Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

EC KPI Widening indicator application for the 3-year window time prior to TwinnToInfect
Second TwinnToInfect Joint Summer School
KPIs definition for TwinnToInfect
First TwinnToInfect Joint Summer School

Communication package, including development of logo/brand, launch of website, brochure and flyer development

Publicaciones

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autores: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Publicado en: PLoS ONE, Edición 8/2, 2013, Página(s) e55582, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0055582

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autores: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Publicado en: Journal of Infectious Diseases, Edición 210/4, 2014, Página(s) 630-640, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiu126

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autores: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Publicado en: PLoS Pathogens, Edición 9/12, 2013, Página(s) e1003802, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autores: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Publicado en: ChemMedChem, Edición 10/12, 2015, Página(s) 2080-2089, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500429

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autores: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Publicado en: Bioinformatics, Edición 31/14, 2015, Página(s) 2364-2370, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autores: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Publicado en: PLOS ONE, Edición 10/3, 2015, Página(s) e0119315, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autores: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Publicado en: The Pediatric Infectious Disease Journal, Edición 33/3, 2014, Página(s) 306-310, ISSN 0891-3668
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autores: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 514/7520, 2014, Página(s) 98-101, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13498

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autores: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Publicado en: Blood, Edición 121/19, 2013, Página(s) 3936-3945, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

Autores: Emília Valadas, Augusto Gomes,Ana Sutre, Sara Brilha, Afonso Wete, Thomas Hänscheid, Francisco Antunes
Publicado en: Journal of Infection in Developing Countries, Edición 6, 2013, ISSN 1972-2680
Editor: Open Learning on Enteric Pathogens

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autores: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Publicado en: ACS Medicinal Chemistry Letters, Edición 5/2, 2014, Página(s) 108-112, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/ml4002985

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autores: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Publicado en: Marine Drugs, Edición 11/10, 2013, Página(s) 4019-4034, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

Using argument notation to engineer biological simulations with increased confidence

Autores: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Publicado en: Journal of the Royal Society Interface, Edición 12, 2015, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2014.1059

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autores: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 10/6, 2014, Página(s) e1004220, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autores: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Publicado en: Infection and Immunity, Edición 83/3, 2015, Página(s) 1172-1180, ISSN 0019-9567
Editor: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autores: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 10/7, 2014, Página(s) e1004269, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Gut disruption in HIV-2 infection despite reduced viremia

Autores: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Publicado en: AIDS, Edición 28/2, 2014, Página(s) 290-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autores: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Publicado en: Journal of Virology, Edición 89/4, 2015, Página(s) 2201-2208, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Insight into lymphoid tissue morphogenesis

Autores: Mark Coles, Henrique Veiga-Fernandes
Publicado en: Immunology Letters, Edición 156/1-2, 2013, Página(s) 46-53, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autores: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Publicado en: Bioorganic & Medicinal Chemistry, Edición 22/15, 2014, Página(s) 3887-3890, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autores: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Publicado en: Journal of Leukocyte Biology, Edición 94/6, 2013, Página(s) 1123-1139, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autores: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Publicado en: Nature Medicine, Edición 20/1, 2013, Página(s) 47-53, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.3424

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autores: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Publicado en: Journal of Autoimmunity, Edición 56, 2015, Página(s) 98-110, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autores: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Publicado en: Frontiers in Immunology, Edición 4, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autores: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Publicado en: Immunology and Cell Biology, Edición 91/10, 2013, Página(s) 652-660, ISSN 0818-9641
Editor: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autores: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Publicado en: Eukaryotic Cell, Edición 14/1, 2014, Página(s) 96-103, ISSN 1535-9778
Editor: American Society for Microbiology
DOI: 10.1128/EC.00166-14

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autores: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Publicado en: BMC Microbiology, 2015, ISSN 1471-2180
Editor: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Repairing thymic function

Autores: Helena Nunes-Cabaço, Ana E. Sousa
Publicado en: Current Opinion in Organ Transplantation, 2013, Página(s) 1, ISSN 1087-2418
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Chemical Interrogation of the Malaria Kinome

Autores: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Publicado en: ChemBioChem, Edición 15/13, 2014, Página(s) 1920-1930, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autores: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Publicado en: PLOS ONE, Edición 10/11, 2015, Página(s) e0142540, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0142540

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autores: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Publicado en: Molecular Microbiology, Edición 93/4, 2014, Página(s) 645-663, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autores: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Publicado en: Trends in Parasitology, Edición 29/10, 2013, Página(s) 469-476, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autores: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Publicado en: The Lancet, Edición 382/9888, 2013, Página(s) 205, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autores: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Publicado en: Immunity, Edición 39/5, 2013, Página(s) 874-884, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autores: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Publicado en: Disease Models & Mechanisms, Edición 7/2, 2014, Página(s) 215-224, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Identification of H-type BSE in Portugal

Autores: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Publicado en: Prion, Edición 9/1, 2015, Página(s) 22-28, ISSN 1933-6896
Editor: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

Malaria infections: What and how can mice teach us

Autores: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Publicado en: Journal of Immunological Methods, Edición 410, 2014, Página(s) 113-122, ISSN 0022-1759
Editor: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autores: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Publicado en: Nucleic Acids Research, 2015, Página(s) gkv987, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv987

Bacillus invictae sp. nov., isolated from a health product

Autores: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Publicado en: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Edición 64/Pt 11, 2014, Página(s) 3867-3876, ISSN 1466-5026
Editor: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autores: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 9/7, 2014, Página(s) e103092, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autores: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Publicado en: PLOS ONE, Edición 10/5, 2015, Página(s) e0125985, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autores: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Publicado en: Eurosurveillance, Edición 52, 2013, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autores: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Publicado en: Proceedings of the National Academy of Sciences, Edición 110/30, 2013, Página(s) E2838-E2847, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autores: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 508/7494, 2014, Página(s) 123-127, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13158

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autores: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publicado en: Haematologica, Edición 99/6, 2014, Página(s) 1062-1068, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autores: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Publicado en: Cell Reports, Edición 10/12, 2015, Página(s) 2043-2054, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Classification of current anticancer immunotherapies

Autores: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Publicado en: Oncotarget, Edición 5/24, 2015, Página(s) 12472-12508, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.2998

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autores: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Publicado en: The Journal of Rheumatology, Edición 40/8, 2013, Página(s) 1293-1302, ISSN 0315-162X
Editor: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autores: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Publicado en: Malaria Journal, Edición 14/1, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0657-8

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autores: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Publicado en: Cell Host & Microbe, Edición 14/1, 2013, Página(s) 104-115, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autores: Maria João Frias, José Melo-Cristino, Mário Ramirez
Publicado en: Molecular Microbiology, Edición 87/2, 2013, Página(s) 430-445, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autores: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Publicado en: PLoS ONE, Edición 9/5, 2014, Página(s) e96981, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autores: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Publicado en: PLoS ONE, Edición 9/4, 2014, Página(s) e94358, ISSN 1932-6203
Editor: Public Library of Science
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What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autores: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Publicado en: Stem Cells International, Edición 2015, 2015, Página(s) 1-14, ISSN 1687-966X
Editor: HINDAWI PUBLISHING CORPORATION
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Methaemoglobin and COHb in patients with malaria

Autores: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Publicado en: Malaria Journal, Edición 13/1, 2014, Página(s) 285, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-285

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autores: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Publicado en: AIDS, Edición 28/7, 2014, Página(s) 1075-1077, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autores: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Publicado en: Stem Cell Research & Therapy, Edición 5/1, 2014, Página(s) 9, ISSN 1757-6512
Editor: BioMed Central
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2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autores: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Publicado en: Bioorganic & Medicinal Chemistry Letters, Edición 24/17, 2014, Página(s) 4151-4157, ISSN 0960-894X
Editor: Pergamon Press Ltd.
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Utilising a simulation platform to understand the effect of domain model assumptions

Autores: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Publicado en: Natural Computing, Edición 14/1, 2015, Página(s) 99-107, ISSN 1567-7818
Editor: Kluwer Academic Publishers
DOI: 10.1007/s11047-014-9428-7

Feeding immunity: skepticism, delicacies and delights

Autores: Marc Veldhoen, Henrique Veiga-Fernandes
Publicado en: Nature Immunology, Edición 16/3, 2015, Página(s) 215-219, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/ni.3100

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autores: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 190/12, 2013, Página(s) 6673-6680, ISSN 0022-1767
Editor: American Association of Immunologists
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Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autores: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 56/11, 2013, Página(s) 4811-4815, ISSN 0022-2623
Editor: American Chemical Society
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Parasite Glycobiology: A Bittersweet Symphony

Autores: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Publicado en: PLOS Pathogens, Edición 11/11, 2015, Página(s) e1005169, ISSN 1553-7366
Editor: Public Library of Science
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Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autores: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Publicado en: Proceedings of the National Academy of Sciences, Edición 110/25, 2013, Página(s) 10240-10245, ISSN 0027-8424
Editor: National Academy of Sciences
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Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autores: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Publicado en: Clinical and Vaccine Immunology, Edición 20/2, 2013, Página(s) 313-316, ISSN 1556-6811
Editor: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autores: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Publicado en: European Journal of Medicinal Chemistry, Edición 80, 2014, Página(s) 523-534, ISSN 0223-5234
Editor: Elsevier BV
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Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autores: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 56/19, 2013, Página(s) 7679-7690, ISSN 0022-2623
Editor: American Chemical Society
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Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autores: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Publicado en: PLoS Pathogens, Edición 9/10, 2013, Página(s) e1003673, ISSN 1553-7366
Editor: Public Library of Science
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Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autores: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Publicado en: ChemMedChem, Edición 10/5, 2015, Página(s) 883-890, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
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Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autores: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Publicado en: Proceedings of the National Academy of Sciences, Edición 111/34, 2014, Página(s) E3562-E3570, ISSN 0027-8424
Editor: National Academy of Sciences
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A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autores: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Publicado en: PLoS ONE, Edición 8/4, 2013, Página(s) e61606, ISSN 1932-6203
Editor: Public Library of Science
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Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autores: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Publicado en: International Journal of Medical Microbiology, Edición 303/8, 2013, Página(s) 505-513, ISSN 1438-4221
Editor: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Functional development of γδ T cells

Autores: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Publicado en: European Journal of Immunology, Edición 43/8, 2013, Página(s) 1988-1994, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autores: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Publicado en: ChemMedChem, Edición 9/2, 2014, Página(s) 305-310, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
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Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autores: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Publicado en: Journal of Medicinal Chemistry, Edición 57/11, 2014, Página(s) 4916-4923, ISSN 0022-2623
Editor: American Chemical Society
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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autores: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Publicado en: Journal of Clinical Microbiology, Edición 51/4, 2013, Página(s) 1099-1109, ISSN 0095-1137
Editor: American Society for Microbiology
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Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autores: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Publicado en: The Journal of Immunology, Edición 194/10, 2015, Página(s) 4860-4870, ISSN 0022-1767
Editor: American Association of Immunologists
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Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Autores: Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Publicado en: PLOS Biology, Edición 16/5, 2018, Página(s) e2004990, ISSN 1545-7885
Editor: PUBLIC LIBRARY SCIENCE
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Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Autores: Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Publicado en: Journal of Autoimmunity, Edición 87, 2018, Página(s) 26-37, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Autores: Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Publicado en: Trends in Immunology, Edición 38/5, 2017, Página(s) 336-344, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2017.01.007

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors

Autores: Joana Barros-Martins, Nina Schmolka, Diana Fontinha, Marta Pires de Miranda, J. Pedro Simas, Ingrid Brok, Cristina Ferreira, Marc Veldhoen, Bruno Silva-Santos, Karine Serre
Publicado en: The Journal of Immunology, Edición 196/9, 2016, Página(s) 3642-3652, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1501921

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Autores: Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Publicado en: Nature Immunology, Edición 17/6, 2016, Página(s) 721-727, ISSN 1529-2908
Editor: Nature Publishing Group
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Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Autores: A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Publicado en: Clinical Cancer Research, Edición 22/23, 2016, Página(s) 5795-5804, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0597

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

Autores: Ana Henriques, Cláudia Silva, Mariana Santiago, Maria João Henriques, António Martinho, Hélder Trindade, José António Pereira da Silva, Bruno Silva-Santos, Artur Paiva
Publicado en: Inflammation Research, Edición 65/12, 2016, Página(s) 985-994, ISSN 1023-3830
Editor: Birkhauser Verlag
DOI: 10.1007/s00011-016-0982-6

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Autores: Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Publicado en: EMBO reports, Edición 18/11, 2017, Página(s) 1957-1967, ISSN 1469-221X
Editor: Nature Publishing Group
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Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autores: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Publicado en: Leukemia, Edición 31/7, 2016, Página(s) 1603-1610, ISSN 0887-6924
Editor: Nature Publishing Group
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Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Autores: Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Publicado en: Cancer Immunology Research, Edición 5/9, 2017, Página(s) 812-820, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
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γδ T cells get adaptive

Autores: Bruno Silva-Santos, Jessica Strid
Publicado en: Nature Immunology, Edición 18/4, 2017, Página(s) 370-372, ISSN 1529-2908
Editor: Nature Publishing Group
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Got my γδ17 T cells to keep me warm

Autores: Pedro H. Papotto, Bruno Silva-Santos
Publicado en: Nature Immunology, Edición 19/5, 2018, Página(s) 427-429, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-018-0090-6

Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Autores: André E. Simões, Biagio Di Lorenzo, Bruno Silva-Santos
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
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Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia

Autores: Augusto Ministro, Paula de Oliveira, Raquel J. Nunes, André dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D. Becker, João Goyri-O’Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Publicado en: Cardiovascular Research, Edición 113/7, 2017, Página(s) 783-794, ISSN 0008-6363
Editor: Elsevier BV
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MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Autores: Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Publicado en: Science Immunology, Edición 3/23, 2018, Página(s) eaao1392, ISSN 2470-9468
Editor: Science Immunology
DOI: 10.1126/sciimmunol.aao1392

The Emerging Complexity of γδT17 Cells

Autores: Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00796

Control of T cell effector functions by miRNAs

Autores: Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Publicado en: Cancer Letters, Edición 427, 2018, Página(s) 63-73, ISSN 0304-3835
Editor: Elsevier BV
DOI: 10.1016/j.canlet.2018.04.011

Immunology's Twinning Triangle

Autores: Bruno Silva-Santos, James Di Santo, Caetano Reis e Sousa
Publicado en: European Journal of Immunology, Edición 46/10, 2016, Página(s) 2283-2285, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
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VEGFR2–Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy

Autores: Sandrina Nóbrega-Pereira, Francisco Caiado, Tânia Carvalho, Inês Matias, Gonçalo Graça, Luís G. Gonçalves, Bruno Silva-Santos, Haakan Norell, Sérgio Dias
Publicado en: Cancer Research, Edición 78/3, 2018, Página(s) 731-741, ISSN 0008-5472
Editor: American Association for Cancer Research
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Peripheral clonal selection shapes the human γδ T-cell repertoire

Autores: Biagio Di Lorenzo, Julie Déchanet-Merville, Bruno Silva-Santos
Publicado en: Cellular & Molecular Immunology, Edición 14/9, 2017, Página(s) 733-735, ISSN 1672-7681
Editor: Nature Publishing Group
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Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing

Autores: Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
Publicado en: Sleep and Breathing, Edición 22/1, 2018, Página(s) 211-221, ISSN 1520-9512
Editor: Thieme Medical Publishers
DOI: 10.1007/s11325-017-1602-6

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Autores: Bruno Silva-Santos, Jessica Strid
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: FRONTIERS MEDIA SA
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Multifaceted CK2 in malignant and healthy T cells

Autores: Sérgio T. Ribeiro, João T. Barata, Bruno Silva-Santos
Publicado en: Oncotarget, Edición 8/53, 2017, ISSN 1949-2553
Editor: Impact Journals
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Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

Autores: Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S. Deepe, George Samonis, João F. Lacerda, António Campos, Dimitrios P. Kontoyiannis, Nikolaos Mihalopoulos, Kyung J. Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A. Brakhage, Nuno M. Neves, Jean-Paul Latge, Georgios
Publicado en: Nature Microbiology, Edición 3/7, 2018, Página(s) 791-803, ISSN 2058-5276
Editor: NATURE PUBLISHING GROUP
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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

Autores: Gera Goverse, Rosalie Molenaar, Laurence Macia, Jian Tan, Martje N. Erkelens, Tanja Konijn, Marlene Knippenberg, Emma C. L. Cook, Diana Hanekamp, Marc Veldhoen, Anita Hartog, Guus Roeselers, Charles R. Mackay, Reina E. Mebius
Publicado en: The Journal of Immunology, Edición 198/5, 2017, Página(s) 2172-2181, ISSN 0022-1767
Editor: American Association of Immunologists
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Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Autores: Masahiro Hirakawa, Tiago Matos, Hongye Liu, John Koreth, Haesook T. Kim, Nicole E. Paul, Kazuyuki Murase, Jennifer Whangbo, Ana C. Alho, Sarah Nikiforow, Corey Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Joseph H. Antin, Bruce R. Blazar, Joao F. Lacerda, Robert J. Soiffer, Jerome Ritz
Publicado en: JCI Insight, Edición 1/18, 2016, ISSN 2379-3708
Editor: AMER SOC CLINICAL INVESTIGATION INC
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Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autores: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Publicado en: Cell Host & Microbe, Edición 19/6, 2016, Página(s) 837-848, ISSN 1931-3128
Editor: Cell Press
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Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Autores: Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras,
Publicado en: Nature, Edición 555/7696, 2018, Página(s) 382-386, ISSN 0028-0836
Editor: Nature Publishing Group
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Interleukin 17 is a chief orchestrator of immunity

Autores: Marc Veldhoen
Publicado en: Nature Immunology, Edición 18/6, 2017, Página(s) 612-621, ISSN 1529-2908
Editor: Nature Publishing Group
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IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Autores: Cristina Cunha, Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B. Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G. Castro, Ric
Publicado en: Journal of Allergy and Clinical Immunology, Edición 140/3, 2017, Página(s) 867-870.e9, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2017.02.034

Trypanosoma brucei metabolism is under circadian control

Autores: Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L. Barbosa-Morais, Joseph S. Takahashi, Luisa M. Figueiredo
Publicado en: Nature Microbiology, Edición 2, 2017, Página(s) 17032, ISSN 2058-5276
Editor: NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.32

Trypanosoma brucei triggers a marked immune response in male reproductive organs

Autores: Tânia Carvalho, Sandra Trindade, Sílvia Pimenta, Ana B. Santos, Filipa Rijo-Ferreira, Luísa M. Figueiredo
Publicado en: PLOS Neglected Tropical Diseases, Edición 12/8, 2018, Página(s) e0006690, ISSN 1935-2735
Editor: PUBLIC LIBRARY SCIENCE
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Two flagellar BAR domain proteins in Trypanosoma brucei with stage-specific regulation

Autores: Zdenka Cicova, Mario Dejung, Tomas Skalicky, Nicole Eisenhuth, Steffen Hanselmann, Brooke Morriswood, Luisa M. Figueiredo, Falk Butter, Christian J. Janzen
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
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Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

Autores: A. C. Alho, H. T. Kim, M. J. Chammas, C. G. Reynolds, T. R. Matos, E. Forcade, J. Whangbo, S. Nikiforow, C. S. Cutler, J. Koreth, V. T. Ho, P. Armand, J. H. Antin, E. P. Alyea, J. F. Lacerda, R. J. Soiffer, J. Ritz
Publicado en: Blood, Edición 127/5, 2016, Página(s) 646-657, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-10-672345

Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges

Autores: Agostinho Carvalho, Cláudio Duarte-Oliveira, Samuel M. Gonçalves, António Campos, João F. Lacerda, Cristina Cunha
Publicado en: Current Fungal Infection Reports, Edición 11/1, 2017, Página(s) 16-24, ISSN 1936-3761
Editor: Current Medicine Group
DOI: 10.1007/s12281-017-0272-y

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

Autores: Philippe Büscher, Jean-Mathieu Bart, Marleen Boelaert, Bruno Bucheton, Giuliano Cecchi, Nakul Chitnis, David Courtin, Luisa M. Figueiredo, José-Ramon Franco, Pascal Grébaut, Epco Hasker, Hamidou Ilboudo, Vincent Jamonneau, Mathurin Koffi, Veerle Lejon, Annette MacLeod, Justin Masumu, Enock Matovu, Raffaele Mattioli, Harry Noyes, Albert Picado, Kat S. Rock, Brice Rotureau, Gustave Simo, Sophie T
Publicado en: Trends in Parasitology, Edición 34/3, 2018, Página(s) 197-207, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2017.11.008

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Autores: Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdon
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04912-3

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

Autores: David R Withers, Matthew R Hepworth, Xinxin Wang, Emma C Mackley, Emily E Halford, Emma E Dutton, Clare L Marriott, Verena Brucklacher-Waldert, Marc Veldhoen, Judith Kelsen, Robert N Baldassano, Gregory F Sonnenberg
Publicado en: Nature Medicine, Edición 22/3, 2016, Página(s) 319-323, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.4046

Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia

Autores: José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F. Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Publicado en: Annals of Hematology, Edición 96/11, 2017, Página(s) 1921-1929, ISSN 0939-5555
Editor: Springer Verlag
DOI: 10.1007/s00277-017-3090-y

Sleeping sickness is a circadian disorder

Autores: Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02484-2

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Autores: Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M. Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E. Boulais, Ryan R. Brinkman, Martin Büscher, Dirk H. Busch, Timothy P. Bushnell, Xuetao Cao, Andrea Cavani, P
Publicado en: European Journal of Immunology, Edición 47/10, 2017, Página(s) 1584-1797, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646632

Host AMPK Is a Modulator of Plasmodium Liver Infection

Autores: Margarida T. Grilo Ruivo, Iset Medina Vera, Joana Sales-Dias, Patrícia Meireles, Nil Gural, Sangeeta N. Bhatia, Maria M. Mota, Liliana Mancio-Silva
Publicado en: Cell Reports, Edición 16/10, 2016, Página(s) 2539-2545, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.08.001

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Autores: Rachel Fellows, Jérémy Denizot, Claudia Stellato, Alessandro Cuomo, Payal Jain, Elena Stoyanova, Szabina Balázsi, Zoltán Hajnády, Anke Liebert, Juri Kazakevych, Hector Blackburn, Renan Oliveira Corrêa, José Luís Fachi, Fabio Takeo Sato, Willian R. Ribeiro, Caroline Marcantonio Ferreira, Hélène Perée, Mariangela Spagnuolo, Raphaël Mattiuz, Csaba Matolcsi, Joana Guedes, Jonathan Clark, M
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02651-5

Fighting for Resources: Who Started the Battle? Who Is Winning It?

Autores: Vanessa Zuzarte-Luis, Maria M. Mota
Publicado en: Cell Metabolism, Edición 27/4, 2018, Página(s) 708-709, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2018.03.007

Adipose Tissue: A Safe Haven for Parasites?

Autores: Herbert B. Tanowitz, Philipp E. Scherer, Maria M. Mota, Luisa M. Figueiredo
Publicado en: Trends in Parasitology, Edición 33/4, 2017, Página(s) 276-284, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2016.11.008

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

Autores: Cláudia Sá e Cunha, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm, Jude Marek Przyborski, Maria M. Mota, Miguel Prudêncio, Ann-Kristin Mueller
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/7, 2017, Página(s) E1138-E1147, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1606419114

Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation

Autores: Marc Veldhoen, Birte Blankenhaus, Špela Konjar, Cristina Ferreira
Publicado en: European Journal of Immunology, Edición 48/9, 2018, Página(s) 1430-1440, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646745

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

Autores: Shengyong Ng, Sandra March, Ani Galstian, Nil Gural, Kelly R. Stevens, Maria M. Mota, Sangeeta N. Bhatia
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep45424

Host cell autophagy contributes to Plasmodium liver development

Autores: Carolina Thieleke-Matos, Mafalda Lopes da Silva, Laura Cabrita-Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte-Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Publicado en: Cellular Microbiology, Edición 18/3, 2016, Página(s) 437-450, ISSN 1462-5814
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12524

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

Autores: Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, Guillaume Bouyer, Kirsten K. Hanson, Iset Vera, Jon K. Pittman, Henry M. Staines, Maria M. Mota
Publicado en: Nature Communications, Edición 7/1, 2016, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms10403

Parasite Sensing of Host Nutrients and Environmental Cues

Autores: Vanessa Zuzarte-Luís, Maria M. Mota
Publicado en: Cell Host & Microbe, Edición 23/6, 2018, Página(s) 749-758, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2018.05.018

Maria Mota: The Pleasure of Discovery

Autores: Maria M. Mota
Publicado en: Trends in Parasitology, Edición 32/6, 2016, Página(s) 429-430, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2016.01.003

Nutrient sensing modulates malaria parasite virulence

Autores: Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker, Maria M. Mota
Publicado en: Nature, Edición 547/7662, 2017, Página(s) 213-216, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature23009

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Autores: Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen
Publicado en: Cell Reports, Edición 19/11, 2017, Página(s) 2357-2370, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2017.05.052

Th17 Cells Require You to Chew before You Swallow

Autores: Marc Veldhoen
Publicado en: Immunity, Edición 46/1, 2017, Página(s) 8-10, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2016.12.016

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology

Autores: Verena Brucklacher-Waldert, Cristina Ferreira, Silvia Innocentin, Shraddha Kamdar, David R. Withers, Marika C. Kullberg, Marc Veldhoen
Publicado en: The Journal of Immunology, Edición 196/12, 2016, Página(s) 4893-4904, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1600137

Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

Autores: TAÍS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C. M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÊNCIO, SARAH D'ALESSANDRO, NICOLETTA BASILICO, DIOGO R. M. MOREIRA, ALZIR A. BATISTA, MILENA B. P. SOARES
Publicado en: Parasitology, Edición 143/12, 2016, Página(s) 1543-1556, ISSN 0031-1820
Editor: Cambridge University Press
DOI: 10.1017/s0031182016001153

Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Autores: Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Publicado en: Journal of Medicinal Chemistry, Edición 60/4, 2017, Página(s) 1432-1448, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01641

Inhibition of Plasmodium liver infection by ivermectin

Autores: António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Publicado en: Antimicrobial Agents and Chemotherapy, 2017, Página(s) AAC.02005-16, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.02005-16

Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates

Autores: Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Publicado en: Particle & Particle Systems Characterization, Edición 33/12, 2016, Página(s) 906-915, ISSN 0934-0866
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ppsc.201600187

Platinum( ii )–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function

Autores: Taís S. Macedo, Wilmer Villarreal, Camila C. Couto, Diogo R. M. Moreira, Maribel Navarro, Marta Machado, Miguel Prudêncio, Alzir A. Batista, Milena B. P. Soares
Publicado en: Metallomics, Edición 9/11, 2017, Página(s) 1548-1561, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1039/c7mt00196g

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Autores: Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 61/6, 2017, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.02699-16

Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds

Autores: Marta Machado, Margarida Sanches-Vaz, João P. Cruz, António M. Mendes, Miguel Prudêncio
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 7, 2017, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00329

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

Autores: Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio, Rui Moreira
Publicado en: ChemMedChem, Edición 11/19, 2016, Página(s) 2194-2204, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201600327

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

Autores: António M. Mendes, Marta Machado, Nataniel Gonçalves-Rosa, Isaie J. Reuling, Lander Foquet, Cláudia Marques, Ahmed M. Salman, Annie S. P. Yang, Kara A. Moser, Ankit Dwivedi, Cornelus C. Hermsen, Belén Jiménez-Díaz, Sara Viera, Jorge M. Santos, Inês Albuquerque, Sangeeta N. Bhatia, John Bial, Iñigo Angulo-Barturen, Joana C. Silva, Geert Leroux-Roels, Chris J. Janse, Shahid M. Khan, Maria M.
Publicado en: npj Vaccines, Edición 3/1, 2018, ISSN 2059-0105
Editor: SPRINGERNATURE
DOI: 10.1038/s41541-018-0068-2

Primaquine-based ionic liquids as a novel class of antimalarial hits

Autores: Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Publicado en: RSC Advances, Edición 6/61, 2016, Página(s) 56134-56138, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/c6ra10759a

Novel squaramides with in vitro liver stage antiplasmodial activity

Autores: Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Publicado en: Bioorganic & Medicinal Chemistry, Edición 24/8, 2016, Página(s) 1786-1792, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2016.03.005

Primaquine hybrids as promising antimycobacterial and antimalarial agents

Autores: Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Publicado en: European Journal of Medicinal Chemistry, Edición 143, 2018, Página(s) 769-779, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2017.11.083

Uptake and metabolism of arginine impact Plasmodium development in the liver

Autores: Patrícia Meireles, António M. Mendes, Rita I. Aroeira, Bryan C. Mounce, Marco Vignuzzi, Henry M. Staines, Miguel Prudêncio
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-04424-y

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Autores: Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Publicado en: Archives of Pharmacal Research, Edición 41/2, 2018, Página(s) 208-218, ISSN 0253-6269
Editor: Pharmaceutical Society of Korea
DOI: 10.1007/s12272-017-1000-4

GLUT1-mediated glucose uptake plays a crucial role during Plasmodium hepatic infection

Autores: Patrícia Meireles, Joana Sales-Dias, Carolina M. Andrade, João Mello-Vieira, Liliana Mancio-Silva, J. Pedro Simas, Henry M. Staines, Miguel Prudêncio
Publicado en: Cellular Microbiology, Edición 19/2, 2017, Página(s) e12646, ISSN 1462-5814
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12646

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Autores: Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publicado en: European Journal of Medicinal Chemistry, Edición 149, 2018, Página(s) 69-78, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2018.02.048

SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

Autores: Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
Publicado en: ChemistryOpen, Edición 7/8, 2018, Página(s) 624-638, ISSN 2191-1363
Editor: WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.201800117

Tumor cell recognition by γδ T lymphocytes

Autores: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 21624011, 2013, Página(s) e22892, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.22892

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autores: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Publicado en: Biology of Blood and Marrow Transplantation, Edición 10838791, 2013, Página(s) 703-712, ISSN 1083-8791
Editor: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

Autores: E. R. Martins, A. Andreu, J. Melo-Cristino, M. Ramirez
Publicado en: Clinical and Vaccine Immunology, Edición 15566811, 2013, Página(s) 313-316, ISSN 1556-6811
Editor: American Society for Microbiology
DOI: 10.1128/CVI.00529-12

A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax

Autores: Sandra March, Shengyong Ng, Soundarapandian Velmurugan, Ani Galstian, Jing Shan, David J. Logan, Anne E. Carpenter, David Thomas, B. Kim Lee Sim, Maria M. Mota, Stephen L. Hoffman, Sangeeta N. Bhatia
Publicado en: Cell Host & Microbe, Edición 19313128, 2013, Página(s) 104-115, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2013.06.005

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autores: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2013, Página(s) 289-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

Repairing thymic function

Autores: Helena Nunes-Cabaço, Ana E. Sousa
Publicado en: Current Opinion in Organ Transplantation, Edición 10872418, 2013, Página(s) 1, ISSN 1087-2418
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOT.0b013e3283615df9

Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution

Autores: J. A. Carriço, A. J. Sabat, A.W. Friedrich, Mário Ramirez
Publicado en: Eurosurveillance, Edición 52, 2013, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autores: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publicado en: European Journal of Clinical Microbiology & Infectious Diseases, Edición 09349723, 2013, Página(s) 115-125, ISSN 0934-9723
Editor: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Functional development of γδ T cells

Autores: Immo Prinz, Bruno Silva-Santos, Daniel J. Pennington
Publicado en: European Journal of Immunology, Edición 00142980, 2013, Página(s) 1988-1994, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201343759

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autores: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publicado en: European Journal of Medicinal Chemistry, Edición 02235234, 2013, Página(s) 872-880, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

Autores: Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L. Zhao, Miguel P. Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J. Pedro Simas, Tobias B. Huber, David Baltimore, Vineet Gupta, Douglas R. Green, João A. Ferreira, Luis F. Moita
Publicado en: Immunity, Edición 10747613, 2013, Página(s) 874-884, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2013.08.039

Insight into lymphoid tissue morphogenesis

Autores: Mark Coles, Henrique Veiga-Fernandes
Publicado en: Immunology Letters, Edición 01652478, 2013, Página(s) 46-53, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2013.08.001

The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective

Autores: Marta Caridade, Vanessa G Oliveira, Ana Agua-Doce, Luis Graca, Ruy M Ribeiro
Publicado en: Immunology and Cell Biology, Edición 08189641, 2013, Página(s) 652-660, ISSN 0818-9641
Editor: Blackwell Publishing Inc.
DOI: 10.1038/icb.2013.63

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autores: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Publicado en: International Journal of Antimicrobial Agents, Edición 09248579, 2013, Página(s) 490-492, ISSN 0924-8579
Editor: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Changes in Streptococcus pyogenes causing invasive disease in Portugal: Evidence for superantigen gene loss and acquisition

Autores: Ana Friães, Joana P. Lopes, José Melo-Cristino, Mario Ramirez
Publicado en: International Journal of Medical Microbiology, Edición 14384221, 2013, Página(s) 505-513, ISSN 1438-4221
Editor: Elsevier BV
DOI: 10.1016/j.ijmm.2013.07.004

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autores: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Publicado en: Journal of Biological Chemistry, Edición 00219258, 2013, Página(s) 3858-3870, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp. equisimilis

Autores: M. D. Pinho, S. C. Matos, C. Pomba, A. Lubke-Becker, L. H. Wieler, S. Preziuso, J. Melo-Cristino, M. Ramirez
Publicado en: Journal of Clinical Microbiology, Edición 00951137, 2013, Página(s) 1099-1109, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.02912-12

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autores: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Publicado en: Journal of Clinical Microbiology, Edición 00951137, 2013, Página(s) 644-646, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autores: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publicado en: Journal of Hematology & Oncology, Edición 17568722, 2013, Página(s) 87, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/1756-8722-6-87

At the Bench: Preclinical rationale for exploiting NK cells and T lymphocytes for the treatment of high-risk leukemias

Autores: H. Norell, A. Moretta, B. Silva-Santos, L. Moretta
Publicado en: Journal of Leukocyte Biology, Edición 07415400, 2013, Página(s) 1123-1139, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.0613312

Structural Optimization of Quinolon-4(1 H )-imines as Dual-Stage Antimalarials: Toward Increased Potency and Metabolic Stability

Autores: Ana S. Ressurreição, Daniel Gonçalves, Ana R. Sitoe, Inês S. Albuquerque, Jiri Gut, Ana Góis, Lídia M. Gonçalves, Maria R. Bronze, Thomas Hanscheid, Giancarlo A. Biagini, Philip J. Rosenthal, Miguel Prudêncio, Paul O’Neill, Maria M. Mota, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2013, Página(s) 7679-7690, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm4011466

Quinolin-4(1 H )-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria

Autores: Tiago Rodrigues, Filipa P. da Cruz, Maria J. Lafuente-Monasterio, Daniel Gonçalves, Ana S. Ressurreição, Ana R. Sitoe, Maria R. Bronze, Jiri Gut, Gisbert Schneider, Maria M. Mota, Philip J. Rosenthal, Miguel Prudêncio, Francisco-Javier Gamo, Francisca Lopes, Rui Moreira
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2013, Página(s) 4811-4815, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm400246e

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autores: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Publicado en: Journal of Translational Medicine, Edición 14795876, 2013, Página(s) 18, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/1479-5876-11-18

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autores: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Publicado en: Journal of Microbiological Methods, Edición 01677012, 2013, Página(s) 102-107, ISSN 0167-7012
Editor: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

Assessment of Dual Life Stage Antiplasmodial Activity of British Seaweeds

Autores: Jasmine Spavieri, Andrea Allmendinger, Marcel Kaiser, Maurice Itoe, Gerald Blunden, Maria Mota, Deniz Tasdemir
Publicado en: Marine Drugs, Edición 16603397, 2013, Página(s) 4019-4034, ISSN 1660-3397
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/md11104019

Export of the pneumococcal phage SV1 lysin requires choline-containing teichoic acids and is holin-independent

Autores: Maria João Frias, José Melo-Cristino, Mário Ramirez
Publicado en: Molecular Microbiology, Edición 0950382X, 2013, Página(s) 430-445, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12108

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autores: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Publicado en: PLoS Computational Biology, Edición 1553734X, 2013, Página(s) e1002916, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum

Autores: Maria Rebelo, Claudia Sousa, Howard M. Shapiro, Maria M. Mota, Martin P. Grobusch, Thomas Hänscheid
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e61606, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0061606

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autores: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e59960, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0059960

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autores: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e73704, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0073704

The Use of Machine Learning Methodologies to Analyse Antibiotic and Biocide Susceptibility in Staphylococcus aureus

Autores: Joana Rosado Coelho, João André Carriço, Daniel Knight, Jose-Luis Martínez, Ian Morrissey, Marco Rinaldo Oggioni, Ana Teresa Freitas
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e55582, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0055582

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Autores: Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, LÃ©nia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003673, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003673

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autores: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) 6494-6499, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autores: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003554, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

The Genetic Basis of Escherichia coli Pathoadaptation to Macrophages

Autores: Migla Miskinyte, Ana Sousa, Ricardo S. Ramiro, Jorge A. Moura de Sousa, Jerzy Kotlinowski, Iris Caramalho, Sara Magalhães, Miguel P. Soares, Isabel Gordo
Publicado en: PLoS Pathogens, Edición 15537366, 2013, Página(s) e1003802, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003802

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

Autores: K. K. Hanson, A. S. Ressurreicao, K. Buchholz, M. Prudencio, J. D. Herman-Ornelas, M. Rebelo, W. L. Beatty, D. F. Wirth, T. Hanscheid, R. Moreira, M. Marti, M. M. Mota
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) E2838-E2847, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1306097110

Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells

Autores: R. G. J. Klein Wolterink, N. Serafini, M. van Nimwegen, C. A. J. Vosshenrich, M. J. W. de Bruijn, D. Fonseca Pereira, H. Veiga Fernandes, R. W. Hendriks, J. P. Di Santo
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2013, Página(s) 10240-10245, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1217158110

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autores: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Publicado en: The Journal of Immunology, Edición 00221767, 2013, Página(s) 805-811, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic T Lymphocytes to Tumor Beds

Autores: T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 00221767, 2013, Página(s) 6673-6680, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1300434

Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola

BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis

Autores: R. A. Moura, H. Canhao, J. Polido-Pereira, A. M. Rodrigues, M. Navalho, A. F. Mourao, C. Resende, R. Campanilho-Marques, J. Madruga Dias, J. A. P. da Silva, L. Graca, J. E. Fonseca
Publicado en: The Journal of Rheumatology, Edición 0315162X, 2013, Página(s) 1293-1302, ISSN 0315-162X
Editor: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.3899/jrheum.121110

The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander?

