Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect
Second TwinnToInfect Joint Summer School
KPIs definition for TwinnToInfect
First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Pubblicazioni

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autori: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Pubblicato in: PLoS ONE, Numero 8/2, 2013, Pagina/e e55582, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0055582

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autori: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Pubblicato in: Journal of Infectious Diseases, Numero 210/4, 2014, Pagina/e 630-640, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiu126

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autori: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Pubblicato in: PLoS Pathogens, Numero 9/12, 2013, Pagina/e e1003802, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autori: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Pubblicato in: ChemMedChem, Numero 10/12, 2015, Pagina/e 2080-2089, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500429

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autori: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Pubblicato in: Bioinformatics, Numero 31/14, 2015, Pagina/e 2364-2370, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autori: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Pubblicato in: PLOS ONE, Numero 10/3, 2015, Pagina/e e0119315, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autori: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Pubblicato in: The Pediatric Infectious Disease Journal, Numero 33/3, 2014, Pagina/e 306-310, ISSN 0891-3668
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autori: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Pubblicato in: Nature, Numero 514/7520, 2014, Pagina/e 98-101, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature13498

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autori: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Pubblicato in: Blood, Numero 121/19, 2013, Pagina/e 3936-3945, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Autori: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Pubblicato in: Journal of Infection in Developing Countries, Numero 6, 2013, ISSN 1972-2680
Editore: Open Learning on Enteric Pathogens

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autori: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Pubblicato in: ACS Medicinal Chemistry Letters, Numero 5/2, 2014, Pagina/e 108-112, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/ml4002985

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autori: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Pubblicato in: Marine Drugs, Numero 11/10, 2013, Pagina/e 4019-4034, ISSN 1660-3397
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

Using argument notation to engineer biological simulations with increased confidence

Autori: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Pubblicato in: Journal of the Royal Society Interface, Numero 12, 2015, ISSN 1742-5689
Editore: The Royal Society
DOI: 10.1098/rsif.2014.1059

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autori: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Pubblicato in: PLoS Pathogens, Numero 10/6, 2014, Pagina/e e1004220, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autori: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Pubblicato in: Infection and Immunity, Numero 83/3, 2015, Pagina/e 1172-1180, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autori: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Pubblicato in: PLoS Pathogens, Numero 10/7, 2014, Pagina/e e1004269, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Gut disruption in HIV-2 infection despite reduced viremia

Autori: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Pubblicato in: AIDS, Numero 28/2, 2014, Pagina/e 290-292, ISSN 0269-9370
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autori: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Pubblicato in: Journal of Virology, Numero 89/4, 2015, Pagina/e 2201-2208, ISSN 0022-538X
Editore: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Insight into lymphoid tissue morphogenesis

Autori: Mark Coles, Henrique Veiga-Fernandes
Pubblicato in: Immunology Letters, Numero 156/1-2, 2013, Pagina/e 46-53, ISSN 0165-2478
Editore: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autori: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 22/15, 2014, Pagina/e 3887-3890, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autori: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Pubblicato in: Journal of Leukocyte Biology, Numero 94/6, 2013, Pagina/e 1123-1139, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autori: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Pubblicato in: Nature Medicine, Numero 20/1, 2013, Pagina/e 47-53, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/nm.3424

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autori: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Pubblicato in: Journal of Autoimmunity, Numero 56, 2015, Pagina/e 98-110, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autori: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Pubblicato in: Frontiers in Immunology, Numero 4, 2013, ISSN 1664-3224
Editore: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autori: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Pubblicato in: Immunology and Cell Biology, Numero 91/10, 2013, Pagina/e 652-660, ISSN 0818-9641
Editore: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autori: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Pubblicato in: Eukaryotic Cell, Numero 14/1, 2014, Pagina/e 96-103, ISSN 1535-9778
Editore: American Society for Microbiology
DOI: 10.1128/EC.00166-14

