Discovering how polycomb domains form and function in gene regulation

Publikacje

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Autorzy: Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-17823-z

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Autorzy: David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Opublikowane w: Cell Reports, Numer 20/10, 2017, Strona(/y) 2313-2327, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2017.08.030

ATACing DNA Methylation during Differentiation

Autorzy: Skirmantas Kriaucionis, Robert J. Klose
Opublikowane w: Molecular Cell, Numer 77/6, 2020, Strona(/y) 1159-1161, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2020.02.026

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Autorzy: Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Opublikowane w: eLife, Numer 5, 2016, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.18591

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

Autorzy: Anne H Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W King, Haruhiko Koseki, Robert J Klose
Opublikowane w: Nucleic Acids Research, Numer 47/17, 2019, Strona(/y) 9005-9023, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkz607

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Autorzy: Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Opublikowane w: Genes & Development, Numer 35/9-10, 2021, Strona(/y) 749-770, ISSN 0890-9369
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347005.120

PRC1 Catalytic Activity Is Central to Polycomb System Function

Autorzy: Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Opublikowane w: Molecular Cell, Numer 77/4, 2020, Strona(/y) 857-874.e9, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Autorzy: Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Opublikowane w: Nucleic Acids Research, Numer 48/6, 2020, Strona(/y) 2942-2955, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkaa064

Getting under the skin of Polycomb-dependent gene regulation

Autorzy: Neil P. Blackledge, Robert J. Klose
Opublikowane w: Genes & Development, Numer 35/5-6, 2021, Strona(/y) 301-303, ISSN 0890-9369
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348257.121

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Autorzy: Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Opublikowane w: Molecular Cell, Numer 74/5, 2019, Strona(/y) 1020-1036.e8, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Autorzy: Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Opublikowane w: eLife, Numer 7, 2018, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.37084

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Autorzy: Martin Cusack, Hamish W. King, Paolo Spingardi, Benedikt M. Kessler, Robert J. Klose, Skirmantas Kriaucionis
Opublikowane w: Genome Research, Numer 30/10, 2020, Strona(/y) 1393-1406, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.257576.119

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Autorzy: Miles K. Huseyin, Robert J. Klose
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-21130-6

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Autorzy: Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Opublikowane w: Genome Research, Numer 28/10, 2018, Strona(/y) 1494-1507, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Autorzy: Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Opublikowane w: Cell Reports, Numer 18/2, 2017, Strona(/y) 482-495, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2016.12.054

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Autorzy: Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numer 1863/8, 2020, Strona(/y) 194567, ISSN 1874-9399
Wydawca: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194567

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

Autorzy: Hamish W King, Robert J Klose
Opublikowane w: eLife, Numer 6, 2017, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.22631

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Autorzy: James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Opublikowane w: Cell Reports, Numer 30/3, 2020, Strona(/y) 820-835.e10, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

Autorzy: Paula Dobrinić, Aleksander T. Szczurek, Robert J. Klose
Opublikowane w: Nature Structural & Molecular Biology, Numer 28/10, 2021, Strona(/y) 811-824, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/s41594-021-00661-y

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