Autores: Márcia Boura, Rosangela Frita, Ana Góis, Tânia Carvalho, Thomas Hänscheid
Publicado en: Trends in Parasitology, Edición 14714922, 2013, Página(s) 469-476, ISSN 1471-4922
Editor: Elsevier BV
DOI: 10.1016/j.pt.2013.07.005

First case of infection with vancomycin-resistant Staphylococcus aureus in Europe

Autores: José Melo-Cristino, Cristina Resina, Viviana Manuel, Luís Lito, Mário Ramirez
Publicado en: The Lancet, Edición 01406736, 2013, Página(s) 205, ISSN 0140-6736
Editor: The Lancet Publishing Group
DOI: 10.1016/S0140-6736(13)61219-2

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autores: Karine Serre, Bruno Silva-Santos
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Recruitment of γδ T lymphocytes to tumors

Autores: Telma Lança, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 21624011, 2013, Página(s) e25461, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.25461

Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models

Autores: Marta Caridade, Luis Graca, Ruy M. Ribeiro
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00378

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autores: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Publicado en: Frontiers in Immunology, Edición 16643224, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10

Autores: V. G. Oliveira, A. Agua-Doce, M. A. Curotto de Lafaille, J. J. Lafaille, L. Graca
Publicado en: Blood, Edición 00064971, 2013, Página(s) 3936-3945, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2012-09-457135

Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities

Autores: Daniela Miranda, Rita Capela, Inês S. Albuquerque, Patrícia Meireles, Isa Paiva, Fátima Nogueira, Richard Amewu, Jiri Gut, Philip J. Rosenthal, Rudi Oliveira, Maria M. Mota, Rui Moreira, Francesc Marti, Miguel Prudêncio, Paul M. O’Neill, Francisca Lopes
Publicado en: ACS Medicinal Chemistry Letters, Edición 19485875, 2014, Página(s) 108-112, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/ml4002985

Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection

Autores: Inês Jorge, Beatriz Amaral, Luis M.S.R. Soares-Almeida, Russell B. Foxall, Rita Tendeiro, João M. Santos, Ana E. Sousa, Rui M.M. Victorino
Publicado en: AIDS, Edición 02699370, 2014, Página(s) 1075-1077, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000205

Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite

Autores: Cátia Ramalhete, Filipa P. da Cruz, Silva Mulhovo, Inês J. Sousa, Miguel X. Fernandes, Miguel Prudêncio, Maria-José U. Ferreira
Publicado en: Bioorganic & Medicinal Chemistry, Edición 09680896, 2014, Página(s) 3887-3890, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2014.06.019

Gut disruption in HIV-2 infection despite reduced viremia

Autores: Susana M. Fernandes, Ana R. Pires, Cristina Ferreira, Rita Tendeiro, Luís Correia, Sérgio E. Paulo, Rui M.M. Victorino, Ana E. Sousa
Publicado en: AIDS, Edición 02699370, 2014, Página(s) 290-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0000000000000114

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

Autores: Néstor M. Carballeira, Angela Gono Bwalya, Maurice Ayamba Itoe, Adriano D. Andricopulo, María Lorena Cordero-Maldonado, Marcel Kaiser, Maria M. Mota, Alexander D. Crawford, Rafael V.C. Guido, Deniz Tasdemir
Publicado en: Bioorganic & Medicinal Chemistry Letters, Edición 0960894X, 2014, Página(s) 4151-4157, ISSN 0960-894X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2014.07.050

N- Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity

Autores: Ana Gomes, Bianca Pérez, Inês Albuquerque, Marta Machado, Miguel Prudêncio, Fátima Nogueira, Cátia Teixeira, Paula Gomes
Publicado en: ChemMedChem, Edición 18607179, 2014, Página(s) 305-310, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201300459

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autores: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Publicado en: Cell, Edición 00928674, 2014, Página(s) 340-356, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2014.03.030

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autores: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Publicado en: Comparative Immunology, Microbiology and Infectious Diseases, Edición 01479571, 2014, Página(s) 169-172, ISSN 0147-9571
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

iNKT Cells: Innate Lymphocytes with a Diverse Response

Autores: Marta Monteiro, Luis Graca
Publicado en: Critical Reviews in Immunology, Edición 10408401, 2014, Página(s) 81-90, ISSN 1040-8401
Editor: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

Chemical Interrogation of the Malaria Kinome

Autores: Emily R. Derbyshire, Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, Chandrasekhar V. Miduturu, Ralph Mazitschek, Piotr Sliz, Maria M. Mota, Nathanael S. Gray, Jon Clardy
Publicado en: ChemBioChem, Edición 14394227, 2014, Página(s) 1920-1930, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201400025

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Autores: S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota, S. N. Bhatia
Publicado en: Disease Models & Mechanisms, Edición 17548403, 2014, Página(s) 215-224, ISSN 1754-8403
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dmm.013490

Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012

Autores: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Publicado en: Eurosurveillance, Edición 52, 2014, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

Autores: L B Olafsdottir, H Erlendsdóttir, J Melo-Cristino, D M Weinberger, M Ramirez, K G Kristinsson, M Gottfredsson
Publicado en: Eurosurveillance, Edición 52, 2014, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

Autores: Marta P. Carrasco, Ana S. Newton, Lídia Gonçalves, Ana Góis, Marta Machado, Jiri Gut, Fátima Nogueira, Thomas Hänscheid, Rita C. Guedes, Daniel J.V.A. dos Santos, Philip J. Rosenthal, Rui Moreira
Publicado en: European Journal of Medicinal Chemistry, Edición 02235234, 2014, Página(s) 523-534, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2014.04.076

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autores: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) 1062-1068, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autores: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Publicado en: FEMS Microbiology Ecology, Edición 01686496, 2014, Página(s) 689-698, ISSN 0168-6496
Editor: Blackwell
DOI: 10.1111/1574-6941.12426

Bacillus invictae sp. nov., isolated from a health product

Autores: R. Branquinho, C. Sousa, H. Osorio, L. Meirinhos-Soares, J. Lopes, J. A. Carrico, H.-J. Busse, A. Abdulmawjood, G. Klein, P. Kampfer, M. E. Pintado, L. V. Peixe
Publicado en: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Edición 14665026, 2014, Página(s) 3867-3876, ISSN 1466-5026
Editor: Society for General Microbiology
DOI: 10.1099/ijs.0.067850-0

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autores: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Publicado en: Journal of Clinical Immunology, Edición 02719142, 2014, Página(s) 573-583, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Malaria infections: What and how can mice teach us

Autores: Vanessa Zuzarte-Luis, Maria M. Mota, Ana M. Vigário
Publicado en: Journal of Immunological Methods, Edición 00221759, 2014, Página(s) 113-122, ISSN 0022-1759
Editor: Elsevier BV
DOI: 10.1016/j.jim.2014.05.001

Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials

Autores: Rudi Oliveira, Rita C. Guedes, Patrícia Meireles, Inês S. Albuquerque, Lídia M. Gonçalves, Elisabete Pires, Maria Rosário Bronze, Jiri Gut, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Paul M. O’Neill, Francisca Lopes
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2014, Página(s) 4916-4923, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/jm5004528

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autores: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Publicado en: Malaria Journal, Edición 14752875, 2014, Página(s) 15, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-15

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autores: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Publicado en: Nanomedicine, Edición 17435889, 2014, Página(s) 2639-2656, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm.14.135

T rypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivo

Autores: Ana C. Pena, Mafalda R. Pimentel, Helena Manso, Rita Vaz-Drago, Daniel Pinto-Neves, Francisco Aresta-Branco, Filipa Rijo-Ferreira, Fabien Guegan, Luis Pedro Coelho, Maria Carmo-Fonseca, Nuno L. Barbosa-Morais, Luisa M. Figueiredo
Publicado en: Molecular Microbiology, Edición 0950382X, 2014, Página(s) 645-663, ISSN 0950-382X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mmi.12677

Methaemoglobin and COHb in patients with malaria

Autores: Thomas Hänscheid, Tom Gresnigt, Sascha Löhr, Arnaud Flamen, Thomas Zoller, José Melo-Cristino, Martin P Grobusch
Publicado en: Malaria Journal, Edición 14752875, 2014, Página(s) 285, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-285

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Autores: Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos, Inês A. M. Barbosa, Rita G. Domingues, Teresa Bento, Afonso R. M. Almeida, Hélder Ribeiro, Alexandre J. Potocnik, Hideki Enomoto, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 00280836, 2014, Página(s) 98-101, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13498

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

Autores: Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius, Henrique Veiga-Fernandes
Publicado en: Nature, Edición 00280836, 2014, Página(s) 123-127, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature13158

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Autores: Peter Liehl, Vanessa Zuzarte-Luís, Jennie Chan, Thomas Zillinger, Fernanda Baptista, Daniel Carapau, Madlen Konert, Kirsten K Hanson, Céline Carret, Caroline Lassnig, Mathias Müller, Ulrich Kalinke, Mohsan Saeed, Angelo Ferreira Chora, Douglas T Golenbock, Birgit Strobl, Miguel Prudêncio, Luis P Coelho, Stefan H Kappe, Giulio Superti-Furga, Andreas Pichlmair, Ana M Vigário, Charles M Rice, Katherine A Fitzgerald, Winfried Barchet, Maria M Mota
Publicado en: Nature Medicine, Edición 10788956, 2013, Página(s) 47-53, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/nm.3424

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autores: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e92138, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0092138

Scarlet Fever Is Caused By a Limited Number of Streptococcus pyogenes Lineages and Is Associated with the Exotoxin Genes ssa, speA and speC

Autores: Catarina Silva-Costa, Joao A. Carriço, Mario Ramirez, Jose Melo-Cristino
Publicado en: The Pediatric Infectious Disease Journal, Edición 08913668, 2014, Página(s) 306-310, ISSN 0891-3668
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/INF.0000000000000088

Non-Invasive Pneumococcal Pneumonia in Portugal—Serotype Distribution and Antimicrobial Resistance

Autores: Andreia N. Horácio, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e103092, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0103092

Evaluation of a Novel Magneto-Optical Method for the Detection of Malaria Parasites

Autores: Ágnes Orbán, Ádám Butykai, András Molnár, Zsófia Pröhle, Gergö Fülöp, Tivadar Zelles, Wasan Forsyth, Danika Hill, Ivo Müller, Louis Schofield, Maria Rebelo, Thomas Hänscheid, Stephan Karl, István Kézsmárki
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e96981, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0096981

Classification of current anticancer immunotherapies

Autores: Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N. Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P. Colombo, Lisa Coussens, Madhav V. Dhodapkar, Alexander M. Eggermont, Douglas T. Fearon, Wolf H. Fridman, Jitka Fučíková, Dmitry I. Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M. Kirkwood, Eva Klein, Alexander Knuth, Claire E. Lewis, Roland Liblau, Michael T. Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J. Melief, Elizabeth A. Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E. Peter, Kenneth J. Pienta, Angel Porgador, George C. Prendergast, Gabriel A. Rabinovich, Nicholas P. Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J. Smyth, Daniel E. Speiser, Radek Spisek, Pramod K. Srivastava, James E. Talmadge, Eric Tartour, Sjoerd H. Van Der Burg, Benoît J. Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S. Weber, Theresa L. Whiteside, Jedd D. Wolchok, Laurence Zitvogel, Weiping Zou, Guido Kroemer
Publicado en: Oncotarget, Edición 19492553, 2015, Página(s) 12472-12508, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.2998

Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data

Autores: José Paulo Martins, Jorge Miguel Santos, Joana Marto de Almeida, Mariana Alves Filipe, Mariana Vargas Teixeira de Almeida, Sílvia Cristina Paiva Almeida, Ana Água-Doce, Alexandre Varela, Mari Gilljam, Birgitta Stellan, Susanne Pohl, Kurt Dittmar, Werner Lindenmaier, Evren Alici, Luís Graça, Pedro Estilita Cruz, Helder Joaquim Cruz, Rita Nogueira Bárcia
Publicado en: Stem Cell Research & Therapy, Edición 17576512, 2014, Página(s) 9, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/scrt398

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event

Autores: Jérémie Decalf, Cristina Godinho-Silva, Diana Fontinha, Sofia Marques, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2014, Página(s) e1004269, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004269

Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

Autores: M. Rei, N. Goncalves-Sousa, T. Lanca, R. G. Thompson, S. Mensurado, F. R. Balkwill, H. Kulbe, D. J. Pennington, B. Silva-Santos
Publicado en: Proceedings of the National Academy of Sciences, Edición 00278424, 2014, Página(s) E3562-E3570, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1403424111

Induction of Prophages by Fluoroquinolones in Streptococcus pneumoniae: Implications for Emergence of Resistance in Genetically-Related Clones

Autores: Elena López, Arnau Domenech, María-José Ferrándiz, Maria João Frias, Carmen Ardanuy, Mario Ramirez, Ernesto García, Josefina Liñares, Adela G. de la Campa
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e94358, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0094358

Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

Autores: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G. Stevenson, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 15537366, 2014, Página(s) e1004220, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1004220

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autores: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 00221767, 2014, Página(s) 2237-2243, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autores: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Publicado en: Journal of Clinical Investigation, Edición 00219738, 2014, Página(s) 4857-4866, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autores: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Publicado en: The Journal of Immunology, Edición 00221767, 2014, Página(s) 5854-5862, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

Enteric Mucosa Integrity in the Presence of a Preserved Innate Interleukin 22 Compartment in HIV Type 1-Treated Individuals

Autores: S. M. Fernandes, A. R. Pires, C. Ferreira, R. B. Foxall, J. Rino, C. Santos, L. Correia, J. Pocas, H. Veiga-Fernandes, A. E. Sousa
Publicado en: Journal of Infectious Diseases, Edición 00221899, 2014, Página(s) 630-640, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiu126

Chicago 2014 – 30years of γδ T cells

Autores: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Publicado en: Cellular Immunology, Edición 00088749, 2015, Página(s) 3-9, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autores: M. Rei, D. J. Pennington, B. Silva-Santos
Publicado en: Cancer Research, Edición 00085472, 2015, Página(s) 798-802, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection

Autores: Kirsten K. Hanson, Sandra March, Shengyong Ng, Sangeeta N. Bhatia, Maria M. Mota
Publicado en: Eukaryotic Cell, Edición 15359778, 2014, Página(s) 96-103, ISSN 1535-9778
Editor: American Society for Microbiology
DOI: 10.1128/EC.00166-14

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

Autores: Nuno A. L. Pereira, Ângelo Monteiro, Marta Machado, Jiri Gut, Elies Molins, M. Jesus Perry, Jorge Dourado, Rui Moreira, Philip J. Rosenthal, Miguel Prudêncio, Maria M. M. Santos
Publicado en: ChemMedChem, Edición 18607179, 2015, Página(s) 2080-2089, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500429

Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections

Autores: Peter Liehl, Patrícia Meireles, Inês S. Albuquerque, Mykola Pinkevych, Fernanda Baptista, Maria M. Mota, Miles P. Davenport, Miguel Prudêncio
Publicado en: Infection and Immunity, Edición 00199567, 2015, Página(s) 1172-1180, ISSN 0019-9567
Editor: American Society for Microbiology
DOI: 10.1128/IAI.02796-14

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autores: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Publicado en: Stem Cell Reports, Edición 22136711, 2015, Página(s) 348-359, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autores: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Publicado en: Journal of Medicinal Chemistry, Edición 00222623, 2016, Página(s) 264-281, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

Autores: Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. Pires, Tânia Carvalho, Ana I. Pinheiro, Rui S. Soares, Ana E. Sousa
Publicado en: Journal of Virology, Edición 0022538X, 2015, Página(s) 2201-2208, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.03047-14

Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus

Autores: Iris Caramalho, Vânia Nunes-Silva, Ana R. Pires, Catarina Mota, Ana I. Pinto, Helena Nunes-Cabaço, Russell B. Foxall, Ana E. Sousa
Publicado en: Journal of Autoimmunity, Edición 08968411, 2015, Página(s) 98-110, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2014.11.002

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autores: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Publicado en: European Journal of Medicinal Chemistry, Edición 02235234, 2015, Página(s) 266-273, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s -Triazine-Based Hybrids

Autores: Catarina A. B. Rodrigues, Raquel F. M. Frade, Inês S. Albuquerque, Maria J. Perry, Jiri Gut, Marta Machado, Philip J. Rosenthal, Miguel Prudêncio, Carlos A. M. Afonso, Rui Moreira
Publicado en: ChemMedChem, Edición 18607179, 2015, Página(s) 883-890, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500011

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autores: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Publicado en: Nucleic Acids Research, Edición 03051048, 2015, Página(s) gkv1459, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv1459

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autores: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Publicado en: ChemMedChem, Edición 18607179, 2015, Página(s) 1344-1349, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500164

Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Autores: M. D. Lewis, J. Behrends, C. Sa e Cunha, A. M. Mendes, F. Lasitschka, J. M. Sattler, K. Heiss, T. W. A. Kooij, M. Prudencio, G. Bringmann, F. Frischknecht, A.-K. Mueller
Publicado en: The Journal of Immunology, Edición 00221767, 2015, Página(s) 4860-4870, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1400863

Sugar activation and glycosylation in Plasmodium

Autores: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Publicado en: Malaria Journal, Edición 14752875, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0949-z

Parasite Glycobiology: A Bittersweet Symphony

Autores: Joao A. Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A. J. Ferguson, Françoise H. Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B. H. Wilson, Luis Izquierdo
Publicado en: PLOS Pathogens, Edición 15537366, 2015, Página(s) e1005169, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1005169

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autores: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Publicado en: Scientific Reports, Edición 20452322, 2015, Página(s) 12057, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep12057

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autores: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publicado en: Journal of Antimicrobial Chemotherapy, Edición 03057453, 2015, Página(s) 2729-2733, ISSN 0305-7453
Editor: Oxford University Press
DOI: 10.1093/jac/dkv182

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autores: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Publicado en: Clinical Microbiology and Infection, Edición 1198743X, 2015, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autores: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Publicado en: Malaria Journal, Edición 14752875, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0913-y

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

Autores: Sofia Santos Costa, Miguel Viveiros, Adriana E. Rosato, José Melo-Cristino, Isabel Couto
Publicado en: BMC Microbiology, Edición 14712180, 2015, ISSN 1471-2180
Editor: BioMed Central
DOI: 10.1186/s12866-015-0572-8

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

Autores: Luis Pedro Coelho, Catarina Pato, Ana Friães, Ariane Neumann, Maren von Köckritz-Blickwede, Mário Ramirez, João André Carriço
Publicado en: Bioinformatics, Edición 13674803, 2015, Página(s) 2364-2370, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btv156

Genomic Analysis Reveals the Molecular Basis for Capsule Loss in the Group B Streptococcus Population

Autores: Roberto Rosini, Edmondo Campisi, Matteo De Chiara, Hervé Tettelin, Daniela Rinaudo, Chiara Toniolo, Matteo Metruccio, Silvia Guidotti, Uffe B. Skov Sørensen, Mogens Kilian, Mario Ramirez, Robert Janulczyk, Claudio Donati, Guido Grandi, Immaculada Margarit
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0125985, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0125985

Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Autores: Maria Rebelo, Carolina Tempera, José F Fernandes, Martin P Grobusch, Thomas Hänscheid
Publicado en: Malaria Journal, Edición 14752875, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0657-8

Not Seeing the Forest for the Trees: Size of the Minimum Spanning Trees (MSTs) Forest and Branch Significance in MST-Based Phylogenetic Analysis

Autores: Andreia Sofia Teixeira, Pedro T. Monteiro, João A Carriço, Mário Ramirez, Alexandre P. Francisco
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0119315, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0119315

Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells

Autores: Diana Fontinha, Filipa B. Lopes, Sofia Marques, J. Pedro Simas
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0142540, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0142540

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autores: Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun, Colin E. McVey
Publicado en: Nucleic Acids Research, Edición 03051048, 2015, Página(s) gkv987, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv987

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autores: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Publicado en: The Journal of Immunology, Edición 00221767, 2015, Página(s) 3463-3471, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autores: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Publicado en: Journal of Biological Chemistry, Edición 00219258, 2015, Página(s) 28084-28096, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

Identification of H-type BSE in Portugal

Autores: Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João Silva, Paula Almeida, Paula Tavares, Cristina Ochoa, Carla Lima, Maria J Marques Pinto, J Pedro Simas
Publicado en: Prion, Edición 19336896, 2015, Página(s) 22-28, ISSN 1933-6896
Editor: Landes Bioscience
DOI: 10.1080/19336896.2014.997615

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Autores: Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes
Publicado en: Cell Reports, Edición 22111247, 2015, Página(s) 2043-2054, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2015.02.057

Using argument notation to engineer biological simulations with increased confidence

Autores: Kieran Alden, Paul S. Andrews, Fiona A. C. Polack, Henrique Veiga-Fernandes, Mark C. Coles, Jon Timmis
Publicado en: Journal of the Royal Society Interface, Edición 17425689, 2015, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2014.1059

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autores: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Publicado en: Journal of Controlled Release, Edición 01683659, 2015, Página(s) 91-103, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Feeding immunity: skepticism, delicacies and delights

Autores: Marc Veldhoen, Henrique Veiga-Fernandes
Publicado en: Nature Immunology, Edición 15292908, 2015, Página(s) 215-219, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/ni.3100

Utilising a simulation platform to understand the effect of domain model assumptions

Autores: Kieran Alden, Paul S. Andrews, Henrique Veiga-Fernandes, Jon Timmis, Mark Coles
Publicado en: Natural Computing, Edición 15677818, 2015, Página(s) 99-107, ISSN 1567-7818
Editor: Kluwer Academic Publishers
DOI: 10.1007/s11047-014-9428-7

What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Autores: R. N. Bárcia, J. M. Santos, M. Filipe, M. Teixeira, J. P. Martins, J. Almeida, A. Água-Doce, S. C. P. Almeida, A. Varela, S. Pohl, K. E. J. Dittmar, S. Calado, S. I. Simões, M. M. Gaspar, M. E. M. Cruz, W. Lindenmaier, L. Graça, H. Cruz, P. E. Cruz
Publicado en: Stem Cells International, Edición 1687966X, 2015, Página(s) 1-14, ISSN 1687-966X
Editor: HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2015/583984

Point-of-care tests: where is the point?

Autores: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Publicado en: The Lancet Infectious Diseases, Edición 14733099, 2014, Página(s) 922, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Pherotype Influences Biofilm Growth and Recombination in Streptococcus pneumoniae

Autores: Margarida Carrolo, Francisco Rodrigues Pinto, José Melo-Cristino, Mário Ramirez
Publicado en: PLoS ONE, Edición 9/3, 2014, Página(s) e92138, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0092138

The Emerging Protumor Role of T Lymphocytes: Implications for Cancer Immunotherapy

Autores: M. Rei, D. J. Pennington, B. Silva-Santos
Publicado en: Cancer Research, Edición 75/5, 2015, Página(s) 798-802, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-3228

Role of Src Homology Domain Binding in Signaling Complexes Assembled by the Murid -Herpesvirus M2 Protein

Autores: M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo, J. P. Simas
Publicado en: Journal of Biological Chemistry, Edición 288/6, 2013, Página(s) 3858-3870, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M112.439810

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

Autores: Kelly Hudspeth, Bruno Silva-Santos, Domenico Mavilio
Publicado en: Frontiers in Immunology, Edición 4, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00069

Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds

Autores: Tiago Rodrigues, Ana S. Ressurreição, Filipa P. da Cruz, Inês S. Albuquerque, Jiri Gut, Marta P. Carrasco, Daniel Gonçalves, Rita C. Guedes, Daniel J.V.A. dos Santos, Maria M. Mota, Philip J. Rosenthal, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Publicado en: European Journal of Medicinal Chemistry, Edición 69, 2013, Página(s) 872-880, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2013.09.008

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Autores: Natasa Terzić, Jelena Konstantinović, Mikloš Tot, Jovana Burojević, Olgica Djurković-Djaković, Jelena Srbljanović, Tijana Štajner, Tatjana Verbić, Mario Zlatović, Marta Machado, Inês S. Albuquerque, Miguel Prudêncio, Richard J. Sciotti, Stevan Pecic, Sarah D’Alessandro, Donatella Taramelli, Bogdan A. Šolaja
Publicado en: Journal of Medicinal Chemistry, Edición 59/1, 2016, Página(s) 264-281, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.5b01374

Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation

Autores: Rita I. Azevedo, Maria V.D. Soares, Adriana S. Albuquerque, Rita Tendeiro, Rui S. Soares, Miguel Martins, Dário Ligeiro, Rui M.M. Victorino, João F. Lacerda, Ana E. Sousa
Publicado en: Biology of Blood and Marrow Transplantation, Edición 19/5, 2013, Página(s) 703-712, ISSN 1083-8791
Editor: Elsevier BV
DOI: 10.1016/j.bbmt.2013.01.017

How Many Sputum Culture Results Do We Need To Monitor Multidrug-Resistant-Tuberculosis (MDR-TB) Patients during Treatment?

Autores: S. Janssen, X. Padanilam, R. Louw, R. Mahanyele, G. Coetzee, T. Hanscheid, T. Leenstra, M. P. Grobusch
Publicado en: Journal of Clinical Microbiology, Edición 51/2, 2013, Página(s) 644-646, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.02837-12

Declining macrolide resistance in Streptococcus pyogenes in Portugal (2007–13) was accompanied by continuous clonal changes

Autores: C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publicado en: Journal of Antimicrobial Chemotherapy, Edición 70/10, 2015, Página(s) 2729-2733, ISSN 0305-7453
Editor: Oxford University Press
DOI: 10.1093/jac/dkv182

Spartan: A Comprehensive Tool for Understanding Uncertainty in Simulations of Biological Systems

Autores: Kieran Alden, Mark Read, Jon Timmis, Paul S. Andrews, Henrique Veiga-Fernandes, Mark Coles
Publicado en: PLoS Computational Biology, Edición 9/2, 2013, Página(s) e1002916, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1002916

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

Autores: Joana M Silva, Gaëlle Vandermeulen, Vanessa G Oliveira, Sandra N Pinto, Catarina Rodrigues, Ana Salgado, Carlos A Afonso, Ana S Viana, Christine Jérôme, Liana C Silva, Luis Graca, Véronique Préat, Helena F Florindo
Publicado en: Nanomedicine, Edición 9/17, 2014, Página(s) 2639-2656, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm.14.135

Tumor cell recognition by γδ T lymphocytes

Autores: Daniel V. Correia, Antonio C. Lopes, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 2/1, 2013, Página(s) e22892, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.22892

N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials

Autores: Ana Gomes, Marta Machado, Lis Lobo, Fátima Nogueira, Miguel Prudêncio, Cátia Teixeira, Paula Gomes
Publicado en: ChemMedChem, Edición 10/8, 2015, Página(s) 1344-1349, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201500164

Stabilization of Myc through Heterotypic Poly-Ubiquitination by mLANA Is Critical for γ-Herpesvirus Lymphoproliferation

Autores: Lénia Rodrigues, Nikita Popov, Kenneth M. Kaye, J. Pedro Simas
Publicado en: PLoS Pathogens, Edición 9/8, 2013, Página(s) e1003554, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1003554

Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

Autores: Joana M. Silva, Eva Zupancic, Gaëlle Vandermeulen, Vanessa G. Oliveira, Ana Salgado, Mafalda Videira, Manuela Gaspar, Luis Graca, Véronique Préat, Helena F. Florindo
Publicado en: Journal of Controlled Release, Edición 198, 2015, Página(s) 91-103, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2014.11.033

Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

Autores: J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, B. Silva-Santos
Publicado en: The Journal of Immunology, Edición 192/5, 2014, Página(s) 2237-2243, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1303119

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Autores: Shoichiro Tsuji, Lucas Stein, Nobuhiko Kamada, Gabriel Nuñez, Richard Bram, Bruce A. Vallance, Ana E. Sousa, Jeffrey L. Platt, Marilia Cascalho
Publicado en: Journal of Clinical Investigation, Edición 124/11, 2014, Página(s) 4857-4866, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI74428

Sugar activation and glycosylation in Plasmodium

Autores: Marta Cova, João A. Rodrigues, Terry K. Smith, Luis Izquierdo
Publicado en: Malaria Journal, Edición 14/1, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0949-z

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence

Autores: Shijun Li, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Bruno Correia, J. Pedro Simas, Maria A. Carrondo, Colin E. McVey, Kenneth M. Kaye
Publicado en: Journal of Biological Chemistry, Edición 290/47, 2015, Página(s) 28084-28096, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M115.674622

