Imaging synaptic contributors to dementia

Información del proyecto

ALZSYN

Identificador del acuerdo de subvención: 681181

DOI

10.3030/681181

Proyecto cerrado

Fecha de la firma de la CE 28 Octubre 2016

Fecha de inicio 1 Noviembre 2016

Fecha de finalización 30 Abril 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 000 000,00

Aportación de la UE

€ 2 000 000,00

Coordinado por

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (27)

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autores: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Publicado en: Neuron, Edición 109/5, 2021, Página(s) 767-777.e5, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

Autores: Qiaochu Li, Daniel-Cosmin Marcu, Ottavia Palazzo, Frances Turner, Declan King, Tara L Spires-Jones, Melanie I Stefan, Karl Emanuel Busch
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.59711

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Autores: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Publicado en: Clinical Epigenetics, Edición 12/1, 2020, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-020-00903-8

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Autores: Grant T. Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C. Hall, Lai Ding, Alexandra DeSousa, Matthew P. Frosch, John Collinge, David A. Harris, Michael S. Perkinton, Tara L. Spires-Jones, Tracy L. Young-Pearse, Andrew Billinton, Dominic M. Walsh
Publicado en: Acta Neuropathologica, Edición 139/3, 2020, Página(s) 503-526, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-02114-9

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Autores: Sarah A. Kent, Tara L. Spires-Jones, Claire S. Durrant
Publicado en: Acta Neuropathologica, Edición 140/4, 2020, Página(s) 417-447, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02196-w

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

Autores: Nicholas J. Izzo, Carla M. Yuede, Kelsie M. LaBarbera, Colleen S. Limegrover, Courtney Rehak, Raymond Yurko, Lora Waybright, Gary Look, Gilbert Rishton, Hank Safferstein, Mary E. Hamby, Claire Williams, Kelsey Sadlek, Hannah M. Edwards, Charles S. Davis, Michael Grundman, Lon S. Schneider, Steven T. DeKosky, Daniel Chelsky, Ian Pike, Christopher Henstridge, Kaj Blennow, Henrik Zetterberg, Harry Le
Publicado en: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1002/alz.12302

Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau

Autores: Jane Tulloch, Olga Netsyk, Eleanor K. Pickett, Abigail G. Herrmann, Pooja Jain, Anna J. Stevenson, Iris Oren, Oliver Hardt, Tara L. Spires‐Jones
Publicado en: European Journal of Neuroscience, Edición 53/2, 2021, Página(s) 637-648, ISSN 0953-816X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14918

Selective vulnerability of inhibitory networks in multiple sclerosis

Autores: Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland, Anna C. Williams
Publicado en: Acta Neuropathologica, Edición 141/3, 2021, Página(s) 415-429, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02258-z

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Autores: Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano
Publicado en: Alzheimer's Research & Therapy, Edición 12/1, 2020, ISSN 1758-9193
Editor: BioMed Central
DOI: 10.1186/s13195-020-00588-4

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Autores: Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth
Publicado en: Cell Reports, Edición 29/11, 2019, Página(s) 3592-3604.e5, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.11.044

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease

Autores: Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Raúl Nuñez-Llaves, Joan Luque-Cabecerans, Laia Muñoz-Llahuna, Jordi Andilla, Olivia Belbin, Tara L. Spires-Jones, Ellen Gelpi, Jordi Clarimon, Pablo Loza-Alvarez, Juan Fortea, Alberto Lleó
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-41443-3

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Autores: M. Tzioras, C. Davies, A. Newman, R. Jackson, T. Spires‐Jones
Publicado en: Neuropathology and Applied Neurobiology, Edición 45/4, 2018, Página(s) 327-346, ISSN 0305-1846
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nan.12529

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Autores: Martí Colom-Cadena, Jordi Pegueroles, Abigail G Herrmann, Christopher M Henstridge, Laia Muñoz, Marta Querol-Vilaseca, Carla San Martín-Paniello, Joan Luque-Cabecerans, Jordi Clarimon, Olivia Belbin, Raúl Núñez-Llaves, Rafael Blesa, Colin Smith, Chris-Anne McKenzie, Matthew P Frosch, Allyson Roe, Juan Fortea, Jordi Andilla, Pablo Loza-Alvarez, Ellen Gelpi, Bradley T Hyman, Tara L Spires-Jone
Publicado en: Brain, Edición 140/12, 2017, Página(s) 3204-3214, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awx275

