Understanding and manipulating the dynamics of chromosome topologies in transcriptional control

Project Information

CHROMTOPOLOGY

Grant agreement ID: 678624

DOI 10.3030/678624

Project closed

EC signature date 30 May 2016

Start date 1 June 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France

Publications

Peer reviewed articles (8)

Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.

Author(s): Jaafar Alomairi; Anne Molitor; Nori Sadouni; Saadat Hussain; Magali Torres; Wiam Saadi; Lan T.M. Dao; Guillaume Charbonnier; David Santiago-Algarra; Jean-Christophe Andrau; Denis Puthier; Tom Sexton; Salvatore Spicuglia
Published in: PLoS ONE, Issue 15(5), 2020, Page(s) pp.e0233191, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0233191

Precise measurements of chromatin diffusion dynamics by modeling using Gaussian processes

Author(s): Guilherme M Oliveira, Attila Oravecz, Dominique Kobi, Manon Maroquenne, Kerstin Bystricky, Tom Sexton, Nacho Molina
Published in: Nature Communications, Issue 12(1), 2021, Page(s) 6184, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26466-7

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

Author(s): Daniela Rovito, Anna-Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu, Vanessa Dacleu-Siewe, Khalil Ben Rayana, Kamar Ghaibour, Maxime Parisotto, Arnaud Ferry, Scott A Jelinsky, Gilles Laverny, Bruno P Klaholz, Tom Sexton, Isabelle M L Billas, Delphine Duteil, Daniel Metzger
Published in: Nucleic Acids Res, Issue 49(8), 2021, Page(s) 4472-4492, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab226

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Author(s): Muhammad Ahmad Maqbool; Léo Pioger; Amal Zine El Aabidine; Nezih Karasu; Anne Molitor; Lan T.M. Dao; Guillaume Charbonnier; Francois van Laethem; Romain Fenouil; Frederic Koch; Georges Lacaud; Ivo Gut; Marta Gut; Sebastian Amigorena; Olivier Joffre; Tom Sexton; Salvatore Spicuglia; Jean-Christophe Andrau
Published in: https://hal-amu.archives-ouvertes.fr/hal-03015018, Issue 4, 2020, Page(s) 108048, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108048

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice

Author(s): Rafael Alcalá-Vida, Jonathan Seguin, Caroline Lotz, Anne M Molitor, Ibai Irastorza-Azcarate, Ali Awada, Nezih Karasu, Aurélie Bombardier, Brigitte Cosquer, Jose Luis Gomez Skarmeta , Jean-Christophe Cassel, Anne-Laurence Boutillier, Thomas Sexton, Karine Merienne
Published in: Nature Communications, Issue 12(1), 2021, Page(s) 364, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20605-2

Defining Functionally Relevant Spatial Chromatin Domains: It is a TAD Complicated

Author(s): Natalia Sikorska, Tom Sexton
Published in: J. Mol. Biol., Issue 432(3), 2020, Page(s) 653-664, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.12.006

ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Author(s): Yousra Ben Zouari, Anne M. Molitor, Natalia Sikorska, Vera Pancaldi, Tom Sexton
Published in: Genome Biology, Issue 20/1, 2019, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-019-1706-3

4See: A Flexible Browser to Explore 4C Data

Author(s): Yousra Ben Zouari, Angeliki Platania, Anne M. Molitor, Tom Sexton
Published in: Frontiers in Genetics, Issue 10, 2020, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2019.01372

Other (4)

Additional file 1: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Author(s): Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Published in: Genome Biology, Issue 20(1), 2021, Page(s) 6184, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.6084/m9.figshare.8172704

Additional file 3: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Author(s): Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Published in: Genome Biology, Issue 20(1), 2021, Page(s) 6184, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.6084/m9.figshare.8172722.v1

Additional file 2: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Author(s): Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Published in: Genome Biology, Issue 20(1), 2019, ISSN 1474-760X
Publisher: Biomed Central
DOI: 10.6084/m9.figshare.8172713.v1

Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus

Author(s): Tiegh Taylor, Natalia Sikorska, Virlana M Shchuka, Sanjay Chahar, Chenfan Ji, Neil N Macpherson, Sakthi D Moorthy, Jennifer A Mitchell, Tom Sexton
Published in: bioRxiv, 2022
Publisher: Preprint
DOI: 10.1101/2022.02.09.479674