Understanding and manipulating the dynamics of chromosome topologies in transcriptional control

Información del proyecto

CHROMTOPOLOGY

Identificador del acuerdo de subvención: 678624

DOI 10.3030/678624

Proyecto cerrado

Fecha de la firma de la CE 30 Mayo 2016

Fecha de inicio 1 Junio 2016

Fecha de finalización 31 Diciembre 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 500 000,00

Aportación de la UE € 1 500 000,00

Coordinado por

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France

Publicaciones

Peer reviewed articles (8)

Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.

Autores: Jaafar Alomairi; Anne Molitor; Nori Sadouni; Saadat Hussain; Magali Torres; Wiam Saadi; Lan T.M. Dao; Guillaume Charbonnier; David Santiago-Algarra; Jean-Christophe Andrau; Denis Puthier; Tom Sexton; Salvatore Spicuglia
Publicado en: PLoS ONE, Edición 15(5), 2020, Página(s) pp.e0233191, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0233191

Precise measurements of chromatin diffusion dynamics by modeling using Gaussian processes

Autores: Guilherme M Oliveira, Attila Oravecz, Dominique Kobi, Manon Maroquenne, Kerstin Bystricky, Tom Sexton, Nacho Molina
Publicado en: Nature Communications, Edición 12(1), 2021, Página(s) 6184, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26466-7

Myod1 and GR coordinate myofiber-specific transcriptional enhancers

Autores: Daniela Rovito, Anna-Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu, Vanessa Dacleu-Siewe, Khalil Ben Rayana, Kamar Ghaibour, Maxime Parisotto, Arnaud Ferry, Scott A Jelinsky, Gilles Laverny, Bruno P Klaholz, Tom Sexton, Isabelle M L Billas, Delphine Duteil, Daniel Metzger
Publicado en: Nucleic Acids Res, Edición 49(8), 2021, Página(s) 4472-4492, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkab226

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation

Autores: Muhammad Ahmad Maqbool; Léo Pioger; Amal Zine El Aabidine; Nezih Karasu; Anne Molitor; Lan T.M. Dao; Guillaume Charbonnier; Francois van Laethem; Romain Fenouil; Frederic Koch; Georges Lacaud; Ivo Gut; Marta Gut; Sebastian Amigorena; Olivier Joffre; Tom Sexton; Salvatore Spicuglia; Jean-Christophe Andrau
Publicado en: https://hal-amu.archives-ouvertes.fr/hal-03015018, Edición 4, 2020, Página(s) 108048, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2020.108048

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice

Autores: Rafael Alcalá-Vida, Jonathan Seguin, Caroline Lotz, Anne M Molitor, Ibai Irastorza-Azcarate, Ali Awada, Nezih Karasu, Aurélie Bombardier, Brigitte Cosquer, Jose Luis Gomez Skarmeta , Jean-Christophe Cassel, Anne-Laurence Boutillier, Thomas Sexton, Karine Merienne
Publicado en: Nature Communications, Edición 12(1), 2021, Página(s) 364, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-20605-2

Defining Functionally Relevant Spatial Chromatin Domains: It is a TAD Complicated

Autores: Natalia Sikorska, Tom Sexton
Publicado en: J. Mol. Biol., Edición 432(3), 2020, Página(s) 653-664, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2019.12.006

ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Autores: Yousra Ben Zouari, Anne M. Molitor, Natalia Sikorska, Vera Pancaldi, Tom Sexton
Publicado en: Genome Biology, Edición 20/1, 2019, ISSN 1474-760X
Editor: BMC
DOI: 10.1186/s13059-019-1706-3

4See: A Flexible Browser to Explore 4C Data

Autores: Yousra Ben Zouari, Angeliki Platania, Anne M. Molitor, Tom Sexton
Publicado en: Frontiers in Genetics, Edición 10, 2020, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2019.01372

Other (4)

Additional file 1: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Autores: Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Publicado en: Genome Biology, Edición 20(1), 2021, Página(s) 6184, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.6084/m9.figshare.8172704

Additional file 3: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Autores: Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Publicado en: Genome Biology, Edición 20(1), 2021, Página(s) 6184, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.6084/m9.figshare.8172722.v1

Additional file 2: of ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C

Autores: Zouari, Yousra Ben; Molitor, Anne; Sikorska, Natalia; Pancaldi, Vera; Sexton, Tom
Publicado en: Genome Biology, Edición 20(1), 2019, ISSN 1474-760X
Editor: Biomed Central
DOI: 10.6084/m9.figshare.8172713.v1

Transcriptional regulation and chromatin architecture maintenance are decoupled modular functions at the Sox2 locus

Autores: Tiegh Taylor, Natalia Sikorska, Virlana M Shchuka, Sanjay Chahar, Chenfan Ji, Neil N Macpherson, Sakthi D Moorthy, Jennifer A Mitchell, Tom Sexton
Publicado en: bioRxiv, 2022
Editor: Preprint
DOI: 10.1101/2022.02.09.479674