The Majority of Adult Pneumococcal Invasive Infections in Portugal Are Still Potentially Vaccine Preventable in Spite of Significant Declines of Serotypes 1 and 5

Autores: Andreia N. Horácio, Jorge Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino
Publicado en: PLoS ONE, Edición 8/9, 2013, Página(s) e73704, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0073704

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

Autores: M. Monteiro, A. Agua-Doce, C. F. Almeida, D. Fonseca-Pereira, H. Veiga-Fernandes, L. Graca
Publicado en: The Journal of Immunology, Edición 195/7, 2015, Página(s) 3463-3471, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1403170

Phylogenetic and clonality analysis of Bacillus pumilus isolates uncovered a highly heterogeneous population of different closely related species and clones

Autores: Raquel Branquinho, Luís Meirinhos-Soares, João A. Carriço, Manuela Pintado, Luísa V. Peixe
Publicado en: FEMS Microbiology Ecology, Edición 90/3, 2014, Página(s) 689-698, ISSN 0168-6496
Editor: Blackwell
DOI: 10.1111/1574-6941.12426

Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014

Autores: E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Publicado en: Clinical Microbiology and Infection, 2015, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2015.11.020

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Autores: Rita Tendeiro, Adriana S. Albuquerque, Russell B. Foxall, Rita Cavaleiro, Rui S. Soares, António P. Baptista, Maria V.D. Soares, Perpétua Gomes, Ana E. Sousa
Publicado en: AIDS, Edición 27/2, 2013, Página(s) 289-292, ISSN 0269-9370
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/QAD.0b013e32835ab234

The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis

Autores: Jorge M Santos, Rita N Bárcia, Sandra I Simões, Manuela M Gaspar, Susana Calado, Ana Água-Doce, Sílvia CP Almeida, Joana Almeida, Mariana Filipe, Mariana Teixeira, José P Martins, Luís Graça, Maria EM Cruz, Pedro Cruz, Helder Cruz
Publicado en: Journal of Translational Medicine, Edición 11/1, 2013, Página(s) 18, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/1479-5876-11-18

iNKT Cells: Innate Lymphocytes with a Diverse Response

Autores: Marta Monteiro, Luis Graca
Publicado en: Critical Reviews in Immunology, Edición 34/1, 2014, Página(s) 81-90, ISSN 1040-8401
Editor: Begell House
DOI: 10.1615/CritRevImmunol.2014010088

Superantigen gene complement of Streptococcus pyogenes—relationship with other typing methods and short-term stability

Autores: A. Friães, F. R. Pinto, C. Silva-Costa, M. Ramirez, J. Melo-Cristino
Publicado en: European Journal of Clinical Microbiology & Infectious Diseases, Edición 32/1, 2013, Página(s) 115-125, ISSN 0934-9723
Editor: Springer Verlag
DOI: 10.1007/s10096-012-1726-3

Autores: S I Aguiar, M J Brito, A N Horácio, J P Lopes, M Ramirez, J Melo-Cristino
Publicado en: Eurosurveillance, Edición 52, 2014, ISSN 1560-7917
Editor: EUR CENTRE DIS PREVENTION & CONTROL

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autores: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publicado en: Journal of Hematology & Oncology, Edición 6/1, 2013, Página(s) 87, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/1756-8722-6-87

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF- and IL-1

Autores: M. Monteiro, C. F. Almeida, A. Agua-Doce, L. Graca
Publicado en: The Journal of Immunology, Edición 190/2, 2013, Página(s) 805-811, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1201010

Extensive Dissemination of Methicillin-Resistant Staphylococcus aureus (MRSA) between the Hospital and the Community in a Country with a High Prevalence of Nosocomial MRSA

Autores: Diana Espadinha, Nuno A. Faria, Maria Miragaia, Luís Marques Lito, José Melo-Cristino, Hermínia de Lencastre
Publicado en: PLoS ONE, Edición 8/4, 2013, Página(s) e59960, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0059960

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Autores: Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia
Publicado en: Stem Cell Reports, Edición 4/3, 2015, Página(s) 348-359, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2015.01.002

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Autores: Christoph S.N. Klose, Melanie Flach, Luisa Möhle, Leif Rogell, Thomas Hoyler, Karolina Ebert, Carola Fabiunke, Dietmar Pfeifer, Veronika Sexl, Diogo Fonseca-Pereira, Rita G. Domingues, Henrique Veiga-Fernandes, Sebastian J. Arnold, Meinrad Busslinger, Ildiko R. Dunay, Yakup Tanriver, Andreas Diefenbach
Publicado en: Cell, Edición 157/2, 2014, Página(s) 340-356, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2014.03.030

Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

Autores: Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Publicado en: Malaria Journal, Edición 14/1, 2015, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/s12936-015-0913-y

Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

Autores: Sofia Santos Costa, Cláudia Mourato, Miguel Viveiros, José Melo-Cristino, Leonard Amaral, Isabel Couto
Publicado en: International Journal of Antimicrobial Agents, Edición 41/5, 2013, Página(s) 490-492, ISSN 0924-8579
Editor: Elsevier BV
DOI: 10.1016/j.ijantimicag.2013.01.003

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Autores: Karine Serre, Bruno Silva-Santos
Publicado en: Frontiers in Immunology, Edición 4, 2013, ISSN 1664-3224
Editor: Frontiers Editorial Office
DOI: 10.3389/fimmu.2013.00431

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

Autores: Ana Friães, Catarina Pato, José Melo-Cristino, Mario Ramirez
Publicado en: Scientific Reports, Edición 5, 2015, Página(s) 12057, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep12057

Chicago 2014 – 30years of γδ T cells

Autores: Marc Bonneville, Zheng W. Chen, Julie Déchanet-Merville, Matthias Eberl, Jean Jacques Fournié, Julie M. Jameson, Richard D. Lopez, Massimo Massaia, Bruno Silva-Santos
Publicado en: Cellular Immunology, Edición 296/1, 2015, Página(s) 3-9, ISSN 0008-8749
Editor: Academic Press
DOI: 10.1016/j.cellimm.2014.11.001

Simple, sensitive and quantitative bioluminescence assay for determination of malaria pre-patent period

Autores: Vanessa Zuzarte-Luis, Joana Sales-Dias, Maria M Mota
Publicado en: Malaria Journal, Edición 13/1, 2014, Página(s) 15, ISSN 1475-2875
Editor: BioMed Central
DOI: 10.1186/1475-2875-13-15

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity

Autores: Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh
Publicado en: European Journal of Medicinal Chemistry, Edición 101, 2015, Página(s) 266-273, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2015.06.045

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

Autores: R. S. Paiva, A. C. Lino, M.-L. Bergman, I. Caramalho, A. E. Sousa, S. Zelenay, J. Demengeot
Publicado en: Proceedings of the National Academy of Sciences, Edición 110/16, 2013, Página(s) 6494-6499, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1221955110

Delta-like 1-Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells

Autores: C. Mota, V. Nunes-Silva, A. R. Pires, P. Matoso, R. M. M. Victorino, A. E. Sousa, I. Caramalho
Publicado en: The Journal of Immunology, Edición 193/12, 2014, Página(s) 5854-5862, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1400198

PCR based differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses

Autores: S. Preziuso, M.D. Pinho, A.R. Attili, J. Melo-Cristino, E. Acke, A.C. Midwinter, V. Cuteri, M. Ramirez
Publicado en: Comparative Immunology, Microbiology and Infectious Diseases, Edición 37/3, 2014, Página(s) 169-172, ISSN 0147-9571
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.cimid.2014.04.001

Point-of-care tests: where is the point?

Autores: Thomas Hänscheid, Maria Rebelo, Martin P Grobusch
Publicado en: The Lancet Infectious Diseases, Edición 14/10, 2014, Página(s) 922, ISSN 1473-3099
Editor: The Lancet Publishing Group
DOI: 10.1016/S1473-3099(14)70914-4

Serotype discrimination of encapsulated Streptococcus pneumoniae strains by Fourier-transform infrared spectroscopy and chemometrics

Autores: M. Vaz, L. Meirinhos-Soares, C.C.S. Sousa, M. Ramirez, J. Melo-Cristino, J.A. Lopes
Publicado en: Journal of Microbiological Methods, Edición 93/2, 2013, Página(s) 102-107, ISSN 0167-7012
Editor: Elsevier BV
DOI: 10.1016/j.mimet.2013.02.008

Recruitment of γδ T lymphocytes to tumors

Autores: Telma Lança, Bruno Silva-Santos
Publicado en: OncoImmunology, Edición 2/8, 2013, Página(s) e25461, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.4161/onci.25461

A transcription-independent epigenetic mechanism is associated with antigenic switching in Trypanosoma brucei

Autores: Francisco Aresta-Branco, Silvia Pimenta, Luisa M. Figueiredo
Publicado en: Nucleic Acids Research, 2015, Página(s) gkv1459, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv1459

Reduced BAFF-R and Increased TACI Expression in Common Variable Immunodeficiency

Autores: Rita R. Barbosa, Susana L. Silva, Sara P. Silva, Alcinda C. Melo, M. Conceição Pereira-Santos, João T. Barata, Lennart Hammarström, Marília Cascalho, Ana E. Sousa
Publicado en: Journal of Clinical Immunology, Edición 34/5, 2014, Página(s) 573-583, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-014-0047-y

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

Autores: Julie C. Ribot, Bruno Silva-Santos
Publicado en: Crossroads Between Innate and Adaptive Immunity IV, 2013, Página(s) 95-105, ISBN 978-1-4614-6217-0
Editor: Springer New York
DOI: 10.1007/978-1-4614-6217-0_11

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

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