Strategies towards Excellence in Immuno-Oncology

Resultado final

Report on overall promotional activities I

Report will summarize the Promotional activities related to the project.

Report from the Steering Group Meeting I

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M36

Report on transfer of know-how and best practices to MUW as a result of twinning visits in collaborating institutions; will include the analysis of added value for potential increase of research capacity / quality of MUW and the analysis of STREAM funds exploitation; will be discussed during the annual Steering Group meetings.

"Report on organization of theoretical workshop - ""Adoptive immunotherapy for cancer"""

Report on organized workshop will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on know-how knowledge dissemination at MUW - M12

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on participation in international research/innovation conferences - M36

Report on the attendance of European and world-wide conferences, symposia and meetings will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits.

Specifications of training material used for the twinning visits

Deliverable D37 will include the list of training materials to be used to deliver high-quality training during the twinning visits.

Report on management activities III

Report will summarize the yearly Management activities.

Report from the Steering Group Meeting III

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on publications, patents and funding support resulting from twinning visits

Report on publications, patents and funding support, resulting from twinning visits.

Report from the Steering Group Meeting II

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M24

Report on overall promotional activities III

Report will summarize the Promotional activities related to the project.

Report on knowledge dissemination - M18

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during hands-on workshop

Report on the promotional activities undertaken before and during the workshop.

"Report on organization of international summer-school - ""Immuno-Oncology"""

Report on organized summer-school will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on participation in international research/innovation conferences - M18

Report on know-how transfer through twinning visits - M12

Report on promotional activities undertaken during theoretical workshop

Report on the promotional activities undertaken before and during the workshop.

Report on prior publications of the coordinator

A one-page statement that the information about prior publications of the coordinator has been provided.

Report on overall promotional activities II

Report will summarize the Promotional activities related to the project.

Report on know-how knowledge dissemination at MUW - M36

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on management activities II

Report will summarize the yearly Management activities.

Report on management activities I

Report will summarize the yearly Management activities.

Report on knowledge dissemination - M36

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during summer-school

Report on the promotional activities undertaken before and during the summer-school.

Report on STREAM webpage launching

Report on the STREAM webpage launching is considered a Milestone in project implementation since it will be the basis for communication and promotion of the project.

"Report on organization of hands-on workshop - ""Application of flow cytometry methods in Immuno-Oncology"""

Report on know-how knowledge dissemination at MUW - M24

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Publicaciones

MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Autores: Anna Polak, Przemysław Kiliszek, Tomasz Sewastianik, Maciej Szydłowski, Ewa Jabłońska, Emilia Białopiotrowicz, Patryk Górniak, Sergiusz Markowicz, Eliza Nowak, Monika A. Grygorowicz, Monika Prochorec-Sobieszek, Dominika Nowis, Jakub Gołąb, Sebastian Giebel, Ewa Lech-Marańda, Krzysztof Warzocha, Przemysław Juszczyński
Publicado en: PLOS ONE, Edición 11/5, 2016, Página(s) e0155893, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0155893

HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Autores: Malgorzata Bobrowicz, Michal Dwojak, Beata Pyrzynska, Joanna Stachura, Angelika Muchowicz, Elise Berthel, Nicole Dalla Venezia, Mieszko Kozikowski, Marta Siernicka, Nina Miazek, Piotr Zapala, Antoni Domagala, Kamil Bojarczuk, Agata Malenda, Joanna Barankiewicz, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Magdalena Gabrysiak, Jean-Jacques Diaz, Marta Karp, Ewa Lech-Maranda, Malgorzata Firczuk,
Publicado en: Blood, Edición 130(14):1628-1638, 2017, Página(s) blood-2016-08-736066, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2016-08-736066

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

Autores: Anna Trzeciecka, Szymon Klossowski, Malgorzata Bajor, Radoslaw Zagozdzon, Pawel Gaj, Angelika Muchowicz, Agata Malinowska, Anna Czerwoniec, Joanna Barankiewicz, Antoni Domagala, Justyna Chlebowska, Monika Prochorec-Sobieszek, Magdalena Winiarska, Ryszard Ostaszewski, Iwonna Gwizdalska, Jakub Golab, Dominika Nowis, Malgorzata Firczuk
Publicado en: Oncotarget, Edición 7/2, 2016, Página(s) 1717-1731, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.6435

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo

Autores: MAGDALENA GABRYSIAK, MALGORZATA WACHOWSKA, JOANNA BARANKIEWICZ, ZOFIA PILCH, ANNA RATAJSKA, EWA SKRZYPEK, MAGDALENA WINIARSKA, ANTONI DOMAGALA, TOMASZ P. RYGIEL, ALICJA JOZKOWICZ, LOUIS BOON, JAKUB GOLAB, MALGORZATA FIRCZUK
Publicado en: Oncology Reports, Edición 35/6, 2016, Página(s) 3151-3158, ISSN 1021-335X
Editor: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/or.2016.4723

The Anatomy of Caprine Female Urethra and Characteristics of Muscle and Bone Marrow Derived Caprine Cells for Autologous Cell Therapy Testing

Autores: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wisniewska, Agnieszka Kulesza, Radoslaw Zagozdzon, Zdzislaw Gajewski, Leszek Paczek
Publicado en: The Anatomical Record, Edición 300/3, 2017, Página(s) 577-588, ISSN 1932-8486
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ar.23498

Iterative Sequencing and Variant Screening (ISVS) as a novel pathogenic mutations search strategy - application for TMPRSS3 mutations screen

Autores: Urszula Lechowicz, Tomasz Gambin, Agnieszka Pollak, Anna Podgorska, Piotr Stawinski, Andre Franke, Britt-Sabina Petersen, Malgorzata Firczuk, Monika Oldak, Henryk Skarzynski, Rafal Ploski
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-02315-w

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

Autores: Beata Pyrzynska, Michal Dwojak, Abdessamad Zerrouqi, Giulia Morlino, Piotr Zapala, Nina Miazek, Agnieszka Zagozdzon, Kamil Bojarczuk, Malgorzata Bobrowicz, Marta Siernicka, Marcin M. Machnicki, Stefania Gobessi, Joanna Barankiewicz, Ewa Lech-Maranda, Dimitar G. Efremov, Przemyslaw Juszczynski, Dinis Calado, Jakub Golab, Magdalena Winiarska
Publicado en: OncoImmunology, Edición 7/5, 2018, Página(s) e1423183, ISSN 2162-402X
Editor: Taylor & Francis
DOI: 10.1080/2162402X.2017.1423183

Application of Genome Editing Techniques in Immunology

Autores: Agata O. Zych, Malgorzata Bajor, Radoslaw Zagozdzon
Publicado en: Archivum Immunologiae et Therapiae Experimentalis, Edición 66/4, 2018, Página(s) 289-298, ISSN 0004-069X
Editor: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0504-z

Selection of an optimal promoter for gene transfer in normal B cells

Autores: Magdalena Winiarska, Dominika Nowis, Malgorzata Firczuk, Agnieszka Zagozdzon, Magdalena Gabrysiak, Radoslaw Sadowski, Joanna Barankiewicz, Michal Dwojak, Jakub Golab
Publicado en: Molecular Medicine Reports, Edición 16/3, 2017, Página(s) 3041-3048, ISSN 1791-2997
Editor: Spandidos Publications
DOI: 10.3892/mmr.2017.6974

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

Autores: Seweryn Mroczek, Justyna Chlebowska, Tomasz M. Kuliński, Olga Gewartowska, Jakub Gruchota, Dominik Cysewski, Vladyslava Liudkovska, Ewa Borsuk, Dominika Nowis, Andrzej Dziembowski
Publicado en: Nature Communications, Edición 8/1, 2017, Página(s) 619, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-00578-5

In vivo imaging system for explants analysis—A new approach for assessment of cell transplantation effects in large animal models

Autores: Weronika Zarychta-Wiśniewska, Anna Burdzinska, Radosław Zagozdzon, Bartosz Dybowski, Marta Butrym, Zdzisław Gajewski, Leszek Paczek
Publicado en: PLOS ONE, Edición 12/9, 2017, Página(s) e0184588, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0184588

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors

Autores: Vincent Yi Sheng Oei, Marta Siernicka, Agnieszka Graczyk-Jarzynka, Hanna Julie Hoel, Weiwen Yang, Daniel Palacios, Hilde Almåsbak, Malgorzata Bajor, Dennis Clement, Ludwig Brandt, Björn Önfelt, Jodie Goodridge, Magdalena Winiarska, Radoslaw Zagozdzon, Johanna Olweus, Jon-Amund Kyte, Karl-Johan Malmberg
Publicado en: Cancer Immunology Research, Edición 6/4, 2018, Página(s) 467-480, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.CIR-17-0207

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

Autores: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk
Publicado en: BMC Cancer, Edición 18/1, 2018, Página(s) 210, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-018-4126-y

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Autores: Natalia Krata, Radosław Zagożdżon, Bartosz Foroncewicz, Krzysztof Mucha
Publicado en: Archivum Immunologiae et Therapiae Experimentalis, Edición 66/3, 2018, Página(s) 211-220, ISSN 0004-069X
Editor: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0496-0

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy

Autores: Antoni Domagala, Klaudyna Fidyt, Malgorzata Bobrowicz, Joanna Stachura, Kacper Szczygiel, Malgorzata Firczuk
Publicado en: International Journal of Molecular Sciences, Edición 19/8, 2018, Página(s) 2256, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082256

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

Autores: Marcin Waligora, Malgorzata M. Bala, Magdalena Koperny, Mateusz T. Wasylewski, Karolina Strzebonska, Rafał R. Jaeschke, Agnieszka Wozniak, Jan Piasecki, Agnieszka Sliwka, Jerzy W. Mitus, Maciej Polak, Dominika Nowis, Dean Fergusson, Jonathan Kimmelman
Publicado en: PLOS Medicine, Edición 15/2, 2018, Página(s) e1002505, ISSN 1549-1676
Editor: PLOS Medicine
DOI: 10.1371/journal.pmed.1002505

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

Autores: Justyna Chlebowska-Tuz, Olga Sokolowska, Pawel Gaj, Michal Lazniewski, Malgorzata Firczuk, Karolina Borowiec, Hanna Sas-Nowosielska, Malgorzata Bajor, Agata Malinowska, Angelika Muchowicz, Kavita Ramji, Piotr Stawinski, Mateusz Sobczak, Zofia Pilch, Anna Rodziewicz-Lurzynska, Malgorzata Zajac, Krzysztof Giannopoulos, Przemyslaw Juszczynski, Grzegorz W. Basak, Dariusz Plewczynski, Rafal Ploski, Jak
Publicado en: Haematologica, Edición 103/11, 2018, Página(s) 1843-1852, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.190231

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure

Autores: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski, Leszek Paczek
Publicado en: Stem Cell Research & Therapy, Edición 9/1, 2018, Página(s) 239, ISSN 1757-6512
Editor: BioMed Central
DOI: 10.1186/s13287-018-0990-2

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Autores: Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publicado en: BMC Cancer, Edición 18/1, 2018, Página(s) 965, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-018-4852-1

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

Autores: Anna A. Marusiak, Monika K. Prelowska, Dawid Mehlich, Michal Lazniewski, Klaudia Kaminska, Adam Gorczynski, Aleksandra Korwat, Olga Sokolowska, Hanna Kedzierska, Jakub Golab, Wojciech Biernat, Dariusz Plewczynski, John Brognard, Dominika Nowis
Publicado en: Oncogene, 2018, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/s41388-018-0618-0

Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

Autores: Agnieszka Graczyk-Jarzynka, Agnieszka Goral, Angelika Muchowicz, Radoslaw Zagozdzon, Magdalena Winiarska, Malgorzata Bajor, Anna Trzeciecka, Klaudyna Fidyt, Joanna Alicja Krupka, Julia Cyran, Kacper Szczygiel, Dimitar G. Efremov, Stefania Gobessi, Adam Jagielski, Karolina Siudakowska, Malgorzata Bobrowicz, Marta Klopotowska, Joanna Barankiewicz, Agata Malenda, Ewa Lech-Maranda, Nina Miazek-Zapala,
Publicado en: Redox Biology, Edición 21, 2019, Página(s) 101062, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2018.11.020

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

Autores: Malgorzata Bajor, Agata O. Zych, Agnieszka Graczyk-Jarzynka, Angelika Muchowicz, Malgorzata Firczuk, Lech Trzeciak, Pawel Gaj, Antoni Domagala, Marta Siernicka, Agnieszka Zagozdzon, Pawel Siedlecki, Monika Kniotek, Patrick C. O’Leary, Jakub Golab, Radoslaw Zagozdzon
Publicado en: British Journal of Cancer, Edición 119/7, 2018, Página(s) 873-884, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-018-0263-y

STING Signaling in Cancer Cells: Important or Not?

Autores: Olga Sokolowska, Dominika Nowis
Publicado en: Archivum Immunologiae et Therapiae Experimentalis, Edición 66/2, 2018, Página(s) 125-132, ISSN 0004-069X
Editor: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0481-7

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy

Autores: Arkadiusz Urbanowicz, Radosław Zagożdżon, Michał Ciszek
Publicado en: Archivum Immunologiae et Therapiae Experimentalis, 2018, ISSN 0004-069X
Editor: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0532-8

The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies

Autores: Zofia Pilch, Katarzyna Tonecka, Marcin Skorzynski, Zuzanna Sas, Agata Braniewska, Tomasz Kryczka, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Publicado en: PLOS ONE, Edición 14/1, 2019, Página(s) e0210796, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0210796

Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome

Autores: Florian Anzengruber, Desislava Ignatova, Tanja Schlaepfer, Yun-Tsan Chang, Lars E. French, Steve Pascolo, Emmanuel Contassot, Malgorzata Bobrowicz, Wolfram Hoetzenecker, Emmanuella Guenova
Publicado en: Leukemia & Lymphoma, 2019, Página(s) 1-9, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.1080/10428194.2018.1564827

Dissection of CD20 regulation in lymphoma using RNAi

Autores: M Słabicki, K S Lee, A Jethwa, L Sellner, F Sacco, T Walther, J Hüllein, S Dietrich, B Wu, D B Lipka, C C Oakes, S Mamidi, B Pyrzyńska, M Winiarska, M Oleś, M Seifert, C Plass, M Kirschfink, M Boettcher, J Gołąb, W Huber, S Fröhling, T Zenz
Publicado en: Leukemia, Edición 30/12, 2016, Página(s) 2409-2412, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.230

Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity

Autores: Ole-Jacob Norum, Ane Sofie Viset Fremstedal, Anette Weyergang, Jakub Golab, Kristian Berg
Publicado en: Journal of Controlled Release, Edición 268, 2017, Página(s) 120-127, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2017.10.015

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice

Autores: Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W. Kilarski, Louis Boon, Tomasz J. Klaus, Jakub Golab
Publicado en: European Journal of Cancer, Edición 83, 2017, Página(s) 19-27, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2017.06.004

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Autores: Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, Robert Koralewski, Wojciech Czestkowski, Anna Jedrzejczak, Jakub Golab, Karolina Dzwonek, Barbara Dymek, Piotr L. Sklepkiewicz, Agnieszka Zagozdzon, Tom Noonan, Keyvan Mahboubi, Bruce Conway, Ryan Sheeler, Paul Beckett, William M. Hungerford, Alberto Podjarny, Andre Mitschler, Alexandra Cousido-Siah, Firas Fadel, Adam Golebiowski
Publicado en: Journal of Medicinal Chemistry, Edición 61/3, 2018, Página(s) 695-710, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01051

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

Autores: Luca Laurenti, Francesco Autore, Idanna Innocenti, Giovanni D’Arena, Marta Coscia, Patrizia Mondello, Patrizia Chiusolo, Silvia Bellesi, Dimitar G. Efremov, Simona Sica, Francesca Romana Mauro
Publicado en: Leukemia & Lymphoma, Edición 57/10, 2016, Página(s) 2429-2431, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2015.1137293

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

Autores: G Lohmann, E Vasyutina, J Bloehdorn, N Reinart, J I Schneider, V Babu, G Knittel, G Crispatzu, P Mayer, C Prinz, J K Muenzner, B Biersack, D G Efremov, L Chessa, C D Herling, S Stilgenbauer, M Hallek, R Schobert, H C Reinhardt, B Schumacher, M Herling
Publicado en: Leukemia, Edición 31/5, 2017, Página(s) 1177-1186, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.294

B-cell receptor signaling in the pathogenesis of lymphoid malignancies

Autores: Kamil Bojarczuk, Malgorzata Bobrowicz, Michal Dwojak, Nina Miazek, Piotr Zapala, Anders Bunes, Marta Siernicka, Maria Rozanska, Magdalena Winiarska
Publicado en: Blood Cells, Molecules, and Diseases, Edición 55/3, 2015, Página(s) 255-265, ISSN 1079-9796
Editor: Academic Press
DOI: 10.1016/j.bcmd.2015.06.016

SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress

Autores: Angelika Muchowicz, Małgorzata Firczuk, Małgorzata Wachowska, Marek Kujawa, Ewa Jankowska-Steifer, Magdalena Gabrysiak, Zofia Pilch, Szymon Kłossowski, Ryszard Ostaszewski, Jakub Golab
Publicado en: Biochemical Pharmacology, Edición 93/4, 2015, Página(s) 418-427, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2014.12.019

Adenanthin targets proteins involved in the regulation of disulphide bonds

Autores: Angelika Muchowicz, Małgorzata Firczuk, Justyna Chlebowska, Dominika Nowis, Joanna Stachura, Joanna Barankiewicz, Anna Trzeciecka, Szymon Kłossowski, Ryszard Ostaszewski, Radosław Zagożdżon, Jian-Xin Pu, Han-Dong Sun, Jakub Golab
Publicado en: Biochemical Pharmacology, Edición 89/2, 2014, Página(s) 210-216, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2014.02.022

Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy

Autores: Aleksandra Maria Dudek-Perić, Jakub Gołąb, Abhishek D Garg, Patrizia Agostinis
Publicado en: OncoImmunology, Edición 4/12, 2015, Página(s) e1054600, ISSN 2162-402X
Editor: Taylor & Francis
DOI: 10.1080/2162402x.2015.1054600

Neurodevelopmental phenotype caused by a de novo PTPN4 single nucleotide variant disrupting protein localization in neuronal dendritic spines

Autores: Krzysztof Szczałuba, Joanna J. Chmielewska, Olga Sokolowska, Małgorzata Rydzanicz, Krystyna Szymańska, Wojciech Feleszko, Paweł Włodarski, Anna Biernacka, Victor Murcia Pienkowski, Anna Walczak, Elżbieta Bargeł, Katarzyna Królewczyk, Agata Nowacka, Piotr Stawiński, Dominika Nowis, Magdalena Dziembowska, Rafał Płoski
Publicado en: Clinical Genetics, Edición 94/6, 2018, Página(s) 581-585, ISSN 0009-9163
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cge.13450

Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment

Autores: Zofia Pilch, Katarzyna Tonecka, Agata Braniewska, Zuzanna Sas, Marcin Skorzynski, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Publicado en: Cancer Immunology Research, Edición 6/8, 2018, Página(s) 930-940, ISSN 2326-6066
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0454

Outcomes of Prolonged Treatment With Intravenous Immunoglobulin Infusions for Acute Antibody-mediated Rejection in Kidney Transplant Recipients

Autores: A. Bujnowska, M. Michon, P. Konopelski, E. Hryniewiecka, A. Jalbrzykowska, A. Perkowska-Ptasinska, T. Cieciura, R. Zagozdzon, L. Paczek, M. Ciszek
Publicado en: Transplantation Proceedings, Edición 50/6, 2018, Página(s) 1720-1725, ISSN 0041-1345
Editor: Appleton & Lange
DOI: 10.1016/j.transproceed.2018.02.110

Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase

Autores: Marzena Mazur, Agnieszka Bartoszewicz, Barbara Dymek, Magdalena Salamon, Gleb Andryianau, Michał Kowalski, Sylwia Olejniczak, Krzysztof Matyszewski, Elżbieta Pluta, Bartłomiej Borek, Filip Stefaniak, Agnieszka Zagozdzon, Marcin Mazurkiewicz, Robert Koralewski, Wojciech Czestkowski, Michał Piotrowicz, Piotr Niedziejko, Mariusz M. Gruza, Karolina Dzwonek, Adam Golebiowski, Jakub Golab, Jacek Olc
Publicado en: Bioorganic & Medicinal Chemistry Letters, Edición 28/3, 2018, Página(s) 310-314, ISSN 0960-894X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2017.12.047

Bortezomib-Induced Muscle Toxicity in Multiple Myeloma

Autores: Valeria Guglielmi, Dominika Nowis, Martina Tinelli, Manuela Malatesta, Laura Paoli, Matteo Marini, Paolo Manganotti, Radoslaw Sadowski, Grzegorz M. Wilczynski, Vittorio Meneghini, Giuliano Tomelleri, Gaetano Vattemi
Publicado en: Journal of Neuropathology & Experimental Neurology, Edición 76/7, 2017, Página(s) 620-630, ISSN 0022-3069
Editor: American Association of Neuropathologists, Inc.
DOI: 10.1093/jnen/nlx043

The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development

Autores: Joanna Stachura, Malgorzata Wachowska, Witold W. Kilarski, Esra Güç, Jakub Golab, Angelika Muchowicz
Publicado en: OncoImmunology, Edición 5/7, 2016, Página(s) e1182278, ISSN 2162-402X
Editor: Taylor&Francis
DOI: 10.1080/2162402X.2016.1182278

New insights into redox homeostasis as a therapeutic target in B-cell malignancies

Autores: Agnieszka Graczyk-Jarzynka, Radoslaw Zagozdzon, Angelika Muchowicz, Marta Siernicka, Malgorzata Firczuk, Przemyslaw Juszczynski
Publicado en: Current Opinion in Hematology, Edición 24/4, 2017, Página(s) 1, ISSN 1065-6251
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOH.0000000000000351

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

Autores: Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, Vincenzo Cerundolo
Publicado en: Cancer Research, Edición 76/21, 2016, Página(s) 6193-6204, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-3502

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199

Autores: K. Bojarczuk, B. K. Sasi, S. Gobessi, I. Innocenti, G. Pozzato, L. Laurenti, D. G. Efremov
Publicado en: Blood, Edición 127/25, 2016, Página(s) 3192-3201, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-10-675009