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autori: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Pubblicato in: BMC Microbiology, 2015, ISSN 1471-2180
Editore: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Repairing thymic function

Autori: Helena Nunes-Cabaço, Ana E. Sousa
Pubblicato in: Current Opinion in Organ Transplantation, 2013, Pagina/e 1, ISSN 1087-2418
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Chemical Interrogation of the Malaria Kinome

Autori: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Pubblicato in: ChemBioChem, Numero 15/13, 2014, Pagina/e 1920-1930, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autori: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Pubblicato in: PLOS ONE, Numero 10/11, 2015, Pagina/e e0142540, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0142540

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autori: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Pubblicato in: Molecular Microbiology, Numero 93/4, 2014, Pagina/e 645-663, ISSN 0950-382X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autori: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Pubblicato in: Trends in Parasitology, Numero 29/10, 2013, Pagina/e 469-476, ISSN 1471-4922
Editore: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autori: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Pubblicato in: The Lancet, Numero 382/9888, 2013, Pagina/e 205, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autori: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Pubblicato in: Immunity, Numero 39/5, 2013, Pagina/e 874-884, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autori: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Pubblicato in: Disease Models & Mechanisms, Numero 7/2, 2014, Pagina/e 215-224, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Identification of H-type BSE in Portugal

Autori: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Pubblicato in: Prion, Numero 9/1, 2015, Pagina/e 22-28, ISSN 1933-6896
Editore: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

Malaria infections: What and how can mice teach us

Autori: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Pubblicato in: Journal of Immunological Methods, Numero 410, 2014, Pagina/e 113-122, ISSN 0022-1759
Editore: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autori: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Pubblicato in: Nucleic Acids Research, 2015, Pagina/e gkv987, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkv987

Bacillus invictae sp. nov., isolated from a health product

Autori: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Pubblicato in: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Numero 64/Pt 11, 2014, Pagina/e 3867-3876, ISSN 1466-5026
Editore: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autori: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Pubblicato in: PLoS ONE, Numero 9/7, 2014, Pagina/e e103092, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autori: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Pubblicato in: PLOS ONE, Numero 10/5, 2015, Pagina/e e0125985, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autori: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Pubblicato in: Eurosurveillance, Numero 52, 2013, ISSN 1560-7917
Editore: EUR CENTRE DIS PREVENTION & CONTROL

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autori: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 110/30, 2013, Pagina/e E2838-E2847, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autori: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Pubblicato in: Nature, Numero 508/7494, 2014, Pagina/e 123-127, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature13158

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autori: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Pubblicato in: Haematologica, Numero 99/6, 2014, Pagina/e 1062-1068, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autori: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Pubblicato in: Cell Reports, Numero 10/12, 2015, Pagina/e 2043-2054, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Classification of current anticancer immunotherapies

Autori: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Pubblicato in: Oncotarget, Numero 5/24, 2015, Pagina/e 12472-12508, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.2998

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autori: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Pubblicato in: The Journal of Rheumatology, Numero 40/8, 2013, Pagina/e 1293-1302, ISSN 0315-162X
Editore: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autori: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Pubblicato in: Malaria Journal, Numero 14/1, 2015, ISSN 1475-2875
Editore: BioMed Central
DOI: 10.1186/s12936-015-0657-8

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autori: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Pubblicato in: Cell Host & Microbe, Numero 14/1, 2013, Pagina/e 104-115, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autori: Maria João Frias, José Melo-Cristino, Mário Ramirez
Pubblicato in: Molecular Microbiology, Numero 87/2, 2013, Pagina/e 430-445, ISSN 0950-382X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autori: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
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Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autori: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
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What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autori: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
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Methaemoglobin and COHb in patients with malaria

Autori: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
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Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autori: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autori: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
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2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autori: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
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Utilising a simulation platform to understand the effect of domain model assumptions

Autori: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
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Feeding immunity: skepticism, delicacies and delights

