CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis

Información del proyecto

CD40-INN

Identificador del acuerdo de subvención: 681493

DOI

10.3030/681493

Proyecto finalizado el 4 Febrero 2023

Fecha de la firma de la CE 7 Noviembre 2016

Fecha de inicio 1 Diciembre 2016

Fecha de finalización 30 Noviembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 420,00

Aportación de la UE

€ 1 999 420,00

Coordinado por

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (27)

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Autores: Laura A Bosmans 1 , Claudia M van Tiel 1 , Suzanne A B M Aarts 1 , Lisa Willemsen 1 , Jeroen Baardman 1 , Bram W van Os 1 , Myrthe den Toom 1 , Linda Beckers 1 , David J Ahern 2 , Johannes H M Levels 3 , Aldo Jongejan 4 , Perry D Moerland 4 , Sanne G S Verberk 5 , Jan van den Bossche 1 5 , Menno M P J de Winther 1 , Christian Weber 6 7 8 9 , Dorothee Atzler 6 9 10 , Cl
Publicado en: CardioVascular Research, Edición 119, 2023, Página(s) 114601160, ISSN 1755-3245
Editor: Oxford Academic
DOI: 10.1093/cvr/cvac084

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Autores: Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23909-z

Immune Checkpoint Inhibitor Therapy Aggravates T CellDriven Plaque Inflammation in Atherosclerosis

Autores: Kikkie Poels; Mandy M. T. van Leent; Celine Boutros; Hubert Tissot; Sverine Roy; Anu E. Meerwaldt; Anu E. Meerwaldt; Yohana C. Toner; Myrthe E. Reiche; Pascal J. H. Kusters; Tsveta S. Malinova; Stephan Huveneers; Audrey E Kaufman; Venkatesh Mani; Zahi A. Fayad; Menno P.J. de Winther; Aurlien Marabelle; Willem J. M. Mulder; Willem J. M. Mulder; Willem J. M. Mulder; Caroline Robert; Caroline Rob
Publicado en: JACC: CardioOncology, 2(4), 599 - 610. Elsevier Inc., 2020, ISSN 2666-0873
Editor: Springer
DOI: 10.1016/j.jaccao.2020.08.007

Adipocytes control hematopoiesis and inflammation through CD40 signaling

Autores: Myrthe E Reiche 1 , Kikkie Poels 2 , Laura A Bosmans 2 , Winnie G Vos 2 , Claudia M Van Tiel 2 , Marion J J Gijbels 3 , Suzanne A B M Aarts 2 , Myrthe Den Toom 2 , Linda Beckers 2 , Christian Weber 4 , Dorothee Atzler 5 , Patrick C N Rensen 6 , Sander Kooijman 6 , Esther Lutgens 7
Publicado en: Haematologica, Edición 108, 2023, Página(s) 1873-1885, ISSN 1592-8721
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.281482

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Autores: Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens
Publicado en: Cells, Edición 9/9, 2020, Página(s) 1987, ISSN 2073-4409
Editor: cells
DOI: 10.3390/cells9091987

Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis

Autores: Kikkie Poels, Mandy M.T. van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Anu E. Meerwaldt, Yohana C.A. Toner, Myrthe E. Reiche, Pascal J.H. Kusters, Tsveta Malinova, Stephan Huveneers, Audrey E. Kaufman, Venkatesh Mani, Zahi A. Fayad, Menno P.J. de Winther, Aurelien Marabelle, Willem J.M. Mulder, Caroline Robert, Tom T.P. Seijkens, Esther Lutgens
Publicado en: JACC: CardioOncology, Edición 2/4, 2020, Página(s) 599-610, ISSN 2666-0873
Editor: jacc
DOI: 10.1016/j.jaccao.2020.08.007

Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis

Autores: Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, Esther Lutgens
Publicado en: Vascular Pharmacology, Edición 139, 2021, Página(s) 106884, ISSN 1537-1891
Editor: Elsevier BV
DOI: 10.1016/j.vph.2021.106884

Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

Autores: Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Michael Lacy, Claudia van Tiel, Remco Ta Megens, Katrin Nitz, Jeroen Baardman, Pascal Kusters, Tom Seijkens, Christina Buerger, Aleksandar Janjic, Carlo Riccardi, Andreas Edsfeldt, Claudia Monaco, Mat Daemen, Menno P J de Winther, Jan Nilsson, Christian Weber, Norbert Gerdes, Isabel Gonçalves, Esther Lutgens
Publicado en: European Heart Journal, Edición 41/31, 2020, Página(s) 2938-2948, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehaa484

2016 Jeffrey M. Hoeg Award Lecture

Autores: Ellen Rouwet, Esther Lutgens
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, Página(s) ATVBAHA.118.307742, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.118.307742

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Autores: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Publicado en: Journal of Neuroinflammation, Edición 14/1, 2017, ISSN 1742-2094
Editor: BioMed Central
DOI: 10.1186/s12974-017-0875-9

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice

Autores: Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Publicado en: European Heart Journal, Edición 38/48, 2017, Página(s) 3590-3599, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehx517

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption

Autores: Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens
Publicado en: The American Journal of Pathology, Edición 187/12, 2017, Página(s) 2912-2919, ISSN 0002-9440
Editor: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2017.08.016

CD40L Deficiency Protects Against Aneurysm FormationHighlights

Autores: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 38/5, 2018, Página(s) 1076-1085, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/ATVBAHA.117.310640

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Autores: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: lippincott
DOI: 10.3389/fimmu.2017.01791

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Autores: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax
Publicado en: Journal of the American College of Cardiology, Edición 71/5, 2018, Página(s) 527-542, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2017.11.055

Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Autores: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens
Publicado en: Cardiovascular Research, Edición 114/3, 2017, Página(s) 368-377, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvx248

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

Autores: José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer
Publicado en: European Journal of Preventive Cardiology, Edición 25/9, 2018, Página(s) 948-955, ISSN 2047-4873
Editor: SAGE Publications Ltd
DOI: 10.1177/2047487318773384

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Autores: Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans
Publicado en: Cardiovascular Research, Edición 115/9, 2019, Página(s) 1385-1392, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvz166

Immunotherapy for cardiovascular disease

Autores: Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber
Publicado en: European Heart Journal, 2019, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehz283

The Link between Hematopoiesis and Atherosclerosis

Autores: Menno P.J. de Winther, Esther Lutgens
Publicado en: New England Journal of Medicine, Edición 380/19, 2019, Página(s) 1869-1871, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmcibr1901397

Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

Autores: Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher
Publicado en: Nature Biomedical Engineering, Edición 2/5, 2018, Página(s) 279-292, ISSN 2157-846X
Editor: Nature
DOI: 10.1038/s41551-018-0221-2

Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

Autores: Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager
Publicado en: International Journal of Cardiology, Edición 279, 2019, Página(s) 141-144, ISSN 0167-5273
Editor: Elsevier BV
DOI: 10.1016/j.ijcard.2018.12.076

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

Autores: Suzanne ABM Aarts, Tom TP Seijkens, Pascal JH Kusters, Claudia M van Tiel, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Cindy PAA van Roomen, Menno PJ de Winther, Gijs Kooij, Esther Lutgens
Publicado en: The Journal of Pathology, Edición 247/4, 2019, Página(s) 471-480, ISSN 0022-3417
Editor: John Wiley & Sons Inc.
DOI: 10.1002/path.5205

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death

Autores: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther
Publicado en: European Heart Journal, Edición 40/4, 2018, Página(s) 372-382, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehy714

Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis

Autores: Michael Lacy, Dorothee Atzler, Rongqi Liu, Menno de Winther, Christian Weber, Esther Lutgens
Publicado en: Pharmacology & Therapeutics, Edición 193, 2019, Página(s) 50-62, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2018.08.012

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Autores: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens
Publicado en: PLOS ONE, Edición 13/8, 2018, Página(s) e0202150, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0202150

Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology

Autores: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans
Publicado en: Cardiovascular Research, Edición 114/11, 2018, Página(s) 1411-1421, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvy184