Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation

Risultati finali

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect
Second TwinnToInfect Joint Summer School
KPIs definition for TwinnToInfect
First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Pubblicazioni

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Autori: Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Pubblicato in: PLOS Biology, Numero 16/5, 2018, Pagina/e e2004990, ISSN 1545-7885
Editore: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.2004990

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Autori: Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Pubblicato in: Journal of Autoimmunity, Numero 87, 2018, Pagina/e 26-37, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Autori: Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Pubblicato in: Trends in Immunology, Numero 38/5, 2017, Pagina/e 336-344, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2017.01.007

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autori: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Pubblicato in: The Journal of Immunology, Numero 196/9, 2016, Pagina/e 3642-3652, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Autori: Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Pubblicato in: Nature Immunology, Numero 17/6, 2016, Pagina/e 721-727, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3424

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Autori: A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Pubblicato in: Clinical Cancer Research, Numero 22/23, 2016, Pagina/e 5795-5804, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0597

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Autori: Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
Pubblicato in: Inflammation Research, Numero 65/12, 2016, Pagina/e 985-994, ISSN 1023-3830
Editore: Birkhauser Verlag
DOI: 10.1007/s00011-016-0982-6

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Autori: Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Pubblicato in: EMBO reports, Numero 18/11, 2017, Pagina/e 1957-1967, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201744200

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autori: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Pubblicato in: Leukemia, Numero 31/7, 2016, Pagina/e 1603-1610, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Autori: Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Pubblicato in: Cancer Immunology Research, Numero 5/9, 2017, Pagina/e 812-820, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0082

γδ T cells get adaptive

Autori: Bruno Silva-Santos, Jessica Strid
Pubblicato in: Nature Immunology, Numero 18/4, 2017, Pagina/e 370-372, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3705

Got my γδ17 T cells to keep me warm

Autori: Pedro H. Papotto, Bruno Silva-Santos
Pubblicato in: Nature Immunology, Numero 19/5, 2018, Pagina/e 427-429, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0090-6

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Autori: André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00929

Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Autori: Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Pubblicato in: Cardiovascular Research, Numero 113/7, 2017, Pagina/e 783-794, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvx065

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Autori: Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Pubblicato in: Science Immunology, Numero 3/23, 2018, Pagina/e eaao1392, ISSN 2470-9468
Editore: Science Immunology
DOI: 10.1126/sciimmunol.aao1392

The Emerging Complexity of γδT17 Cells

Autori: Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00796

Control of T cell effector functions by miRNAs

Autori: Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Pubblicato in: Cancer Letters, Numero 427, 2018, Pagina/e 63-73, ISSN 0304-3835
Editore: Elsevier BV
DOI: 10.1016/j.canlet.2018.04.011

Immunology's Twinning Triangle

Autori: Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
Pubblicato in: European Journal of Immunology, Numero 46/10, 2016, Pagina/e 2283-2285, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201670106

VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Autori: Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Pubblicato in: Cancer Research, Numero 78/3, 2018, Pagina/e 731-741, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-1166

Peripheral clonal selection shapes the human γδ T-cell repertoire

Autori: Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
Pubblicato in: Cellular & Molecular Immunology, Numero 14/9, 2017, Pagina/e 733-735, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/cmi.2017.51

Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Autori: Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
Pubblicato in: Sleep and Breathing, Numero 22/1, 2018, Pagina/e 211-221, ISSN 1520-9512
Editore: Thieme Medical Publishers
DOI: 10.1007/s11325-017-1602-6

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Autori: Bruno Silva-Santos, Jessica Strid
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00851

Multifaceted CK2 in malignant and healthy T cells

Autori: Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
Pubblicato in: Oncotarget, Numero 8/53, 2017, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.21700

Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Autori: Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
Pubblicato in: Nature Microbiology, Numero 3/7, 2018, Pagina/e 791-803, ISSN 2058-5276
Editore: NATURE PUBLISHING GROUP
DOI: 10.1038/s41564-018-0167-x

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Autori: Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
Pubblicato in: The Journal of Immunology, Numero 198/5, 2017, Pagina/e 2172-2181, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1600165

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Autori: Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
Pubblicato in: JCI Insight, Numero 1/18, 2016, ISSN 2379-3708
Editore: AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.89278

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autori: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Pubblicato in: Cell Host & Microbe, Numero 19/6, 2016, Pagina/e 837-848, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2016.05.002

