Strategies towards Excellence in Immuno-Oncology

Risultati finali

Report on overall promotional activities I

Report will summarize the Promotional activities related to the project.

Report from the Steering Group Meeting I

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M36

Report on transfer of know-how and best practices to MUW as a result of twinning visits in collaborating institutions; will include the analysis of added value for potential increase of research capacity / quality of MUW and the analysis of STREAM funds exploitation; will be discussed during the annual Steering Group meetings.

"Report on organization of theoretical workshop - ""Adoptive immunotherapy for cancer"""

Report on organized workshop will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on know-how knowledge dissemination at MUW - M12

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on participation in international research/innovation conferences - M36

Report on the attendance of European and world-wide conferences, symposia and meetings will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits.

Specifications of training material used for the twinning visits

Deliverable D37 will include the list of training materials to be used to deliver high-quality training during the twinning visits.

Report on management activities III

Report will summarize the yearly Management activities.

Report from the Steering Group Meeting III

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on publications, patents and funding support resulting from twinning visits

Report on publications, patents and funding support, resulting from twinning visits.

Report from the Steering Group Meeting II

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M24

Report on overall promotional activities III

Report will summarize the Promotional activities related to the project.

Report on knowledge dissemination - M18

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during hands-on workshop

Report on the promotional activities undertaken before and during the workshop.

"Report on organization of international summer-school - ""Immuno-Oncology"""

Report on organized summer-school will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on participation in international research/innovation conferences - M18

Report on know-how transfer through twinning visits - M12

Report on promotional activities undertaken during theoretical workshop

Report on the promotional activities undertaken before and during the workshop.

Report on prior publications of the coordinator

A one-page statement that the information about prior publications of the coordinator has been provided.

Report on overall promotional activities II

Report will summarize the Promotional activities related to the project.

Report on know-how knowledge dissemination at MUW - M36

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on management activities II

Report will summarize the yearly Management activities.

Report on management activities I

Report will summarize the yearly Management activities.

Report on knowledge dissemination - M36

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during summer-school

Report on the promotional activities undertaken before and during the summer-school.

Report on STREAM webpage launching

Report on the STREAM webpage launching is considered a Milestone in project implementation since it will be the basis for communication and promotion of the project.

"Report on organization of hands-on workshop - ""Application of flow cytometry methods in Immuno-Oncology"""

Report on know-how knowledge dissemination at MUW - M24

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Pubblicazioni

MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Autori: Anna Polak, Przemysław Kiliszek, Tomasz Sewastianik, Maciej Szydłowski, Ewa Jabłońska, Emilia Białopiotrowicz, Patryk Górniak, Sergiusz Markowicz, Eliza Nowak, Monika A. Grygorowicz, Monika Prochorec-Sobieszek, Dominika Nowis, Jakub Gołąb, Sebastian Giebel, Ewa Lech-Marańda, Krzysztof Warzocha, Przemysław Juszczyński
Pubblicato in: PLOS ONE, Numero 11/5, 2016, Pagina/e e0155893, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0155893

HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Autori: Malgorzata Bobrowicz, Michal Dwojak, Beata Pyrzynska, Joanna Stachura, Angelika Muchowicz, Elise Berthel, Nicole Dalla Venezia, Mieszko Kozikowski, Marta Siernicka, Nina Miazek, Piotr Zapala, Antoni Domagala, Kamil Bojarczuk, Agata Malenda, Joanna Barankiewicz, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Magdalena Gabrysiak, Jean-Jacques Diaz, Marta Karp, Ewa Lech-Maranda, Malgorzata Firczuk,
Pubblicato in: Blood, Numero 130(14):1628-1638, 2017, Pagina/e blood-2016-08-736066, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2016-08-736066

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

Autori: Anna Trzeciecka, Szymon Klossowski, Malgorzata Bajor, Radoslaw Zagozdzon, Pawel Gaj, Angelika Muchowicz, Agata Malinowska, Anna Czerwoniec, Joanna Barankiewicz, Antoni Domagala, Justyna Chlebowska, Monika Prochorec-Sobieszek, Magdalena Winiarska, Ryszard Ostaszewski, Iwonna Gwizdalska, Jakub Golab, Dominika Nowis, Malgorzata Firczuk
Pubblicato in: Oncotarget, Numero 7/2, 2016, Pagina/e 1717-1731, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.6435

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo

Autori: MAGDALENA GABRYSIAK, MALGORZATA WACHOWSKA, JOANNA BARANKIEWICZ, ZOFIA PILCH, ANNA RATAJSKA, EWA SKRZYPEK, MAGDALENA WINIARSKA, ANTONI DOMAGALA, TOMASZ P. RYGIEL, ALICJA JOZKOWICZ, LOUIS BOON, JAKUB GOLAB, MALGORZATA FIRCZUK
Pubblicato in: Oncology Reports, Numero 35/6, 2016, Pagina/e 3151-3158, ISSN 1021-335X
Editore: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/or.2016.4723

The Anatomy of Caprine Female Urethra and Characteristics of Muscle and Bone Marrow Derived Caprine Cells for Autologous Cell Therapy Testing

Autori: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wisniewska, Agnieszka Kulesza, Radoslaw Zagozdzon, Zdzislaw Gajewski, Leszek Paczek
Pubblicato in: The Anatomical Record, Numero 300/3, 2017, Pagina/e 577-588, ISSN 1932-8486
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ar.23498

Iterative Sequencing and Variant Screening (ISVS) as a novel pathogenic mutations search strategy - application for TMPRSS3 mutations screen

Autori: Urszula Lechowicz, Tomasz Gambin, Agnieszka Pollak, Anna Podgorska, Piotr Stawinski, Andre Franke, Britt-Sabina Petersen, Malgorzata Firczuk, Monika Oldak, Henryk Skarzynski, Rafal Ploski
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-02315-w

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

Autori: Beata Pyrzynska, Michal Dwojak, Abdessamad Zerrouqi, Giulia Morlino, Piotr Zapala, Nina Miazek, Agnieszka Zagozdzon, Kamil Bojarczuk, Malgorzata Bobrowicz, Marta Siernicka, Marcin M. Machnicki, Stefania Gobessi, Joanna Barankiewicz, Ewa Lech-Maranda, Dimitar G. Efremov, Przemyslaw Juszczynski, Dinis Calado, Jakub Golab, Magdalena Winiarska
Pubblicato in: OncoImmunology, Numero 7/5, 2018, Pagina/e e1423183, ISSN 2162-402X
Editore: Taylor & Francis
DOI: 10.1080/2162402X.2017.1423183

Application of Genome Editing Techniques in Immunology

Autori: Agata O. Zych, Malgorzata Bajor, Radoslaw Zagozdzon
Pubblicato in: Archivum Immunologiae et Therapiae Experimentalis, Numero 66/4, 2018, Pagina/e 289-298, ISSN 0004-069X
Editore: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0504-z

Selection of an optimal promoter for gene transfer in normal B cells

Autori: Magdalena Winiarska, Dominika Nowis, Malgorzata Firczuk, Agnieszka Zagozdzon, Magdalena Gabrysiak, Radoslaw Sadowski, Joanna Barankiewicz, Michal Dwojak, Jakub Golab
Pubblicato in: Molecular Medicine Reports, Numero 16/3, 2017, Pagina/e 3041-3048, ISSN 1791-2997
Editore: Spandidos Publications
DOI: 10.3892/mmr.2017.6974

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

Autori: Seweryn Mroczek, Justyna Chlebowska, Tomasz M. Kuliński, Olga Gewartowska, Jakub Gruchota, Dominik Cysewski, Vladyslava Liudkovska, Ewa Borsuk, Dominika Nowis, Andrzej Dziembowski
Pubblicato in: Nature Communications, Numero 8/1, 2017, Pagina/e 619, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-00578-5

In vivo imaging system for explants analysis—A new approach for assessment of cell transplantation effects in large animal models

Autori: Weronika Zarychta-Wiśniewska, Anna Burdzinska, Radosław Zagozdzon, Bartosz Dybowski, Marta Butrym, Zdzisław Gajewski, Leszek Paczek
Pubblicato in: PLOS ONE, Numero 12/9, 2017, Pagina/e e0184588, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0184588

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors

Autori: Vincent Yi Sheng Oei, Marta Siernicka, Agnieszka Graczyk-Jarzynka, Hanna Julie Hoel, Weiwen Yang, Daniel Palacios, Hilde Almåsbak, Malgorzata Bajor, Dennis Clement, Ludwig Brandt, Björn Önfelt, Jodie Goodridge, Magdalena Winiarska, Radoslaw Zagozdzon, Johanna Olweus, Jon-Amund Kyte, Karl-Johan Malmberg
Pubblicato in: Cancer Immunology Research, Numero 6/4, 2018, Pagina/e 467-480, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.CIR-17-0207

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

Autori: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk
Pubblicato in: BMC Cancer, Numero 18/1, 2018, Pagina/e 210, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-018-4126-y

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Autori: Natalia Krata, Radosław Zagożdżon, Bartosz Foroncewicz, Krzysztof Mucha
Pubblicato in: Archivum Immunologiae et Therapiae Experimentalis, Numero 66/3, 2018, Pagina/e 211-220, ISSN 0004-069X
Editore: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0496-0

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy

Autori: Antoni Domagala, Klaudyna Fidyt, Malgorzata Bobrowicz, Joanna Stachura, Kacper Szczygiel, Malgorzata Firczuk
Pubblicato in: International Journal of Molecular Sciences, Numero 19/8, 2018, Pagina/e 2256, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082256

