Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation

Livrables

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect
Second TwinnToInfect Joint Summer School
KPIs definition for TwinnToInfect
First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Publications

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Auteurs: Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Publié dans: PLOS Biology, Numéro 16/5, 2018, Page(s) e2004990, ISSN 1545-7885
Éditeur: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.2004990

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Auteurs: Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Publié dans: Journal of Autoimmunity, Numéro 87, 2018, Page(s) 26-37, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Auteurs: Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Publié dans: Trends in Immunology, Numéro 38/5, 2017, Page(s) 336-344, ISSN 1471-4906
Éditeur: Elsevier BV
DOI: 10.1016/j.it.2017.01.007

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Auteurs: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Publié dans: The Journal of Immunology, Numéro 196/9, 2016, Page(s) 3642-3652, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Auteurs: Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Publié dans: Nature Immunology, Numéro 17/6, 2016, Page(s) 721-727, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3424

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Auteurs: A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Publié dans: Clinical Cancer Research, Numéro 22/23, 2016, Page(s) 5795-5804, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0597

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Auteurs: Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
Publié dans: Inflammation Research, Numéro 65/12, 2016, Page(s) 985-994, ISSN 1023-3830
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00011-016-0982-6

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Auteurs: Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Publié dans: EMBO reports, Numéro 18/11, 2017, Page(s) 1957-1967, ISSN 1469-221X
Éditeur: Nature Publishing Group
DOI: 10.15252/embr.201744200

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Auteurs: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Publié dans: Leukemia, Numéro 31/7, 2016, Page(s) 1603-1610, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Auteurs: Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Publié dans: Cancer Immunology Research, Numéro 5/9, 2017, Page(s) 812-820, ISSN 2326-6066
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0082

γδ T cells get adaptive

Auteurs: Bruno Silva-Santos, Jessica Strid
Publié dans: Nature Immunology, Numéro 18/4, 2017, Page(s) 370-372, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3705

Got my γδ17 T cells to keep me warm

Auteurs: Pedro H. Papotto, Bruno Silva-Santos
Publié dans: Nature Immunology, Numéro 19/5, 2018, Page(s) 427-429, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-018-0090-6

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Auteurs: André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00929

Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Auteurs: Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Publié dans: Cardiovascular Research, Numéro 113/7, 2017, Page(s) 783-794, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvx065

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Auteurs: Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Publié dans: Science Immunology, Numéro 3/23, 2018, Page(s) eaao1392, ISSN 2470-9468
Éditeur: Science Immunology
DOI: 10.1126/sciimmunol.aao1392

The Emerging Complexity of γδT17 Cells

Auteurs: Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00796

Control of T cell effector functions by miRNAs

Auteurs: Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Publié dans: Cancer Letters, Numéro 427, 2018, Page(s) 63-73, ISSN 0304-3835
Éditeur: Elsevier BV
DOI: 10.1016/j.canlet.2018.04.011

Immunology's Twinning Triangle

Auteurs: Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
Publié dans: European Journal of Immunology, Numéro 46/10, 2016, Page(s) 2283-2285, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201670106

VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Auteurs: Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Publié dans: Cancer Research, Numéro 78/3, 2018, Page(s) 731-741, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-1166

Peripheral clonal selection shapes the human γδ T-cell repertoire

Auteurs: Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
Publié dans: Cellular & Molecular Immunology, Numéro 14/9, 2017, Page(s) 733-735, ISSN 1672-7681
Éditeur: Nature Publishing Group
DOI: 10.1038/cmi.2017.51

Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Auteurs: Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
Publié dans: Sleep and Breathing, Numéro 22/1, 2018, Page(s) 211-221, ISSN 1520-9512
Éditeur: Thieme Medical Publishers
DOI: 10.1007/s11325-017-1602-6

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Auteurs: Bruno Silva-Santos, Jessica Strid
Publié dans: Frontiers in Immunology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00851

Multifaceted CK2 in malignant and healthy T cells

Auteurs: Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
Publié dans: Oncotarget, Numéro 8/53, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.21700

Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Auteurs: Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
Publié dans: Nature Microbiology, Numéro 3/7, 2018, Page(s) 791-803, ISSN 2058-5276
Éditeur: NATURE PUBLISHING GROUP
DOI: 10.1038/s41564-018-0167-x

