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Discovering how polycomb domains form and function in gene regulation

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Publications

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Author(s): Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
DOI: 10.7554/eLife.18591

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Author(s): Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Published in: Genome Research, Issue 28/10, 2018, Page(s) 1494-1507, ISSN 1088-9051
DOI: 10.1101/gr.237180.118

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Author(s): Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Published in: Molecular Cell, Issue 74/5, 2019, Page(s) 1020-1036.e8, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.03.024

Cohesin disrupts polycomb-dependent chromosome interactions

Author(s): JDP Rhodes, A Feldmann, B Hernández-Rodríguez, N Díaz, JM Brown, NA Fursova, NP Blackledge, P Prathapan, P Dobrinic, M Huseyin, A Szczurek, K Kruse, KA Nasmyth, VJ Buckle, JM Vaquerizas, RJ Klose
Published in: BioRxiv, 2019
DOI: 10.1101/593970

PRC1 catalytic activity is central to Polycomb system function

Author(s): Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Published in: BioRxiv, 2019
DOI: 10.1101/667667