CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis

Publikacje

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Autorzy: Laura A Bosmans 1 , Claudia M van Tiel 1 , Suzanne A B M Aarts 1 , Lisa Willemsen 1 , Jeroen Baardman 1 , Bram W van Os 1 , Myrthe den Toom 1 , Linda Beckers 1 , David J Ahern 2 , Johannes H M Levels 3 , Aldo Jongejan 4 , Perry D Moerland 4 , Sanne G S Verberk 5 , Jan van den Bossche 1 5 , Menno M P J de Winther 1 , Christian Weber 6 7 8 9 , Dorothee Atzler 6 9 10 , Cl
Opublikowane w: CardioVascular Research, Numer 119, 2023, Strona(/y) 114601160, ISSN 1755-3245
Wydawca: Oxford Academic
DOI: 10.1093/cvr/cvac084

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Autorzy: Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23909-z

Adipocytes control hematopoiesis and inflammation through CD40 signaling

Autorzy: Myrthe E Reiche 1 , Kikkie Poels 2 , Laura A Bosmans 2 , Winnie G Vos 2 , Claudia M Van Tiel 2 , Marion J J Gijbels 3 , Suzanne A B M Aarts 2 , Myrthe Den Toom 2 , Linda Beckers 2 , Christian Weber 4 , Dorothee Atzler 5 , Patrick C N Rensen 6 , Sander Kooijman 6 , Esther Lutgens 7
Opublikowane w: Haematologica, Numer 108, 2023, Strona(/y) 1873-1885, ISSN 1592-8721
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281482

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Autorzy: Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens
Opublikowane w: Cells, Numer 9/9, 2020, Strona(/y) 1987, ISSN 2073-4409
Wydawca: cells
DOI: 10.3390/cells9091987

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

Autorzy: Kikkie Poels, Mandy M.T. van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Anu E. Meerwaldt, Yohana C.A. Toner, Myrthe E. Reiche, Pascal J.H. Kusters, Tsveta Malinova, Stephan Huveneers, Audrey E. Kaufman, Venkatesh Mani, Zahi A. Fayad, Menno P.J. de Winther, Aurelien Marabelle, Willem J.M. Mulder, Caroline Robert, Tom T.P. Seijkens, Esther Lutgens
Opublikowane w: JACC: CardioOncology, Numer 2/4, 2020, Strona(/y) 599-610, ISSN 2666-0873
Wydawca: jacc
DOI: 10.1016/j.jaccao.2020.08.007

Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis

Autorzy: Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, Esther Lutgens
Opublikowane w: Vascular Pharmacology, Numer 139, 2021, Strona(/y) 106884, ISSN 1537-1891
Wydawca: Elsevier BV
DOI: 10.1016/j.vph.2021.106884

Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

Autorzy: Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Michael Lacy, Claudia van Tiel, Remco Ta Megens, Katrin Nitz, Jeroen Baardman, Pascal Kusters, Tom Seijkens, Christina Buerger, Aleksandar Janjic, Carlo Riccardi, Andreas Edsfeldt, Claudia Monaco, Mat Daemen, Menno P J de Winther, Jan Nilsson, Christian Weber, Norbert Gerdes, Isabel Gonçalves, Esther Lutgens
Opublikowane w: European Heart Journal, Numer 41/31, 2020, Strona(/y) 2938-2948, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehaa484

2016 Jeffrey M. Hoeg Award Lecture

Autorzy: Ellen Rouwet, Esther Lutgens
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, Strona(/y) ATVBAHA.118.307742, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.118.307742

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Autorzy: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Opublikowane w: Journal of Neuroinflammation, Numer 14/1, 2017, ISSN 1742-2094
Wydawca: BioMed Central
DOI: 10.1186/s12974-017-0875-9

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice

Autorzy: Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Opublikowane w: European Heart Journal, Numer 38/48, 2017, Strona(/y) 3590-3599, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehx517

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption

Autorzy: Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens
Opublikowane w: The American Journal of Pathology, Numer 187/12, 2017, Strona(/y) 2912-2919, ISSN 0002-9440
Wydawca: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2017.08.016

CD40L Deficiency Protects Against Aneurysm FormationHighlights

Autorzy: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 38/5, 2018, Strona(/y) 1076-1085, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.117.310640

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Autorzy: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: lippincott
DOI: 10.3389/fimmu.2017.01791

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Autorzy: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Opublikowane w: Journal of the American College of Cardiology, Numer 71/5, 2018, Strona(/y) 527-542, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Autorzy: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Opublikowane w: Cardiovascular Research, Numer 114/3, 2017, Strona(/y) 368-377, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvx248

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

Autorzy: José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer
Opublikowane w: European Journal of Preventive Cardiology, Numer 25/9, 2018, Strona(/y) 948-955, ISSN 2047-4873
Wydawca: SAGE Publications Ltd
DOI: 10.1177/2047487318773384

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Autorzy: Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans
Opublikowane w: Cardiovascular Research, Numer 115/9, 2019, Strona(/y) 1385-1392, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvz166

Immunotherapy for cardiovascular disease

Autorzy: Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Opublikowane w: European Heart Journal, 2019, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehz283

The Link between Hematopoiesis and Atherosclerosis

Autorzy: Menno P.J. de Winther, Esther Lutgens
Opublikowane w: New England Journal of Medicine, Numer 380/19, 2019, Strona(/y) 1869-1871, ISSN 0028-4793
Wydawca: Massachusetts Medical Society
DOI: 10.1056/nejmcibr1901397

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

Autorzy: Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher
Opublikowane w: Nature Biomedical Engineering, Numer 2/5, 2018, Strona(/y) 279-292, ISSN 2157-846X
Wydawca: Nature
DOI: 10.1038/s41551-018-0221-2

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Autorzy: Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Opublikowane w: International Journal of Cardiology, Numer 279, 2019, Strona(/y) 141-144, ISSN 0167-5273
Wydawca: Elsevier BV
DOI: 10.1016/j.ijcard.2018.12.076

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

Autorzy: Suzanne ABM Aarts, Tom TP Seijkens, Pascal JH Kusters, Claudia M van Tiel, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Cindy PAA van Roomen, Menno PJ de Winther, Gijs Kooij, Esther Lutgens
Opublikowane w: The Journal of Pathology, Numer 247/4, 2019, Strona(/y) 471-480, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5205

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Autorzy: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Opublikowane w: European Heart Journal, Numer 40/4, 2018, Strona(/y) 372-382, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis

Autorzy: Michael Lacy, Dorothee Atzler, Rongqi Liu, Menno de Winther, Christian Weber, Esther Lutgens
Opublikowane w: Pharmacology & Therapeutics, Numer 193, 2019, Strona(/y) 50-62, ISSN 0163-7258
Wydawca: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.08.012

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Autorzy: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Opublikowane w: PLOS ONE, Numer 13/8, 2018, Strona(/y) e0202150, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Autorzy: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Opublikowane w: Cardiovascular Research, Numer 114/11, 2018, Strona(/y) 1411-1421, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvy184

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