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Autori: Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
Pubblicato in: Nature, Numero 555/7696, 2018, Pagina/e 382-386, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature25974

Interleukin 17 is a chief orchestrator of immunity

Autori: Marc Veldhoen
Pubblicato in: Nature Immunology, Numero 18/6, 2017, Pagina/e 612-621, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3742

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Autori: Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ric
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 140/3, 2017, Pagina/e 867-870.e9, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2017.02.034

Trypanosoma brucei metabolism is under circadian control

Autori: Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L. Barbosa-Morais, Joseph S. Takahashi, Luisa M. Figueiredo
Pubblicato in: Nature Microbiology, Numero 2, 2017, Pagina/e 17032, ISSN 2058-5276
Editore: NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.32

Trypanosoma brucei triggers a marked immune response in male reproductive organs

Autori: Tânia Carvalho, Sandra Trindade, Sílvia Pimenta, Ana B. Santos, Filipa Rijo-Ferreira, Luísa M. Figueiredo
Pubblicato in: PLOS Neglected Tropical Diseases, Numero 12/8, 2018, Pagina/e e0006690, ISSN 1935-2735
Editore: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0006690

Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation

Autori: Zdenka Cicova, Mario Dejung, Tomas Skalicky, Nicole Eisenhuth, Steffen Hanselmann, Brooke Morriswood, Luisa M. Figueiredo, Falk Butter, Christian J. Janzen
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep35826

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Autori: A. C. Alho, H. T. Kim, M. J. Chammas, C. G. Reynolds, T. R. Matos, E. Forcade, J. Whangbo, S. Nikiforow, C. S. Cutler, J. Koreth, V. T. Ho, P. Armand, J. H. Antin, E. P. Alyea, J. F. Lacerda, R. J. Soiffer, J. Ritz
Pubblicato in: Blood, Numero 127/5, 2016, Pagina/e 646-657, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2015-10-672345

Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges

Autori: Agostinho Carvalho, Cláudio Duarte-Oliveira, Samuel M. Gonçalves, António Campos, João F. Lacerda, Cristina Cunha
Pubblicato in: Current Fungal Infection Reports, Numero 11/1, 2017, Pagina/e 16-24, ISSN 1936-3761
Editore: Current Medicine Group
DOI: 10.1007/s12281-017-0272-y

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Autori: Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M. Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry Noyes, Albert Picado, Kat S. Rock, Brice Rotureau, Gustave Simo, Sophie T
Pubblicato in: Trends in Parasitology, Numero 34/3, 2018, Pagina/e 197-207, ISSN 1471-4922
Editore: Elsevier BV
DOI: 10.1016/j.pt.2017.11.008

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Autori: Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdon
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04912-3

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Autori: David R Withers, Matthew R Hepworth, Xinxin Wang, Emma C Mackley, Emily E Halford, Emma E Dutton, Clare L Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N Baldassano, Gregory F Sonnenberg
Pubblicato in: Nature Medicine, Numero 22/3, 2016, Pagina/e 319-323, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.4046

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Autori: José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F. Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Pubblicato in: Annals of Hematology, Numero 96/11, 2017, Pagina/e 1921-1929, ISSN 0939-5555
Editore: Springer Verlag
DOI: 10.1007/s00277-017-3090-y

Sleeping sickness is a circadian disorder

Autori: Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02484-2

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Autori: Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, P
Pubblicato in: European Journal of Immunology, Numero 47/10, 2017, Pagina/e 1584-1797, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Host AMPK Is a Modulator of Plasmodium Liver Infection

Autori: Margarida T. Grilo Ruivo, Iset Medina Vera, Joana Sales-Dias, Patrícia Meireles, Nil Gural, Sangeeta N. Bhatia, Maria M. Mota, Liliana Mancio-Silva
Pubblicato in: Cell Reports, Numero 16/10, 2016, Pagina/e 2539-2545, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.08.001

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Autori: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Autori: Vanessa Zuzarte-Luis, Maria M. Mota
Pubblicato in: Cell Metabolism, Numero 27/4, 2018, Pagina/e 708-709, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2018.03.007

Adipose Tissue: A Safe Haven for Parasites?

