Objective CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection.TETRA PROJECTOur SME-led project will address the limitations of standard clinical care and competitor products under development and will:- Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients- Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases- Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication- Prepare a dossier for MAA submissionBENEFITSOur product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of €517 million per year.We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases. Fields of science medical and health sciencesmedical biotechnologycells technologiesstem cells Keywords ATMP tissue engineering medical device trachea cell therapy mesenchymal stem cell scaffold regenerative medicine stenosis Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) PHC-15-2015 - Clinical research on regenerative medicine Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2015-single-stage_RTD Funding Scheme RIA - Research and Innovation action Coordinator VIDEREGEN LIMITED Net EU contribution € 1 563 340,80 Address Innovation centre 1, liverpool science park, 131 m ant L3 5TF Liverpool United Kingdom See on map Region North West (England) Merseyside Liverpool Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,17 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EURAM LIMITED Participation ended United Kingdom Net EU contribution € 65 496,20 Address Lucy tower street tower house LN1 1XW Lincoln See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East Midlands (England) Lincolnshire Lincolnshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 CELL THERAPY CATAPULT LIMITED United Kingdom Net EU contribution € 281 681,00 Address 12th floor tower wing guy's hospital great maze pond SE1 9RT London See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region London Inner London — East Lewisham and Southwark Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 TMC PHARMA SERVICES LIMITED United Kingdom Net EU contribution € 1 127 146,00 Address Lodge farm barn, elvetham park estate RG27 8AS Hartley wintney See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 NHS BLOOD AND TRANSPLANT United Kingdom Net EU contribution € 535 250,00 Address Oak house reeds crescent WD24 4QN Watford See on map Region East of England Bedfordshire and Hertfordshire Hertfordshire Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany Net EU contribution € 903 250,00 Address Ismaninger strasse 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 455 118,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,75 UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST United Kingdom Net EU contribution € 669 578,00 Address Euston road 250 NW1 2PG London See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,75 UNIVERSITA DEGLI STUDI DI BRESCIA Italy Net EU contribution € 346 266,00 Address Piazza mercato 15 25121 Brescia See on map Region Nord-Ovest Lombardia Brescia Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,25 MEDIZINISCHE UNIVERSITAET WIEN Participation ended Austria Net EU contribution € 2 546,00 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,08 INSTYTUT GRUZLICY I CHOROB PLUC Poland Net EU contribution € 365 000,00 Address Ul. plocka 26 01138 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE UNIVERSITY OF MANCHESTER United Kingdom Net EU contribution € 30 700,00 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MANCHESTER UNIVERSITY NHS FOUNDATION TRUST United Kingdom Net EU contribution € 483 512,00 Address Oxford road M13 9WL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50