IL-4 regulates B-cell receptor signaling in CLL

Autores: D. G. Efremov
Publicado en: Blood, Edición 128/4, 2016, Página(s) 468-469, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2016-06-719872

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Autores: Andreas T. Björklund, Trevor Clancy, Jodie P. Goodridge, Vivien Béziat, Marie Schaffer, Eivind Hovig, Hans-Gustaf Ljunggren, Per T. Ljungman, Karl-Johan Malmberg
Publicado en: The Journal of Immunology, Edición 196/3, 2016, Página(s) 1400-1411, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.1501434

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells

Autores: P. J. Brown, D. M. Gascoyne, L. Lyne, H. Spearman, S. L. Felce, N. McFadden, P. Chakravarty, S. Barrans, S. Lynham, D. P. Calado, M. Ward, A. H. Banham
Publicado en: Haematologica, Edición 101/7, 2016, Página(s) 861-871, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142141

Modulation of cancer-specific immune responses by amino acid degrading enzymes

Autores: Elina Timosenko, Andreas V Hadjinicolaou, Vincenzo Cerundolo
Publicado en: Immunotherapy, Edición 9/1, 2017, Página(s) 83-97, ISSN 1750-743X
Editor: Future Medicine Ltd.
DOI: 10.2217/imt-2016-0118

FOXO discriminates tonic from chronic in DLBCL

Autores: D. G. Efremov
Publicado en: Blood, Edición 127/6, 2016, Página(s) 669-670, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-12-683441

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Autores: Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat
Publicado en: Cell Reports, Edición 15/5, 2016, Página(s) 1088-1099, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.04.005

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA

Autores: Nadia Mensali, Fan Ying, Vincent Oei Yi Sheng, Weiwen Yang, Even Walseng, Shraddha Kumari, Lars-Egil Fallang, Arne Kolstad, Wolfgang Uckert, Karl Johan Malmberg, Sébastien Wälchli, Johanna Olweus
Publicado en: OncoImmunology, Edición 5/5, 2016, Página(s) e1138199, ISSN 2162-402X
Editor: Taylor&Francis
DOI: 10.1080/2162402X.2016.1138199

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

Autores: Luca Laurenti, Idanna Innocenti, Francecso Autore, Simona Sica, Dimitar Efremov
Publicado en: OncoTargets and Therapy, 2016, Página(s) 421, ISSN 1178-6930
Editor: Dove Medical Press Ltd
DOI: 10.2147/OTT.S72845

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

Autores: Maryaline Coffre, David Benhamou, David Rieß, Lili Blumenberg, Valentina Snetkova, Marcus J. Hines, Tirtha Chakraborty, Sofia Bajwa, Kari Jensen, Mark M.W. Chong, Lelise Getu, Gregg J. Silverman, Robert Blelloch, Dan R. Littman, Dinis Calado, Doron Melamed, Jane A. Skok, Klaus Rajewsky, Sergei B. Koralov
Publicado en: Cell Reports, Edición 17/9, 2016, Página(s) 2271-2285, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.11.006

Cognate HLA absence in trans diminishes human NK cell education

Autores: Vanessa Landtwing, Ana Raykova, Gaetana Pezzino, Vivien Béziat, Emanuela Marcenaro, Claudine Graf, Alessandro Moretta, Riccarda Capaul, Andrea Zbinden, Guido Ferlazzo, Karl-Johan Malmberg, Obinna Chijioke, Christian Münz
Publicado en: Journal of Clinical Investigation, Edición 126/10, 2016, Página(s) 3772-3782, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI86923

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Autores: Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, Martin Herrmann, James W. Hodge, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, Walter G. Land, Frank Madeo, Angelo A. Manfredi, Stephen R. Mattarollo, Christian Maueroder, Nicolò Merendino, Gabriele Multhoff, Thomas Pabst, Jean-Ehrland Ricci, Chiara Riganti, Erminia Romano, Nicole Rufo, Mark J. Smyth, Jürgen Sonnemann, Radek Spisek, John Stagg, Erika Vacchelli, Peter Vandenabeele, Lien Vandenberk, Benoit J. Van den Eynde, Stefaan Van Gool, Francesca Velotti, Laurence Zitvogel, Patrizia Agostinis
Publicado en: Frontiers in Immunology, Edición 16643224, 2015, Página(s) 588, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00588

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity

Autores: Malgorzata Wachowska, Angelika Muchowicz, Jakub Golab
Publicado en: Frontiers in Oncology, Edición 2234943X, 2015, Página(s) 176, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2015.00176

Review Cancer stem cells in haematological malignancies

Autores: Radoslaw Zagozdzon, Jakub Golab
Publicado en: Współczesna Onkologia, Edición 14282526, 2015, Página(s) 1-6, ISSN 1428-2526
Editor: Termedia
DOI: 10.5114/wo.2014.47127

Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

Autores: Marta Siernicka, Magdalena Winiarska, Malgorzata Bajor, Malgorzata Firczuk, Angelika Muchowicz, Malgorzata Bobrowicz, Cyril Fauriat, Jakub Golab, Daniel Olive, Radoslaw Zagozdzon
Publicado en: Immunology, Edición 00192805, 2015, Página(s) 173-183, ISSN 0019-2805
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imm.12494

Sorafenib improves rituximab and ofatumumab efficacy by decreasing the expression of complement regulatory proteins

Autores: M Dwojak, M Bobrowicz, J Bil, K Bojarczuk, B Pyrzynska, M Siernicka, A Malenda, E Lech-Maranda, W Tomczak, K Giannopoulos, J Golab, M Winiarska
Publicado en: Blood Cancer Journal, Edición 20445385, 2015, Página(s) e300, ISSN 2044-5385
Editor: Nature Publishing Group
DOI: 10.1038/bcj.2015.27

