Discovering how polycomb domains form and function in gene regulation

Project Information

PolyDomFormFuncReg

Grant agreement ID: 681440

DOI 10.3030/681440

Project closed

EC signature date 7 March 2016

Start date 1 June 2016

End date 31 May 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 416,00

EU contribution € 1 999 416,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Author(s): Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17823-z

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Author(s): David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Published in: Cell Reports, Issue 20/10, 2017, Page(s) 2313-2327, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.08.030

ATACing DNA Methylation during Differentiation

Author(s): Skirmantas Kriaucionis, Robert J. Klose
Published in: Molecular Cell, Issue 77/6, 2020, Page(s) 1159-1161, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.02.026

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Author(s): Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.18591

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

Author(s): Anne H Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W King, Haruhiko Koseki, Robert J Klose
Published in: Nucleic Acids Research, Issue 47/17, 2019, Page(s) 9005-9023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz607

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Author(s): Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Published in: Genes & Development, Issue 35/9-10, 2021, Page(s) 749-770, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347005.120

PRC1 Catalytic Activity Is Central to Polycomb System Function

Author(s): Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Published in: Molecular Cell, Issue 77/4, 2020, Page(s) 857-874.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Author(s): Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Published in: Nucleic Acids Research, Issue 48/6, 2020, Page(s) 2942-2955, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa064

Getting under the skin of Polycomb-dependent gene regulation

Author(s): Neil P. Blackledge, Robert J. Klose
Published in: Genes & Development, Issue 35/5-6, 2021, Page(s) 301-303, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348257.121

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Author(s): Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Published in: Molecular Cell, Issue 74/5, 2019, Page(s) 1020-1036.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Author(s): Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.37084

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Author(s): Martin Cusack, Hamish W. King, Paolo Spingardi, Benedikt M. Kessler, Robert J. Klose, Skirmantas Kriaucionis
Published in: Genome Research, Issue 30/10, 2020, Page(s) 1393-1406, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.257576.119

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Author(s): Miles K. Huseyin, Robert J. Klose
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21130-6

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Author(s): Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Published in: Genome Research, Issue 28/10, 2018, Page(s) 1494-1507, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Author(s): Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Published in: Cell Reports, Issue 18/2, 2017, Page(s) 482-495, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.12.054

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Author(s): Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Issue 1863/8, 2020, Page(s) 194567, ISSN 1874-9399
Publisher: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194567

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

Author(s): Hamish W King, Robert J Klose
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.22631

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Author(s): James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Published in: Cell Reports, Issue 30/3, 2020, Page(s) 820-835.e10, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

Author(s): Paula Dobrinić, Aleksander T. Szczurek, Robert J. Klose
Published in: Nature Structural & Molecular Biology, Issue 28/10, 2021, Page(s) 811-824, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00661-y