Autori: Marc Veldhoen, Henrique Veiga-Fernandes
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Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autori: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autori: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
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Parasite Glycobiology: A Bittersweet Symphony

Autori: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autori: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
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Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autori: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
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Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autori: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autori: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autori: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
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Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autori: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autori: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autori: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autori: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
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Functional development of γδ T cells

Autori: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
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N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autori: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autori: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autori: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
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Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autori: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
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Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Autori: Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
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Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Autori: Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
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Thymic Determinants of γδ T Cell Differentiation

Autori: Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Pubblicato in: Trends in Immunology, Numero 38/5, 2017, Pagina/e 336-344, ISSN 1471-4906
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Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autori: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
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TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Autori: Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
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Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Autori: A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
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Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Autori: Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
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IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Autori: Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
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Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autori: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
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Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Autori: Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
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γδ T cells get adaptive

Autori: Bruno Silva-Santos, Jessica Strid
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Got my γδ17 T cells to keep me warm

Autori: Pedro H. Papotto, Bruno Silva-Santos
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Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Autori: André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
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Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Autori: Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
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MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Autori: Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
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The Emerging Complexity of γδT17 Cells

Autori: Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
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Control of T cell effector functions by miRNAs

Autori: Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
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Immunology's Twinning Triangle

Autori: Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
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VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Autori: Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
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Peripheral clonal selection shapes the human γδ T-cell repertoire

Autori: Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
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Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Autori: Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
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Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Autori: Bruno Silva-Santos, Jessica Strid
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Multifaceted CK2 in malignant and healthy T cells

Autori: Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
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Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Autori: Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Autori: Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
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Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Autori: Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
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Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autori: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
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Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Autori: Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
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Interleukin 17 is a chief orchestrator of immunity

Autori: Marc Veldhoen
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Host AMPK Is a Modulator of Plasmodium Liver Infection

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Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

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Parasite Sensing of Host Nutrients and Environmental Cues

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Th17 Cells Require You to Chew before You Swallow

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Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

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Inhibition of Plasmodium liver infection by ivermectin

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Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

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Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

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Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

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Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

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A Plasmodium berghei sporozoite-based vaccination platform against human malaria

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Primaquine-based ionic liquids as a novel class of antimalarial hits

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Primaquine hybrids as promising antimycobacterial and antimalarial agents

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Uptake and metabolism of arginine impact Plasmodium development in the liver

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Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

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GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

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Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

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SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

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Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

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Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autori: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
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Editore: Elsevier BV
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Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autori: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
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Insight into lymphoid tissue morphogenesis

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The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autori: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autori: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autori: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
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Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autori: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autori: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
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Editore: American Society for Microbiology
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How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autori: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
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Editore: American Society for Microbiology
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miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autori: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
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At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autori: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autori: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
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Editore: American Chemical Society
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autori: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
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The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autori: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
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Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autori: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
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Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autori: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
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Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autori: Maria João Frias, José Melo-Cristino, Mário Ramirez
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Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autori: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
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Editore: Public Library of Science
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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autori: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
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Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autori: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
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The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autori: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
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The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autori: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
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Editore: Public Library of Science
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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autori: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
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Editore: Public Library of Science
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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autori: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
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Editore: National Academy of Sciences
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Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autori: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Pubblicato in: PLoS Pathogens, Numero 15537366, 2013, Pagina/e e1003554, ISSN 1553-7366
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The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autori: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
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Editore: Public Library of Science
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Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autori: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
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Editore: National Academy of Sciences
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autori: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
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Editore: National Academy of Sciences
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Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autori: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Pubblicato in: The Journal of Immunology, Numero 00221767, 2013, Pagina/e 805-811, ISSN 0022-1767
Editore: American Association of Immunologists
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Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autori: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
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Editore: American Association of Immunologists
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Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autori: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
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The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autori: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
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First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autori: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
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Editore: The Lancet Publishing Group
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Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autori: Karine Serre, Bruno Silva-Santos
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Recruitment of γδ T lymphocytes to tumors

Autori: Telma Lança, Bruno Silva-Santos
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Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autori: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Pubblicato in: Frontiers in Immunology, Numero 16643224, 2013, ISSN 1664-3224
Editore: Frontiers Editorial Office
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Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autori: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
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Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autori: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
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Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autori: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
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Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autori: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
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Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autori: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
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Gut disruption in HIV-2 infection despite reduced viremia

Autori: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
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2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autori: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
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N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autori: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
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Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autori: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
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Editore: Cell Press
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PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autori: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
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iNKT Cells: Innate Lymphocytes with a Diverse Response

Autori: Marta Monteiro, Luis Graca
Pubblicato in: Critical Reviews in Immunology, Numero 10408401, 2014, Pagina/e 81-90, ISSN 1040-8401
Editore: Begell House
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Chemical Interrogation of the Malaria Kinome

Autori: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
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Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autori: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
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Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Autori: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Pubblicato in: Eurosurveillance, Numero 52, 2014, ISSN 1560-7917
Editore: EUR CENTRE DIS PREVENTION & CONTROL

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Autori: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Pubblicato in: Eurosurveillance, Numero 52, 2014, ISSN 1560-7917
Editore: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autori: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autori: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
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Editore: Ferrata Storti Foundation
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Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autori: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Pubblicato in: FEMS Microbiology Ecology, Numero 01686496, 2014, Pagina/e 689-698, ISSN 0168-6496
Editore: Blackwell
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Bacillus invictae sp. nov., isolated from a health product

Autori: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Pubblicato in: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Numero 14665026, 2014, Pagina/e 3867-3876, ISSN 1466-5026
Editore: Society for General Microbiology
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Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autori: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
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Malaria infections: What and how can mice teach us

Autori: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autori: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autori: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

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T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autori: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
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Methaemoglobin and COHb in patients with malaria

Autori: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autori: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
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Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autori: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autori: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
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Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autori: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
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Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autori: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
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Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autori: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
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Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

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Classification of current anticancer immunotherapies

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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autori: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
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Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autori: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autori: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
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Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autori: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
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Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autori: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
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Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autori: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
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TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autori: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
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Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autori: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
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Editore: American Association of Immunologists
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Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autori: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
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Chicago 2014 – 30years of γδ T cells

Autori: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
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The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autori: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
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Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autori: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
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Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autori: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
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Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autori: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
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Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autori: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
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Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autori: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
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Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autori: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
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Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autori: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
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Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autori: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
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A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autori: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
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N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autori: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
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Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autori: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
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Sugar activation and glycosylation in Plasmodium

Autori: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
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Parasite Glycobiology: A Bittersweet Symphony

Autori: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
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Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autori: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
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Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autori: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
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Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autori: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
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Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autori: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
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Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autori: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
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Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autori: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
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Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autori: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
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Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autori: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
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Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autori: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
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Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autori: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
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KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autori: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
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IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autori: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
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The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autori: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
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Editore: American Society for Biochemistry and Molecular Biology Inc.
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Identification of H-type BSE in Portugal

Autori: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
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Editore: Landes Bioscience
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NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autori: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
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Editore: Cell Press
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Using argument notation to engineer biological simulations with increased confidence

Autori: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Pubblicato in: Journal of the Royal Society Interface, Numero 17425689, 2015, ISSN 1742-5689
Editore: The Royal Society
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In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autori: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Pubblicato in: Journal of Controlled Release, Numero 01683659, 2015, Pagina/e 91-103, ISSN 0168-3659
Editore: Elsevier BV
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Feeding immunity: skepticism, delicacies and delights

Autori: Marc Veldhoen, Henrique Veiga-Fernandes
Pubblicato in: Nature Immunology, Numero 15292908, 2015, Pagina/e 215-219, ISSN 1529-2908
Editore: Nature Publishing Group
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Utilising a simulation platform to understand the effect of domain model assumptions

Autori: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
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Editore: Kluwer Academic Publishers
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What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autori: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
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Editore: HINDAWI PUBLISHING CORPORATION
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Point-of-care tests: where is the point?

