Publications Peer reviewed articles (26) Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state Author(s): Laura A Bosmans 1 , Claudia M van Tiel 1 , Suzanne A B M Aarts 1 , Lisa Willemsen 1 , Jeroen Baardman 1 , Bram W van Os 1 , Myrthe den Toom 1 , Linda Beckers 1 , David J Ahern 2 , Johannes H M Levels 3 , Aldo Jongejan 4 , Perry D Moerland 4 , Sanne G S Verberk 5 , Jan van den Bossche 1 5 , Menno M P J de Winther 1 , Christian Weber 6 7 8 9 , Dorothee Atzler 6 9 10 , Cl Published in: CardioVascular Research, Issue 119, 2023, Page(s) 114601160, ISSN 1755-3245 Publisher: Oxford Academic DOI: 10.1093/cvr/cvac084 Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease Author(s): Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-23909-z Adipocytes control hematopoiesis and inflammation through CD40 signaling Author(s): Myrthe E Reiche 1 , Kikkie Poels 2 , Laura A Bosmans 2 , Winnie G Vos 2 , Claudia M Van Tiel 2 , Marion J J Gijbels 3 , Suzanne A B M Aarts 2 , Myrthe Den Toom 2 , Linda Beckers 2 , Christian Weber 4 , Dorothee Atzler 5 , Patrick C N Rensen 6 , Sander Kooijman 6 , Esther Lutgens 7 Published in: Haematologica, Issue 108, 2023, Page(s) 1873-1885, ISSN 1592-8721 Publisher: Ferrata Storti Foundation DOI: 10.3324/haematol.2022.281482 Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice Author(s): Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens Published in: Cells, Issue 9/9, 2020, Page(s) 1987, ISSN 2073-4409 Publisher: cells DOI: 10.3390/cells9091987 Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis Author(s): Kikkie Poels, Mandy M.T. van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Anu E. Meerwaldt, Yohana C.A. Toner, Myrthe E. Reiche, Pascal J.H. Kusters, Tsveta Malinova, Stephan Huveneers, Audrey E. Kaufman, Venkatesh Mani, Zahi A. Fayad, Menno P.J. de Winther, Aurelien Marabelle, Willem J.M. Mulder, Caroline Robert, Tom T.P. Seijkens, Esther Lutgens Published in: JACC: CardioOncology, Issue 2/4, 2020, Page(s) 599-610, ISSN 2666-0873 Publisher: jacc DOI: 10.1016/j.jaccao.2020.08.007 Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis Author(s): Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, Esther Lutgens Published in: Vascular Pharmacology, Issue 139, 2021, Page(s) 106884, ISSN 1537-1891 Publisher: Elsevier BV DOI: 10.1016/j.vph.2021.106884 Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans Author(s): Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Michael Lacy, Claudia van Tiel, Remco Ta Megens, Katrin Nitz, Jeroen Baardman, Pascal Kusters, Tom Seijkens, Christina Buerger, Aleksandar Janjic, Carlo Riccardi, Andreas Edsfeldt, Claudia Monaco, Mat Daemen, Menno P J de Winther, Jan Nilsson, Christian Weber, Norbert Gerdes, Isabel Gonçalves, Esther Lutgens Published in: European Heart Journal, Issue 41/31, 2020, Page(s) 2938-2948, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehaa484 2016 Jeffrey M. Hoeg Award Lecture Author(s): Ellen Rouwet, Esther Lutgens Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, Page(s) ATVBAHA.118.307742, ISSN 1079-5642 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/ATVBAHA.118.307742 Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens Published in: Journal of Neuroinflammation, Issue 14/1, 2017, ISSN 1742-2094 Publisher: BioMed Central DOI: 10.1186/s12974-017-0875-9 CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice Author(s): Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes Published in: European Heart Journal, Issue 38/48, 2017, Page(s) 3590-3599, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehx517 Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption Author(s): Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens Published in: The American Journal of Pathology, Issue 187/12, 2017, Page(s) 2912-2919, ISSN 0002-9440 Publisher: American Society for Investigative Pathology DOI: 10.1016/j.ajpath.2017.08.016 CD40L Deficiency Protects Against Aneurysm FormationHighlights Author(s): Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 38/5, 2018, Page(s) 1076-1085, ISSN 1079-5642 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/ATVBAHA.117.310640 The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Author(s): Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224 Publisher: lippincott DOI: 10.3389/fimmu.2017.01791 Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis Author(s): Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax Published in: Journal of the American College of Cardiology, Issue 71/5, 2018, Page(s) 527-542, ISSN 0735-1097 Publisher: Elsevier BV DOI: 10.1016/j.jacc.2017.11.055 Exploring immune checkpoints as potential therapeutic targets in atherosclerosis Author(s): Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens Published in: Cardiovascular Research, Issue 114/3, 2017, Page(s) 368-377, ISSN 0008-6363 Publisher: Elsevier BV DOI: 10.1093/cvr/cvx248 Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice Author(s): José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer Published in: European Journal of Preventive Cardiology, Issue 25/9, 2018, Page(s) 948-955, ISSN 2047-4873 Publisher: SAGE Publications Ltd DOI: 10.1177/2047487318773384 Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology Author(s): Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans Published in: Cardiovascular Research, Issue 115/9, 2019, Page(s) 1385-1392, ISSN 0008-6363 Publisher: Elsevier BV DOI: 10.1093/cvr/cvz166 Immunotherapy for cardiovascular disease Author(s): Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber Published in: European Heart Journal, 2019, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehz283 The Link between Hematopoiesis and Atherosclerosis Author(s): Menno P.J. de Winther, Esther Lutgens Published in: New England Journal of Medicine, Issue 380/19, 2019, Page(s) 1869-1871, ISSN 0028-4793 Publisher: Massachusetts Medical Society DOI: 10.1056/nejmcibr1901397 Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates Author(s): Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher Published in: Nature Biomedical Engineering, Issue 2/5, 2018, Page(s) 279-292, ISSN 2157-846X Publisher: Nature DOI: 10.1038/s41551-018-0221-2 Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure Author(s): Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager Published in: International Journal of Cardiology, Issue 279, 2019, Page(s) 141-144, ISSN 0167-5273 Publisher: Elsevier BV DOI: 10.1016/j.ijcard.2018.12.076 Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis Author(s): Suzanne ABM Aarts, Tom TP Seijkens, Pascal JH Kusters, Claudia M van Tiel, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Cindy PAA van Roomen, Menno PJ de Winther, Gijs Kooij, Esther Lutgens Published in: The Journal of Pathology, Issue 247/4, 2019, Page(s) 471-480, ISSN 0022-3417 Publisher: John Wiley & Sons Inc. DOI: 10.1002/path.5205 Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death Author(s): Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther Published in: European Heart Journal, Issue 40/4, 2018, Page(s) 372-382, ISSN 0195-668X Publisher: Oxford University Press DOI: 10.1093/eurheartj/ehy714 Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis Author(s): Michael Lacy, Dorothee Atzler, Rongqi Liu, Menno de Winther, Christian Weber, Esther Lutgens Published in: Pharmacology & Therapeutics, Issue 193, 2019, Page(s) 50-62, ISSN 0163-7258 Publisher: Pergamon Press DOI: 10.1016/j.pharmthera.2018.08.012 Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction Author(s): Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens Published in: PLOS ONE, Issue 13/8, 2018, Page(s) e0202150, ISSN 1932-6203 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0202150 Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology Author(s): Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans Published in: Cardiovascular Research, Issue 114/11, 2018, Page(s) 1411-1421, ISSN 0008-6363 Publisher: Elsevier BV DOI: 10.1093/cvr/cvy184 Searching for OpenAIRE data... 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