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Auteurs: Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
Publié dans: The Journal of Immunology, Numéro 198/5, 2017, Page(s) 2172-2181, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1600165

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Auteurs: Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
Publié dans: JCI Insight, Numéro 1/18, 2016, ISSN 2379-3708
Éditeur: AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.89278

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Auteurs: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Publié dans: Cell Host & Microbe, Numéro 19/6, 2016, Page(s) 837-848, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2016.05.002

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Auteurs: Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
Publié dans: Nature, Numéro 555/7696, 2018, Page(s) 382-386, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature25974

Interleukin 17 is a chief orchestrator of immunity

Auteurs: Marc Veldhoen
Publié dans: Nature Immunology, Numéro 18/6, 2017, Page(s) 612-621, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3742

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Auteurs: Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ric
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 140/3, 2017, Page(s) 867-870.e9, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2017.02.034

Trypanosoma brucei metabolism is under circadian control

Auteurs: Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L. Barbosa-Morais, Joseph S. Takahashi, Luisa M. Figueiredo
Publié dans: Nature Microbiology, Numéro 2, 2017, Page(s) 17032, ISSN 2058-5276
Éditeur: NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.32

Trypanosoma brucei triggers a marked immune response in male reproductive organs

Auteurs: Tânia Carvalho, Sandra Trindade, Sílvia Pimenta, Ana B. Santos, Filipa Rijo-Ferreira, Luísa M. Figueiredo
Publié dans: PLOS Neglected Tropical Diseases, Numéro 12/8, 2018, Page(s) e0006690, ISSN 1935-2735
Éditeur: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0006690

Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation

Auteurs: Zdenka Cicova, Mario Dejung, Tomas Skalicky, Nicole Eisenhuth, Steffen Hanselmann, Brooke Morriswood, Luisa M. Figueiredo, Falk Butter, Christian J. Janzen
Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep35826

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Auteurs: A. C. Alho, H. T. Kim, M. J. Chammas, C. G. Reynolds, T. R. Matos, E. Forcade, J. Whangbo, S. Nikiforow, C. S. Cutler, J. Koreth, V. T. Ho, P. Armand, J. H. Antin, E. P. Alyea, J. F. Lacerda, R. J. Soiffer, J. Ritz
Publié dans: Blood, Numéro 127/5, 2016, Page(s) 646-657, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2015-10-672345

Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges

Auteurs: Agostinho Carvalho, Cláudio Duarte-Oliveira, Samuel M. Gonçalves, António Campos, João F. Lacerda, Cristina Cunha
Publié dans: Current Fungal Infection Reports, Numéro 11/1, 2017, Page(s) 16-24, ISSN 1936-3761
Éditeur: Current Medicine Group
DOI: 10.1007/s12281-017-0272-y

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Auteurs: Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M. Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry Noyes, Albert Picado, Kat S. Rock, Brice Rotureau, Gustave Simo, Sophie T
Publié dans: Trends in Parasitology, Numéro 34/3, 2018, Page(s) 197-207, ISSN 1471-4922
Éditeur: Elsevier BV
DOI: 10.1016/j.pt.2017.11.008

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Auteurs: Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdon
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-04912-3

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Auteurs: David R Withers, Matthew R Hepworth, Xinxin Wang, Emma C Mackley, Emily E Halford, Emma E Dutton, Clare L Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N Baldassano, Gregory F Sonnenberg
Publié dans: Nature Medicine, Numéro 22/3, 2016, Page(s) 319-323, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/nm.4046

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Auteurs: José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F. Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Publié dans: Annals of Hematology, Numéro 96/11, 2017, Page(s) 1921-1929, ISSN 0939-5555
Éditeur: Springer Verlag
DOI: 10.1007/s00277-017-3090-y

Sleeping sickness is a circadian disorder

Auteurs: Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02484-2

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Auteurs: Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, P
Publié dans: European Journal of Immunology, Numéro 47/10, 2017, Page(s) 1584-1797, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Host AMPK Is a Modulator of Plasmodium Liver Infection

Auteurs: Margarida T. Grilo Ruivo, Iset Medina Vera, Joana Sales-Dias, Patrícia Meireles, Nil Gural, Sangeeta N. Bhatia, Maria M. Mota, Liliana Mancio-Silva
Publié dans: Cell Reports, Numéro 16/10, 2016, Page(s) 2539-2545, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2016.08.001

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Auteurs: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Auteurs: Vanessa Zuzarte-Luis, Maria M. Mota
Publié dans: Cell Metabolism, Numéro 27/4, 2018, Page(s) 708-709, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2018.03.007

Adipose Tissue: A Safe Haven for Parasites?

