Imaging synaptic contributors to dementia

Pubblicazioni

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autori: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Pubblicato in: Neuron, Numero 109/5, 2021, Pagina/e 767-777.e5, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

Autori: Qiaochu Li, Daniel-Cosmin Marcu, Ottavia Palazzo, Frances Turner, Declan King, Tara L Spires-Jones, Melanie I Stefan, Karl Emanuel Busch
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.59711

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Autori: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Pubblicato in: Clinical Epigenetics, Numero 12/1, 2020, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-020-00903-8

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Autori: Grant T. Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C. Hall, Lai Ding, Alexandra DeSousa, Matthew P. Frosch, John Collinge, David A. Harris, Michael S. Perkinton, Tara L. Spires-Jones, Tracy L. Young-Pearse, Andrew Billinton, Dominic M. Walsh
Pubblicato in: Acta Neuropathologica, Numero 139/3, 2020, Pagina/e 503-526, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-019-02114-9

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Autori: Sarah A. Kent, Tara L. Spires-Jones, Claire S. Durrant
Pubblicato in: Acta Neuropathologica, Numero 140/4, 2020, Pagina/e 417-447, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-020-02196-w

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

Autori: Nicholas J. Izzo, Carla M. Yuede, Kelsie M. LaBarbera, Colleen S. Limegrover, Courtney Rehak, Raymond Yurko, Lora Waybright, Gary Look, Gilbert Rishton, Hank Safferstein, Mary E. Hamby, Claire Williams, Kelsey Sadlek, Hannah M. Edwards, Charles S. Davis, Michael Grundman, Lon S. Schneider, Steven T. DeKosky, Daniel Chelsky, Ian Pike, Christopher Henstridge, Kaj Blennow, Henrik Zetterberg, Harry Le
Pubblicato in: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Editore: Elsevier BV
DOI: 10.1002/alz.12302

Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau

Autori: Jane Tulloch, Olga Netsyk, Eleanor K. Pickett, Abigail G. Herrmann, Pooja Jain, Anna J. Stevenson, Iris Oren, Oliver Hardt, Tara L. Spires‐Jones
Pubblicato in: European Journal of Neuroscience, Numero 53/2, 2021, Pagina/e 637-648, ISSN 0953-816X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14918

Selective vulnerability of inhibitory networks in multiple sclerosis

Autori: Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland, Anna C. Williams
Pubblicato in: Acta Neuropathologica, Numero 141/3, 2021, Pagina/e 415-429, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-020-02258-z

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Autori: Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano
Pubblicato in: Alzheimer's Research & Therapy, Numero 12/1, 2020, ISSN 1758-9193
Editore: BioMed Central
DOI: 10.1186/s13195-020-00588-4

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Autori: Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth
Pubblicato in: Cell Reports, Numero 29/11, 2019, Pagina/e 3592-3604.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.11.044

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease

Autori: Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Raúl Nuñez-Llaves, Joan Luque-Cabecerans, Laia Muñoz-Llahuna, Jordi Andilla, Olivia Belbin, Tara L. Spires-Jones, Ellen Gelpi, Jordi Clarimon, Pablo Loza-Alvarez, Juan Fortea, Alberto Lleó
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-41443-3

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Autori: M. Tzioras, C. Davies, A. Newman, R. Jackson, T. Spires‐Jones
Pubblicato in: Neuropathology and Applied Neurobiology, Numero 45/4, 2018, Pagina/e 327-346, ISSN 0305-1846
Editore: Blackwell Publishing Inc.
DOI: 10.1111/nan.12529

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Autori: Martí Colom-Cadena, Jordi Pegueroles, Abigail G Herrmann, Christopher M Henstridge, Laia Muñoz, Marta Querol-Vilaseca, Carla San Martín-Paniello, Joan Luque-Cabecerans, Jordi Clarimon, Olivia Belbin, Raúl Núñez-Llaves, Rafael Blesa, Colin Smith, Chris-Anne McKenzie, Matthew P Frosch, Allyson Roe, Juan Fortea, Jordi Andilla, Pablo Loza-Alvarez, Ellen Gelpi, Bradley T Hyman, Tara L Spires-Jone
Pubblicato in: Brain, Numero 140/12, 2017, Pagina/e 3204-3214, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awx275