Autori: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Pubblicato in: The Lancet Infectious Diseases, Numero 14733099, 2014, Pagina/e 922, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autori: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Pubblicato in: PLoS ONE, Numero 9/3, 2014, Pagina/e e92138, ISSN 1932-6203
Editore: Public Library of Science
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The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autori: M. Rei, D. J. Pennington, B. Silva-Santos
Pubblicato in: Cancer Research, Numero 75/5, 2015, Pagina/e 798-802, ISSN 0008-5472
Editore: American Association for Cancer Research
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Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autori: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Pubblicato in: Journal of Biological Chemistry, Numero 288/6, 2013, Pagina/e 3858-3870, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
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Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autori: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Pubblicato in: Frontiers in Immunology, Numero 4, 2013, ISSN 1664-3224
Editore: Frontiers Editorial Office
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Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autori: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
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Editore: Elsevier BV
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Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autori: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
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Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autori: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Pubblicato in: Biology of Blood and Marrow Transplantation, Numero 19/5, 2013, Pagina/e 703-712, ISSN 1083-8791
Editore: Elsevier BV
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How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autori: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Pubblicato in: Journal of Clinical Microbiology, Numero 51/2, 2013, Pagina/e 644-646, ISSN 0095-1137
Editore: American Society for Microbiology
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Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autori: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Pubblicato in: Journal of Antimicrobial Chemotherapy, Numero 70/10, 2015, Pagina/e 2729-2733, ISSN 0305-7453
Editore: Oxford University Press
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Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autori: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Pubblicato in: PLoS Computational Biology, Numero 9/2, 2013, Pagina/e e1002916, ISSN 1553-734X
Editore: Public Library of Science
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Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autori: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
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Editore: Future Medicine Ltd.
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Tumor cell recognition by γδ T lymphocytes

Autori: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Pubblicato in: OncoImmunology, Numero 2/1, 2013, Pagina/e e22892, ISSN 2162-4011
Editore: Landes Bioscience
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N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autori: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Pubblicato in: ChemMedChem, Numero 10/8, 2015, Pagina/e 1344-1349, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
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Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autori: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Pubblicato in: PLoS Pathogens, Numero 9/8, 2013, Pagina/e e1003554, ISSN 1553-7366
Editore: Public Library of Science
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Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autori: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Pubblicato in: Journal of Controlled Release, Numero 198, 2015, Pagina/e 91-103, ISSN 0168-3659
Editore: Elsevier BV
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Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autori: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Pubblicato in: The Journal of Immunology, Numero 192/5, 2014, Pagina/e 2237-2243, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autori: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Pubblicato in: Journal of Clinical Investigation, Numero 124/11, 2014, Pagina/e 4857-4866, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Sugar activation and glycosylation in Plasmodium

Autori: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Pubblicato in: Malaria Journal, Numero 14/1, 2015, ISSN 1475-2875
Editore: BioMed Central
DOI: 10.1186/s12936-015-0949-z

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autori: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Pubblicato in: Journal of Biological Chemistry, Numero 290/47, 2015, Pagina/e 28084-28096, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autori: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Pubblicato in: PLoS ONE, Numero 8/9, 2013, Pagina/e e73704, ISSN 1932-6203
Editore: Public Library of Science
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IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autori: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Pubblicato in: The Journal of Immunology, Numero 195/7, 2015, Pagina/e 3463-3471, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autori: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Pubblicato in: FEMS Microbiology Ecology, Numero 90/3, 2014, Pagina/e 689-698, ISSN 0168-6496
Editore: Blackwell
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Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autori: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Pubblicato in: Clinical Microbiology and Infection, 2015, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autori: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Pubblicato in: AIDS, Numero 27/2, 2013, Pagina/e 289-292, ISSN 0269-9370
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autori: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Pubblicato in: Journal of Translational Medicine, Numero 11/1, 2013, Pagina/e 18, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/1479-5876-11-18

iNKT Cells: Innate Lymphocytes with a Diverse Response

Autori: Marta Monteiro, Luis Graca
Pubblicato in: Critical Reviews in Immunology, Numero 34/1, 2014, Pagina/e 81-90, ISSN 1040-8401
Editore: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autori: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Pubblicato in: European Journal of Clinical Microbiology & Infectious Diseases, Numero 32/1, 2013, Pagina/e 115-125, ISSN 0934-9723
Editore: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Autori: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Pubblicato in: Eurosurveillance, Numero 52, 2014, ISSN 1560-7917
Editore: EUR CENTRE DIS PREVENTION & CONTROL