Auteurs: Herbert B. Tanowitz, Philipp E. Scherer, Maria M. Mota, Luisa M. Figueiredo
Publié dans: Trends in Parasitology, Numéro 33/4, 2017, Page(s) 276-284, ISSN 1471-4922
Éditeur: Elsevier BV
DOI: 10.1016/j.pt.2016.11.008

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

Auteurs: Cláudia Sá e Cunha, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm, Jude Marek Przyborski, Maria M. Mota, Miguel Prudêncio, Ann-Kristin Mueller
Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/7, 2017, Page(s) E1138-E1147, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1606419114

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Auteurs: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Publié dans: European Journal of Immunology, Numéro 48/9, 2018, Page(s) 1430-1440, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

Auteurs: Shengyong Ng, Sandra March, Ani Galstian, Nil Gural, Kelly R. Stevens, Maria M. Mota, Sangeeta N. Bhatia
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep45424

Host cell autophagy contributes to Plasmodium liver development

Auteurs: Carolina Thieleke-Matos, Mafalda Lopes da Silva, Laura Cabrita-Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte-Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Publié dans: Cellular Microbiology, Numéro 18/3, 2016, Page(s) 437-450, ISSN 1462-5814
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12524

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

Auteurs: Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, Guillaume Bouyer, Kirsten K. Hanson, Iset Vera, Jon K. Pittman, Henry M. Staines, Maria M. Mota
Publié dans: Nature Communications, Numéro 7/1, 2016, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms10403

Parasite Sensing of Host Nutrients and Environmental Cues

Auteurs: Vanessa Zuzarte-Luís, Maria M. Mota
Publié dans: Cell Host & Microbe, Numéro 23/6, 2018, Page(s) 749-758, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2018.05.018

Maria Mota: The Pleasure of Discovery

Auteurs: Maria M. Mota
Publié dans: Trends in Parasitology, Numéro 32/6, 2016, Page(s) 429-430, ISSN 1471-4922
Éditeur: Elsevier BV
DOI: 10.1016/j.pt.2016.01.003

Nutrient sensing modulates malaria parasite virulence

Auteurs: Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota
Publié dans: Nature, Numéro 547/7662, 2017, Page(s) 213-216, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/nature23009

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Auteurs: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Publié dans: Cell Reports, Numéro 19/11, 2017, Page(s) 2357-2370, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Th17 Cells Require You to Chew before You Swallow

Auteurs: Marc Veldhoen
Publié dans: Immunity, Numéro 46/1, 2017, Page(s) 8-10, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology

Auteurs: Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg, Marc Veldhoen
Publié dans: The Journal of Immunology, Numéro 196/12, 2016, Page(s) 4893-4904, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1600137

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Auteurs: TAÍS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C. M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÊNCIO, SARAH D'ALESSANDRO, NICOLETTA BASILICO, DIOGO R. M. MOREIRA, ALZIR A. BATISTA, MILENA B. P. SOARES
Publié dans: Parasitology, Numéro 143/12, 2016, Page(s) 1543-1556, ISSN 0031-1820
Éditeur: Cambridge University Press
DOI: 10.1017/s0031182016001153

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Auteurs: Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Publié dans: Journal of Medicinal Chemistry, Numéro 60/4, 2017, Page(s) 1432-1448, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01641

Inhibition of Plasmodium liver infection by ivermectin

Auteurs: António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Publié dans: Antimicrobial Agents and Chemotherapy, 2017, Page(s) AAC.02005-16, ISSN 0066-4804
Éditeur: American Society for Microbiology
DOI: 10.1128/aac.02005-16

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Auteurs: Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Publié dans: Particle & Particle Systems Characterization, Numéro 33/12, 2016, Page(s) 906-915, ISSN 0934-0866
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.201600187

Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Auteurs: Taís S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudêncio, Alzir A. Batista, Milena B. P. Soares
Publié dans: Metallomics, Numéro 9/11, 2017, Page(s) 1548-1561, ISSN 1756-5901
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c7mt00196g

