Discovering how polycomb domains form and function in gene regulation

Informazioni relative al progetto

PolyDomFormFuncReg

ID dell’accordo di sovvenzione: 681440

DOI

10.3030/681440

Progetto chiuso

Data della firma CE 7 Marzo 2016

Data di avvio 1 Giugno 2016

Data di completamento 31 Maggio 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 416,00

Contributo UE

€ 1 999 416,00

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Autori: Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17823-z

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Autori: David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Pubblicato in: Cell Reports, Numero 20/10, 2017, Pagina/e 2313-2327, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.08.030

ATACing DNA Methylation during Differentiation

Autori: Skirmantas Kriaucionis, Robert J. Klose
Pubblicato in: Molecular Cell, Numero 77/6, 2020, Pagina/e 1159-1161, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.02.026

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Autori: Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Pubblicato in: eLife, Numero 5, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.18591

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

Autori: Anne H Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W King, Haruhiko Koseki, Robert J Klose
Pubblicato in: Nucleic Acids Research, Numero 47/17, 2019, Pagina/e 9005-9023, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz607

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Autori: Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Pubblicato in: Genes & Development, Numero 35/9-10, 2021, Pagina/e 749-770, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347005.120

PRC1 Catalytic Activity Is Central to Polycomb System Function

Autori: Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Pubblicato in: Molecular Cell, Numero 77/4, 2020, Pagina/e 857-874.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Autori: Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Pubblicato in: Nucleic Acids Research, Numero 48/6, 2020, Pagina/e 2942-2955, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa064

Getting under the skin of Polycomb-dependent gene regulation

Autori: Neil P. Blackledge, Robert J. Klose
Pubblicato in: Genes & Development, Numero 35/5-6, 2021, Pagina/e 301-303, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348257.121

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Autori: Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Pubblicato in: Molecular Cell, Numero 74/5, 2019, Pagina/e 1020-1036.e8, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Autori: Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.37084

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Autori: Martin Cusack, Hamish W. King, Paolo Spingardi, Benedikt M. Kessler, Robert J. Klose, Skirmantas Kriaucionis
Pubblicato in: Genome Research, Numero 30/10, 2020, Pagina/e 1393-1406, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.257576.119

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Autori: Miles K. Huseyin, Robert J. Klose
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21130-6

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Autori: Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Pubblicato in: Genome Research, Numero 28/10, 2018, Pagina/e 1494-1507, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Autori: Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Pubblicato in: Cell Reports, Numero 18/2, 2017, Pagina/e 482-495, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.12.054

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Autori: Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numero 1863/8, 2020, Pagina/e 194567, ISSN 1874-9399
Editore: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194567

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

Autori: Hamish W King, Robert J Klose
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.22631

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Autori: James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Pubblicato in: Cell Reports, Numero 30/3, 2020, Pagina/e 820-835.e10, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

Autori: Paula Dobrinić, Aleksander T. Szczurek, Robert J. Klose
Pubblicato in: Nature Structural & Molecular Biology, Numero 28/10, 2021, Pagina/e 811-824, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-021-00661-y