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CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis


2016 Jeffrey M. Hoeg Award Lecture

Published in: ISSN 1079-5642
DOI: 10.1161/ATVBAHA.118.307742

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Published in: Journal of Neuroinflammation, Issue 14/1, 2017, ISSN 1742-2094
DOI: 10.1186/s12974-017-0875-9

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice

Author(s): Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Published in: European Heart Journal, Issue 38/48, 2017, Page(s) 3590-3599, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehx517

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption

Author(s): Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens
Published in: The American Journal of Pathology, Issue 187/12, 2017, Page(s) 2912-2919, ISSN 0002-9440
DOI: 10.1016/j.ajpath.2017.08.016

CD40L Deficiency Protects Against Aneurysm FormationHighlights

Published in: ISSN 1079-5642
DOI: 10.1161/ATVBAHA.117.310640

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.01791

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Author(s): Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Published in: Journal of the American College of Cardiology, Issue 71/5, 2018, Page(s) 527-542, ISSN 0735-1097
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Author(s): Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Published in: Cardiovascular Research, Issue 114/3, 2017, Page(s) 368-377, ISSN 0008-6363
DOI: 10.1093/cvr/cvx248

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

Author(s): José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer
Published in: European Journal of Preventive Cardiology, Issue 25/9, 2018, Page(s) 948-955, ISSN 2047-4873
DOI: 10.1177/2047487318773384

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Author(s): Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans
Published in: Cardiovascular Research, Issue 115/9, 2019, Page(s) 1385-1392, ISSN 0008-6363
DOI: 10.1093/cvr/cvz166

Immunotherapy for cardiovascular disease

Author(s): Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Published in: European Heart Journal, 2019, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehz283

The Link between Hematopoiesis and Atherosclerosis

Author(s): Menno P.J. de Winther, Esther Lutgens
Published in: New England Journal of Medicine, Issue 380/19, 2019, Page(s) 1869-1871, ISSN 0028-4793
DOI: 10.1056/nejmcibr1901397

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

Author(s): Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher
Published in: Nature Biomedical Engineering, Issue 2/5, 2018, Page(s) 279-292, ISSN 2157-846X
DOI: 10.1038/s41551-018-0221-2

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Author(s): Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Published in: International Journal of Cardiology, Issue 279, 2019, Page(s) 141-144, ISSN 0167-5273
DOI: 10.1016/j.ijcard.2018.12.076

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

Published in: ISSN 0022-3417
DOI: 10.1002/path.5205

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Author(s): Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Published in: European Heart Journal, Issue 40/4, 2018, Page(s) 372-382, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehy714

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Author(s): Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Published in: PLOS ONE, Issue 13/8, 2018, Page(s) e0202150, ISSN 1932-6203
DOI: 10.1371/journal.pone.0202150

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Author(s): Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Published in: Cardiovascular Research, Issue 114/11, 2018, Page(s) 1411-1421, ISSN 0008-6363
DOI: 10.1093/cvr/cvy184