Imaging synaptic contributors to dementia

Publikacje

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autorzy: Pablo Largo-Barrientos, Nuno Apóstolo, Eline Creemers, Zsuzsanna Callaerts-Vegh, Jef Swerts, Caitlin Davies, Joseph McInnes, Keimpe Wierda, Bart De Strooper, Tara Spires-Jones, Joris de Wit, Valerie Uytterhoeven, Patrik Verstreken
Opublikowane w: Neuron, Numer 109/5, 2021, Strona(/y) 767-777.e5, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2020.12.016

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

Autorzy: Qiaochu Li, Daniel-Cosmin Marcu, Ottavia Palazzo, Frances Turner, Declan King, Tara L Spires-Jones, Melanie I Stefan, Karl Emanuel Busch
Opublikowane w: eLife, Numer 9, 2020, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.59711

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

Autorzy: Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Opublikowane w: Clinical Epigenetics, Numer 12/1, 2020, ISSN 1868-7075
Wydawca: Springer Verlag
DOI: 10.1186/s13148-020-00903-8

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Autorzy: Grant T. Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C. Hall, Lai Ding, Alexandra DeSousa, Matthew P. Frosch, John Collinge, David A. Harris, Michael S. Perkinton, Tara L. Spires-Jones, Tracy L. Young-Pearse, Andrew Billinton, Dominic M. Walsh
Opublikowane w: Acta Neuropathologica, Numer 139/3, 2020, Strona(/y) 503-526, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-019-02114-9

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

Autorzy: Sarah A. Kent, Tara L. Spires-Jones, Claire S. Durrant
Opublikowane w: Acta Neuropathologica, Numer 140/4, 2020, Strona(/y) 417-447, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-020-02196-w

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

Autorzy: Nicholas J. Izzo, Carla M. Yuede, Kelsie M. LaBarbera, Colleen S. Limegrover, Courtney Rehak, Raymond Yurko, Lora Waybright, Gary Look, Gilbert Rishton, Hank Safferstein, Mary E. Hamby, Claire Williams, Kelsey Sadlek, Hannah M. Edwards, Charles S. Davis, Michael Grundman, Lon S. Schneider, Steven T. DeKosky, Daniel Chelsky, Ian Pike, Christopher Henstridge, Kaj Blennow, Henrik Zetterberg, Harry Le
Opublikowane w: Alzheimer's & Dementia, 2021, ISSN 1552-5260
Wydawca: Elsevier BV
DOI: 10.1002/alz.12302

Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau

Autorzy: Jane Tulloch, Olga Netsyk, Eleanor K. Pickett, Abigail G. Herrmann, Pooja Jain, Anna J. Stevenson, Iris Oren, Oliver Hardt, Tara L. Spires‐Jones
Opublikowane w: European Journal of Neuroscience, Numer 53/2, 2021, Strona(/y) 637-648, ISSN 0953-816X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14918

Selective vulnerability of inhibitory networks in multiple sclerosis

Autorzy: Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland, Anna C. Williams
Opublikowane w: Acta Neuropathologica, Numer 141/3, 2021, Strona(/y) 415-429, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-020-02258-z

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Autorzy: Martí Colom-Cadena, Tara Spires-Jones, Henrik Zetterberg, Kaj Blennow, Anthony Caggiano, Steven T. DeKosky, Howard Fillit, John E. Harrison, Lon S. Schneider, Phillip Scheltens, Willem de Haan, Michael Grundman, Christopher H. van Dyck, Nicholas J. Izzo, Susan M. Catalano
Opublikowane w: Alzheimer's Research & Therapy, Numer 12/1, 2020, ISSN 1758-9193
Wydawca: BioMed Central
DOI: 10.1186/s13195-020-00588-4

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Autorzy: Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth
Opublikowane w: Cell Reports, Numer 29/11, 2019, Strona(/y) 3592-3604.e5, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.11.044

Nanoscale structure of amyloid-β plaques in Alzheimer’s disease

Autorzy: Marta Querol-Vilaseca, Martí Colom-Cadena, Jordi Pegueroles, Raúl Nuñez-Llaves, Joan Luque-Cabecerans, Laia Muñoz-Llahuna, Jordi Andilla, Olivia Belbin, Tara L. Spires-Jones, Ellen Gelpi, Jordi Clarimon, Pablo Loza-Alvarez, Juan Fortea, Alberto Lleó
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-41443-3

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

Autorzy: M. Tzioras, C. Davies, A. Newman, R. Jackson, T. Spires‐Jones
Opublikowane w: Neuropathology and Applied Neurobiology, Numer 45/4, 2018, Strona(/y) 327-346, ISSN 0305-1846
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/nan.12529

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Autorzy: Martí Colom-Cadena, Jordi Pegueroles, Abigail G Herrmann, Christopher M Henstridge, Laia Muñoz, Marta Querol-Vilaseca, Carla San Martín-Paniello, Joan Luque-Cabecerans, Jordi Clarimon, Olivia Belbin, Raúl Núñez-Llaves, Rafael Blesa, Colin Smith, Chris-Anne McKenzie, Matthew P Frosch, Allyson Roe, Juan Fortea, Jordi Andilla, Pablo Loza-Alvarez, Ellen Gelpi, Bradley T Hyman, Tara L Spires-Jone
Opublikowane w: Brain, Numer 140/12, 2017, Strona(/y) 3204-3214, ISSN 0006-8950
Wydawca: Oxford University Press
DOI: 10.1093/brain/awx275