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Auteurs: Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Publié dans: Antimicrobial Agents and Chemotherapy, Numéro 61/6, 2017, ISSN 0066-4804
Éditeur: American Society for Microbiology
DOI: 10.1128/aac.02699-16

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Auteurs: Marta Machado, Margarida Sanches-Vaz, João P. Cruz, António M. Mendes, Miguel Prudêncio
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 7, 2017, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00329

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Auteurs: Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio, Rui Moreira
Publié dans: ChemMedChem, Numéro 11/19, 2016, Page(s) 2194-2204, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201600327

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Auteurs: António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M.
Publié dans: npj Vaccines, Numéro 3/1, 2018, ISSN 2059-0105
Éditeur: SPRINGERNATURE
DOI: 10.1038/s41541-018-0068-2

Primaquine-based ionic liquids as a novel class of antimalarial hits

Auteurs: Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Publié dans: RSC Advances, Numéro 6/61, 2016, Page(s) 56134-56138, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c6ra10759a

Novel squaramides with in vitro liver stage antiplasmodial activity

Auteurs: Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Publié dans: Bioorganic & Medicinal Chemistry, Numéro 24/8, 2016, Page(s) 1786-1792, ISSN 0968-0896
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2016.03.005

Primaquine hybrids as promising antimycobacterial and antimalarial agents

Auteurs: Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Publié dans: European Journal of Medicinal Chemistry, Numéro 143, 2018, Page(s) 769-779, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2017.11.083

Uptake and metabolism of arginine impact Plasmodium development in the liver

Auteurs: Patrícia Meireles, António M. Mendes, Rita I. Aroeira, Bryan C. Mounce, Marco Vignuzzi, Henry M. Staines, Miguel Prudêncio
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-04424-y

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Auteurs: Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Publié dans: Archives of Pharmacal Research, Numéro 41/2, 2018, Page(s) 208-218, ISSN 0253-6269
Éditeur: Pharmaceutical Society of Korea
DOI: 10.1007/s12272-017-1000-4

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Auteurs: Patrícia Meireles, Joana Sales-Dias, Carolina M. Andrade, João Mello-Vieira, Liliana Mancio-Silva, J. Pedro Simas, Henry M. Staines, Miguel Prudêncio
Publié dans: Cellular Microbiology, Numéro 19/2, 2017, Page(s) e12646, ISSN 1462-5814
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12646

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Auteurs: Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publié dans: European Journal of Medicinal Chemistry, Numéro 149, 2018, Page(s) 69-78, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2018.02.048

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Auteurs: Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
Publié dans: ChemistryOpen, Numéro 7/8, 2018, Page(s) 624-638, ISSN 2191-1363
Éditeur: WILEY-V C H VERLAG GMBH
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Tumor cell recognition by γδ T lymphocytes

Auteurs: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Publié dans: OncoImmunology, Numéro 21624011, 2013, Page(s) e22892, ISSN 2162-4011
Éditeur: Landes Bioscience
DOI: 10.4161/onci.22892

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Auteurs: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Publié dans: Biology of Blood and Marrow Transplantation, Numéro 10838791, 2013, Page(s) 703-712, ISSN 1083-8791
Éditeur: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Auteurs: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Publié dans: Clinical and Vaccine Immunology, Numéro 15566811, 2013, Page(s) 313-316, ISSN 1556-6811
Éditeur: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Auteurs: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Publié dans: Cell Host & Microbe, Numéro 19313128, 2013, Page(s) 104-115, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Auteurs: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Publié dans: AIDS, Numéro 02699370, 2013, Page(s) 289-292, ISSN 0269-9370
Éditeur: Lippincott Williams & Wilkins Ltd.
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Repairing thymic function

Auteurs: Helena Nunes-Cabaço, Ana E. Sousa
Publié dans: Current Opinion in Organ Transplantation, Numéro 10872418, 2013, Page(s) 1, ISSN 1087-2418
Éditeur: Lippincott Williams & Wilkins Ltd.
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Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Auteurs: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Publié dans: Eurosurveillance, Numéro 52, 2013, ISSN 1560-7917
Éditeur: EUR CENTRE DIS PREVENTION & CONTROL

