Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Journal of the American Chemical Society, Edición 140/11, 2018, Página(s) 4004-4017, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b12874

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Autores: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Publicado en: Leukemia, Edición 33/9, 2019, Página(s) 2155-2168, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

Autores: Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L. Oliveira, Claudio D. Navo, Pedro M. S. D. Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J. Moreno-Vargas, Gonçalo J. L. Bernardes
Publicado en: Chemical Science, Edición 10/16, 2019, Página(s) 4515-4522, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c9sc00125e

Ethynylbenziodoxolone Reactivity in Cysteine Bioconjugation

Autores: Srinivasa Rao Adusumalli, Gonçalo J.L. Bernardes
Publicado en: Chem, Edición 5/8, 2019, Página(s) 1932-1934, ISSN 2451-9294
Editor: Cell Press
DOI: 10.1016/j.chempr.2019.07.014

Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice

Autores: Miguel Chaves-Ferreira, Inês S. Albuquerque, Dijana Matak-Vinkovic, Ana C. Coelho, Sandra M. Carvalho, Lígia M. Saraiva, Carlos C. Romão, Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, 2015, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201409344

Chemo- and Regioselective Lysine Modification on Native Proteins.

Autores: Matos, Maria J; Oliveira, Bruno L; Martínez-Sáez, Nuria; Guerreiro, Ana; Cal, Pedro MSD; Bertoldo, Jean; Maneiro, María; Perkins, Elizabeth; Howard, Julie; Deery, Michael J; Chalker, Justin M; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo JL
Publicado en: Journal of the American Chemical Society, Edición 12, 2018, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.17863/cam.22987

A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis

Autores: Kymberley R. Scroggie, Lisa J. Alcock, Maria J. Matos, Gonçalo J. L. Bernardes, Michael V. Perkins, Justin M. Chalker
Publicado en: Peptide Science, 2018, Página(s) e24069, ISSN 2475-8817
Editor: John Wiley & Sons, Inc
DOI: 10.1002/pep2.24069

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Autores: Jean B. Bertoldo; Jean B. Bertoldo; Tiago Rodrigues; Lavinia Dunsmore; Francesco A. Aprile; Marta C. Marques; Leonardo Astolfi Rosado; Omar Boutureira; Thomas Steinbrecher; Woody Sherman; Francisco Corzana; Hernán Terenzi; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Publicado en: Chem, Edición 10, 2017, ISSN 2451-9294
Editor: Elsevier
DOI: 10.1016/j.chempr.2017.07.009

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

Autores: Lavinia Dunsmore, Claudio D. Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R. Ruivo, Tiago Rodrigues, Filipa P. da Cruz, Oliver Werz, George Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Nature Chemistry, 2022, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-022-00964-7

Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells.

Autores: Shuang Sun; Bruno L. Oliveira; Gonzalo Jiménez-Osés; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 5, 2018, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201811338

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Autores: Carvalho, S. B., Freire, J. M., Moleirinho, M. G., Monteiro, F., Gaspar, D., Castanho, M. A. R. B., Carrondo, M. J. T., Alves, P. M., Bernardes, G. J. L., & Peixoto, C.
Publicado en: Bioconjugate Chemistry, 2016, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00372

Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo

Autores: Martínez‐Sáez, N., Sun, S., Oldrini, D., Sormanni, P., Boutureira, O., Carboni, F., Compañón, I., Deery, M. J., Vendruscolo, M., Corzana, F., Adamo, R., & Bernardes, G. J. L.
Publicado en: Angewandte Chemie International Edition, 2017, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708847

Norbornene probes for the study of cysteine oxidation

Autores: Alcock, L. J., Farrell, K. D., Akol, M. T., Jones, G. H., Tierney, M. M., Kramer, H. B., Pukala, T. L., Bernardes, G. J. L., Perkins, M. V., & Chalker, J. M.
Publicado en: ACS Chemical Biology, 2019, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.8b01104

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Autores: Jiménez‐Moreno, E., Guo, Z., Oliveira, B. L., Albuquerque, I. S., Kitowski, A., Guerreiro, A., Boutureira, O., Rodrigues, T., Jiménez‐Osés, G., & Bernardes, G. J. L.
Publicado en: Angewandte Chemie, 2016, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201609607

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Autores: Worthington, M. J. H., Kucera, R. L., Albuquerque, I. S., Gibson, C. T., Sibley, A., Slattery, A. D., Campbell, J. A., Alboaiji, S. F. K., Muller, K. A., Young, J., Adamson, N., Gascooke, J. R., Jampaiah, D., Sabri, Y. M., Bhargava, S. K., Ippolito, S. J., Lewis, D. A., Quinton, J. S., Ellis, A. V., Johs, A., Bernardes, G. J. L., Chalker, J. M.
Publicado en: Chemistry — A European Journal, 2017, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702871

De novo design of potent and selective mimics of IL-2 and IL-15

Autores: Daniel-Adriano Silva; Shawn Yu; Umut Ulge; Jamie B. Spangler; Jamie B. Spangler; Kevin Jude; Carlos Labão-Almeida; Lestat R. Ali; Alfredo Quijano-Rubio; Mikel Ruterbusch; Isabel Leung; Tamara Biary; Stephanie J. Crowley; Enrique Marcos; Carl Walkey; Brian D. Weitzner; Fátima Pardo-Avila; Javier Castellanos; Lauren Carter; Lance Stewart; Stanley R. Riddell; Marion Pepper; Gonçalo J. L. Bernardes
Publicado en: Nature, Edición 10, 2019, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0830-7

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides

Autores: Juraj Konč; Libby Brown; Daniel R. Whiten; Yukun Zuo; Peter Ravn; Peter Ravn; David Klenerman; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 1, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202109713

Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation

Autores: Bruno L. Oliveira; Bruno L. Oliveira; Benjamin J Stenton; V B Unnikrishnan; Cátia Rebelo de Almeida; João Conde; Magda Negrão; Felipe S. S. Schneider; Carlos Cordeiro; Miguel Godinho Ferreira; Giovanni F. Caramori; Josiel B. Domingos; Rita Fior; Gonçalo J. L. Bernardes; Gonçalo J. L. Bernardes
Publicado en: Journal of the American Chemical Society, Edición 15, 2020, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c01622

Buscando datos de OpenAIRE...

Publicaciones

Compartir esta página

Descargar