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Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation


EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect

Second TwinnToInfect Joint Summer School

Second TwinnToInfect Joint Summer School

KPIs definition for TwinnToInfect

KPIs definition for TwinnToInfect

First TwinnToInfect Joint Summer School

First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Communication package, including development of logo/brand, launch of website, brochure and flyer development


Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Author(s): Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Published in: PLOS Biology, Issue 16/5, 2018, Page(s) e2004990, ISSN 1545-7885
DOI: 10.1371/journal.pbio.2004990

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Author(s): Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Published in: Journal of Autoimmunity, Issue 87, 2018, Page(s) 26-37, ISSN 0896-8411
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Author(s): Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Published in: Trends in Immunology, Issue 38/5, 2017, Page(s) 336-344, ISSN 1471-4906
DOI: 10.1016/

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Author(s): Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Published in: The Journal of Immunology, Issue 196/9, 2016, Page(s) 3642-3652, ISSN 0022-1767
DOI: 10.4049/jimmunol.1501921

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Author(s): Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Published in: Nature Immunology, Issue 17/6, 2016, Page(s) 721-727, ISSN 1529-2908
DOI: 10.1038/ni.3424

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Author(s): A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Published in: Clinical Cancer Research, Issue 22/23, 2016, Page(s) 5795-5804, ISSN 1078-0432
DOI: 10.1158/1078-0432.ccr-16-0597

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Author(s): Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
Published in: Inflammation Research, Issue 65/12, 2016, Page(s) 985-994, ISSN 1023-3830
DOI: 10.1007/s00011-016-0982-6

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Author(s): Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Published in: EMBO reports, Issue 18/11, 2017, Page(s) 1957-1967, ISSN 1469-221X
DOI: 10.15252/embr.201744200

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Author(s): S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Published in: Leukemia, Issue 31/7, 2016, Page(s) 1603-1610, ISSN 0887-6924
DOI: 10.1038/leu.2016.363

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Author(s): Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Published in: Cancer Immunology Research, Issue 5/9, 2017, Page(s) 812-820, ISSN 2326-6066
DOI: 10.1158/2326-6066.cir-17-0082

γδ T cells get adaptive

Author(s): Bruno Silva-Santos, Jessica Strid
Published in: Nature Immunology, Issue 18/4, 2017, Page(s) 370-372, ISSN 1529-2908
DOI: 10.1038/ni.3705

Got my γδ17 T cells to keep me warm

Author(s): Pedro H. Papotto, Bruno Silva-Santos
Published in: Nature Immunology, Issue 19/5, 2018, Page(s) 427-429, ISSN 1529-2908
DOI: 10.1038/s41590-018-0090-6

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Author(s): André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00929

Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Author(s): Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Published in: Cardiovascular Research, Issue 113/7, 2017, Page(s) 783-794, ISSN 0008-6363
DOI: 10.1093/cvr/cvx065

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Author(s): Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Published in: Science Immunology, Issue 3/23, 2018, Page(s) eaao1392, ISSN 2470-9468
DOI: 10.1126/sciimmunol.aao1392

The Emerging Complexity of γδT17 Cells

Author(s): Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00796

Control of T cell effector functions by miRNAs

Author(s): Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Published in: Cancer Letters, Issue 427, 2018, Page(s) 63-73, ISSN 0304-3835
DOI: 10.1016/j.canlet.2018.04.011

Immunology's Twinning Triangle

Author(s): Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
Published in: European Journal of Immunology, Issue 46/10, 2016, Page(s) 2283-2285, ISSN 0014-2980
DOI: 10.1002/eji.201670106

VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Author(s): Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Published in: Cancer Research, Issue 78/3, 2018, Page(s) 731-741, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-17-1166

Peripheral clonal selection shapes the human γδ T-cell repertoire

Author(s): Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
Published in: Cellular & Molecular Immunology, Issue 14/9, 2017, Page(s) 733-735, ISSN 1672-7681
DOI: 10.1038/cmi.2017.51

Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Author(s): Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
Published in: Sleep and Breathing, Issue 22/1, 2018, Page(s) 211-221, ISSN 1520-9512
DOI: 10.1007/s11325-017-1602-6

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Author(s): Bruno Silva-Santos, Jessica Strid
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
DOI: 10.3389/fimmu.2018.00851

Multifaceted CK2 in malignant and healthy T cells

Author(s): Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
Published in: Oncotarget, Issue 8/53, 2017, ISSN 1949-2553
DOI: 10.18632/oncotarget.21700

Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Author(s): Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
Published in: Nature Microbiology, Issue 3/7, 2018, Page(s) 791-803, ISSN 2058-5276
DOI: 10.1038/s41564-018-0167-x

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Author(s): Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
Published in: The Journal of Immunology, Issue 198/5, 2017, Page(s) 2172-2181, ISSN 0022-1767
DOI: 10.4049/jimmunol.1600165

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Author(s): Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
Published in: JCI Insight, Issue 1/18, 2016, ISSN 2379-3708
DOI: 10.1172/jci.insight.89278