Clusterin accumulates in synapses in Alzheimer’s disease and is increased in apolipoprotein E4 carriers

Autorzy: Rosemary J Jackson, Jamie Rose, Jane Tulloch, Chris Henstridge, Colin Smith, Tara L Spires-Jones
Opublikowane w: Brain Communications, 2019, ISSN 2632-1297
Wydawca: Oxford University Press
DOI: 10.1093/braincomms/fcz003

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Autorzy: Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
Opublikowane w: The Journal of Neuroscience, Numer 37/49, 2017, Strona(/y) 11947-11966, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/jneurosci.2009-17.2017

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autorzy: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie-Cosmin Stancu, Nuno Apóstolo, Kris Gevaert, Ilse Dewachter, Tara L. Spires-Jones, Bart De Strooper, Joris De Wit, Lujia Zhou, Patrik Verstreken
Opublikowane w: Neuron, Numer 97/4, 2018, Strona(/y) 823-835.e8, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2018.01.022

Interactions of pathological proteins in neurodegenerative diseases

Autorzy: Tara L. Spires-Jones, Johannes Attems, Dietmar Rudolf Thal
Opublikowane w: Acta Neuropathologica, Numer 134/2, 2017, Strona(/y) 187-205, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-017-1709-7

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Autorzy: Rosa C. Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John L. Robinson, Edward B. Lee, Jamie Rose, Stanley Appel, Virginia M.-Y. Lee, John Q. Trojanowski, Tara Spires-Jones, Paul E. Schulz, Lawrence Rajendran
Opublikowane w: Neuron, Numer 95/2, 2017, Strona(/y) 297-308.e6, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2017.05.037

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis

Autorzy: Christopher M. Henstridge, Dimitrios I. Sideris, Emily Carroll, Sanziana Rotariu, Sally Salomonsson, Makis Tzioras, Chris-Anne McKenzie, Colin Smith, Christine A. F. von Arnim, Albert C. Ludolph, Dorothée Lulé, Danielle Leighton, Jon Warner, Elaine Cleary, Judith Newton, Robert Swingler, Siddharthan Chandran, Thomas H. Gillingwater, Sharon Abrahams, Tara L. Spires-Jones
Opublikowane w: Acta Neuropathologica, Numer 135/2, 2018, Strona(/y) 213-226, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-017-1797-4

Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes

Autorzy: Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Carmen Hierro-Bujalance, Esperanza Ortegon, Eleanor Pickett, Rosemary Jackson, Fernando Hernandez-Pacho, Tara Spires-Jones, Monica Garcia-Alloza
Opublikowane w: Molecular Neurobiology, Numer 55/7, 2018, Strona(/y) 6130-6144, ISSN 0893-7648
Wydawca: Humana Press, Inc.
DOI: 10.1007/s12035-017-0825-7

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Autorzy: Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires-Jones
Opublikowane w: Synapse, Numer 71/6, 2017, Strona(/y) e21965, ISSN 0887-4476
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/syn.21965

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Autorzy: Christopher M. Henstridge, Bradley T. Hyman, Tara L. Spires-Jones
Opublikowane w: Nature Reviews Neuroscience, Numer 20/2, 2019, Strona(/y) 94-108, ISSN 1471-003X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41583-018-0113-1

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Autorzy: Eleanor K. Pickett, Jamie Rose, Caoimhe McCrory, Chris-Anne McKenzie, Declan King, Colin Smith, Thomas H. Gillingwater, Christopher M. Henstridge, Tara L. Spires-Jones
Opublikowane w: Acta Neuropathologica, Numer 136/5, 2018, Strona(/y) 747-757, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-018-1903-2

sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca 2+ homeostasis and CREB1-signaling

Autorzy: Raphael Hesse, Bjoern von Einem, Franziska Wagner, Patricia Bott, Daniel Schwanzar, Rosemary J. Jackson, Karl Josef Föhr, Ludwig Lausser, Katja S. Kroker, Christian Proepper, Paul Walther, Hans A. Kestler, Tara L. Spires-Jones, Tobias Boeckers, Holger Rosenbrock, Christine A.F. von Arnim
Opublikowane w: Experimental Neurology, Numer 304, 2018, Strona(/y) 1-13, ISSN 0014-4886
Wydawca: Academic Press
DOI: 10.1016/j.expneurol.2018.02.010

Microglial contribution to synaptic uptake in the prefrontal cortex in schizophrenia

Autorzy: M. Tzioras, A. J. Stevenson, D. Boche, T. L. Spires‐Jones
Opublikowane w: Neuropathology and Applied Neurobiology, Numer 47/2, 2021, Strona(/y) 346-351, ISSN 0305-1846
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/nan.12660

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Autorzy: Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0847-7

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

Autorzy: Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen
Opublikowane w: Stem Cell Research, Numer 46, 2020, Strona(/y) 101851, ISSN 1873-5061
Wydawca: Elsevier
DOI: 10.1016/j.scr.2020.101851

Wyszukiwanie danych OpenAIRE...

Publikacje

Udostępnij tę stronę

Pobierz