Autori: Herbert B. Tanowitz, Philipp E. Scherer, Maria M. Mota, Luisa M. Figueiredo
Pubblicato in: Trends in Parasitology, Numero 33/4, 2017, Pagina/e 276-284, ISSN 1471-4922
Editore: Elsevier BV
DOI: 10.1016/j.pt.2016.11.008

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

Autori: Cláudia Sá e Cunha, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm, Jude Marek Przyborski, Maria M. Mota, Miguel Prudêncio, Ann-Kristin Mueller
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 114/7, 2017, Pagina/e E1138-E1147, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1606419114

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Autori: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Pubblicato in: European Journal of Immunology, Numero 48/9, 2018, Pagina/e 1430-1440, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

Autori: Shengyong Ng, Sandra March, Ani Galstian, Nil Gural, Kelly R. Stevens, Maria M. Mota, Sangeeta N. Bhatia
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep45424

Host cell autophagy contributes to Plasmodium liver development

Autori: Carolina Thieleke-Matos, Mafalda Lopes da Silva, Laura Cabrita-Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte-Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Pubblicato in: Cellular Microbiology, Numero 18/3, 2016, Pagina/e 437-450, ISSN 1462-5814
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12524

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

Autori: Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, Guillaume Bouyer, Kirsten K. Hanson, Iset Vera, Jon K. Pittman, Henry M. Staines, Maria M. Mota
Pubblicato in: Nature Communications, Numero 7/1, 2016, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms10403

Parasite Sensing of Host Nutrients and Environmental Cues

Autori: Vanessa Zuzarte-Luís, Maria M. Mota
Pubblicato in: Cell Host & Microbe, Numero 23/6, 2018, Pagina/e 749-758, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2018.05.018

Maria Mota: The Pleasure of Discovery

Autori: Maria M. Mota
Pubblicato in: Trends in Parasitology, Numero 32/6, 2016, Pagina/e 429-430, ISSN 1471-4922
Editore: Elsevier BV
DOI: 10.1016/j.pt.2016.01.003

Nutrient sensing modulates malaria parasite virulence

Autori: Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota
Pubblicato in: Nature, Numero 547/7662, 2017, Pagina/e 213-216, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature23009

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Autori: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Pubblicato in: Cell Reports, Numero 19/11, 2017, Pagina/e 2357-2370, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Th17 Cells Require You to Chew before You Swallow

Autori: Marc Veldhoen
Pubblicato in: Immunity, Numero 46/1, 2017, Pagina/e 8-10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology

Autori: Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg, Marc Veldhoen
Pubblicato in: The Journal of Immunology, Numero 196/12, 2016, Pagina/e 4893-4904, ISSN 0022-1767
Editore: American Association of Immunologists
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Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Autori: TAÍS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C. M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÊNCIO, SARAH D'ALESSANDRO, NICOLETTA BASILICO, DIOGO R. M. MOREIRA, ALZIR A. BATISTA, MILENA B. P. SOARES
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Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Autori: Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
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Editore: American Chemical Society
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Inhibition of Plasmodium liver infection by ivermectin

Autori: António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Pubblicato in: Antimicrobial Agents and Chemotherapy, 2017, Pagina/e AAC.02005-16, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/aac.02005-16

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Autori: Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
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Editore: John Wiley & Sons Ltd.
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Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Autori: Taís S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudêncio, Alzir A. Batista, Milena B. P. Soares
Pubblicato in: Metallomics, Numero 9/11, 2017, Pagina/e 1548-1561, ISSN 1756-5901
Editore: Royal Society of Chemistry
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Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Autori: Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 61/6, 2017, ISSN 0066-4804
Editore: American Society for Microbiology
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Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Autori: Marta Machado, Margarida Sanches-Vaz, João P. Cruz, António M. Mendes, Miguel Prudêncio
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 7, 2017, ISSN 2235-2988
Editore: Frontiers Media S. A.
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Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Autori: Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio, Rui Moreira
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Editore: Wiley - V C H Verlag GmbbH & Co.
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A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Autori: António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M.
Pubblicato in: npj Vaccines, Numero 3/1, 2018, ISSN 2059-0105
Editore: SPRINGERNATURE
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Primaquine-based ionic liquids as a novel class of antimalarial hits

Autori: Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
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Editore: Royal Society of Chemistry
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Novel squaramides with in vitro liver stage antiplasmodial activity

Autori: Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
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Primaquine hybrids as promising antimycobacterial and antimalarial agents

Autori: Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
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Uptake and metabolism of arginine impact Plasmodium development in the liver