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Author(s): Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Published in: Cell Host & Microbe, Issue 19/6, 2016, Page(s) 837-848, ISSN 1931-3128
DOI: 10.1016/j.chom.2016.05.002

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Author(s): Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
Published in: Nature, Issue 555/7696, 2018, Page(s) 382-386, ISSN 0028-0836
DOI: 10.1038/nature25974

Interleukin 17 is a chief orchestrator of immunity

Author(s): Marc Veldhoen
Published in: Nature Immunology, Issue 18/6, 2017, Page(s) 612-621, ISSN 1529-2908
DOI: 10.1038/ni.3742

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Author(s): Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ric
Published in: Journal of Allergy and Clinical Immunology, Issue 140/3, 2017, Page(s) 867-870.e9, ISSN 0091-6749
DOI: 10.1016/j.jaci.2017.02.034

Trypanosoma brucei metabolism is under circadian control

Author(s): Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L. Barbosa-Morais, Joseph S. Takahashi, Luisa M. Figueiredo
Published in: Nature Microbiology, Issue 2, 2017, Page(s) 17032, ISSN 2058-5276
DOI: 10.1038/nmicrobiol.2017.32

Trypanosoma brucei triggers a marked immune response in male reproductive organs

Author(s): Tânia Carvalho, Sandra Trindade, Sílvia Pimenta, Ana B. Santos, Filipa Rijo-Ferreira, Luísa M. Figueiredo
Published in: PLOS Neglected Tropical Diseases, Issue 12/8, 2018, Page(s) e0006690, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0006690

Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation

Author(s): Zdenka Cicova, Mario Dejung, Tomas Skalicky, Nicole Eisenhuth, Steffen Hanselmann, Brooke Morriswood, Luisa M. Figueiredo, Falk Butter, Christian J. Janzen
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep35826

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Author(s): A. C. Alho, H. T. Kim, M. J. Chammas, C. G. Reynolds, T. R. Matos, E. Forcade, J. Whangbo, S. Nikiforow, C. S. Cutler, J. Koreth, V. T. Ho, P. Armand, J. H. Antin, E. P. Alyea, J. F. Lacerda, R. J. Soiffer, J. Ritz
Published in: Blood, Issue 127/5, 2016, Page(s) 646-657, ISSN 0006-4971
DOI: 10.1182/blood-2015-10-672345

Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges

Author(s): Agostinho Carvalho, Cláudio Duarte-Oliveira, Samuel M. Gonçalves, António Campos, João F. Lacerda, Cristina Cunha
Published in: Current Fungal Infection Reports, Issue 11/1, 2017, Page(s) 16-24, ISSN 1936-3761
DOI: 10.1007/s12281-017-0272-y

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Author(s): Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M. Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry Noyes, Albert Picado, Kat S. Rock, Brice Rotureau, Gustave Simo, Sophie T
Published in: Trends in Parasitology, Issue 34/3, 2018, Page(s) 197-207, ISSN 1471-4922
DOI: 10.1016/

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Author(s): Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdon
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-04912-3

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Author(s): David R Withers, Matthew R Hepworth, Xinxin Wang, Emma C Mackley, Emily E Halford, Emma E Dutton, Clare L Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N Baldassano, Gregory F Sonnenberg
Published in: Nature Medicine, Issue 22/3, 2016, Page(s) 319-323, ISSN 1078-8956
DOI: 10.1038/nm.4046

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Author(s): José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F. Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Published in: Annals of Hematology, Issue 96/11, 2017, Page(s) 1921-1929, ISSN 0939-5555
DOI: 10.1007/s00277-017-3090-y

Sleeping sickness is a circadian disorder

Author(s): Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02484-2

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Author(s): Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, P
Published in: European Journal of Immunology, Issue 47/10, 2017, Page(s) 1584-1797, ISSN 0014-2980
DOI: 10.1002/eji.201646632

Host AMPK Is a Modulator of Plasmodium Liver Infection

Author(s): Margarida T. Grilo Ruivo, Iset Medina Vera, Joana Sales-Dias, Patrícia Meireles, Nil Gural, Sangeeta N. Bhatia, Maria M. Mota, Liliana Mancio-Silva
Published in: Cell Reports, Issue 16/10, 2016, Page(s) 2539-2545, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.08.001

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Author(s): Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-017-02651-5

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Author(s): Vanessa Zuzarte-Luis, Maria M. Mota
Published in: Cell Metabolism, Issue 27/4, 2018, Page(s) 708-709, ISSN 1550-4131
DOI: 10.1016/j.cmet.2018.03.007

Adipose Tissue: A Safe Haven for Parasites?

