Matrix during cancer progression

Informazioni relative al progetto

MATRICAN

ID dell’accordo di sovvenzione: 682881

DOI 10.3030/682881

Progetto chiuso

Data della firma CE 8 Agosto 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 997 500,00

Contributo UE € 1 997 500,00

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

Pubblicazioni

Peer reviewed articles (7)

Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer

Autori: Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler, Chris Denis Madsen
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 40/1, 2021, ISSN 1756-9966
Editore: Springer Nature
DOI: 10.1186/s13046-021-01944-4

Organ-Specific, Fibroblast-Derived Matrix as a Tool for Studying Breast Cancer Metastasis

Autori: Adina R. D. Jensen, Edward R. Horton, Lene H. Blicher, Elin J. Pietras, Cornelia Steinhauer, Raphael Reuten, Erwin M. Schoof, Janine T. Erler
Pubblicato in: Cancers, Numero 13/13, 2021, Pagina/e 3331, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133331

Basement membrane stiffness determines metastases formation

Autori: Raphael Reuten, Sina Zendehroud, Monica Nicolau, Lutz Fleischhauer, Anu Laitala, Stefanie Kiderlen, Denise Nikodemus, Lena Wullkopf, Sebastian Rune Nielsen, Sarah McNeilly, Carina Prein, Maria Rafaeva, Erwin M. Schoof, Benjamin Furtwängler, Bo T. Porse, Hyobin Kim, Kyoung Jae Won, Stefanie Sudhop, Kamilla Westarp Zornhagen, Frank Suhr, Eleni Maniati, Oliver M. T. Pearce, Manuel Koch, Lene Broeng
Pubblicato in: Nature Materials, 2021, ISSN 1476-1122
Editore: Nature Publishing Group
DOI: 10.1038/s41563-020-00894-0

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

Autori: Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23731-7

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Autori: Alejandro E Mayorca-Guiliani, Chris D Madsen, Thomas R Cox, Edward R Horton, Freja A Venning, Janine T Erler
Pubblicato in: Nature Medicine, Numero 23/7, 2017, Pagina/e 890-898, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.4352

Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

Autori: Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar
Pubblicato in: Life Science Alliance, Numero 2/3, 2019, Pagina/e e201900304, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.201900304

Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D

Autori: Alejandro E Mayorca-Guiliani, Oliver Willacy, Chris D. Madsen, Maria Rafaeva, Stefanie Elisabeth Heumüller, Felix Bock, Gerhard Sengle, Manuel Koch, Thomas Imhof, Frank Zaucke, Raimund Wagener, Takako Sasaki, Janine T. Erler, Raphael Reuten
Pubblicato in: Nature Protocols, 2019, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-019-0225-8