Autori: Patrícia Meireles, António M. Mendes, Rita I. Aroeira, Bryan C. Mounce, Marco Vignuzzi, Henry M. Staines, Miguel Prudêncio
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
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Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Autori: Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
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Editore: Pharmaceutical Society of Korea
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GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Autori: Patrícia Meireles, Joana Sales-Dias, Carolina M. Andrade, João Mello-Vieira, Liliana Mancio-Silva, J. Pedro Simas, Henry M. Staines, Miguel Prudêncio
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Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Autori: Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Pubblicato in: European Journal of Medicinal Chemistry, Numero 149, 2018, Pagina/e 69-78, ISSN 0223-5234
Editore: Elsevier BV
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SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Autori: Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
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Tumor cell recognition by γδ T lymphocytes

Autori: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
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Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autori: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
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Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autori: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
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Editore: American Society for Microbiology
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A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autori: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
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Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autori: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
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Repairing thymic function

Autori: Helena Nunes-Cabaço, Ana E. Sousa
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Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autori: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Pubblicato in: Eurosurveillance, Numero 52, 2013, ISSN 1560-7917
Editore: EUR CENTRE DIS PREVENTION & CONTROL

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autori: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
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Functional development of γδ T cells

Autori: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
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Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autori: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
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Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autori: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
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Insight into lymphoid tissue morphogenesis

Autori: Mark Coles, Henrique Veiga-Fernandes
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The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autori: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autori: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autori: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
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Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autori: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autori: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
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How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autori: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
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miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autori: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
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At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autori: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autori: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
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Editore: American Chemical Society
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autori: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
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The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autori: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
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Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autori: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
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Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autori: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
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Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autori: Maria João Frias, José Melo-Cristino, Mário Ramirez
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Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autori: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autori: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
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Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

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The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autori: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
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The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autori: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autori: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
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Editore: National Academy of Sciences
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Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autori: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
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The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autori: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
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Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autori: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
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Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

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Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

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Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Autori: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
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BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

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The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

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First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

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Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

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Recruitment of γδ T lymphocytes to tumors

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Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

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Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

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Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autori: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
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Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

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Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

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Gut disruption in HIV-2 infection despite reduced viremia

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N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

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iNKT Cells: Innate Lymphocytes with a Diverse Response

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Chemical Interrogation of the Malaria Kinome

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Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

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Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

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Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

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Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

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Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autori: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
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Bacillus invictae sp. nov., isolated from a health product

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Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

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Malaria infections: What and how can mice teach us

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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

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Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

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Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autori: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
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Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autori: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
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Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

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Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

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Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

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Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

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Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

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TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autori: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
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Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autori: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
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Editore: American Association of Immunologists
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Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autori: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Pubblicato in: Journal of Infectious Diseases, Numero 00221899, 2014, Pagina/e 630-640, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Chicago 2014 – 30years of γδ T cells

Autori: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Pubblicato in: Cellular Immunology, Numero 00088749, 2015, Pagina/e 3-9, ISSN 0008-8749
Editore: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autori: M. Rei, D. J. Pennington, B. Silva-Santos
Pubblicato in: Cancer Research, Numero 00085472, 2015, Pagina/e 798-802, ISSN 0008-5472
Editore: American Association for Cancer Research
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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autori: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
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Editore: American Society for Microbiology
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Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autori: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
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Editore: Wiley - V C H Verlag GmbbH & Co.
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Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autori: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Pubblicato in: Infection and Immunity, Numero 00199567, 2015, Pagina/e 1172-1180, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autori: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Pubblicato in: Stem Cell Reports, Numero 22136711, 2015, Pagina/e 348-359, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autori: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Pubblicato in: Journal of Medicinal Chemistry, Numero 00222623, 2016, Pagina/e 264-281, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autori: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Pubblicato in: Journal of Virology, Numero 0022538X, 2015, Pagina/e 2201-2208, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autori: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Pubblicato in: Journal of Autoimmunity, Numero 08968411, 2015, Pagina/e 98-110, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autori: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Pubblicato in: European Journal of Medicinal Chemistry, Numero 02235234, 2015, Pagina/e 266-273, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autori: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Pubblicato in: ChemMedChem, Numero 18607179, 2015, Pagina/e 883-890, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500011

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autori: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Pubblicato in: Nucleic Acids Research, Numero 03051048, 2015, Pagina/e gkv1459, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkv1459