Author(s): Herbert B. Tanowitz, Philipp E. Scherer, Maria M. Mota, Luisa M. Figueiredo
Published in: Trends in Parasitology, Issue 33/4, 2017, Page(s) 276-284, ISSN 1471-4922
DOI: 10.1016/

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

Author(s): Cláudia Sá e Cunha, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm, Jude Marek Przyborski, Maria M. Mota, Miguel Prudêncio, Ann-Kristin Mueller
Published in: Proceedings of the National Academy of Sciences, Issue 114/7, 2017, Page(s) E1138-E1147, ISSN 0027-8424
DOI: 10.1073/pnas.1606419114

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Author(s): Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Published in: European Journal of Immunology, Issue 48/9, 2018, Page(s) 1430-1440, ISSN 0014-2980
DOI: 10.1002/eji.201646745

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

Author(s): Shengyong Ng, Sandra March, Ani Galstian, Nil Gural, Kelly R. Stevens, Maria M. Mota, Sangeeta N. Bhatia
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/srep45424

Host cell autophagy contributes to Plasmodium liver development

Author(s): Carolina Thieleke-Matos, Mafalda Lopes da Silva, Laura Cabrita-Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte-Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Published in: Cellular Microbiology, Issue 18/3, 2016, Page(s) 437-450, ISSN 1462-5814
DOI: 10.1111/cmi.12524

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

Author(s): Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, Guillaume Bouyer, Kirsten K. Hanson, Iset Vera, Jon K. Pittman, Henry M. Staines, Maria M. Mota
Published in: Nature Communications, Issue 7/1, 2016, ISSN 2041-1723
DOI: 10.1038/ncomms10403

Parasite Sensing of Host Nutrients and Environmental Cues

Author(s): Vanessa Zuzarte-Luís, Maria M. Mota
Published in: Cell Host & Microbe, Issue 23/6, 2018, Page(s) 749-758, ISSN 1931-3128
DOI: 10.1016/j.chom.2018.05.018

Maria Mota: The Pleasure of Discovery

Author(s): Maria M. Mota
Published in: Trends in Parasitology, Issue 32/6, 2016, Page(s) 429-430, ISSN 1471-4922
DOI: 10.1016/

Nutrient sensing modulates malaria parasite virulence

Author(s): Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota
Published in: Nature, Issue 547/7662, 2017, Page(s) 213-216, ISSN 0028-0836
DOI: 10.1038/nature23009

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Author(s): Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Published in: Cell Reports, Issue 19/11, 2017, Page(s) 2357-2370, ISSN 2211-1247
DOI: 10.1016/j.celrep.2017.05.052

Th17 Cells Require You to Chew before You Swallow

Author(s): Marc Veldhoen
Published in: Immunity, Issue 46/1, 2017, Page(s) 8-10, ISSN 1074-7613
DOI: 10.1016/j.immuni.2016.12.016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology

Author(s): Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg, Marc Veldhoen
Published in: The Journal of Immunology, Issue 196/12, 2016, Page(s) 4893-4904, ISSN 0022-1767
DOI: 10.4049/jimmunol.1600137

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Published in: Parasitology, Issue 143/12, 2016, Page(s) 1543-1556, ISSN 0031-1820
DOI: 10.1017/s0031182016001153

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Author(s): Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Published in: Journal of Medicinal Chemistry, Issue 60/4, 2017, Page(s) 1432-1448, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.6b01641

Inhibition of Plasmodium liver infection by ivermectin

Author(s): António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Published in: Antimicrobial Agents and Chemotherapy, 2017, Page(s) AAC.02005-16, ISSN 0066-4804
DOI: 10.1128/aac.02005-16

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Author(s): Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Published in: Particle & Particle Systems Characterization, Issue 33/12, 2016, Page(s) 906-915, ISSN 0934-0866
DOI: 10.1002/ppsc.201600187

Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Author(s): Taís S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudêncio, Alzir A. Batista, Milena B. P. Soares
Published in: Metallomics, Issue 9/11, 2017, Page(s) 1548-1561, ISSN 1756-5901
DOI: 10.1039/c7mt00196g

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Author(s): Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Published in: Antimicrobial Agents and Chemotherapy, Issue 61/6, 2017, ISSN 0066-4804
DOI: 10.1128/aac.02699-16

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Author(s): Marta Machado, Margarida Sanches-Vaz, João P. Cruz, António M. Mendes, Miguel Prudêncio
Published in: Frontiers in Cellular and Infection Microbiology, Issue 7, 2017, ISSN 2235-2988
DOI: 10.3389/fcimb.2017.00329

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Author(s): Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio, Rui Moreira
Published in: ChemMedChem, Issue 11/19, 2016, Page(s) 2194-2204, ISSN 1860-7179
DOI: 10.1002/cmdc.201600327

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Author(s): António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M.
Published in: npj Vaccines, Issue 3/1, 2018, ISSN 2059-0105
DOI: 10.1038/s41541-018-0068-2

Primaquine-based ionic liquids as a novel class of antimalarial hits

Author(s): Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Published in: RSC Advances, Issue 6/61, 2016, Page(s) 56134-56138, ISSN 2046-2069
DOI: 10.1039/c6ra10759a

Novel squaramides with in vitro liver stage antiplasmodial activity

Author(s): Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Published in: Bioorganic & Medicinal Chemistry, Issue 24/8, 2016, Page(s) 1786-1792, ISSN 0968-0896
DOI: 10.1016/j.bmc.2016.03.005

Primaquine hybrids as promising antimycobacterial and antimalarial agents

Author(s): Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Published in: European Journal of Medicinal Chemistry, Issue 143, 2018, Page(s) 769-779, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2017.11.083