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Autores: Rosemary J Jackson, Jamie Rose, Jane Tulloch, Chris Henstridge, Colin Smith, Tara L Spires-Jones
Publicado en: Brain Communications, 2019, ISSN 2632-1297
Editor: Oxford University Press
DOI: 10.1093/braincomms/fcz003

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Autores: Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
Publicado en: The Journal of Neuroscience, Edición 37/49, 2017, Página(s) 11947-11966, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.2009-17.2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autores: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Publicado en: Neuron, Edición 97/4, 2018, Página(s) 823-835.e8, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

Interactions of pathological proteins in neurodegenerative diseases

Autores: Tara L. Spires-Jones, Johannes Attems, Dietmar Rudolf Thal
Publicado en: Acta Neuropathologica, Edición 134/2, 2017, Página(s) 187-205, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-017-1709-7

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Autores: Rosa C. Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John L. Robinson, Edward B. Lee, Jamie Rose, Stanley Appel, Virginia M.-Y. Lee, John Q. Trojanowski, Tara Spires-Jones, Paul E. Schulz, Lawrence Rajendran
Publicado en: Neuron, Edición 95/2, 2017, Página(s) 297-308.e6, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2017.05.037

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Autores: Christopher M. Henstridge, Dimitrios I. Sideris, Emily Carroll, Sanziana Rotariu, Sally Salomonsson, Makis Tzioras, Chris-Anne McKenzie, Colin Smith, Christine A. F. von Arnim, Albert C. Ludolph, Dorothée Lulé, Danielle Leighton, Jon Warner, Elaine Cleary, Judith Newton, Robert Swingler, Siddharthan Chandran, Thomas H. Gillingwater, Sharon Abrahams, Tara L. Spires-Jones
Publicado en: Acta Neuropathologica, Edición 135/2, 2018, Página(s) 213-226, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-017-1797-4

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

Autores: Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Publicado en: Molecular Neurobiology, Edición 55/7, 2018, Página(s) 6130-6144, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-017-0825-7

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Autores: Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires-Jones
Publicado en: Synapse, Edición 71/6, 2017, Página(s) e21965, ISSN 0887-4476
Editor: John Wiley & Sons Inc.
DOI: 10.1002/syn.21965

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Autores: Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires-Jones
Publicado en: Nature Reviews Neuroscience, Edición 20/2, 2019, Página(s) 94-108, ISSN 1471-003X
Editor: Nature Publishing Group
DOI: 10.1038/s41583-018-0113-1

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Autores: Eleanor K. Pickett, Jamie Rose, Caoimhe McCrory, Chris-Anne McKenzie, Declan King, Colin Smith, Thomas H. Gillingwater, Christopher M. Henstridge, Tara L. Spires-Jones
Publicado en: Acta Neuropathologica, Edición 136/5, 2018, Página(s) 747-757, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-018-1903-2

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca 2+ homeostasis and CREB1-signaling

Autores: Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl Josef Föhr, Ludwig Lausser, Katja S. Kroker, Christian Proepper, Paul Walther, Hans A. Kestler, Tara L. Spires-Jones, Tobias Boeckers, Holger Rosenbrock, Christine A.F. von Arnim
Publicado en: Experimental Neurology, Edición 304, 2018, Página(s) 1-13, ISSN 0014-4886
Editor: Academic Press
DOI: 10.1016/j.expneurol.2018.02.010

Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia

Autores: M. Tzioras, A. J. Stevenson, D. Boche, T. L. Spires‐Jones
Publicado en: Neuropathology and Applied Neurobiology, Edición 47/2, 2021, Página(s) 346-351, ISSN 0305-1846
Editor: Blackwell Publishing Inc.
DOI: 10.1111/nan.12660

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Autores: Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0847-7

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

Autores: Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Publicado en: Stem Cell Research, Edición 46, 2020, Página(s) 101851, ISSN 1873-5061
Editor: Elsevier
DOI: 10.1016/j.scr.2020.101851