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Auteurs: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publié dans: European Journal of Clinical Microbiology & Infectious Diseases, Numéro 09349723, 2013, Page(s) 115-125, ISSN 0934-9723
Éditeur: Springer Verlag
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Functional development of γδ T cells

Auteurs: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Publié dans: European Journal of Immunology, Numéro 00142980, 2013, Page(s) 1988-1994, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
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Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Auteurs: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publié dans: European Journal of Medicinal Chemistry, Numéro 02235234, 2013, Page(s) 872-880, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Auteurs: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Publié dans: Immunity, Numéro 10747613, 2013, Page(s) 874-884, ISSN 1074-7613
Éditeur: Cell Press
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Insight into lymphoid tissue morphogenesis

Auteurs: Mark Coles, Henrique Veiga-Fernandes
Publié dans: Immunology Letters, Numéro 01652478, 2013, Page(s) 46-53, ISSN 0165-2478
Éditeur: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Auteurs: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Publié dans: Immunology and Cell Biology, Numéro 08189641, 2013, Page(s) 652-660, ISSN 0818-9641
Éditeur: Blackwell Publishing Inc.
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Auteurs: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Publié dans: International Journal of Antimicrobial Agents, Numéro 09248579, 2013, Page(s) 490-492, ISSN 0924-8579
Éditeur: Elsevier BV
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Auteurs: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Publié dans: International Journal of Medical Microbiology, Numéro 14384221, 2013, Page(s) 505-513, ISSN 1438-4221
Éditeur: Elsevier BV
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Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Auteurs: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Publié dans: Journal of Biological Chemistry, Numéro 00219258, 2013, Page(s) 3858-3870, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Auteurs: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Publié dans: Journal of Clinical Microbiology, Numéro 00951137, 2013, Page(s) 1099-1109, ISSN 0095-1137
Éditeur: American Society for Microbiology
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How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Auteurs: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Publié dans: Journal of Clinical Microbiology, Numéro 00951137, 2013, Page(s) 644-646, ISSN 0095-1137
Éditeur: American Society for Microbiology
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miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Auteurs: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publié dans: Journal of Hematology & Oncology, Numéro 17568722, 2013, Page(s) 87, ISSN 1756-8722
Éditeur: BioMed Central
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At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Auteurs: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Publié dans: Journal of Leukocyte Biology, Numéro 07415400, 2013, Page(s) 1123-1139, ISSN 0741-5400
Éditeur: Federation of American Societies for Experimental Biology
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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Auteurs: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2013, Page(s) 7679-7690, ISSN 0022-2623
Éditeur: American Chemical Society
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Auteurs: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2013, Page(s) 4811-4815, ISSN 0022-2623
Éditeur: American Chemical Society
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The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Auteurs: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Publié dans: Journal of Translational Medicine, Numéro 14795876, 2013, Page(s) 18, ISSN 1479-5876
Éditeur: BioMed Central
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Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Auteurs: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Publié dans: Journal of Microbiological Methods, Numéro 01677012, 2013, Page(s) 102-107, ISSN 0167-7012
Éditeur: Elsevier BV
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Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Auteurs: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Publié dans: Marine Drugs, Numéro 16603397, 2013, Page(s) 4019-4034, ISSN 1660-3397
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
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Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Auteurs: Maria João Frias, José Melo-Cristino, Mário Ramirez
Publié dans: Molecular Microbiology, Numéro 0950382X, 2013, Page(s) 430-445, ISSN 0950-382X
Éditeur: Blackwell Publishing Inc.
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Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Auteurs: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Publié dans: PLoS Computational Biology, Numéro 1553734X, 2013, Page(s) e1002916, ISSN 1553-734X
Éditeur: Public Library of Science
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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Auteurs: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e61606, ISSN 1932-6203
Éditeur: Public Library of Science
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Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Auteurs: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
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Éditeur: Public Library of Science
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The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Auteurs: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
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Éditeur: Public Library of Science
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The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Auteurs: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
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Éditeur: Public Library of Science
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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Auteurs: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Publié dans: PLoS Pathogens, Numéro 15537366, 2013, Page(s) e1003673, ISSN 1553-7366
Éditeur: Public Library of Science
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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Auteurs: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2013, Page(s) 6494-6499, ISSN 0027-8424
Éditeur: National Academy of Sciences
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Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Auteurs: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Publié dans: PLoS Pathogens, Numéro 15537366, 2013, Page(s) e1003554, ISSN 1553-7366
Éditeur: Public Library of Science
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The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Auteurs: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
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Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Auteurs: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Auteurs: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
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Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Auteurs: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
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Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Auteurs: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
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Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Auteurs: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
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BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Auteurs: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
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The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Auteurs: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
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First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Auteurs: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
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Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Auteurs: Karine Serre, Bruno Silva-Santos
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Recruitment of γδ T lymphocytes to tumors

