CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis

Project Information

CD40-INN

Grant agreement ID: 681493

DOI 10.3030/681493

Project terminated on 4 February 2023

EC signature date 7 November 2016

Start date 1 December 2016

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 420,00

EU contribution € 1 999 420,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Author(s): Laura A Bosmans 1 , Claudia M van Tiel 1 , Suzanne A B M Aarts 1 , Lisa Willemsen 1 , Jeroen Baardman 1 , Bram W van Os 1 , Myrthe den Toom 1 , Linda Beckers 1 , David J Ahern 2 , Johannes H M Levels 3 , Aldo Jongejan 4 , Perry D Moerland 4 , Sanne G S Verberk 5 , Jan van den Bossche 1 5 , Menno M P J de Winther 1 , Christian Weber 6 7 8 9 , Dorothee Atzler 6 9 10 , Cl
Published in: CardioVascular Research, Issue 119, 2023, Page(s) 114601160, ISSN 1755-3245
Publisher: Oxford Academic
DOI: 10.1093/cvr/cvac084

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Author(s): Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23909-z

Immune Checkpoint Inhibitor Therapy Aggravates T CellDriven Plaque Inflammation in Atherosclerosis

Author(s): Kikkie Poels; Mandy M. T. van Leent; Celine Boutros; Hubert Tissot; Sverine Roy; Anu E. Meerwaldt; Anu E. Meerwaldt; Yohana C. Toner; Myrthe E. Reiche; Pascal J. H. Kusters; Tsveta S. Malinova; Stephan Huveneers; Audrey E Kaufman; Venkatesh Mani; Zahi A. Fayad; Menno P.J. de Winther; Aurlien Marabelle; Willem J. M. Mulder; Willem J. M. Mulder; Willem J. M. Mulder; Caroline Robert; Caroline Rob
Published in: JACC: CardioOncology, 2(4), 599 - 610. Elsevier Inc., 2020, ISSN 2666-0873
Publisher: Springer
DOI: 10.1016/j.jaccao.2020.08.007

Adipocytes control hematopoiesis and inflammation through CD40 signaling

Author(s): Myrthe E Reiche 1 , Kikkie Poels 2 , Laura A Bosmans 2 , Winnie G Vos 2 , Claudia M Van Tiel 2 , Marion J J Gijbels 3 , Suzanne A B M Aarts 2 , Myrthe Den Toom 2 , Linda Beckers 2 , Christian Weber 4 , Dorothee Atzler 5 , Patrick C N Rensen 6 , Sander Kooijman 6 , Esther Lutgens 7
Published in: Haematologica, Issue 108, 2023, Page(s) 1873-1885, ISSN 1592-8721
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281482

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Author(s): Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens
Published in: Cells, Issue 9/9, 2020, Page(s) 1987, ISSN 2073-4409
Publisher: cells
DOI: 10.3390/cells9091987

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

Author(s): Kikkie Poels, Mandy M.T. van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Anu E. Meerwaldt, Yohana C.A. Toner, Myrthe E. Reiche, Pascal J.H. Kusters, Tsveta Malinova, Stephan Huveneers, Audrey E. Kaufman, Venkatesh Mani, Zahi A. Fayad, Menno P.J. de Winther, Aurelien Marabelle, Willem J.M. Mulder, Caroline Robert, Tom T.P. Seijkens, Esther Lutgens
Published in: JACC: CardioOncology, Issue 2/4, 2020, Page(s) 599-610, ISSN 2666-0873
Publisher: jacc
DOI: 10.1016/j.jaccao.2020.08.007

Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis

Author(s): Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, Esther Lutgens
Published in: Vascular Pharmacology, Issue 139, 2021, Page(s) 106884, ISSN 1537-1891
Publisher: Elsevier BV
DOI: 10.1016/j.vph.2021.106884

Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

Author(s): Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Michael Lacy, Claudia van Tiel, Remco Ta Megens, Katrin Nitz, Jeroen Baardman, Pascal Kusters, Tom Seijkens, Christina Buerger, Aleksandar Janjic, Carlo Riccardi, Andreas Edsfeldt, Claudia Monaco, Mat Daemen, Menno P J de Winther, Jan Nilsson, Christian Weber, Norbert Gerdes, Isabel Gonçalves, Esther Lutgens
Published in: European Heart Journal, Issue 41/31, 2020, Page(s) 2938-2948, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaa484

2016 Jeffrey M. Hoeg Award Lecture

Author(s): Ellen Rouwet, Esther Lutgens
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, Page(s) ATVBAHA.118.307742, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.118.307742

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Published in: Journal of Neuroinflammation, Issue 14/1, 2017, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-017-0875-9

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice

Author(s): Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Published in: European Heart Journal, Issue 38/48, 2017, Page(s) 3590-3599, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehx517

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption

Author(s): Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens
Published in: The American Journal of Pathology, Issue 187/12, 2017, Page(s) 2912-2919, ISSN 0002-9440
Publisher: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2017.08.016

CD40L Deficiency Protects Against Aneurysm FormationHighlights

Author(s): Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 38/5, 2018, Page(s) 1076-1085, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.117.310640

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
Publisher: lippincott
DOI: 10.3389/fimmu.2017.01791

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Author(s): Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Published in: Journal of the American College of Cardiology, Issue 71/5, 2018, Page(s) 527-542, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Author(s): Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Published in: Cardiovascular Research, Issue 114/3, 2017, Page(s) 368-377, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvx248

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

Author(s): José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer
Published in: European Journal of Preventive Cardiology, Issue 25/9, 2018, Page(s) 948-955, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1177/2047487318773384

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Author(s): Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans
Published in: Cardiovascular Research, Issue 115/9, 2019, Page(s) 1385-1392, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvz166

Immunotherapy for cardiovascular disease

Author(s): Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Published in: European Heart Journal, 2019, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehz283

The Link between Hematopoiesis and Atherosclerosis

Author(s): Menno P.J. de Winther, Esther Lutgens
Published in: New England Journal of Medicine, Issue 380/19, 2019, Page(s) 1869-1871, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmcibr1901397

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

Author(s): Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher
Published in: Nature Biomedical Engineering, Issue 2/5, 2018, Page(s) 279-292, ISSN 2157-846X
Publisher: Nature
DOI: 10.1038/s41551-018-0221-2

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Author(s): Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Published in: International Journal of Cardiology, Issue 279, 2019, Page(s) 141-144, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2018.12.076

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

Author(s): Suzanne ABM Aarts, Tom TP Seijkens, Pascal JH Kusters, Claudia M van Tiel, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Cindy PAA van Roomen, Menno PJ de Winther, Gijs Kooij, Esther Lutgens
Published in: The Journal of Pathology, Issue 247/4, 2019, Page(s) 471-480, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5205

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Author(s): Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Published in: European Heart Journal, Issue 40/4, 2018, Page(s) 372-382, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis

Author(s): Michael Lacy, Dorothee Atzler, Rongqi Liu, Menno de Winther, Christian Weber, Esther Lutgens
Published in: Pharmacology & Therapeutics, Issue 193, 2019, Page(s) 50-62, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.08.012

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Author(s): Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Published in: PLOS ONE, Issue 13/8, 2018, Page(s) e0202150, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Author(s): Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Published in: Cardiovascular Research, Issue 114/11, 2018, Page(s) 1411-1421, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy184