Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation

Rezultaty

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect
Second TwinnToInfect Joint Summer School
KPIs definition for TwinnToInfect
First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Publikacje

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Autorzy: Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Opublikowane w: PLOS Biology, Numer 16/5, 2018, Strona(/y) e2004990, ISSN 1545-7885
Wydawca: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.2004990

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Autorzy: Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Opublikowane w: Journal of Autoimmunity, Numer 87, 2018, Strona(/y) 26-37, ISSN 0896-8411
Wydawca: Academic Press
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Autorzy: Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Opublikowane w: Trends in Immunology, Numer 38/5, 2017, Strona(/y) 336-344, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/j.it.2017.01.007

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autorzy: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Opublikowane w: The Journal of Immunology, Numer 196/9, 2016, Strona(/y) 3642-3652, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Autorzy: Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Opublikowane w: Nature Immunology, Numer 17/6, 2016, Strona(/y) 721-727, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/ni.3424

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Autorzy: A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Opublikowane w: Clinical Cancer Research, Numer 22/23, 2016, Strona(/y) 5795-5804, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0597

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Autorzy: Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
Opublikowane w: Inflammation Research, Numer 65/12, 2016, Strona(/y) 985-994, ISSN 1023-3830
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00011-016-0982-6

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Autorzy: Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Opublikowane w: EMBO reports, Numer 18/11, 2017, Strona(/y) 1957-1967, ISSN 1469-221X
Wydawca: Nature Publishing Group
DOI: 10.15252/embr.201744200

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autorzy: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Opublikowane w: Leukemia, Numer 31/7, 2016, Strona(/y) 1603-1610, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Autorzy: Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Opublikowane w: Cancer Immunology Research, Numer 5/9, 2017, Strona(/y) 812-820, ISSN 2326-6066
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0082

γδ T cells get adaptive

Autorzy: Bruno Silva-Santos, Jessica Strid
Opublikowane w: Nature Immunology, Numer 18/4, 2017, Strona(/y) 370-372, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/ni.3705

Got my γδ17 T cells to keep me warm

Autorzy: Pedro H. Papotto, Bruno Silva-Santos
Opublikowane w: Nature Immunology, Numer 19/5, 2018, Strona(/y) 427-429, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/s41590-018-0090-6

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Autorzy: André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00929

Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Autorzy: Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Opublikowane w: Cardiovascular Research, Numer 113/7, 2017, Strona(/y) 783-794, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvx065

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Autorzy: Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Opublikowane w: Science Immunology, Numer 3/23, 2018, Strona(/y) eaao1392, ISSN 2470-9468
Wydawca: Science Immunology
DOI: 10.1126/sciimmunol.aao1392

The Emerging Complexity of γδT17 Cells

Autorzy: Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00796

Control of T cell effector functions by miRNAs

Autorzy: Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Opublikowane w: Cancer Letters, Numer 427, 2018, Strona(/y) 63-73, ISSN 0304-3835
Wydawca: Elsevier BV
DOI: 10.1016/j.canlet.2018.04.011

Immunology's Twinning Triangle

Autorzy: Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
Opublikowane w: European Journal of Immunology, Numer 46/10, 2016, Strona(/y) 2283-2285, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201670106

VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Autorzy: Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Opublikowane w: Cancer Research, Numer 78/3, 2018, Strona(/y) 731-741, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-17-1166

Peripheral clonal selection shapes the human γδ T-cell repertoire

Autorzy: Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
Opublikowane w: Cellular & Molecular Immunology, Numer 14/9, 2017, Strona(/y) 733-735, ISSN 1672-7681
Wydawca: Nature Publishing Group
DOI: 10.1038/cmi.2017.51

Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Autorzy: Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
Opublikowane w: Sleep and Breathing, Numer 22/1, 2018, Strona(/y) 211-221, ISSN 1520-9512
Wydawca: Thieme Medical Publishers
DOI: 10.1007/s11325-017-1602-6

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Autorzy: Bruno Silva-Santos, Jessica Strid
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00851

Multifaceted CK2 in malignant and healthy T cells

Autorzy: Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
Opublikowane w: Oncotarget, Numer 8/53, 2017, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.21700

Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Autorzy: Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
Opublikowane w: Nature Microbiology, Numer 3/7, 2018, Strona(/y) 791-803, ISSN 2058-5276
Wydawca: NATURE PUBLISHING GROUP
DOI: 10.1038/s41564-018-0167-x

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Autorzy: Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
Opublikowane w: The Journal of Immunology, Numer 198/5, 2017, Strona(/y) 2172-2181, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1600165

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Autorzy: Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
Opublikowane w: JCI Insight, Numer 1/18, 2016, ISSN 2379-3708
Wydawca: AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.89278

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autorzy: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Opublikowane w: Cell Host & Microbe, Numer 19/6, 2016, Strona(/y) 837-848, ISSN 1931-3128
Wydawca: Cell Press
DOI: 10.1016/j.chom.2016.05.002

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Autorzy: Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
Opublikowane w: Nature, Numer 555/7696, 2018, Strona(/y) 382-386, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature25974

Interleukin 17 is a chief orchestrator of immunity

Autorzy: Marc Veldhoen
Opublikowane w: Nature Immunology, Numer 18/6, 2017, Strona(/y) 612-621, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/ni.3742

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Autorzy: Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ric
Opublikowane w: Journal of Allergy and Clinical Immunology, Numer 140/3, 2017, Strona(/y) 867-870.e9, ISSN 0091-6749
Wydawca: Mosby Inc.
DOI: 10.1016/j.jaci.2017.02.034

Trypanosoma brucei metabolism is under circadian control

Autorzy: Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L. Barbosa-Morais, Joseph S. Takahashi, Luisa M. Figueiredo
Opublikowane w: Nature Microbiology, Numer 2, 2017, Strona(/y) 17032, ISSN 2058-5276
Wydawca: NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.32

Trypanosoma brucei triggers a marked immune response in male reproductive organs

Autorzy: Tânia Carvalho, Sandra Trindade, Sílvia Pimenta, Ana B. Santos, Filipa Rijo-Ferreira, Luísa M. Figueiredo
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 12/8, 2018, Strona(/y) e0006690, ISSN 1935-2735
Wydawca: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0006690

Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation

Autorzy: Zdenka Cicova, Mario Dejung, Tomas Skalicky, Nicole Eisenhuth, Steffen Hanselmann, Brooke Morriswood, Luisa M. Figueiredo, Falk Butter, Christian J. Janzen
Opublikowane w: Scientific Reports, Numer 6/1, 2016, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep35826

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Autorzy: A. C. Alho, H. T. Kim, M. J. Chammas, C. G. Reynolds, T. R. Matos, E. Forcade, J. Whangbo, S. Nikiforow, C. S. Cutler, J. Koreth, V. T. Ho, P. Armand, J. H. Antin, E. P. Alyea, J. F. Lacerda, R. J. Soiffer, J. Ritz
Opublikowane w: Blood, Numer 127/5, 2016, Strona(/y) 646-657, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2015-10-672345

Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges

Autorzy: Agostinho Carvalho, Cláudio Duarte-Oliveira, Samuel M. Gonçalves, António Campos, João F. Lacerda, Cristina Cunha
Opublikowane w: Current Fungal Infection Reports, Numer 11/1, 2017, Strona(/y) 16-24, ISSN 1936-3761
Wydawca: Current Medicine Group
DOI: 10.1007/s12281-017-0272-y

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Autorzy: Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M. Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry Noyes, Albert Picado, Kat S. Rock, Brice Rotureau, Gustave Simo, Sophie T
Opublikowane w: Trends in Parasitology, Numer 34/3, 2018, Strona(/y) 197-207, ISSN 1471-4922
Wydawca: Elsevier BV
DOI: 10.1016/j.pt.2017.11.008

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Autorzy: Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdon
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-04912-3

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Autorzy: David R Withers, Matthew R Hepworth, Xinxin Wang, Emma C Mackley, Emily E Halford, Emma E Dutton, Clare L Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N Baldassano, Gregory F Sonnenberg
Opublikowane w: Nature Medicine, Numer 22/3, 2016, Strona(/y) 319-323, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/nm.4046

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Autorzy: José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F. Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Opublikowane w: Annals of Hematology, Numer 96/11, 2017, Strona(/y) 1921-1929, ISSN 0939-5555
Wydawca: Springer Verlag
DOI: 10.1007/s00277-017-3090-y

Sleeping sickness is a circadian disorder

Autorzy: Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02484-2

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Autorzy: Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, P
Opublikowane w: European Journal of Immunology, Numer 47/10, 2017, Strona(/y) 1584-1797, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Host AMPK Is a Modulator of Plasmodium Liver Infection

Autorzy: Margarida T. Grilo Ruivo, Iset Medina Vera, Joana Sales-Dias, Patrícia Meireles, Nil Gural, Sangeeta N. Bhatia, Maria M. Mota, Liliana Mancio-Silva
Opublikowane w: Cell Reports, Numer 16/10, 2016, Strona(/y) 2539-2545, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2016.08.001

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Autorzy: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Opublikowane w: Nature Communications, Numer 9/1, 2018, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Autorzy: Vanessa Zuzarte-Luis, Maria M. Mota
Opublikowane w: Cell Metabolism, Numer 27/4, 2018, Strona(/y) 708-709, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2018.03.007

Adipose Tissue: A Safe Haven for Parasites?

Autorzy: Herbert B. Tanowitz, Philipp E. Scherer, Maria M. Mota, Luisa M. Figueiredo
Opublikowane w: Trends in Parasitology, Numer 33/4, 2017, Strona(/y) 276-284, ISSN 1471-4922
Wydawca: Elsevier BV
DOI: 10.1016/j.pt.2016.11.008

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

Autorzy: Cláudia Sá e Cunha, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm, Jude Marek Przyborski, Maria M. Mota, Miguel Prudêncio, Ann-Kristin Mueller
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 114/7, 2017, Strona(/y) E1138-E1147, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1606419114

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Autorzy: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Opublikowane w: European Journal of Immunology, Numer 48/9, 2018, Strona(/y) 1430-1440, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

Autorzy: Shengyong Ng, Sandra March, Ani Galstian, Nil Gural, Kelly R. Stevens, Maria M. Mota, Sangeeta N. Bhatia
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep45424

Host cell autophagy contributes to Plasmodium liver development

Autorzy: Carolina Thieleke-Matos, Mafalda Lopes da Silva, Laura Cabrita-Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte-Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Opublikowane w: Cellular Microbiology, Numer 18/3, 2016, Strona(/y) 437-450, ISSN 1462-5814
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12524

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

Autorzy: Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, Guillaume Bouyer, Kirsten K. Hanson, Iset Vera, Jon K. Pittman, Henry M. Staines, Maria M. Mota
Opublikowane w: Nature Communications, Numer 7/1, 2016, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/ncomms10403

Parasite Sensing of Host Nutrients and Environmental Cues

Autorzy: Vanessa Zuzarte-Luís, Maria M. Mota
Opublikowane w: Cell Host & Microbe, Numer 23/6, 2018, Strona(/y) 749-758, ISSN 1931-3128
Wydawca: Cell Press
DOI: 10.1016/j.chom.2018.05.018

Maria Mota: The Pleasure of Discovery

Autorzy: Maria M. Mota
Opublikowane w: Trends in Parasitology, Numer 32/6, 2016, Strona(/y) 429-430, ISSN 1471-4922
Wydawca: Elsevier BV
DOI: 10.1016/j.pt.2016.01.003

Nutrient sensing modulates malaria parasite virulence

Autorzy: Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota
Opublikowane w: Nature, Numer 547/7662, 2017, Strona(/y) 213-216, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature23009

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Autorzy: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Opublikowane w: Cell Reports, Numer 19/11, 2017, Strona(/y) 2357-2370, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Th17 Cells Require You to Chew before You Swallow

Autorzy: Marc Veldhoen
Opublikowane w: Immunity, Numer 46/1, 2017, Strona(/y) 8-10, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology

Autorzy: Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg, Marc Veldhoen
Opublikowane w: The Journal of Immunology, Numer 196/12, 2016, Strona(/y) 4893-4904, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1600137

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Autorzy: TAÍS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C. M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÊNCIO, SARAH D'ALESSANDRO, NICOLETTA BASILICO, DIOGO R. M. MOREIRA, ALZIR A. BATISTA, MILENA B. P. SOARES
Opublikowane w: Parasitology, Numer 143/12, 2016, Strona(/y) 1543-1556, ISSN 0031-1820
Wydawca: Cambridge University Press
DOI: 10.1017/s0031182016001153

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Autorzy: Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Opublikowane w: Journal of Medicinal Chemistry, Numer 60/4, 2017, Strona(/y) 1432-1448, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01641

Inhibition of Plasmodium liver infection by ivermectin

Autorzy: António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Opublikowane w: Antimicrobial Agents and Chemotherapy, 2017, Strona(/y) AAC.02005-16, ISSN 0066-4804
Wydawca: American Society for Microbiology
DOI: 10.1128/aac.02005-16

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Autorzy: Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Opublikowane w: Particle & Particle Systems Characterization, Numer 33/12, 2016, Strona(/y) 906-915, ISSN 0934-0866
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.201600187

Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Autorzy: Taís S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudêncio, Alzir A. Batista, Milena B. P. Soares
Opublikowane w: Metallomics, Numer 9/11, 2017, Strona(/y) 1548-1561, ISSN 1756-5901
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c7mt00196g

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Autorzy: Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Opublikowane w: Antimicrobial Agents and Chemotherapy, Numer 61/6, 2017, ISSN 0066-4804
Wydawca: American Society for Microbiology
DOI: 10.1128/aac.02699-16

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Autorzy: Marta Machado, Margarida Sanches-Vaz, João P. Cruz, António M. Mendes, Miguel Prudêncio
Opublikowane w: Frontiers in Cellular and Infection Microbiology, Numer 7, 2017, ISSN 2235-2988
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00329

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Autorzy: Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio, Rui Moreira
Opublikowane w: ChemMedChem, Numer 11/19, 2016, Strona(/y) 2194-2204, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201600327

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Autorzy: António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M.
Opublikowane w: npj Vaccines, Numer 3/1, 2018, ISSN 2059-0105
Wydawca: SPRINGERNATURE
DOI: 10.1038/s41541-018-0068-2

Primaquine-based ionic liquids as a novel class of antimalarial hits

Autorzy: Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Opublikowane w: RSC Advances, Numer 6/61, 2016, Strona(/y) 56134-56138, ISSN 2046-2069
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c6ra10759a

Novel squaramides with in vitro liver stage antiplasmodial activity

Autorzy: Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Opublikowane w: Bioorganic & Medicinal Chemistry, Numer 24/8, 2016, Strona(/y) 1786-1792, ISSN 0968-0896
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2016.03.005

Primaquine hybrids as promising antimycobacterial and antimalarial agents

Autorzy: Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Opublikowane w: European Journal of Medicinal Chemistry, Numer 143, 2018, Strona(/y) 769-779, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2017.11.083

Uptake and metabolism of arginine impact Plasmodium development in the liver

Autorzy: Patrícia Meireles, António M. Mendes, Rita I. Aroeira, Bryan C. Mounce, Marco Vignuzzi, Henry M. Staines, Miguel Prudêncio
Opublikowane w: Scientific Reports, Numer 7/1, 2017, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-017-04424-y

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Autorzy: Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Opublikowane w: Archives of Pharmacal Research, Numer 41/2, 2018, Strona(/y) 208-218, ISSN 0253-6269
Wydawca: Pharmaceutical Society of Korea
DOI: 10.1007/s12272-017-1000-4

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Autorzy: Patrícia Meireles, Joana Sales-Dias, Carolina M. Andrade, João Mello-Vieira, Liliana Mancio-Silva, J. Pedro Simas, Henry M. Staines, Miguel Prudêncio
Opublikowane w: Cellular Microbiology, Numer 19/2, 2017, Strona(/y) e12646, ISSN 1462-5814
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12646

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Autorzy: Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Opublikowane w: European Journal of Medicinal Chemistry, Numer 149, 2018, Strona(/y) 69-78, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2018.02.048

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Autorzy: Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
Opublikowane w: ChemistryOpen, Numer 7/8, 2018, Strona(/y) 624-638, ISSN 2191-1363
Wydawca: WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.201800117

Tumor cell recognition by γδ T lymphocytes

Autorzy: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Opublikowane w: OncoImmunology, Numer 21624011, 2013, Strona(/y) e22892, ISSN 2162-4011
Wydawca: Landes Bioscience
DOI: 10.4161/onci.22892

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autorzy: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Opublikowane w: Biology of Blood and Marrow Transplantation, Numer 10838791, 2013, Strona(/y) 703-712, ISSN 1083-8791
Wydawca: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autorzy: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Opublikowane w: Clinical and Vaccine Immunology, Numer 15566811, 2013, Strona(/y) 313-316, ISSN 1556-6811
Wydawca: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autorzy: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Opublikowane w: Cell Host & Microbe, Numer 19313128, 2013, Strona(/y) 104-115, ISSN 1931-3128
Wydawca: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autorzy: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Opublikowane w: AIDS, Numer 02699370, 2013, Strona(/y) 289-292, ISSN 0269-9370
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

Repairing thymic function

Autorzy: Helena Nunes-Cabaço, Ana E. Sousa
Opublikowane w: Current Opinion in Organ Transplantation, Numer 10872418, 2013, Strona(/y) 1, ISSN 1087-2418
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autorzy: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Opublikowane w: Eurosurveillance, Numer 52, 2013, ISSN 1560-7917
Wydawca: EUR CENTRE DIS PREVENTION & CONTROL

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autorzy: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Opublikowane w: European Journal of Clinical Microbiology & Infectious Diseases, Numer 09349723, 2013, Strona(/y) 115-125, ISSN 0934-9723
Wydawca: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Functional development of γδ T cells

Autorzy: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Opublikowane w: European Journal of Immunology, Numer 00142980, 2013, Strona(/y) 1988-1994, ISSN 0014-2980
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autorzy: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Opublikowane w: European Journal of Medicinal Chemistry, Numer 02235234, 2013, Strona(/y) 872-880, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autorzy: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Opublikowane w: Immunity, Numer 10747613, 2013, Strona(/y) 874-884, ISSN 1074-7613
Wydawca: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

Insight into lymphoid tissue morphogenesis

Autorzy: Mark Coles, Henrique Veiga-Fernandes
Opublikowane w: Immunology Letters, Numer 01652478, 2013, Strona(/y) 46-53, ISSN 0165-2478
Wydawca: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autorzy: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Opublikowane w: Immunology and Cell Biology, Numer 08189641, 2013, Strona(/y) 652-660, ISSN 0818-9641
Wydawca: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autorzy: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Opublikowane w: International Journal of Antimicrobial Agents, Numer 09248579, 2013, Strona(/y) 490-492, ISSN 0924-8579
Wydawca: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autorzy: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Opublikowane w: International Journal of Medical Microbiology, Numer 14384221, 2013, Strona(/y) 505-513, ISSN 1438-4221
Wydawca: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autorzy: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Opublikowane w: Journal of Biological Chemistry, Numer 00219258, 2013, Strona(/y) 3858-3870, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autorzy: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Opublikowane w: Journal of Clinical Microbiology, Numer 00951137, 2013, Strona(/y) 1099-1109, ISSN 0095-1137
Wydawca: American Society for Microbiology
DOI: 10.1128/JCM.02912-12

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autorzy: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Opublikowane w: Journal of Clinical Microbiology, Numer 00951137, 2013, Strona(/y) 644-646, ISSN 0095-1137
Wydawca: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autorzy: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Opublikowane w: Journal of Hematology & Oncology, Numer 17568722, 2013, Strona(/y) 87, ISSN 1756-8722
Wydawca: BioMed Central
DOI: 10.1186/1756-8722-6-87

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autorzy: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Opublikowane w: Journal of Leukocyte Biology, Numer 07415400, 2013, Strona(/y) 1123-1139, ISSN 0741-5400
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autorzy: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Opublikowane w: Journal of Medicinal Chemistry, Numer 00222623, 2013, Strona(/y) 7679-7690, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/jm4011466

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autorzy: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Opublikowane w: Journal of Medicinal Chemistry, Numer 00222623, 2013, Strona(/y) 4811-4815, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/jm400246e

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autorzy: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Opublikowane w: Journal of Translational Medicine, Numer 14795876, 2013, Strona(/y) 18, ISSN 1479-5876
Wydawca: BioMed Central
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autorzy: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Opublikowane w: Journal of Microbiological Methods, Numer 01677012, 2013, Strona(/y) 102-107, ISSN 0167-7012
Wydawca: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autorzy: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Opublikowane w: Marine Drugs, Numer 16603397, 2013, Strona(/y) 4019-4034, ISSN 1660-3397
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autorzy: Maria João Frias, José Melo-Cristino, Mário Ramirez
Opublikowane w: Molecular Microbiology, Numer 0950382X, 2013, Strona(/y) 430-445, ISSN 0950-382X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autorzy: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Opublikowane w: PLoS Computational Biology, Numer 1553734X, 2013, Strona(/y) e1002916, ISSN 1553-734X
Wydawca: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autorzy: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Opublikowane w: PLoS ONE, Numer 19326203, 2013, Strona(/y) e61606, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0061606

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autorzy: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Opublikowane w: PLoS ONE, Numer 19326203, 2013, Strona(/y) e59960, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0059960

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autorzy: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Opublikowane w: PLoS ONE, Numer 19326203, 2013, Strona(/y) e73704, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0073704

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autorzy: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Opublikowane w: PLoS ONE, Numer 19326203, 2013, Strona(/y) e55582, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0055582

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autorzy: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Opublikowane w: PLoS Pathogens, Numer 15537366, 2013, Strona(/y) e1003673, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autorzy: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 00278424, 2013, Strona(/y) 6494-6499, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autorzy: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Opublikowane w: PLoS Pathogens, Numer 15537366, 2013, Strona(/y) e1003554, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autorzy: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Opublikowane w: PLoS Pathogens, Numer 15537366, 2013, Strona(/y) e1003802, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autorzy: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 00278424, 2013, Strona(/y) E2838-E2847, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autorzy: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 00278424, 2013, Strona(/y) 10240-10245, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autorzy: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Opublikowane w: The Journal of Immunology, Numer 00221767, 2013, Strona(/y) 805-811, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autorzy: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Opublikowane w: The Journal of Immunology, Numer 00221767, 2013, Strona(/y) 6673-6680, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1300434

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Autorzy: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Opublikowane w: Journal of Infection in Developing Countries, Numer 6, 2013, ISSN 1972-2680
Wydawca: Open Learning on Enteric Pathogens

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autorzy: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Opublikowane w: The Journal of Rheumatology, Numer 0315162X, 2013, Strona(/y) 1293-1302, ISSN 0315-162X
Wydawca: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autorzy: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Opublikowane w: Trends in Parasitology, Numer 14714922, 2013, Strona(/y) 469-476, ISSN 1471-4922
Wydawca: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autorzy: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Opublikowane w: The Lancet, Numer 01406736, 2013, Strona(/y) 205, ISSN 0140-6736
Wydawca: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autorzy: Karine Serre, Bruno Silva-Santos
Opublikowane w: Frontiers in Immunology, Numer 16643224, 2013, ISSN 1664-3224
Wydawca: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Recruitment of γδ T lymphocytes to tumors

Autorzy: Telma Lança, Bruno Silva-Santos
Opublikowane w: OncoImmunology, Numer 21624011, 2013, Strona(/y) e25461, ISSN 2162-4011
Wydawca: Landes Bioscience
DOI: 10.4161/onci.25461

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autorzy: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Opublikowane w: Frontiers in Immunology, Numer 16643224, 2013, ISSN 1664-3224
Wydawca: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autorzy: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Opublikowane w: Frontiers in Immunology, Numer 16643224, 2013, ISSN 1664-3224
Wydawca: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autorzy: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Opublikowane w: Blood, Numer 00064971, 2013, Strona(/y) 3936-3945, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autorzy: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Opublikowane w: ACS Medicinal Chemistry Letters, Numer 19485875, 2014, Strona(/y) 108-112, ISSN 1948-5875
Wydawca: American Chemical Society
DOI: 10.1021/ml4002985

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autorzy: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Opublikowane w: AIDS, Numer 02699370, 2014, Strona(/y) 1075-1077, ISSN 0269-9370
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000205

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autorzy: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Opublikowane w: Bioorganic & Medicinal Chemistry, Numer 09680896, 2014, Strona(/y) 3887-3890, ISSN 0968-0896
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

Gut disruption in HIV-2 infection despite reduced viremia

Autorzy: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Opublikowane w: AIDS, Numer 02699370, 2014, Strona(/y) 290-292, ISSN 0269-9370
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autorzy: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Opublikowane w: Bioorganic & Medicinal Chemistry Letters, Numer 0960894X, 2014, Strona(/y) 4151-4157, ISSN 0960-894X
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2014.07.050

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autorzy: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Opublikowane w: ChemMedChem, Numer 18607179, 2014, Strona(/y) 305-310, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autorzy: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Opublikowane w: Cell, Numer 00928674, 2014, Strona(/y) 340-356, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2014.03.030

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autorzy: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Opublikowane w: Comparative Immunology, Microbiology and Infectious Diseases, Numer 01479571, 2014, Strona(/y) 169-172, ISSN 0147-9571
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Autorzy: Marta Monteiro, Luis Graca
Opublikowane w: Critical Reviews in Immunology, Numer 10408401, 2014, Strona(/y) 81-90, ISSN 1040-8401
Wydawca: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

Chemical Interrogation of the Malaria Kinome

Autorzy: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Opublikowane w: ChemBioChem, Numer 14394227, 2014, Strona(/y) 1920-1930, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autorzy: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Opublikowane w: Disease Models & Mechanisms, Numer 17548403, 2014, Strona(/y) 215-224, ISSN 1754-8403
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Autorzy: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Opublikowane w: Eurosurveillance, Numer 52, 2014, ISSN 1560-7917
Wydawca: EUR CENTRE DIS PREVENTION & CONTROL

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Autorzy: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Opublikowane w: Eurosurveillance, Numer 52, 2014, ISSN 1560-7917
Wydawca: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autorzy: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Opublikowane w: European Journal of Medicinal Chemistry, Numer 02235234, 2014, Strona(/y) 523-534, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2014.04.076

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autorzy: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Opublikowane w: Haematologica, Numer 03906078, 2014, Strona(/y) 1062-1068, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autorzy: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Opublikowane w: FEMS Microbiology Ecology, Numer 01686496, 2014, Strona(/y) 689-698, ISSN 0168-6496
Wydawca: Blackwell
DOI: 10.1111/1574-6941.12426

Bacillus invictae sp. nov., isolated from a health product

Autorzy: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Opublikowane w: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Numer 14665026, 2014, Strona(/y) 3867-3876, ISSN 1466-5026
Wydawca: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autorzy: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Opublikowane w: Journal of Clinical Immunology, Numer 02719142, 2014, Strona(/y) 573-583, ISSN 0271-9142
Wydawca: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Malaria infections: What and how can mice teach us

Autorzy: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Opublikowane w: Journal of Immunological Methods, Numer 00221759, 2014, Strona(/y) 113-122, ISSN 0022-1759
Wydawca: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autorzy: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Opublikowane w: Journal of Medicinal Chemistry, Numer 00222623, 2014, Strona(/y) 4916-4923, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/jm5004528

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autorzy: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Opublikowane w: Malaria Journal, Numer 14752875, 2014, Strona(/y) 15, ISSN 1475-2875
Wydawca: BioMed Central
DOI: 10.1186/1475-2875-13-15

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autorzy: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Opublikowane w: Nanomedicine, Numer 17435889, 2014, Strona(/y) 2639-2656, ISSN 1743-5889
Wydawca: Future Medicine Ltd.
DOI: 10.2217/nnm.14.135

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autorzy: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Opublikowane w: Molecular Microbiology, Numer 0950382X, 2014, Strona(/y) 645-663, ISSN 0950-382X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

Methaemoglobin and COHb in patients with malaria

Autorzy: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Opublikowane w: Malaria Journal, Numer 14752875, 2014, Strona(/y) 285, ISSN 1475-2875
Wydawca: BioMed Central
DOI: 10.1186/1475-2875-13-285

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autorzy: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Opublikowane w: Nature, Numer 00280836, 2014, Strona(/y) 98-101, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature13498

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autorzy: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Opublikowane w: Nature, Numer 00280836, 2014, Strona(/y) 123-127, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature13158

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autorzy: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Opublikowane w: Nature Medicine, Numer 10788956, 2013, Strona(/y) 47-53, ISSN 1078-8956
Wydawca: Nature Publishing Group
DOI: 10.1038/nm.3424

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autorzy: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Opublikowane w: PLoS ONE, Numer 19326203, 2014, Strona(/y) e92138, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0092138

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autorzy: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Opublikowane w: The Pediatric Infectious Disease Journal, Numer 08913668, 2014, Strona(/y) 306-310, ISSN 0891-3668
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autorzy: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Opublikowane w: PLoS ONE, Numer 19326203, 2014, Strona(/y) e103092, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autorzy: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Opublikowane w: PLoS ONE, Numer 19326203, 2014, Strona(/y) e96981, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Classification of current anticancer immunotherapies

Autorzy: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Opublikowane w: Oncotarget, Numer 19492553, 2015, Strona(/y) 12472-12508, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.2998

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autorzy: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Opublikowane w: Stem Cell Research & Therapy, Numer 17576512, 2014, Strona(/y) 9, ISSN 1757-6512
Wydawca: BioMed Central
DOI: 10.1186/scrt398

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autorzy: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Opublikowane w: PLoS Pathogens, Numer 15537366, 2014, Strona(/y) e1004269, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autorzy: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 00278424, 2014, Strona(/y) E3562-E3570, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1403424111

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autorzy: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Opublikowane w: PLoS ONE, Numer 19326203, 2014, Strona(/y) e94358, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0094358

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autorzy: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Opublikowane w: PLoS Pathogens, Numer 15537366, 2014, Strona(/y) e1004220, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autorzy: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Opublikowane w: The Journal of Immunology, Numer 00221767, 2014, Strona(/y) 2237-2243, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autorzy: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Opublikowane w: Journal of Clinical Investigation, Numer 00219738, 2014, Strona(/y) 4857-4866, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autorzy: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Opublikowane w: The Journal of Immunology, Numer 00221767, 2014, Strona(/y) 5854-5862, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autorzy: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Opublikowane w: Journal of Infectious Diseases, Numer 00221899, 2014, Strona(/y) 630-640, ISSN 0022-1899
Wydawca: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Chicago 2014 – 30years of γδ T cells

Autorzy: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Opublikowane w: Cellular Immunology, Numer 00088749, 2015, Strona(/y) 3-9, ISSN 0008-8749
Wydawca: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autorzy: M. Rei, D. J. Pennington, B. Silva-Santos
Opublikowane w: Cancer Research, Numer 00085472, 2015, Strona(/y) 798-802, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autorzy: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Opublikowane w: Eukaryotic Cell, Numer 15359778, 2014, Strona(/y) 96-103, ISSN 1535-9778
Wydawca: American Society for Microbiology
DOI: 10.1128/EC.00166-14

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autorzy: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Opublikowane w: ChemMedChem, Numer 18607179, 2015, Strona(/y) 2080-2089, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500429

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autorzy: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Opublikowane w: Infection and Immunity, Numer 00199567, 2015, Strona(/y) 1172-1180, ISSN 0019-9567
Wydawca: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autorzy: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Opublikowane w: Stem Cell Reports, Numer 22136711, 2015, Strona(/y) 348-359, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autorzy: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Opublikowane w: Journal of Medicinal Chemistry, Numer 00222623, 2016, Strona(/y) 264-281, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autorzy: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Opublikowane w: Journal of Virology, Numer 0022538X, 2015, Strona(/y) 2201-2208, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autorzy: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Opublikowane w: Journal of Autoimmunity, Numer 08968411, 2015, Strona(/y) 98-110, ISSN 0896-8411
Wydawca: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autorzy: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Opublikowane w: European Journal of Medicinal Chemistry, Numer 02235234, 2015, Strona(/y) 266-273, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autorzy: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Opublikowane w: ChemMedChem, Numer 18607179, 2015, Strona(/y) 883-890, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500011

