Pubblicazioni Peer reviewed articles (26) Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state Autori: Laura A Bosmans 1 , Claudia M van Tiel 1 , Suzanne A B M Aarts 1 , Lisa Willemsen 1 , Jeroen Baardman 1 , Bram W van Os 1 , Myrthe den Toom 1 , Linda Beckers 1 , David J Ahern 2 , Johannes H M Levels 3 , Aldo Jongejan 4 , Perry D Moerland 4 , Sanne G S Verberk 5 , Jan van den Bossche 1 5 , Menno M P J de Winther 1 , Christian Weber 6 7 8 9 , Dorothee Atzler 6 9 10 , Cl Pubblicato in: CardioVascular Research, Numero 119, 2023, Pagina/e 114601160, ISSN 1755-3245 Editore: Oxford Academic DOI: 10.1093/cvr/cvac084 Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease Autori: Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, N Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-021-23909-z Adipocytes control hematopoiesis and inflammation through CD40 signaling Autori: Myrthe E Reiche 1 , Kikkie Poels 2 , Laura A Bosmans 2 , Winnie G Vos 2 , Claudia M Van Tiel 2 , Marion J J Gijbels 3 , Suzanne A B M Aarts 2 , Myrthe Den Toom 2 , Linda Beckers 2 , Christian Weber 4 , Dorothee Atzler 5 , Patrick C N Rensen 6 , Sander Kooijman 6 , Esther Lutgens 7 Pubblicato in: Haematologica, Numero 108, 2023, Pagina/e 1873-1885, ISSN 1592-8721 Editore: Ferrata Storti Foundation DOI: 10.3324/haematol.2022.281482 Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice Autori: Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens Pubblicato in: Cells, Numero 9/9, 2020, Pagina/e 1987, ISSN 2073-4409 Editore: cells DOI: 10.3390/cells9091987 Immune Checkpoint Inhibitor Therapy Aggravates T Cell–Driven Plaque Inflammation in Atherosclerosis Autori: Kikkie Poels, Mandy M.T. van Leent, Celine Boutros, Hubert Tissot, Séverine Roy, Anu E. Meerwaldt, Yohana C.A. Toner, Myrthe E. Reiche, Pascal J.H. Kusters, Tsveta Malinova, Stephan Huveneers, Audrey E. Kaufman, Venkatesh Mani, Zahi A. Fayad, Menno P.J. de Winther, Aurelien Marabelle, Willem J.M. Mulder, Caroline Robert, Tom T.P. Seijkens, Esther Lutgens Pubblicato in: JACC: CardioOncology, Numero 2/4, 2020, Pagina/e 599-610, ISSN 2666-0873 Editore: jacc DOI: 10.1016/j.jaccao.2020.08.007 Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis Autori: Laura A. Bosmans, Annelie Shami, Dorothee Atzler, Christian Weber, Isabel Gonçalves, Esther Lutgens Pubblicato in: Vascular Pharmacology, Numero 139, 2021, Pagina/e 106884, ISSN 1537-1891 Editore: Elsevier BV DOI: 10.1016/j.vph.2021.106884 Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans Autori: Annelie Shami, Dorothee Atzler, Laura A Bosmans, Holger Winkels, Svenja Meiler, Michael Lacy, Claudia van Tiel, Remco Ta Megens, Katrin Nitz, Jeroen Baardman, Pascal Kusters, Tom Seijkens, Christina Buerger, Aleksandar Janjic, Carlo Riccardi, Andreas Edsfeldt, Claudia Monaco, Mat Daemen, Menno P J de Winther, Jan Nilsson, Christian Weber, Norbert Gerdes, Isabel Gonçalves, Esther Lutgens Pubblicato in: European Heart Journal, Numero 41/31, 2020, Pagina/e 2938-2948, ISSN 0195-668X Editore: Oxford University Press DOI: 10.1093/eurheartj/ehaa484 2016 Jeffrey M. Hoeg Award Lecture Autori: Ellen Rouwet, Esther Lutgens Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, Pagina/e ATVBAHA.118.307742, ISSN 1079-5642 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/ATVBAHA.118.307742 Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation Autori: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens Pubblicato in: Journal of Neuroinflammation, Numero 14/1, 2017, ISSN 1742-2094 Editore: BioMed Central DOI: 10.1186/s12974-017-0875-9 CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice Autori: Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes Pubblicato in: European Heart Journal, Numero 38/48, 2017, Pagina/e 3590-3599, ISSN 0195-668X Editore: Oxford University Press DOI: 10.1093/eurheartj/ehx517 Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption Autori: Pascal Kusters, Tom Seijkens, Christina Bürger, Bart Legein, Holger Winkels, Marion Gijbels, Christian Barthels, Remy Bennett, Linda Beckers, Dorothee Atzler, Erik Biessen, Thomas Brocker, Christian Weber, Norbert Gerdes, Esther Lutgens Pubblicato in: The American Journal of Pathology, Numero 187/12, 2017, Pagina/e 2912-2919, ISSN 0002-9440 Editore: American Society for Investigative Pathology DOI: 10.1016/j.ajpath.2017.08.016 CD40L Deficiency Protects Against Aneurysm FormationHighlights Autori: Pascal J.H. Kusters, Tom T.P. Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 38/5, 2018, Pagina/e 1076-1085, ISSN 1079-5642 Editore: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/ATVBAHA.117.310640 The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Autori: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224 Editore: lippincott DOI: 10.3389/fimmu.2017.01791 Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis Autori: Tom T.P. Seijkens, Claudia M. van Tiel, Pascal J.H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A.B.M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slütter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T.A. Megens, Cornelis van ‘t Veer, Gijs Kooij, Roy Schrijver, Marten A. Hoeksema, Louis Boon, Francois Fay, Jun Tang, Samantha Bax Pubblicato in: Journal of the American College of Cardiology, Numero 71/5, 2018, Pagina/e 527-542, ISSN 0735-1097 Editore: Elsevier BV DOI: 10.1016/j.jacc.2017.11.055 Exploring immune checkpoints as potential therapeutic targets in atherosclerosis Autori: Pascal J H Kusters, Esther Lutgens, Tom T P Seijkens Pubblicato in: Cardiovascular Research, Numero 114/3, 2017, Pagina/e 368-377, ISSN 0008-6363 Editore: Elsevier BV DOI: 10.1093/cvr/cvx248 Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice Autori: José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel FJ Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer Pubblicato in: European Journal of Preventive Cardiology, Numero 25/9, 2018, Pagina/e 948-955, ISSN 2047-4873 Editore: SAGE Publications Ltd DOI: 10.1177/2047487318773384 Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology Autori: Daniel F J Ketelhuth, Esther Lutgens, Magnus Bäck, Christoph J Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E Dumitriu, Imo Hoefer, Peter Libby, Luke O’Neill, Christian Weber, Paul C Evans Pubblicato in: Cardiovascular Research, Numero 115/9, 2019, Pagina/e 1385-1392, ISSN 0008-6363 Editore: Elsevier BV DOI: 10.1093/cvr/cvz166 Immunotherapy for cardiovascular disease Autori: Esther Lutgens, Dorothee Atzler, Yvonne Döring, Johan Duchene, Sabine Steffens, Christian Weber Pubblicato in: European Heart Journal, 2019, ISSN 0195-668X Editore: Oxford University Press DOI: 10.1093/eurheartj/ehz283 The Link between Hematopoiesis and Atherosclerosis Autori: Menno P.J. de Winther, Esther Lutgens Pubblicato in: New England Journal of Medicine, Numero 380/19, 2019, Pagina/e 1869-1871, ISSN 0028-4793 Editore: Massachusetts Medical Society DOI: 10.1056/nejmcibr1901397 Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates Autori: Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher Pubblicato in: Nature Biomedical Engineering, Numero 2/5, 2018, Pagina/e 279-292, ISSN 2157-846X Editore: Nature DOI: 10.1038/s41551-018-0221-2 Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure Autori: Lena Bosch, Judith de Haan, Tom Seijkens, Claudia van Tiel, Maike Brans, Gerard Pasterkamp, Esther Lutgens, Saskia de Jager Pubblicato in: International Journal of Cardiology, Numero 279, 2019, Pagina/e 141-144, ISSN 0167-5273 Editore: Elsevier BV DOI: 10.1016/j.ijcard.2018.12.076 Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis Autori: Suzanne ABM Aarts, Tom TP Seijkens, Pascal JH Kusters, Claudia M van Tiel, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Cindy PAA van Roomen, Menno PJ de Winther, Gijs Kooij, Esther Lutgens Pubblicato in: The Journal of Pathology, Numero 247/4, 2019, Pagina/e 471-480, ISSN 0022-3417 Editore: John Wiley & Sons Inc. DOI: 10.1002/path.5205 Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death Autori: Tom T P Seijkens, Kikkie Poels, Svenja Meiler, Claudia M van Tiel, Pascal J H Kusters, Myrthe Reiche, Dorothee Atzler, Holger Winkels, Marc Tjwa, Hessel Poelman, Bram Slütter, Johan Kuiper, Marion Gijbels, Jan Albert Kuivenhoven, Ljubica Perisic Matic, Gabrielle Paulsson-Berne, Ulf Hedin, Göran K Hansson, Gerry A F Nicolaes, Mat J A P Daemen, Christian Weber, Norbert Gerdes, Menno P J de Winther Pubblicato in: European Heart Journal, Numero 40/4, 2018, Pagina/e 372-382, ISSN 0195-668X Editore: Oxford University Press DOI: 10.1093/eurheartj/ehy714 Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis Autori: Michael Lacy, Dorothee Atzler, Rongqi Liu, Menno de Winther, Christian Weber, Esther Lutgens Pubblicato in: Pharmacology & Therapeutics, Numero 193, 2019, Pagina/e 50-62, ISSN 0163-7258 Editore: Pergamon Press DOI: 10.1016/j.pharmthera.2018.08.012 Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction Autori: Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens Pubblicato in: PLOS ONE, Numero 13/8, 2018, Pagina/e e0202150, ISSN 1932-6203 Editore: Public Library of Science DOI: 10.1371/journal.pone.0202150 Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology Autori: Andrea Caporali, Magnus Bäck, Mat J Daemen, Imo E Hoefer, Elizabeth A Jones, Esther Lutgens, Christian M Matter, Marie-Luce Bochaton-Piallat, Arndt F Siekmann, Judith C Sluimer, Sabine Steffens, José Tuñón, Cecile Vindis, Jolanda J Wentzel, Seppo Ylä-Herttuala, Paul C Evans Pubblicato in: Cardiovascular Research, Numero 114/11, 2018, Pagina/e 1411-1421, ISSN 0008-6363 Editore: Elsevier BV DOI: 10.1093/cvr/cvy184 È in corso la ricerca di dati su OpenAIRE... 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