Uptake and metabolism of arginine impact Plasmodium development in the liver

Author(s): Patrícia Meireles, António M. Mendes, Rita I. Aroeira, Bryan C. Mounce, Marco Vignuzzi, Henry M. Staines, Miguel Prudêncio
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
DOI: 10.1038/s41598-017-04424-y

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Author(s): Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Published in: Archives of Pharmacal Research, Issue 41/2, 2018, Page(s) 208-218, ISSN 0253-6269
DOI: 10.1007/s12272-017-1000-4

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Author(s): Patrícia Meireles, Joana Sales-Dias, Carolina M. Andrade, João Mello-Vieira, Liliana Mancio-Silva, J. Pedro Simas, Henry M. Staines, Miguel Prudêncio
Published in: Cellular Microbiology, Issue 19/2, 2017, Page(s) e12646, ISSN 1462-5814
DOI: 10.1111/cmi.12646

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Author(s): Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Published in: European Journal of Medicinal Chemistry, Issue 149, 2018, Page(s) 69-78, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2018.02.048

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Author(s): Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
Published in: ChemistryOpen, Issue 7/8, 2018, Page(s) 624-638, ISSN 2191-1363
DOI: 10.1002/open.201800117

Tumor cell recognition by γδ T lymphocytes

Author(s): Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Published in: OncoImmunology, Issue 2/1, 2013, Page(s) e22892, ISSN 2162-4011
DOI: 10.4161/onci.22892

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Author(s): Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Published in: Biology of Blood and Marrow Transplantation, Issue 19/5, 2013, Page(s) 703-712, ISSN 1083-8791
DOI: 10.1016/j.bbmt.2013.01.017

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Author(s): E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Published in: Clinical and Vaccine Immunology, Issue 20/2, 2013, Page(s) 313-316, ISSN 1556-6811
DOI: 10.1128/CVI.00529-12

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Author(s): Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Published in: Cell Host & Microbe, Issue 14/1, 2013, Page(s) 104-115, ISSN 1931-3128
DOI: 10.1016/j.chom.2013.06.005

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Author(s): Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Published in: AIDS, Issue 27/2, 2013, Page(s) 289-292, ISSN 0269-9370
DOI: 10.1097/QAD.0b013e32835ab234

Repairing thymic function

Author(s): Helena Nunes-Cabaço, Ana E. Sousa
Published in: Current Opinion in Organ Transplantation, 2013, Page(s) 1, ISSN 1087-2418
DOI: 10.1097/MOT.0b013e3283615df9

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Author(s): J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Published in: Eurosurveillance, Issue 52, 2013, ISSN 1560-7917

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Author(s): A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Published in: European Journal of Clinical Microbiology & Infectious Diseases, Issue 32/1, 2013, Page(s) 115-125, ISSN 0934-9723
DOI: 10.1007/s10096-012-1726-3

Functional development of γδ T cells

Author(s): Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Published in: European Journal of Immunology, Issue 43/8, 2013, Page(s) 1988-1994, ISSN 0014-2980
DOI: 10.1002/eji.201343759

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Author(s): Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Published in: European Journal of Medicinal Chemistry, Issue 69, 2013, Page(s) 872-880, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Author(s): Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vi
Published in: Immunity, Issue 39/5, 2013, Page(s) 874-884, ISSN 1074-7613
DOI: 10.1016/j.immuni.2013.08.039

Insight into lymphoid tissue morphogenesis

Author(s): Mark Coles, Henrique Veiga-Fernandes
Published in: Immunology Letters, Issue 156/1-2, 2013, Page(s) 46-53, ISSN 0165-2478
DOI: 10.1016/j.imlet.2013.08.001

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Author(s): Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Published in: Immunology and Cell Biology, Issue 91/10, 2013, Page(s) 652-660, ISSN 0818-9641
DOI: 10.1038/icb.2013.63

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Author(s): Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Published in: International Journal of Antimicrobial Agents, Issue 41/5, 2013, Page(s) 490-492, ISSN 0924-8579
DOI: 10.1016/j.ijantimicag.2013.01.003

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Author(s): Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Published in: International Journal of Medical Microbiology, Issue 303/8, 2013, Page(s) 505-513, ISSN 1438-4221
DOI: 10.1016/j.ijmm.2013.07.004

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid  -Herpesvirus M2 Protein

Author(s): M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Published in: Journal of Biological Chemistry, Issue 288/6, 2013, Page(s) 3858-3870, ISSN 0021-9258
DOI: 10.1074/jbc.M112.439810

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Author(s): M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Published in: Journal of Clinical Microbiology, Issue 51/4, 2013, Page(s) 1099-1109, ISSN 0095-1137
DOI: 10.1128/JCM.02912-12

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Author(s): S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Published in: Journal of Clinical Microbiology, Issue 51/2, 2013, Page(s) 644-646, ISSN 0095-1137
DOI: 10.1128/JCM.02837-12

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Author(s): Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Published in: Journal of Hematology & Oncology, Issue 6/1, 2013, Page(s) 87, ISSN 1756-8722
DOI: 10.1186/1756-8722-6-87

At the Bench: Preclinical rationale for exploiting NK cells and    T lymphocytes for the treatment of high-risk leukemias

Author(s): H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Published in: Journal of Leukocyte Biology, Issue 94/6, 2013, Page(s) 1123-1139, ISSN 0741-5400
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Author(s): Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Published in: Journal of Medicinal Chemistry, Issue 56/19, 2013, Page(s) 7679-7690, ISSN 0022-2623
DOI: 10.1021/jm4011466

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Author(s): Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Published in: Journal of Medicinal Chemistry, Issue 56/11, 2013, Page(s) 4811-4815, ISSN 0022-2623
DOI: 10.1021/jm400246e

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Author(s): Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Published in: Journal of Translational Medicine, Issue 11/1, 2013, Page(s) 18, ISSN 1479-5876
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Author(s): M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Published in: Journal of Microbiological Methods, Issue 93/2, 2013, Page(s) 102-107, ISSN 0167-7012
DOI: 10.1016/j.mimet.2013.02.008

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Author(s): Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Published in: Marine Drugs, Issue 11/10, 2013, Page(s) 4019-4034, ISSN 1660-3397
DOI: 10.3390/md11104019

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Author(s): Maria João Frias, José Melo-Cristino, Mário Ramirez
Published in: Molecular Microbiology, Issue 87/2, 2013, Page(s) 430-445, ISSN 0950-382X
DOI: 10.1111/mmi.12108

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Author(s): Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Published in: PLoS Computational Biology, Issue 9/2, 2013, Page(s) e1002916, ISSN 1553-734X
DOI: 10.1371/journal.pcbi.1002916

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Author(s): Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Published in: PLoS ONE, Issue 8/4, 2013, Page(s) e61606, ISSN 1932-6203
DOI: 10.1371/journal.pone.0061606

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Author(s): Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Published in: PLoS ONE, Issue 8/4, 2013, Page(s) e59960, ISSN 1932-6203
DOI: 10.1371/journal.pone.0059960

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Author(s): Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Published in: PLoS ONE, Issue 8/9, 2013, Page(s) e73704, ISSN 1932-6203
DOI: 10.1371/journal.pone.0073704

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Author(s): Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Published in: PLoS ONE, Issue 8/2, 2013, Page(s) e55582, ISSN 1932-6203
DOI: 10.1371/journal.pone.0055582

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Author(s): Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, Lénia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Published in: PLoS Pathogens, Issue 9/10, 2013, Page(s) e1003673, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Author(s): R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Published in: Proceedings of the National Academy of Sciences, Issue 110/16, 2013, Page(s) 6494-6499, ISSN 0027-8424
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Author(s): Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Published in: PLoS Pathogens, Issue 9/8, 2013, Page(s) e1003554, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1003554

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Author(s): Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Published in: PLoS Pathogens, Issue 9/12, 2013, Page(s) e1003802, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1003802

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Author(s): K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Published in: Proceedings of the National Academy of Sciences, Issue 110/30, 2013, Page(s) E2838-E2847, ISSN 0027-8424
DOI: 10.1073/pnas.1306097110

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Author(s): R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Published in: Proceedings of the National Academy of Sciences, Issue 110/25, 2013, Page(s) 10240-10245, ISSN 0027-8424
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF-  and IL-1 

Author(s): M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Published in: The Journal of Immunology, Issue 190/2, 2013, Page(s) 805-811, ISSN 0022-1767
DOI: 10.4049/jimmunol.1201010

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic    T Lymphocytes to Tumor Beds

Author(s): T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Published in: The Journal of Immunology, Issue 190/12, 2013, Page(s) 6673-6680, ISSN 0022-1767
DOI: 10.4049/jimmunol.1300434

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Author(s): Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Published in: Journal of Infection in Developing Countries, Issue 6, 2013, ISSN 1972-2680

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Author(s): R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Published in: The Journal of Rheumatology, Issue 40/8, 2013, Page(s) 1293-1302, ISSN 0315-162X
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Author(s): Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Published in: Trends in Parasitology, Issue 29/10, 2013, Page(s) 469-476, ISSN 1471-4922
DOI: 10.1016/

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Author(s): José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Published in: The Lancet, Issue 382/9888, 2013, Page(s) 205, ISSN 0140-6736
DOI: 10.1016/S0140-6736(13)61219-2

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Author(s): Karine Serre, Bruno Silva-Santos
Published in: Frontiers in Immunology, Issue 4, 2013, ISSN 1664-3224
DOI: 10.3389/fimmu.2013.00431

Recruitment of γδ T lymphocytes to tumors

Author(s): Telma Lança, Bruno Silva-Santos
Published in: OncoImmunology, Issue 2/8, 2013, Page(s) e25461, ISSN 2162-4011
DOI: 10.4161/onci.25461

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Author(s): Marta Caridade, Luis Graca, Ruy M. Ribeiro
Published in: Frontiers in Immunology, Issue 4, 2013, ISSN 1664-3224
DOI: 10.3389/fimmu.2013.00378

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Author(s): Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Published in: Frontiers in Immunology, Issue 4, 2013, ISSN 1664-3224
DOI: 10.3389/fimmu.2013.00069

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Author(s): V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Published in: Blood, Issue 121/19, 2013, Page(s) 3936-3945, ISSN 0006-4971
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Author(s): Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Published in: ACS Medicinal Chemistry Letters, Issue 5/2, 2014, Page(s) 108-112, ISSN 1948-5875
DOI: 10.1021/ml4002985

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Author(s): Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Published in: AIDS, Issue 28/7, 2014, Page(s) 1075-1077, ISSN 0269-9370
DOI: 10.1097/QAD.0000000000000205

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Author(s): Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Published in: Bioorganic & Medicinal Chemistry, Issue 22/15, 2014, Page(s) 3887-3890, ISSN 0968-0896
DOI: 10.1016/j.bmc.2014.06.019

Gut disruption in HIV-2 infection despite reduced viremia

Author(s): Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Published in: AIDS, Issue 28/2, 2014, Page(s) 290-292, ISSN 0269-9370
DOI: 10.1097/QAD.0000000000000114

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Author(s): Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Published in: Bioorganic & Medicinal Chemistry Letters, Issue 24/17, 2014, Page(s) 4151-4157, ISSN 0960-894X
DOI: 10.1016/j.bmcl.2014.07.050

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Author(s): Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Published in: ChemMedChem, Issue 9/2, 2014, Page(s) 305-310, ISSN 1860-7179
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Author(s): Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Published in: Cell, Issue 157/2, 2014, Page(s) 340-356, ISSN 0092-8674
DOI: 10.1016/j.cell.2014.03.030

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Author(s): S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Published in: Comparative Immunology, Microbiology and Infectious Diseases, Issue 37/3, 2014, Page(s) 169-172, ISSN 0147-9571
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Author(s): Marta Monteiro, Luis Graca
Published in: Critical Reviews in Immunology, Issue 34/1, 2014, Page(s) 81-90, ISSN 1040-8401
DOI: 10.1615/CritRevImmunol.2014010088

Chemical Interrogation of the Malaria Kinome

Author(s): Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Published in: ChemBioChem, Issue 15/13, 2014, Page(s) 1920-1930, ISSN 1439-4227
DOI: 10.1002/cbic.201400025

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Author(s): S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Published in: Disease Models & Mechanisms, Issue 7/2, 2014, Page(s) 215-224, ISSN 1754-8403
DOI: 10.1242/dmm.013490

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Author(s): S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Published in: Eurosurveillance, Issue 52, 2014, ISSN 1560-7917

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Author(s): L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Published in: Eurosurveillance, Issue 52, 2014, ISSN 1560-7917

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Author(s): Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Published in: European Journal of Medicinal Chemistry, Issue 80, 2014, Page(s) 523-534, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2014.04.076

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Author(s): A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Published in: Haematologica, Issue 99/6, 2014, Page(s) 1062-1068, ISSN 0390-6078
DOI: 10.3324/haematol.2013.096438

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Author(s): Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Published in: FEMS Microbiology Ecology, Issue 90/3, 2014, Page(s) 689-698, ISSN 0168-6496
DOI: 10.1111/1574-6941.12426

Bacillus invictae sp. nov., isolated from a health product

Author(s): R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Published in: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Issue 64/Pt 11, 2014, Page(s) 3867-3876, ISSN 1466-5026
DOI: 10.1099/ijs.0.067850-0

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Author(s): Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Published in: Journal of Clinical Immunology, Issue 34/5, 2014, Page(s) 573-583, ISSN 0271-9142
DOI: 10.1007/s10875-014-0047-y

Malaria infections: What and how can mice teach us

Author(s): Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Published in: Journal of Immunological Methods, Issue 410, 2014, Page(s) 113-122, ISSN 0022-1759
DOI: 10.1016/j.jim.2014.05.001

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Author(s): Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Published in: Journal of Medicinal Chemistry, Issue 57/11, 2014, Page(s) 4916-4923, ISSN 0022-2623
DOI: 10.1021/jm5004528

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Author(s): Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Published in: Malaria Journal, Issue 13/1, 2014, Page(s) 15, ISSN 1475-2875
DOI: 10.1186/1475-2875-13-15

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Author(s): Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Published in: Nanomedicine, Issue 9/17, 2014, Page(s) 2639-2656, ISSN 1743-5889
DOI: 10.2217/nnm.14.135

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Author(s): Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Published in: Molecular Microbiology, Issue 93/4, 2014, Page(s) 645-663, ISSN 0950-382X
DOI: 10.1111/mmi.12677

Methaemoglobin and COHb in patients with malaria

Author(s): Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Published in: Malaria Journal, Issue 13/1, 2014, Page(s) 285, ISSN 1475-2875
DOI: 10.1186/1475-2875-13-285

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Author(s): Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Published in: Nature, Issue 514/7520, 2014, Page(s) 98-101, ISSN 0028-0836
DOI: 10.1038/nature13498

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Author(s): Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedr
Published in: Nature, Issue 508/7494, 2014, Page(s) 123-127, ISSN 0028-0836
DOI: 10.1038/nature13158

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Author(s): Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Ka
Published in: Nature Medicine, Issue 20/1, 2013, Page(s) 47-53, ISSN 1078-8956
DOI: 10.1038/nm.3424

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Author(s): Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Published in: PLoS ONE, Issue 9/3, 2014, Page(s) e92138, ISSN 1932-6203
DOI: 10.1371/journal.pone.0092138

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Author(s): Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Published in: The Pediatric Infectious Disease Journal, Issue 33/3, 2014, Page(s) 306-310, ISSN 0891-3668
DOI: 10.1097/INF.0000000000000088

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Author(s): Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Published in: PLoS ONE, Issue 9/7, 2014, Page(s) e103092, ISSN 1932-6203
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Author(s): Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Published in: PLoS ONE, Issue 9/5, 2014, Page(s) e96981, ISSN 1932-6203
DOI: 10.1371/journal.pone.0096981

Classification of current anticancer immunotherapies

Author(s): Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo
Published in: Oncotarget, Issue 5/24, 2015, Page(s) 12472-12508, ISSN 1949-2553
DOI: 10.18632/oncotarget.2998

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Author(s): José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Published in: Stem Cell Research & Therapy, Issue 5/1, 2014, Page(s) 9, ISSN 1757-6512
DOI: 10.1186/scrt398

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Author(s): Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Published in: PLoS Pathogens, Issue 10/7, 2014, Page(s) e1004269, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1004269

Murine CD27(-) V 6(+)    T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Author(s): M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Published in: Proceedings of the National Academy of Sciences, Issue 111/34, 2014, Page(s) E3562-E3570, ISSN 0027-8424
DOI: 10.1073/pnas.1403424111

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Author(s): Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Published in: PLoS ONE, Issue 9/4, 2014, Page(s) e94358, ISSN 1932-6203
DOI: 10.1371/journal.pone.0094358

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Author(s): Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Published in: PLoS Pathogens, Issue 10/6, 2014, Page(s) e1004220, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1004220

Human    Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Author(s): J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Published in: The Journal of Immunology, Issue 192/5, 2014, Page(s) 2237-2243, ISSN 0022-1767
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Author(s): Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Published in: Journal of Clinical Investigation, Issue 124/11, 2014, Page(s) 4857-4866, ISSN 0021-9738
DOI: 10.1172/JCI74428

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Author(s): C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Published in: The Journal of Immunology, Issue 193/12, 2014, Page(s) 5854-5862, ISSN 0022-1767
DOI: 10.4049/jimmunol.1400198

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Author(s): S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Published in: Journal of Infectious Diseases, Issue 210/4, 2014, Page(s) 630-640, ISSN 0022-1899
DOI: 10.1093/infdis/jiu126

Chicago 2014 – 30years of γδ T cells

Author(s): Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Published in: Cellular Immunology, Issue 296/1, 2015, Page(s) 3-9, ISSN 0008-8749
DOI: 10.1016/j.cellimm.2014.11.001

The Emerging Protumor Role of    T Lymphocytes: Implications for Cancer Immunotherapy

Author(s): M. Rei, D. J. Pennington, B. Silva-Santos
Published in: Cancer Research, Issue 75/5, 2015, Page(s) 798-802, ISSN 0008-5472
DOI: 10.1158/0008-5472.CAN-14-3228

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Author(s): Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Published in: Eukaryotic Cell, Issue 14/1, 2014, Page(s) 96-103, ISSN 1535-9778
DOI: 10.1128/EC.00166-14

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Author(s): Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Published in: ChemMedChem, Issue 10/12, 2015, Page(s) 2080-2089, ISSN 1860-7179
DOI: 10.1002/cmdc.201500429

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Author(s): Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Published in: Infection and Immunity, Issue 83/3, 2015, Page(s) 1172-1180, ISSN 0019-9567
DOI: 10.1128/IAI.02796-14

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Author(s): Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Published in: Stem Cell Reports, Issue 4/3, 2015, Page(s) 348-359, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2015.01.002

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Author(s): Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Published in: Journal of Medicinal Chemistry, Issue 59/1, 2016, Page(s) 264-281, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.5b01374

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Author(s): Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Published in: Journal of Virology, Issue 89/4, 2015, Page(s) 2201-2208, ISSN 0022-538X
DOI: 10.1128/JVI.03047-14

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Author(s): Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Published in: Journal of Autoimmunity, Issue 56, 2015, Page(s) 98-110, ISSN 0896-8411
DOI: 10.1016/j.jaut.2014.11.002

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Author(s): Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Published in: European Journal of Medicinal Chemistry, Issue 101, 2015, Page(s) 266-273, ISSN 0223-5234
DOI: 10.1016/j.ejmech.2015.06.045

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Author(s): Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Published in: ChemMedChem, Issue 10/5, 2015, Page(s) 883-890, ISSN 1860-7179
DOI: 10.1002/cmdc.201500011

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Author(s): Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Published in: Nucleic Acids Research, 2015, Page(s) gkv1459, ISSN 0305-1048
DOI: 10.1093/nar/gkv1459