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies

Autores: Magdalena Winiarska, Kamil Bojarczuk, Beata Pyrzynska, Jacek Bil, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Magdalena Krol, Aleksandra Syta, Paulina Podszywalow-Bartnicka, Zofia Pilch, Anna Dabrowska-Iwanicka, Przemyslaw Juszczynski, Dimitar G Efremov, Mikolaj Slabicki, Thorsten Zenz, Aude Le Roy, Daniel Olive, Tomasz P Rygiel, Jeanette HW Leusen, Jakub Golab
Publicado en: mAbs, Edición 19420870, 2014, Página(s) 1300-1313, ISSN 1942-0870
Editor: Landes Bioscience
DOI: 10.4161/mabs.32106

Statins impair glucose uptake in human cells

Autores: D. Nowis, A. Malenda, K. Furs, B. Oleszczak, R. Sadowski, J. Chlebowska, M. Firczuk, J. M. Bujnicki, A. D. Staruch, R. Zagozdzon, E. Glodkowska-Mrowka, L. Szablewski, J. Golab
Publicado en: BMJ Open Diabetes Research & Care, Edición 20524897, 2014, Página(s) e000017-e000017, ISSN 2052-4897
Editor: BMJ in partnership with the American Diabetes Association
DOI: 10.1136/bmjdrc-2014-000017

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Autores: Izabela Mlynarczuk-Bialy, Thorsten R. Doeppner, Jakub Golab, Dominika Nowis, Grzegorz M. Wilczynski, Kamil Parobczak, Moritz E. Wigand, Malgorzata Hajdamowicz, Łukasz P. Biały, Olga Aniolek, Petra Henklein, Mathias Bähr, Boris Schmidt, Ulrike Kuckelkorn, Peter-M. Kloetzel
Publicado en: Translational Oncology, Edición 19365233, 2014, Página(s) 570-579, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2014.07.002

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Autores: Maciej Serda, Danuta S. Kalinowski, Nathalie Rasko, Eliška Potůčková, Anna Mrozek-Wilczkiewicz, Robert Musiol, Jan G. Małecki, Mieczysław Sajewicz, Alicja Ratuszna, Angelika Muchowicz, Jakub Gołąb, Tomáš Šimůnek, Des R. Richardson, Jaroslaw Polanski
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e110291, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0110291

Iron Chelators in Photodynamic Therapy Revisited: Synergistic Effect by Novel Highly Active Thiosemicarbazones

Autores: Anna Mrozek-Wilczkiewicz, Maciej Serda, Robert Musiol, Grzegorz Malecki, Agnieszka Szurko, Angelika Muchowicz, Jakub Golab, Alicja Ratuszna, Jaroslaw Polanski
Publicado en: ACS Medicinal Chemistry Letters, Edición 19485875, 2014, Página(s) 336-339, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/ml400422a

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

Autores: K Bojarczuk, M Siernicka, M Dwojak, M Bobrowicz, B Pyrzynska, P Gaj, M Karp, K Giannopoulos, D G Efremov, C Fauriat, J Golab, M Winiarska
Publicado en: Leukemia, Edición 08876924, 2014, Página(s) 1163-1167, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.12

Danger signalling during cancer cell death: origins, plasticity and regulation

Autores: A D Garg, S Martin, J Golab, P Agostinis
Publicado en: Cell Death and Differentiation, Edición 13509047, 2013, Página(s) 26-38, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/cdd.2013.48

5-Aza-2′-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy

Autores: Malgorzata Wachowska, Magdalena Gabrysiak, Angelika Muchowicz, Weronika Bednarek, Joanna Barankiewicz, Tomasz Rygiel, Louis Boon, Pawel Mroz, Michael R Hamblin, Jakub Golab
Publicado en: European Journal of Cancer, Edición 09598049, 2014, Página(s) 1370-1381, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2014.01.017

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Autores: Witold W. Kilarski, Angelika Muchowicz, Malgorzata Wachowska, Renata Mężyk-Kopeć, Jakub Golab, Melody A. Swartz, Patrycja Nowak-Sliwinska
Publicado en: Angiogenesis, Edición 09696970, 2014, Página(s) 347-357, ISSN 0969-6970
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10456-013-9365-6

GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy

Autores: M Firczuk, M Gabrysiak, J Barankiewicz, A Domagala, D Nowis, M Kujawa, E Jankowska-Steifer, M Wachowska, E Glodkowska-Mrowka, B Korsak, M Winiarska, J Golab
Publicado en: Cell Death and Disease, Edición 20414889, 2013, Página(s) e741, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/cddis.2013.265

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

Autores: Patrick C O’Leary, Marta Terrile, Malgorzata Bajor, Pawel Gaj, Bryan T Hennessy, Gordon B Mills, Agnieszka Zagozdzon, Darran P O’Connor, Donal J Brennan, Kate Connor, Jane Li, Ana Gonzalez-Angulo, Han-Dong Sun, Jian-Xin Pu, Fredrik Pontén, Mathias Uhlén, Karin Jirström, Dominika A Nowis, John P Crown, Radoslaw Zagozdzon, William M Gallagher
Publicado en: Breast Cancer Research, Edición 14655411, 2014, Página(s) R79, ISSN 1465-5411
Editor: BioMed Central
DOI: 10.1186/bcr3691

Interleukin 12: still a promising candidate for tumor immunotherapy?