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autorzy: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Opublikowane w: Nucleic Acids Research, Numer 03051048, 2015, Strona(/y) gkv1459, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkv1459

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autorzy: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Opublikowane w: ChemMedChem, Numer 18607179, 2015, Strona(/y) 1344-1349, ISSN 1860-7179
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500164

Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autorzy: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Opublikowane w: The Journal of Immunology, Numer 00221767, 2015, Strona(/y) 4860-4870, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1400863

Sugar activation and glycosylation in Plasmodium

Autorzy: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Opublikowane w: Malaria Journal, Numer 14752875, 2015, ISSN 1475-2875
Wydawca: BioMed Central
DOI: 10.1186/s12936-015-0949-z

Parasite Glycobiology: A Bittersweet Symphony

Autorzy: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Opublikowane w: PLOS Pathogens, Numer 15537366, 2015, Strona(/y) e1005169, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1005169

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autorzy: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Opublikowane w: Scientific Reports, Numer 20452322, 2015, Strona(/y) 12057, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/srep12057

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autorzy: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Opublikowane w: Journal of Antimicrobial Chemotherapy, Numer 03057453, 2015, Strona(/y) 2729-2733, ISSN 0305-7453
Wydawca: Oxford University Press
DOI: 10.1093/jac/dkv182

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autorzy: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Opublikowane w: Clinical Microbiology and Infection, Numer 1198743X, 2015, ISSN 1198-743X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autorzy: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Opublikowane w: Malaria Journal, Numer 14752875, 2015, ISSN 1475-2875
Wydawca: BioMed Central
DOI: 10.1186/s12936-015-0913-y

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autorzy: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Opublikowane w: BMC Microbiology, Numer 14712180, 2015, ISSN 1471-2180
Wydawca: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autorzy: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Opublikowane w: Bioinformatics, Numer 13674803, 2015, Strona(/y) 2364-2370, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autorzy: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Opublikowane w: PLOS ONE, Numer 19326203, 2015, Strona(/y) e0125985, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autorzy: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Opublikowane w: Malaria Journal, Numer 14752875, 2015, ISSN 1475-2875
Wydawca: BioMed Central
DOI: 10.1186/s12936-015-0657-8

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autorzy: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Opublikowane w: PLOS ONE, Numer 19326203, 2015, Strona(/y) e0119315, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autorzy: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Opublikowane w: PLOS ONE, Numer 19326203, 2015, Strona(/y) e0142540, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0142540

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autorzy: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Opublikowane w: Nucleic Acids Research, Numer 03051048, 2015, Strona(/y) gkv987, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkv987

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autorzy: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Opublikowane w: The Journal of Immunology, Numer 00221767, 2015, Strona(/y) 3463-3471, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autorzy: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Opublikowane w: Journal of Biological Chemistry, Numer 00219258, 2015, Strona(/y) 28084-28096, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

Identification of H-type BSE in Portugal

Autorzy: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Opublikowane w: Prion, Numer 19336896, 2015, Strona(/y) 22-28, ISSN 1933-6896
Wydawca: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autorzy: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Opublikowane w: Cell Reports, Numer 22111247, 2015, Strona(/y) 2043-2054, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Using argument notation to engineer biological simulations with increased confidence

Autorzy: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Opublikowane w: Journal of the Royal Society Interface, Numer 17425689, 2015, ISSN 1742-5689
Wydawca: The Royal Society
DOI: 10.1098/rsif.2014.1059

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autorzy: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Opublikowane w: Journal of Controlled Release, Numer 01683659, 2015, Strona(/y) 91-103, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Feeding immunity: skepticism, delicacies and delights

Autorzy: Marc Veldhoen, Henrique Veiga-Fernandes
Opublikowane w: Nature Immunology, Numer 15292908, 2015, Strona(/y) 215-219, ISSN 1529-2908
Wydawca: Nature Publishing Group
DOI: 10.1038/ni.3100

Utilising a simulation platform to understand the effect of domain model assumptions

Autorzy: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Opublikowane w: Natural Computing, Numer 15677818, 2015, Strona(/y) 99-107, ISSN 1567-7818
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s11047-014-9428-7

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autorzy: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Opublikowane w: Stem Cells International, Numer 1687966X, 2015, Strona(/y) 1-14, ISSN 1687-966X
Wydawca: HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2015/583984

Point-of-care tests: where is the point?

Autorzy: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Opublikowane w: The Lancet Infectious Diseases, Numer 14733099, 2014, Strona(/y) 922, ISSN 1473-3099
Wydawca: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autorzy: Julie C. Ribot, Bruno Silva-Santos
Opublikowane w: Crossroads Between Innate and Adaptive Immunity IV, 2013, Strona(/y) 95-105, ISBN 978-1-4614-6217-0
Wydawca: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

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