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autori: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Pubblicato in: Journal of Hematology & Oncology, Numero 6/1, 2013, Pagina/e 87, ISSN 1756-8722
Editore: BioMed Central
DOI: 10.1186/1756-8722-6-87

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autori: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Pubblicato in: The Journal of Immunology, Numero 190/2, 2013, Pagina/e 805-811, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autori: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Pubblicato in: PLoS ONE, Numero 8/4, 2013, Pagina/e e59960, ISSN 1932-6203
Editore: Public Library of Science
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Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autori: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Pubblicato in: Stem Cell Reports, Numero 4/3, 2015, Pagina/e 348-359, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autori: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Pubblicato in: Cell, Numero 157/2, 2014, Pagina/e 340-356, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2014.03.030

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autori: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Pubblicato in: Malaria Journal, Numero 14/1, 2015, ISSN 1475-2875
Editore: BioMed Central
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autori: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Pubblicato in: International Journal of Antimicrobial Agents, Numero 41/5, 2013, Pagina/e 490-492, ISSN 0924-8579
Editore: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autori: Karine Serre, Bruno Silva-Santos
Pubblicato in: Frontiers in Immunology, Numero 4, 2013, ISSN 1664-3224
Editore: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autori: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Pubblicato in: Scientific Reports, Numero 5, 2015, Pagina/e 12057, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep12057

Chicago 2014 – 30years of γδ T cells

Autori: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Pubblicato in: Cellular Immunology, Numero 296/1, 2015, Pagina/e 3-9, ISSN 0008-8749
Editore: Academic Press
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Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autori: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Pubblicato in: Malaria Journal, Numero 13/1, 2014, Pagina/e 15, ISSN 1475-2875
Editore: BioMed Central
DOI: 10.1186/1475-2875-13-15

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autori: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Pubblicato in: European Journal of Medicinal Chemistry, Numero 101, 2015, Pagina/e 266-273, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autori: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 110/16, 2013, Pagina/e 6494-6499, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autori: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Pubblicato in: The Journal of Immunology, Numero 193/12, 2014, Pagina/e 5854-5862, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autori: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Pubblicato in: Comparative Immunology, Microbiology and Infectious Diseases, Numero 37/3, 2014, Pagina/e 169-172, ISSN 0147-9571
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

Point-of-care tests: where is the point?

Autori: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Pubblicato in: The Lancet Infectious Diseases, Numero 14/10, 2014, Pagina/e 922, ISSN 1473-3099
Editore: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autori: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Pubblicato in: Journal of Microbiological Methods, Numero 93/2, 2013, Pagina/e 102-107, ISSN 0167-7012
Editore: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

Recruitment of γδ T lymphocytes to tumors

Autori: Telma Lança, Bruno Silva-Santos
Pubblicato in: OncoImmunology, Numero 2/8, 2013, Pagina/e e25461, ISSN 2162-4011
Editore: Landes Bioscience
DOI: 10.4161/onci.25461

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autori: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Pubblicato in: Nucleic Acids Research, 2015, Pagina/e gkv1459, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkv1459

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autori: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Pubblicato in: Journal of Clinical Immunology, Numero 34/5, 2014, Pagina/e 573-583, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autori: Julie C. Ribot, Bruno Silva-Santos
Pubblicato in: Crossroads Between Innate and Adaptive Immunity IV, 2013, Pagina/e 95-105, ISBN 978-1-4614-6217-0
Editore: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

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