Autores: Witold Lasek, Radosław Zagożdżon, Marek Jakobisiak
Publicado en: Cancer Immunology, Immunotherapy, Edición 03407004, 2014, Página(s) 419-435, ISSN 0340-7004
Editor: Springer Verlag
DOI: 10.1007/s00262-014-1523-1

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

Autores: A. M. Dudek-Peri , G. B. Ferreira, A. Muchowicz, J. Wouters, N. Prada, S. Martin, S. Kiviluoto, M. Winiarska, L. Boon, C. Mathieu, J. van den Oord, M. Stas, M.-L. Gougeon, J. Golab, A. D. Garg, P. Agostinis
Publicado en: Cancer Research, Edición 00085472, 2015, Página(s) 1603-1614, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-2089

In silico analysis of microRNA-510 as a potential oncomir in human breast cancer

Autores: Pawel Gaj, Radoslaw Zagozdzon
Publicado en: Breast Cancer Research, Edición 14655411, 2014, Página(s) 403, ISSN 1465-5411
Editor: BioMed Central
DOI: 10.1186/bcr3624

Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses

Autores: Malgorzata Wachowska, Magdalena Gabrysiak, Jakub Golab
Publicado en: OncoImmunology, Edición 2162402X, 2014, Página(s) e28837, ISSN 2162-402X
Editor: Landes Bioscience, Austin, TX
DOI: 10.4161/onci.28837

Abstract LB-242: PTEN regulates the CD20 antigen expression and affects rituximab-based therapy of lymphoma malignancies

Autores: Beata Pyrzynska, Kamil Bojarczuk, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Jakub Golab, Magdalena Winiarska
Publicado en: Cancer Research, Edición 00085472, 2015, Página(s) LB-242-LB-242, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/1538-7445.AM2015-LB-242

Abstract P5-07-09: Adenanthin, a new peroxiredoxin inhibitor, induces a switch between estrogen receptor alpha-mediated and Src/Akt-driven signaling in breast cancer cells

Autores: Malgorzata Bajor, Agata O Zych, Patrick C O'Leary, Anna Czekalska, William M Gallagher, Jakub Golab, Radoslaw Zagozdzon
Publicado en: Cancer Research, Edición 00085472, 2015, Página(s) P5-07-09-P5-07-09, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/1538-7445.SABCS14-P5-07-09

Abstract 3919: Targeting urease to human VEGFR2 elicits antitumor activity in triple-negative breast cancer models

Autores: Angelika Muchowicz, Anna Bujak, Beata Pyrzynska, Justyna Karolczak, Abdessamad Zerrouqi, Magdalena Ozga, Lukasz Szewczyk, Baomin Tian, Wah Wong, Marni Uger, Katarzyna Poplawska, Dorota Gierej, Pawel Wisniewski, Heman Chao, Magdalena Winiarska, Radoslaw Zagozdzon
Publicado en: Cancer Research, Edición 78, Suppl 13, 2018, Página(s) 3919-3919
Editor: American Association for Cancer Research

Ovarian cancer cells release arginase-1-containing exosomes to suppress antitumor immune response

Autores: Malgorzata Czystowska, Marta Szajnik, Kavita Ramji, Slawomir Gruca, Artur Stefanowicz, Jakub Golab, Dominika Nowis
Publicado en: Cancer Research, Edición 77, Suppl 13, 2017, Página(s) 3975-3975
Editor: American Association for Cancer Research

FOXO1 determines non-Hodgkin lymphomas response to anti-CD20-based therapy

Autores: Abdessamad Zerrouqi, Beata Pyrzynska, Michal Dwoyak, giulia Morlino, Piotr Zapala, Nina Miazek, Jakub Golab, Magdalena Winiarska
Publicado en: Cancer Research, Edición 78/10, Suppl, 2018, Página(s) B51-B51
Editor: American Association for Cancer Research

Dasatinib Effect on NK Cells and Anti-Tumor Immunity

Autores: Mieszko Lachota, Marta Siernicka, Zofia Pilch, Agnieszka Graczyk-Jarzynka and Magdalena Winiarska
Publicado en: Blood, Edición 132 (Suppl 1), 2018, Página(s) 3004
Editor: ASH

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Autores: Binu K Sasi, Sven Turkalj, Hilal Kalkan, Fabiola Porro, Engin Bojnik, Beata Pyrzynska, Abdessamad Zerrouqi, Malgorzata Bobrowicz, Magdalena Winiarska, Valdemar Priebe, Francesco Bertoni, Larry Mansouri, Richard Rosenquist and Dimitar G Efremov
Publicado en: Blood, Edición 132 (Suppl 1), 2018, Página(s) 2860
Editor: ASH

Lysosomal Disruption Augments Obinutuzumab-Induced Direct Cell Death

Autores: Antoni Domagala, Malgorzata Bobrowicz, Joanna Stachura, Marta Siernicka, Piotr Mrowka, Michal Dwojak, Beata Pyrzynska, Malgorzata Firczuk and Magdalena Winiarska
Publicado en: Blood, Edición 128/22, 2016, Página(s) 2766
Editor: ASH

HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy

Autores: Malgorzata Bobrowicz, Joanna Stachura, Michal Dwojak, Antoni Domagala, Beata Pyrzynska, Elise Berthel, Nicole Dalla Venezia, Marta Siernicka, Malgorzata Firczuk and Magdalena Winiarska
Publicado en: Blood, Edición 128/22, 2016, Página(s) 1586
Editor: ASH

NK cells cytotoxicity is affected by various BTK inhibitors

Autores: Siernicka, M.; Bojarczuk, K.; Bobrowicz, M.; et al.
Publicado en: HAEMATOLOGICA, 2015, Página(s) 549-550, Abstract: E1372
Editor: European-Hematology-Association

Ofatumumab overcomes CD59-dependent resistance to complement-dependent cytotoxicity in human B-cell lymphoma model

Autores: Dwojak, M.; Bobrowicz, M.; Siernicka, M.; et al.
Publicado en: HAEMATOLOGICA, 2015, Página(s) 552-552, Abstract: E1379
Editor: European-Hematology-Association

SRC inhibitors downregulate CD20 and modulate the activity of the CD20 promoter

Autores: Winiarska, M.; Bojarczuk, K.; Pyrzynska, B.; et al
Publicado en: HAEMATOLOGICA, 2014, Página(s) 45, Abstract: P211
Editor: European-Hematology-Association

MEK1 inhibitor selumetinib sensitizes B-cell Acute Lymphoblastic Leukemia (B-ALL) cells to dexamethasone by modulating autophagy

Autores: Polak, A.; Kiliszek, P.; Sewastianik, T.; Szydlowski, M.; Jablonska, E.; Prusisz, W.; Bialopiotrowicz, E.; Markowicz, S.; Nowak, E.; Grygorowicz, M.; Nowis, D.; Bojarczuk, K.; Golab, J.; Juszczynski, P.
Publicado en: HAEMATOLOGICA, 2014, Página(s) 272, Abstract: P751
Editor: European-Hematology-Association

SK053-an allosteric protein disulphide isomerase inhibitor induces differentiation of human acute myeloid leukemia cells

Autores: Golab, J.; Chlebowska, J.; Firczuk, M.; et al.
Publicado en: HAEMATOLOGICA, 2014, Página(s) 296, Abstract: P809
Editor: European-Hematology-Association

FoxO1 transcription factor mediates toxicity of SYK inhibition in DLBCL

Autores: Kiliszek, P.; Szydlowski, M.; Sewastianik, T.; Bialopiotrowicz, E.; Jablonska, E.; Polak, A.; Prusisz, W.; Markowicz, S.; Nowak, E.; Grygorowicz, MA.; Bojarczuk, K.; Winiarska, M.; Golab, J.; Juszczynski, P.
Publicado en: HAEMATOLOGICA, 2014, Página(s) 137, Abstract: P430
Editor: European-Hematology-Association

HDAC6 inhibition augments the efficacy of anti-CD20 monoclonal antibodies by up-regulating CD20 level in malignant B-cells

Autores: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Publicado en: HAEMATOLOGICA, 2014, Página(s) 437, Abstract: P1143
Editor: European-Hematology-Association

Protein disulphide inhibitors induce differentiation of human acute myeloid leukemia cells

Autores: Chlebowska, J.; Firczuk, M.; Furs, K.; et al.
Publicado en: HAEMATOLOGICA, 2014, Página(s) 558, Abstract: PB1430
Editor: European-Hematology-Association

HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies

Autores: Bobrowicz, Malgorzata; Dwojak, Michal; Malenda, Agata; et al.
Publicado en: BLOOD, 2014
Editor: American-Society-of-Hematology

Influence of Btk Inhibitors on Antitumor Activity of Natural Killer Cells

Autores: Siernicka, Marta; Bojarczuk, Kamil; Bobrowicz, Malgorzata; et al.
Publicado en: BLOOD, 2014
Editor: American-Society-of-Hematology

SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell

Autores: Chlebowska, Justyna; Gaj, Pawel; Stawinski, Piotr; et al.
Publicado en: BLOOD, 2014
Editor: American-Society-of-Hematology

Peroxiredoxins-1 and 2 Affect Proliferation and Survival of Lymphoma Cells

Autores: Firczuk, Malgorzata; Trzeciecka, Anna; Bajor, Malgorzata; et al.
Publicado en: BLOOD, 2014
Editor: American-Society-of-Hematology

Inhibitors of B-Cell Receptor Molecules Affect Surface CD20 and Impair Antitumor Activity of Anti-CD20 Monoclonal Antibodies

Autores: Bojarczuk, Kamil; Winiarska, Magdalena; Bobrowicz, Malgorzata; et al.
Publicado en: BLOOD, 2013, Página(s) Abstract: 4217
Editor: American-Society-of-Hematology

SK053 An Inhibitor of Enzymes Involved In Allosteric Disulfide Bonds Formation Induces Differentiation of Human AML Cells

Autores: Chlebowska, Justyna; Firczuk, Malgorzata; Furs, Karolina; et al.
Publicado en: BLOOD, 2013, Página(s) Abstract: 4215
Editor: American-Society-of-Hematology

Inhibitors of SRC family and AKT regulate the activity of CD20 promoter

Autores: Pyrzynska B., Bojarczuk K., Winiarska M. Bil J. Miazek N. Zapala P., Bobrowicz M., Dwojak M., Siernicka M., Golab J.
Publicado en: BLOOD, 2013, Página(s) Abstract: 1838
Editor: American-Society-of-Hematology

A novel pathway regulating CD20 level influence of the inhibition of HDAC6 on the efficacy of anti-CD20 antibodies

Autores: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Publicado en: FEBS JOURNAL, 2014, Página(s) 239-240, Abstract: SUN-509
Editor: FEBS; EMBO

Regulation of CD20 levels in B-cell tumors by SRC family kinases

Autores: Bojarczuk, K.; Winiarska, M.; Bil, J.; et al.
Publicado en: FEBS JOURNAL, 2013, Página(s) 474
Editor: Federat European Biochemical Soc

Thiol-Reactive Peptidomimetic SK053 Targets Dimeric Peroxiredoxins in Human Lymphoma Cell Lines. Oral presentation.

Autores: Firczuk, M; Trzeciecka, A; Klosowski, S; et al.
Publicado en: Journal of International Society of Antioxidants in Health & Nutrition, 2015, Página(s) 43
Editor: International Society of Antioxidants

Influence of BCR inhibitors on CD20 regulation in tumor cells

Autores: Kamil Bojarczuk; Supervisor 1: Dominika Nowis, MD, PhD; Supervisor 2: Magdalena Winiarska, PhD
Publicado en: 2015
Editor: Medical University of Warsaw, I Faculty of Medicine, Warsaw

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