Discovering how polycomb domains form and function in gene regulation

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Author(s): Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17823-z

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Author(s): David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Published in: Cell Reports, 20/10, 2017, Page(s) 2313-2327, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.08.030

ATACing DNA Methylation during Differentiation

Author(s): Skirmantas Kriaucionis, Robert J. Klose
Published in: Molecular Cell, 77/6, 2020, Page(s) 1159-1161, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.02.026

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Author(s): Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Published in: eLife, 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.18591

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

Author(s): Anne H Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W King, Haruhiko Koseki, Robert J Klose
Published in: Nucleic Acids Research, 47/17, 2019, Page(s) 9005-9023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz607

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Author(s): Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Published in: Genes & Development, 35/9-10, 2021, Page(s) 749-770, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347005.120

PRC1 Catalytic Activity Is Central to Polycomb System Function

Author(s): Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Published in: Molecular Cell, 77/4, 2020, Page(s) 857-874.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Author(s): Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Published in: Nucleic Acids Research, 48/6, 2020, Page(s) 2942-2955, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa064

Getting under the skin of Polycomb-dependent gene regulation

Author(s): Neil P. Blackledge, Robert J. Klose
Published in: Genes & Development, 35/5-6, 2021, Page(s) 301-303, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348257.121

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Author(s): Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Published in: Molecular Cell, 74/5, 2019, Page(s) 1020-1036.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Author(s): Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Published in: eLife, 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.37084

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Author(s): Martin Cusack, Hamish W. King, Paolo Spingardi, Benedikt M. Kessler, Robert J. Klose, Skirmantas Kriaucionis
Published in: Genome Research, 30/10, 2020, Page(s) 1393-1406, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.257576.119

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Author(s): Miles K. Huseyin, Robert J. Klose
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21130-6

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Author(s): Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Published in: Genome Research, 28/10, 2018, Page(s) 1494-1507, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Author(s): Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Published in: Cell Reports, 18/2, 2017, Page(s) 482-495, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.12.054

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Author(s): Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1863/8, 2020, Page(s) 194567, ISSN 1874-9399
Publisher: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194567

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Author(s): Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Published in: eLife, 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.18591

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Author(s): Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Published in: Genome Research, 28/10, 2018, Page(s) 1494-1507, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Author(s): Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Published in: Molecular Cell, 74/5, 2019, Page(s) 1020-1036.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Author(s): James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Published in: Cell Reports, 30/3, 2020, Page(s) 820-835.e10, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

Author(s): Hamish W King, Robert J Klose
Published in: eLife, 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.22631

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Author(s): James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Published in: Cell Reports, 30/3, 2020, Page(s) 820-835.e10, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

Author(s): Paula Dobrinić, Aleksander T. Szczurek, Robert J. Klose
Published in: Nature Structural & Molecular Biology, 28/10, 2021, Page(s) 811-824, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00661-y

PRC1 Catalytic Activity Is Central to Polycomb System Function

Author(s): Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Published in: Molecular Cell, 77/4, 2020, Page(s) 857-874.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

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