Discovering how polycomb domains form and function in gene regulation

Publications

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

Auteurs: Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17823-z

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

Auteurs: David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Publié dans: Cell Reports, Numéro 20/10, 2017, Page(s) 2313-2327, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.08.030

ATACing DNA Methylation during Differentiation

Auteurs: Skirmantas Kriaucionis, Robert J. Klose
Publié dans: Molecular Cell, Numéro 77/6, 2020, Page(s) 1159-1161, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2020.02.026

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

Auteurs: Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Publié dans: eLife, Numéro 5, 2016, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.18591

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity

Auteurs: Anne H Turberfield, Takashi Kondo, Manabu Nakayama, Yoko Koseki, Hamish W King, Haruhiko Koseki, Robert J Klose
Publié dans: Nucleic Acids Research, Numéro 47/17, 2019, Page(s) 9005-9023, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkz607

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Auteurs: Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Publié dans: Genes & Development, Numéro 35/9-10, 2021, Page(s) 749-770, ISSN 0890-9369
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347005.120

PRC1 Catalytic Activity Is Central to Polycomb System Function

Auteurs: Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose
Publié dans: Molecular Cell, Numéro 77/4, 2020, Page(s) 857-874.e9, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2019.12.001

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Auteurs: Angelika Feldmann, Emilia Dimitrova, Alexander Kenney, Anna Lastuvkova, Robert J Klose
Publié dans: Nucleic Acids Research, Numéro 48/6, 2020, Page(s) 2942-2955, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkaa064

Getting under the skin of Polycomb-dependent gene regulation

Auteurs: Neil P. Blackledge, Robert J. Klose
Publié dans: Genes & Development, Numéro 35/5-6, 2021, Page(s) 301-303, ISSN 0890-9369
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.348257.121

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Auteurs: Nadezda A. Fursova, Neil P. Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki, Anca M. Farcas, Hamish W. King, Haruhiko Koseki, Robert J. Klose
Publié dans: Molecular Cell, Numéro 74/5, 2019, Page(s) 1020-1036.e8, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2019.03.024

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

Auteurs: Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Publié dans: eLife, Numéro 7, 2018, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.37084

Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors

Auteurs: Martin Cusack, Hamish W. King, Paolo Spingardi, Benedikt M. Kessler, Robert J. Klose, Skirmantas Kriaucionis
Publié dans: Genome Research, Numéro 30/10, 2020, Page(s) 1393-1406, ISSN 1088-9051
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.257576.119

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Auteurs: Miles K. Huseyin, Robert J. Klose
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-21130-6

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Auteurs: Hamish W. King, Nadezda A. Fursova, Neil P. Blackledge, Robert J. Klose
Publié dans: Genome Research, Numéro 28/10, 2018, Page(s) 1494-1507, ISSN 1088-9051
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.237180.118

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Auteurs: Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Publié dans: Cell Reports, Numéro 18/2, 2017, Page(s) 482-495, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2016.12.054

Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

Auteurs: Amy L. Hughes, Jessica R. Kelley, Robert J. Klose
Publié dans: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numéro 1863/8, 2020, Page(s) 194567, ISSN 1874-9399
Éditeur: Elsevier BV
DOI: 10.1016/j.bbagrm.2020.194567

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

Auteurs: Hamish W King, Robert J Klose
Publié dans: eLife, Numéro 6, 2017, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.22631

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Auteurs: James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Publié dans: Cell Reports, Numéro 30/3, 2020, Page(s) 820-835.e10, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2019.12.057

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

Auteurs: Paula Dobrinić, Aleksander T. Szczurek, Robert J. Klose
Publié dans: Nature Structural & Molecular Biology, Numéro 28/10, 2021, Page(s) 811-824, ISSN 1545-9993
Éditeur: Nature Publishing Group
DOI: 10.1038/s41594-021-00661-y

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