Understanding small RNA-mediated transposon control at the level of chromatin in the animal germline

Informazioni relative al progetto

PIWI-Chrom

ID dell’accordo di sovvenzione: 682181

DOI 10.3030/682181

Progetto chiuso

Data della firma CE 24 Maggio 2016

Data di avvio 1 Luglio 2016

Data di completamento 30 Giugno 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 530,00

Contributo UE € 1 999 530,00

Coordinato da

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria

Pubblicazioni

Peer reviewed articles (8)

Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex

Autori: Jakob Schnabl, Juncheng Wang, Maja Gehre, Julia Batki, Veselin I. Andreev, Kim Purkhauser, Nina Fasching, Peter Duchek, Maria Novatchkova, Karl Mechtler, Clemens Plaschka, Dinshaw J. Patel and Julius Brennecke
Pubblicato in: Genes And Development, 2021, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.347989.120

Structure of the human core transcription-export complex reveals a hub for multivalent interactions

Autori: Thomas Pühringer; Ulrich Hohmann; Ulrich Hohmann; Laura Fin; Belén Pacheco-Fiallos; Ulla Schellhaas; Julius Brennecke; Clemens Plaschka
Pubblicato in: eLife, Numero 1, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.61503

A heterochromatin-dependent transcription machinery drives piRNA expression

Autori: Peter Refsing Andersen, Laszlo Tirian, Milica Vunjak, Julius Brennecke
Pubblicato in: Nature, Numero 549/7670, 2017, Pagina/e 54-59, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature23482

A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production

Autori: Mostafa F. ElMaghraby, Peter Refsing Andersen, Florian Pühringer, Ulrich Hohmann, Katharina Meixner, Thomas Lendl, Laszlo Tirian, Julius Brennecke
Pubblicato in: Cell, Numero 178/4, 2019, Pagina/e 964-979.e20, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.07.007

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

Autori: Julia Batki, Jakob Schnabl, Juncheng Wang, Dominik Handler, Veselin I. Andreev, Christian E. Stieger, Maria Novatchkova, Lisa Lampersberger, Kotryna Kauneckaite, Wei Xie, Karl Mechtler, Dinshaw J. Patel, Julius Brennecke
Pubblicato in: Nature Structural & Molecular Biology, Numero 26/8, 2019, Pagina/e 720-731, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-019-0270-6

The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters

Autori: Lisa Baumgartner, Dominik Handler, Sebastian Wolfgang Platzer, Changwei Yu, Peter Duchek, Julius Brennecke
Pubblicato in: eLife, Numero 2050084X, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.80067

A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary

Autori: Mostafa F. ElMaghraby; Mostafa F. ElMaghraby; Laszlo Tirian; Kirsten-André Senti; Katharina Meixner; Julius Brennecke
Pubblicato in: Genetics, 2021, ISSN 1943-2631
Editore: Oxford University Press
DOI: 10.1101/2021.06.29.450424

Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery

Autori: Veselin I. Andreev, Changwei Yu, Juncheng Wang, Jakob Schnabl, Laszlo Tirian, Maja Gehre, Dominik Handler, Peter Duchek, Maria Novatchkova, Lisa Baumgartner, Katharina Meixner, Grzegorz Sienski, Dinshaw J. Patel & Julius Brennecke
Pubblicato in: Nature Structural and Molecular Biology, 2022, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-022-00721-x