Auteurs: Telma Lança, Bruno Silva-Santos
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Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Auteurs: Marta Caridade, Luis Graca, Ruy M. Ribeiro
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Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Auteurs: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
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Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Auteurs: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
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Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Auteurs: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
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Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Auteurs: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Publié dans: AIDS, Numéro 02699370, 2014, Page(s) 1075-1077, ISSN 0269-9370
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Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Auteurs: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
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Gut disruption in HIV-2 infection despite reduced viremia

Auteurs: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
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2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Auteurs: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
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N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Auteurs: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
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Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Auteurs: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
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PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Auteurs: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
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iNKT Cells: Innate Lymphocytes with a Diverse Response

Auteurs: Marta Monteiro, Luis Graca
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Chemical Interrogation of the Malaria Kinome

Auteurs: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
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Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

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Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Auteurs: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
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Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Auteurs: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
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Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Auteurs: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Auteurs: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
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Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Auteurs: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
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Bacillus invictae sp. nov., isolated from a health product

Auteurs: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
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Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Auteurs: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
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Malaria infections: What and how can mice teach us

Auteurs: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Auteurs: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Auteurs: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Auteurs: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
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T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Auteurs: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
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Methaemoglobin and COHb in patients with malaria

Auteurs: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Auteurs: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Auteurs: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Auteurs: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
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Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Auteurs: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
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Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Auteurs: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Publié dans: The Pediatric Infectious Disease Journal, Numéro 08913668, 2014, Page(s) 306-310, ISSN 0891-3668
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Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Auteurs: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
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Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Auteurs: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
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Classification of current anticancer immunotherapies

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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Auteurs: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
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Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Auteurs: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Auteurs: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
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Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Auteurs: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
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Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Auteurs: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Publié dans: PLoS Pathogens, Numéro 15537366, 2014, Page(s) e1004220, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Auteurs: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Publié dans: The Journal of Immunology, Numéro 00221767, 2014, Page(s) 2237-2243, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Auteurs: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Publié dans: Journal of Clinical Investigation, Numéro 00219738, 2014, Page(s) 4857-4866, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Auteurs: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Publié dans: The Journal of Immunology, Numéro 00221767, 2014, Page(s) 5854-5862, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Auteurs: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Publié dans: Journal of Infectious Diseases, Numéro 00221899, 2014, Page(s) 630-640, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Chicago 2014 – 30years of γδ T cells

Auteurs: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Publié dans: Cellular Immunology, Numéro 00088749, 2015, Page(s) 3-9, ISSN 0008-8749
Éditeur: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Auteurs: M. Rei, D. J. Pennington, B. Silva-Santos
Publié dans: Cancer Research, Numéro 00085472, 2015, Page(s) 798-802, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Auteurs: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Publié dans: Eukaryotic Cell, Numéro 15359778, 2014, Page(s) 96-103, ISSN 1535-9778
Éditeur: American Society for Microbiology
DOI: 10.1128/EC.00166-14

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Auteurs: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Publié dans: ChemMedChem, Numéro 18607179, 2015, Page(s) 2080-2089, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500429

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Auteurs: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Publié dans: Infection and Immunity, Numéro 00199567, 2015, Page(s) 1172-1180, ISSN 0019-9567
Éditeur: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Auteurs: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Publié dans: Stem Cell Reports, Numéro 22136711, 2015, Page(s) 348-359, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Auteurs: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Publié dans: Journal of Medicinal Chemistry, Numéro 00222623, 2016, Page(s) 264-281, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Auteurs: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Publié dans: Journal of Virology, Numéro 0022538X, 2015, Page(s) 2201-2208, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Auteurs: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Publié dans: Journal of Autoimmunity, Numéro 08968411, 2015, Page(s) 98-110, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Auteurs: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Publié dans: European Journal of Medicinal Chemistry, Numéro 02235234, 2015, Page(s) 266-273, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Auteurs: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Publié dans: ChemMedChem, Numéro 18607179, 2015, Page(s) 883-890, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500011

