Imaging synaptic contributors to dementia

Project Information

ALZSYN

Grant agreement ID: 681181

DOI 10.3030/681181

Project closed

EC signature date 28 October 2016

Start date 1 November 2016

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

Publications

Peer reviewed articles (27)

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Author(s): Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Published in: Neuron, Issue 109/5, 2021, Page(s) 767-777.e5, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

Author(s): Qiaochu Li, Daniel-Cosmin Marcu, Ottavia Palazzo, Frances Turner, Declan King, Tara L Spires-Jones, Melanie I Stefan, Karl Emanuel Busch
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59711

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Author(s): Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Published in: Clinical Epigenetics, Issue 12/1, 2020, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-020-00903-8

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Author(s): Grant T. Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C. Hall, Lai Ding, Alexandra DeSousa, Matthew P. Frosch, John Collinge, David A. Harris, Michael S. Perkinton, Tara L. Spires-Jones, Tracy L. Young-Pearse, Andrew Billinton, Dominic M. Walsh
Published in: Acta Neuropathologica, Issue 139/3, 2020, Page(s) 503-526, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02114-9

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Author(s): Sarah A. Kent, Tara L. Spires-Jones, Claire S. Durrant
Published in: Acta Neuropathologica, Issue 140/4, 2020, Page(s) 417-447, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02196-w

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

Author(s): Nicholas J. Izzo, Carla M. Yuede, Kelsie M. LaBarbera, Colleen S. Limegrover, Courtney Rehak, Raymond Yurko, Lora Waybright, Gary Look, Gilbert Rishton, Hank Safferstein, Mary E. Hamby, Claire Williams, Kelsey Sadlek, Hannah M. Edwards, Charles S. Davis, Michael Grundman, Lon S. Schneider, Steven T. DeKosky, Daniel Chelsky, Ian Pike, Christopher Henstridge, Kaj Blennow, Henrik Zetterberg, Harry Le
Published in: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.12302

Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau

Author(s): Jane Tulloch, Olga Netsyk, Eleanor K. Pickett, Abigail G. Herrmann, Pooja Jain, Anna J. Stevenson, Iris Oren, Oliver Hardt, Tara L. Spires‐Jones
Published in: European Journal of Neuroscience, Issue 53/2, 2021, Page(s) 637-648, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14918

Selective vulnerability of inhibitory networks in multiple sclerosis

Author(s): Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland, Anna C. Williams
Published in: Acta Neuropathologica, Issue 141/3, 2021, Page(s) 415-429, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02258-z

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Author(s): Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano
Published in: Alzheimer's Research & Therapy, Issue 12/1, 2020, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-020-00588-4

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Author(s): Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth
Published in: Cell Reports, Issue 29/11, 2019, Page(s) 3592-3604.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.11.044

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease

Author(s): Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Raúl Nuñez-Llaves, Joan Luque-Cabecerans, Laia Muñoz-Llahuna, Jordi Andilla, Olivia Belbin, Tara L. Spires-Jones, Ellen Gelpi, Jordi Clarimon, Pablo Loza-Alvarez, Juan Fortea, Alberto Lleó
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-41443-3

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Author(s): M. Tzioras, C. Davies, A. Newman, R. Jackson, T. Spires‐Jones
Published in: Neuropathology and Applied Neurobiology, Issue 45/4, 2018, Page(s) 327-346, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12529

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Author(s): Martí Colom-Cadena, Jordi Pegueroles, Abigail G Herrmann, Christopher M Henstridge, Laia Muñoz, Marta Querol-Vilaseca, Carla San Martín-Paniello, Joan Luque-Cabecerans, Jordi Clarimon, Olivia Belbin, Raúl Núñez-Llaves, Rafael Blesa, Colin Smith, Chris-Anne McKenzie, Matthew P Frosch, Allyson Roe, Juan Fortea, Jordi Andilla, Pablo Loza-Alvarez, Ellen Gelpi, Bradley T Hyman, Tara L Spires-Jone
Published in: Brain, Issue 140/12, 2017, Page(s) 3204-3214, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awx275

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Author(s): Rosemary J Jackson, Jamie Rose, Jane Tulloch, Chris Henstridge, Colin Smith, Tara L Spires-Jones
Published in: Brain Communications, 2019, ISSN 2632-1297
Publisher: Oxford University Press
DOI: 10.1093/braincomms/fcz003

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Author(s): Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
Published in: The Journal of Neuroscience, Issue 37/49, 2017, Page(s) 11947-11966, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2009-17.2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Author(s): Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Published in: Neuron, Issue 97/4, 2018, Page(s) 823-835.e8, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

Interactions of pathological proteins in neurodegenerative diseases

Author(s): Tara L. Spires-Jones, Johannes Attems, Dietmar Rudolf Thal
Published in: Acta Neuropathologica, Issue 134/2, 2017, Page(s) 187-205, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-017-1709-7

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Author(s): Rosa C. Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John L. Robinson, Edward B. Lee, Jamie Rose, Stanley Appel, Virginia M.-Y. Lee, John Q. Trojanowski, Tara Spires-Jones, Paul E. Schulz, Lawrence Rajendran
Published in: Neuron, Issue 95/2, 2017, Page(s) 297-308.e6, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2017.05.037

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Author(s): Christopher M. Henstridge, Dimitrios I. Sideris, Emily Carroll, Sanziana Rotariu, Sally Salomonsson, Makis Tzioras, Chris-Anne McKenzie, Colin Smith, Christine A. F. von Arnim, Albert C. Ludolph, Dorothée Lulé, Danielle Leighton, Jon Warner, Elaine Cleary, Judith Newton, Robert Swingler, Siddharthan Chandran, Thomas H. Gillingwater, Sharon Abrahams, Tara L. Spires-Jones
Published in: Acta Neuropathologica, Issue 135/2, 2018, Page(s) 213-226, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-017-1797-4

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

Author(s): Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Published in: Molecular Neurobiology, Issue 55/7, 2018, Page(s) 6130-6144, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-017-0825-7

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Author(s): Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires-Jones
Published in: Synapse, Issue 71/6, 2017, Page(s) e21965, ISSN 0887-4476
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/syn.21965

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Author(s): Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires-Jones
Published in: Nature Reviews Neuroscience, Issue 20/2, 2019, Page(s) 94-108, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-018-0113-1

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Author(s): Eleanor K. Pickett, Jamie Rose, Caoimhe McCrory, Chris-Anne McKenzie, Declan King, Colin Smith, Thomas H. Gillingwater, Christopher M. Henstridge, Tara L. Spires-Jones
Published in: Acta Neuropathologica, Issue 136/5, 2018, Page(s) 747-757, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-018-1903-2

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca 2+ homeostasis and CREB1-signaling

Author(s): Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl Josef Föhr, Ludwig Lausser, Katja S. Kroker, Christian Proepper, Paul Walther, Hans A. Kestler, Tara L. Spires-Jones, Tobias Boeckers, Holger Rosenbrock, Christine A.F. von Arnim
Published in: Experimental Neurology, Issue 304, 2018, Page(s) 1-13, ISSN 0014-4886
Publisher: Academic Press
DOI: 10.1016/j.expneurol.2018.02.010

Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia

Author(s): M. Tzioras, A. J. Stevenson, D. Boche, T. L. Spires‐Jones
Published in: Neuropathology and Applied Neurobiology, Issue 47/2, 2021, Page(s) 346-351, ISSN 0305-1846
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/nan.12660

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Author(s): Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-019-0847-7

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

Author(s): Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Published in: Stem Cell Research, Issue 46, 2020, Page(s) 101851, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2020.101851