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Autori: Rosemary J Jackson, Jamie Rose, Jane Tulloch, Chris Henstridge, Colin Smith, Tara L Spires-Jones
Pubblicato in: Brain Communications, 2019, ISSN 2632-1297
Editore: Oxford University Press
DOI: 10.1093/braincomms/fcz003

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Autori: Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
Pubblicato in: The Journal of Neuroscience, Numero 37/49, 2017, Pagina/e 11947-11966, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.2009-17.2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autori: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Pubblicato in: Neuron, Numero 97/4, 2018, Pagina/e 823-835.e8, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

Interactions of pathological proteins in neurodegenerative diseases

Autori: Tara L. Spires-Jones, Johannes Attems, Dietmar Rudolf Thal
Pubblicato in: Acta Neuropathologica, Numero 134/2, 2017, Pagina/e 187-205, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-017-1709-7

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Autori: Rosa C. Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John L. Robinson, Edward B. Lee, Jamie Rose, Stanley Appel, Virginia M.-Y. Lee, John Q. Trojanowski, Tara Spires-Jones, Paul E. Schulz, Lawrence Rajendran
Pubblicato in: Neuron, Numero 95/2, 2017, Pagina/e 297-308.e6, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2017.05.037

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Autori: Christopher M. Henstridge, Dimitrios I. Sideris, Emily Carroll, Sanziana Rotariu, Sally Salomonsson, Makis Tzioras, Chris-Anne McKenzie, Colin Smith, Christine A. F. von Arnim, Albert C. Ludolph, Dorothée Lulé, Danielle Leighton, Jon Warner, Elaine Cleary, Judith Newton, Robert Swingler, Siddharthan Chandran, Thomas H. Gillingwater, Sharon Abrahams, Tara L. Spires-Jones
Pubblicato in: Acta Neuropathologica, Numero 135/2, 2018, Pagina/e 213-226, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-017-1797-4

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

Autori: Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Pubblicato in: Molecular Neurobiology, Numero 55/7, 2018, Pagina/e 6130-6144, ISSN 0893-7648
Editore: Humana Press, Inc.
DOI: 10.1007/s12035-017-0825-7

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Autori: Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires-Jones
Pubblicato in: Synapse, Numero 71/6, 2017, Pagina/e e21965, ISSN 0887-4476
Editore: John Wiley & Sons Inc.
DOI: 10.1002/syn.21965

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Autori: Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires-Jones
Pubblicato in: Nature Reviews Neuroscience, Numero 20/2, 2019, Pagina/e 94-108, ISSN 1471-003X
Editore: Nature Publishing Group
DOI: 10.1038/s41583-018-0113-1

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Autori: Eleanor K. Pickett, Jamie Rose, Caoimhe McCrory, Chris-Anne McKenzie, Declan King, Colin Smith, Thomas H. Gillingwater, Christopher M. Henstridge, Tara L. Spires-Jones
Pubblicato in: Acta Neuropathologica, Numero 136/5, 2018, Pagina/e 747-757, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-018-1903-2

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca 2+ homeostasis and CREB1-signaling

Autori: Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl Josef Föhr, Ludwig Lausser, Katja S. Kroker, Christian Proepper, Paul Walther, Hans A. Kestler, Tara L. Spires-Jones, Tobias Boeckers, Holger Rosenbrock, Christine A.F. von Arnim
Pubblicato in: Experimental Neurology, Numero 304, 2018, Pagina/e 1-13, ISSN 0014-4886
Editore: Academic Press
DOI: 10.1016/j.expneurol.2018.02.010

Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia

Autori: M. Tzioras, A. J. Stevenson, D. Boche, T. L. Spires‐Jones
Pubblicato in: Neuropathology and Applied Neurobiology, Numero 47/2, 2021, Pagina/e 346-351, ISSN 0305-1846
Editore: Blackwell Publishing Inc.
DOI: 10.1111/nan.12660

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Autori: Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0847-7

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

Autori: Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Pubblicato in: Stem Cell Research, Numero 46, 2020, Pagina/e 101851, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2020.101851

È in corso la ricerca di dati su OpenAIRE...

Pubblicazioni

Condividi questa pagina

Scarica