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autori: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Pubblicato in: ChemMedChem, Numero 18607179, 2015, Pagina/e 1344-1349, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
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Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autori: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Pubblicato in: The Journal of Immunology, Numero 00221767, 2015, Pagina/e 4860-4870, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1400863

Sugar activation and glycosylation in Plasmodium

Autori: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Pubblicato in: Malaria Journal, Numero 14752875, 2015, ISSN 1475-2875
Editore: BioMed Central
DOI: 10.1186/s12936-015-0949-z

Parasite Glycobiology: A Bittersweet Symphony

Autori: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Pubblicato in: PLOS Pathogens, Numero 15537366, 2015, Pagina/e e1005169, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1005169

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autori: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Pubblicato in: Scientific Reports, Numero 20452322, 2015, Pagina/e 12057, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep12057

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autori: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Pubblicato in: Journal of Antimicrobial Chemotherapy, Numero 03057453, 2015, Pagina/e 2729-2733, ISSN 0305-7453
Editore: Oxford University Press
DOI: 10.1093/jac/dkv182

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autori: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Pubblicato in: Clinical Microbiology and Infection, Numero 1198743X, 2015, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autori: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Pubblicato in: Malaria Journal, Numero 14752875, 2015, ISSN 1475-2875
Editore: BioMed Central
DOI: 10.1186/s12936-015-0913-y

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autori: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Pubblicato in: BMC Microbiology, Numero 14712180, 2015, ISSN 1471-2180
Editore: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autori: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Pubblicato in: Bioinformatics, Numero 13674803, 2015, Pagina/e 2364-2370, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autori: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Pubblicato in: PLOS ONE, Numero 19326203, 2015, Pagina/e e0125985, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autori: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Pubblicato in: Malaria Journal, Numero 14752875, 2015, ISSN 1475-2875
Editore: BioMed Central
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Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autori: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Pubblicato in: PLOS ONE, Numero 19326203, 2015, Pagina/e e0119315, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autori: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Pubblicato in: PLOS ONE, Numero 19326203, 2015, Pagina/e e0142540, ISSN 1932-6203
Editore: Public Library of Science
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KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autori: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Pubblicato in: Nucleic Acids Research, Numero 03051048, 2015, Pagina/e gkv987, ISSN 0305-1048
Editore: Oxford University Press
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IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autori: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Pubblicato in: The Journal of Immunology, Numero 00221767, 2015, Pagina/e 3463-3471, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autori: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Pubblicato in: Journal of Biological Chemistry, Numero 00219258, 2015, Pagina/e 28084-28096, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

Identification of H-type BSE in Portugal

Autori: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Pubblicato in: Prion, Numero 19336896, 2015, Pagina/e 22-28, ISSN 1933-6896
Editore: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autori: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Pubblicato in: Cell Reports, Numero 22111247, 2015, Pagina/e 2043-2054, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Using argument notation to engineer biological simulations with increased confidence

Autori: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Pubblicato in: Journal of the Royal Society Interface, Numero 17425689, 2015, ISSN 1742-5689
Editore: The Royal Society
DOI: 10.1098/rsif.2014.1059

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autori: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Pubblicato in: Journal of Controlled Release, Numero 01683659, 2015, Pagina/e 91-103, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Feeding immunity: skepticism, delicacies and delights

Autori: Marc Veldhoen, Henrique Veiga-Fernandes
Pubblicato in: Nature Immunology, Numero 15292908, 2015, Pagina/e 215-219, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3100

Utilising a simulation platform to understand the effect of domain model assumptions

Autori: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Pubblicato in: Natural Computing, Numero 15677818, 2015, Pagina/e 99-107, ISSN 1567-7818
Editore: Kluwer Academic Publishers
DOI: 10.1007/s11047-014-9428-7

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autori: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Pubblicato in: Stem Cells International, Numero 1687966X, 2015, Pagina/e 1-14, ISSN 1687-966X
Editore: HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2015/583984

Point-of-care tests: where is the point?

Autori: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Pubblicato in: The Lancet Infectious Diseases, Numero 14733099, 2014, Pagina/e 922, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autori: Julie C. Ribot, Bruno Silva-Santos
Pubblicato in: Crossroads Between Innate and Adaptive Immunity IV, 2013, Pagina/e 95-105, ISBN 978-1-4614-6217-0
Editore: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

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