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Auteurs: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Publié dans: Nucleic Acids Research, Numéro 03051048, 2015, Page(s) gkv1459, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkv1459

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Auteurs: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Publié dans: ChemMedChem, Numéro 18607179, 2015, Page(s) 1344-1349, ISSN 1860-7179
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500164

Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Auteurs: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Publié dans: The Journal of Immunology, Numéro 00221767, 2015, Page(s) 4860-4870, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1400863

Sugar activation and glycosylation in Plasmodium

Auteurs: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Publié dans: Malaria Journal, Numéro 14752875, 2015, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-015-0949-z

Parasite Glycobiology: A Bittersweet Symphony

Auteurs: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Publié dans: PLOS Pathogens, Numéro 15537366, 2015, Page(s) e1005169, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1005169

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Auteurs: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Publié dans: Scientific Reports, Numéro 20452322, 2015, Page(s) 12057, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep12057

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Auteurs: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publié dans: Journal of Antimicrobial Chemotherapy, Numéro 03057453, 2015, Page(s) 2729-2733, ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1093/jac/dkv182

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Auteurs: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Publié dans: Clinical Microbiology and Infection, Numéro 1198743X, 2015, ISSN 1198-743X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Auteurs: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Publié dans: Malaria Journal, Numéro 14752875, 2015, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-015-0913-y

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Auteurs: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Publié dans: BMC Microbiology, Numéro 14712180, 2015, ISSN 1471-2180
Éditeur: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Auteurs: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Publié dans: Bioinformatics, Numéro 13674803, 2015, Page(s) 2364-2370, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Auteurs: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0125985, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Auteurs: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Publié dans: Malaria Journal, Numéro 14752875, 2015, ISSN 1475-2875
Éditeur: BioMed Central
DOI: 10.1186/s12936-015-0657-8

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Auteurs: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0119315, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Auteurs: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0142540, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0142540

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Auteurs: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Publié dans: Nucleic Acids Research, Numéro 03051048, 2015, Page(s) gkv987, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkv987

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Auteurs: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Publié dans: The Journal of Immunology, Numéro 00221767, 2015, Page(s) 3463-3471, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Auteurs: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Publié dans: Journal of Biological Chemistry, Numéro 00219258, 2015, Page(s) 28084-28096, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

Identification of H-type BSE in Portugal

Auteurs: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Publié dans: Prion, Numéro 19336896, 2015, Page(s) 22-28, ISSN 1933-6896
Éditeur: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Auteurs: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Publié dans: Cell Reports, Numéro 22111247, 2015, Page(s) 2043-2054, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Using argument notation to engineer biological simulations with increased confidence

Auteurs: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Publié dans: Journal of the Royal Society Interface, Numéro 17425689, 2015, ISSN 1742-5689
Éditeur: The Royal Society
DOI: 10.1098/rsif.2014.1059

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Auteurs: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Publié dans: Journal of Controlled Release, Numéro 01683659, 2015, Page(s) 91-103, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Feeding immunity: skepticism, delicacies and delights

Auteurs: Marc Veldhoen, Henrique Veiga-Fernandes
Publié dans: Nature Immunology, Numéro 15292908, 2015, Page(s) 215-219, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/ni.3100

Utilising a simulation platform to understand the effect of domain model assumptions

Auteurs: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Publié dans: Natural Computing, Numéro 15677818, 2015, Page(s) 99-107, ISSN 1567-7818
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s11047-014-9428-7

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Auteurs: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Publié dans: Stem Cells International, Numéro 1687966X, 2015, Page(s) 1-14, ISSN 1687-966X
Éditeur: HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2015/583984

Point-of-care tests: where is the point?

Auteurs: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Publié dans: The Lancet Infectious Diseases, Numéro 14733099, 2014, Page(s) 922, ISSN 1473-3099
Éditeur: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Auteurs: Julie C. Ribot, Bruno Silva-Santos
Publié dans: Crossroads Between Innate and Adaptive Immunity IV, 2013, Page(s) 95-105, ISBN 978-1-4614-6217-0
Éditeur: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

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