Illuminating aptamers and ribozymes for biomolecular tagging and fluorogen activation

Pubblicazioni

Structure and mechanism of the methyltransferase ribozyme MTR1

Autori: Carolin P. M. Scheitl, Mateusz Mieczkowski, Hermann Schindelin, Claudia Höbartner
Pubblicato in: Nature Chemical Biology, Numero monthly, 2022, Pagina/e 547-555, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-022-00976-x

Large Stokes shift fluorescence activation in an RNA aptamer by intermolecular proton transfer to guanine

Autori: Mateusz Mieczkowski, Christian Steinmetzger, Irene Bessi, Ann-Kathrin Lenz, Alexander Schmiedel, Marco Holzapfel, Christoph Lambert, Vladimir Pena, Claudia Höbartner
Pubblicato in: Nature Communications, Numero 12:3549, 2021, Pagina/e 11, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23932-0

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Autori: Florian Kabinger, Carina Stiller, Jana Schmitzová, Christian Dienemann, Goran Kokic, Hauke S. Hillen, Claudia Höbartner, Patrick Cramer
Pubblicato in: Nature Structural & Molecular Biology, Numero 28:740, 2021, Pagina/e 7, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-021-00651-0

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Autori: Goran Kokic, Hauke S. Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer
Pubblicato in: Nature Communications, Numero 12/1, 2021, Pagina/e 7, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20542-0

The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation

Autori: Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Pubblicato in: Nature Communications, Numero 13:209, 2022, Pagina/e 19, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27905-1

RNA-Cleaving Deoxyribozymes Differentiate Methylated Cytidine Isomers in RNA

Autori: Anam Liaqat, Maksim V. Sednev, Carina Stiller, Claudia Höbartner
Pubblicato in: Angewandte Chemie International Edition, Numero 60:19058, 2021, Pagina/e 5, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202106517

Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes

Autori: Ronald Micura and Claudia Höbartner
Pubblicato in: Chemical Society Reviews, Numero 24/year, 2020, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cs00617c

N 6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes

Autori: Maksim V. Sednev, Volodymyr Mykhailiuk, Priyanka Choudhury, Julia Halang, Katherine E. Sloan, Markus T. Bohnsack, Claudia Höbartner
Pubblicato in: Angewandte Chemie International Edition, Numero 57/46, 2018, Pagina/e 15117-15121, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201808745

Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides

Autori: Tucker J. Carrocci, Lea Lohe, Matthew J. Ashton, Claudia Höbartner, Aaron A. Hoskins
Pubblicato in: Chemical Communications, Numero 53/88, 2017, Pagina/e 11992-11995, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c7cc06703h

A Multicolor Large Stokes Shift Fluorogen-Activating RNA Aptamer with Cationic Chromophores

Autori: Christian Steinmetzger, Navaneethan Palanisamy, Kiran R. Gore, Claudia Höbartner
Pubblicato in: Chemistry - A European Journal, Numero weekly, 2018, Pagina/e 5, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201805882

Structure–fluorescence activation relationships of a large Stokes shift fluorogenic RNA aptamer

Autori: Christian Steinmetzger, Irene Bessi, Ann-Kathrin Lenz, Claudia Höbartner
Pubblicato in: Nucleic Acids Research, 2019, Pagina/e 2019, 47, 11538-11550, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz1084

Direct in Vitro Selection of Trans -Acting Ribozymes for Posttranscriptional, Site-Specific, and Covalent Fluorescent Labeling of RNA

Autori: Mohammad Ghaem Maghami, Carolin P. M. Scheitl, Claudia Höbartner
Pubblicato in: Journal of the American Chemical Society, Numero 141/50, 2019, Pagina/e 19546-19549, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b10531

Supramolecular Fluorescence Resonance Energy Transfer in Nucleobase‐Modified Fluorogenic RNA Aptamers

Autori: Christian Steinmetzger, Carmen Bäuerlein, Claudia Höbartner
Pubblicato in: Angewandte Chemie International Edition, Numero 59/17, 2020, Pagina/e 6760-6764, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201916707

Repurposing Antiviral Drugs for Orthogonal RNA‐Catalyzed Labeling of RNA

Autori: Mohammad Ghaem Maghami, Surjendu Dey, Ann‐Kathrin Lenz, Claudia Höbartner
Pubblicato in: Angewandte Chemie International Edition, Numero 59/24, 2020, Pagina/e 9335-9339, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202001300

N 6‐isopentenyladenosine in RNA determines the cleavage site of endonuclease deoxyribozymes

Autori: Anam Liaqat, Carina Stiller, Manuela Michel, Maksim V Sednev, Claudia Höbartner
Pubblicato in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202006218

New Deoxyribozymes for the Native Ligation of RNA

Autori: Carolin P. M. Scheitl, Sandra Lange, Claudia Höbartner
Pubblicato in: Molecules, Numero 25/16, 2020, Pagina/e 3650, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25163650

Site-specific RNA methylation by a methyltransferase ribozyme

Autori: Carolin P. M. Scheitl, Mohammad Ghaem Maghami, Ann-Kathrin Lenz, Claudia Höbartner
Pubblicato in: Nature, Numero 587/7835, 2020, Pagina/e 663-667, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2854-z

Tuning Exciton Coupling of Merocyanine Nucleoside Dimers by RNA, DNA and GNA Double Helix Conformations

Autori: Julia Dietzsch, David Bialas, Johannes Bandorf, Frank Würthner, Claudia Höbartner
Pubblicato in: Angewandte Chemie Internation Edition, Numero e202116783, 2022, Pagina/e 8, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202116783

In Vitro Selection of Deoxyribozymes for the Detection of RNA Modifications

Autori: Anam Liaqat, Maksim V. Sednev, Claudia Höbartner
Pubblicato in: Ribosome Biogenesis: Methods and Protocols, Methods in Molecular Biology, vol. 2533, 2022, Pagina/e 167-179, ISBN 978-1-0716-2501-9
Editore: Humana Press
DOI: 10.1007/978-1-0716-2501-9_10

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