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Author(s): Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Published in: ChemMedChem, Issue 10/8, 2015, Page(s) 1344-1349, ISSN 1860-7179
DOI: 10.1002/cmdc.201500164

Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Author(s): M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Published in: The Journal of Immunology, Issue 194/10, 2015, Page(s) 4860-4870, ISSN 0022-1767
DOI: 10.4049/jimmunol.1400863

Sugar activation and glycosylation in Plasmodium

Author(s): Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Published in: Malaria Journal, Issue 14/1, 2015, ISSN 1475-2875
DOI: 10.1186/s12936-015-0949-z

Parasite Glycobiology: A Bittersweet Symphony

Author(s): Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Published in: PLOS Pathogens, Issue 11/11, 2015, Page(s) e1005169, ISSN 1553-7366
DOI: 10.1371/journal.ppat.1005169

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Author(s): Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Published in: Scientific Reports, Issue 5, 2015, Page(s) 12057, ISSN 2045-2322
DOI: 10.1038/srep12057

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Author(s): C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Published in: Journal of Antimicrobial Chemotherapy, Issue 70/10, 2015, Page(s) 2729-2733, ISSN 0305-7453
DOI: 10.1093/jac/dkv182

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Author(s): E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Published in: Clinical Microbiology and Infection, 2015, ISSN 1198-743X
DOI: 10.1016/j.cmi.2015.11.020

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Author(s): Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Published in: Malaria Journal, Issue 14/1, 2015, ISSN 1475-2875
DOI: 10.1186/s12936-015-0913-y

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Author(s): Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Published in: BMC Microbiology, 2015, ISSN 1471-2180
DOI: 10.1186/s12866-015-0572-8

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Author(s): Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Published in: Bioinformatics, Issue 31/14, 2015, Page(s) 2364-2370, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btv156

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Author(s): Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Published in: PLOS ONE, Issue 10/5, 2015, Page(s) e0125985, ISSN 1932-6203
DOI: 10.1371/journal.pone.0125985

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Author(s): Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Published in: Malaria Journal, Issue 14/1, 2015, ISSN 1475-2875
DOI: 10.1186/s12936-015-0657-8

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Author(s): Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Published in: PLOS ONE, Issue 10/3, 2015, Page(s) e0119315, ISSN 1932-6203
DOI: 10.1371/journal.pone.0119315

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Author(s): Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Published in: PLOS ONE, Issue 10/11, 2015, Page(s) e0142540, ISSN 1932-6203
DOI: 10.1371/journal.pone.0142540

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Author(s): Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Published in: Nucleic Acids Research, 2015, Page(s) gkv987, ISSN 0305-1048
DOI: 10.1093/nar/gkv987

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Author(s): M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Published in: The Journal of Immunology, Issue 195/7, 2015, Page(s) 3463-3471, ISSN 0022-1767
DOI: 10.4049/jimmunol.1403170

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Author(s): Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Published in: Journal of Biological Chemistry, Issue 290/47, 2015, Page(s) 28084-28096, ISSN 0021-9258
DOI: 10.1074/jbc.M115.674622

Identification of H-type BSE in Portugal

Author(s): Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Published in: Prion, Issue 9/1, 2015, Page(s) 22-28, ISSN 1933-6896
DOI: 10.1080/19336896.2014.997615

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Author(s): Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Published in: Cell Reports, Issue 10/12, 2015, Page(s) 2043-2054, ISSN 2211-1247
DOI: 10.1016/j.celrep.2015.02.057

Using argument notation to engineer biological simulations with increased confidence

Author(s): Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Published in: Journal of the Royal Society Interface, Issue 12, 2015, ISSN 1742-5689
DOI: 10.1098/rsif.2014.1059

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Author(s): Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Published in: Journal of Controlled Release, Issue 198, 2015, Page(s) 91-103, ISSN 0168-3659
DOI: 10.1016/j.jconrel.2014.11.033

Feeding immunity: skepticism, delicacies and delights

Author(s): Marc Veldhoen, Henrique Veiga-Fernandes
Published in: Nature Immunology, Issue 16/3, 2015, Page(s) 215-219, ISSN 1529-2908
DOI: 10.1038/ni.3100

Utilising a simulation platform to understand the effect of domain model assumptions

Author(s): Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Published in: Natural Computing, Issue 14/1, 2015, Page(s) 99-107, ISSN 1567-7818
DOI: 10.1007/s11047-014-9428-7

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Author(s): R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Published in: Stem Cells International, Issue 2015, 2015, Page(s) 1-14, ISSN 1687-966X
DOI: 10.1155/2015/583984

Point-of-care tests: where is the point?

Author(s): Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Published in: The Lancet Infectious Diseases, Issue 14/10, 2014, Page(s) 922, ISSN 1473-3099
DOI: 10.1016/S1473-3099(14)70914-4

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Author(s): Julie C. Ribot, Bruno Silva-Santos
Published in: Crossroads Between Innate and Adaptive Immunity IV, 2013, Page(s) 95-105
DOI: 10.1007/978-1-4614-6217-0_11