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

Autori: Marcin Waligora, Malgorzata M. Bala, Magdalena Koperny, Mateusz T. Wasylewski, Karolina Strzebonska, Rafał R. Jaeschke, Agnieszka Wozniak, Jan Piasecki, Agnieszka Sliwka, Jerzy W. Mitus, Maciej Polak, Dominika Nowis, Dean Fergusson, Jonathan Kimmelman
Pubblicato in: PLOS Medicine, Numero 15/2, 2018, Pagina/e e1002505, ISSN 1549-1676
Editore: PLOS Medicine
DOI: 10.1371/journal.pmed.1002505

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

Autori: Justyna Chlebowska-Tuz, Olga Sokolowska, Pawel Gaj, Michal Lazniewski, Malgorzata Firczuk, Karolina Borowiec, Hanna Sas-Nowosielska, Malgorzata Bajor, Agata Malinowska, Angelika Muchowicz, Kavita Ramji, Piotr Stawinski, Mateusz Sobczak, Zofia Pilch, Anna Rodziewicz-Lurzynska, Malgorzata Zajac, Krzysztof Giannopoulos, Przemyslaw Juszczynski, Grzegorz W. Basak, Dariusz Plewczynski, Rafal Ploski, Jak
Pubblicato in: Haematologica, Numero 103/11, 2018, Pagina/e 1843-1852, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.190231

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure

Autori: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski, Leszek Paczek
Pubblicato in: Stem Cell Research & Therapy, Numero 9/1, 2018, Pagina/e 239, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-018-0990-2

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Autori: Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Pubblicato in: BMC Cancer, Numero 18/1, 2018, Pagina/e 965, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-018-4852-1

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

Autori: Anna A. Marusiak, Monika K. Prelowska, Dawid Mehlich, Michal Lazniewski, Klaudia Kaminska, Adam Gorczynski, Aleksandra Korwat, Olga Sokolowska, Hanna Kedzierska, Jakub Golab, Wojciech Biernat, Dariusz Plewczynski, John Brognard, Dominika Nowis
Pubblicato in: Oncogene, 2018, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-018-0618-0

Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

Autori: Agnieszka Graczyk-Jarzynka, Agnieszka Goral, Angelika Muchowicz, Radoslaw Zagozdzon, Magdalena Winiarska, Malgorzata Bajor, Anna Trzeciecka, Klaudyna Fidyt, Joanna Alicja Krupka, Julia Cyran, Kacper Szczygiel, Dimitar G. Efremov, Stefania Gobessi, Adam Jagielski, Karolina Siudakowska, Malgorzata Bobrowicz, Marta Klopotowska, Joanna Barankiewicz, Agata Malenda, Ewa Lech-Maranda, Nina Miazek-Zapala,
Pubblicato in: Redox Biology, Numero 21, 2019, Pagina/e 101062, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2018.11.020

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

Autori: Malgorzata Bajor, Agata O. Zych, Agnieszka Graczyk-Jarzynka, Angelika Muchowicz, Malgorzata Firczuk, Lech Trzeciak, Pawel Gaj, Antoni Domagala, Marta Siernicka, Agnieszka Zagozdzon, Pawel Siedlecki, Monika Kniotek, Patrick C. O’Leary, Jakub Golab, Radoslaw Zagozdzon
Pubblicato in: British Journal of Cancer, Numero 119/7, 2018, Pagina/e 873-884, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-018-0263-y

STING Signaling in Cancer Cells: Important or Not?

Autori: Olga Sokolowska, Dominika Nowis
Pubblicato in: Archivum Immunologiae et Therapiae Experimentalis, Numero 66/2, 2018, Pagina/e 125-132, ISSN 0004-069X
Editore: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0481-7

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy

Autori: Arkadiusz Urbanowicz, Radosław Zagożdżon, Michał Ciszek
Pubblicato in: Archivum Immunologiae et Therapiae Experimentalis, 2018, ISSN 0004-069X
Editore: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0532-8

The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies

Autori: Zofia Pilch, Katarzyna Tonecka, Marcin Skorzynski, Zuzanna Sas, Agata Braniewska, Tomasz Kryczka, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Pubblicato in: PLOS ONE, Numero 14/1, 2019, Pagina/e e0210796, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0210796

Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome

Autori: Florian Anzengruber, Desislava Ignatova, Tanja Schlaepfer, Yun-Tsan Chang, Lars E. French, Steve Pascolo, Emmanuel Contassot, Malgorzata Bobrowicz, Wolfram Hoetzenecker, Emmanuella Guenova
Pubblicato in: Leukemia & Lymphoma, 2019, Pagina/e 1-9, ISSN 1042-8194
Editore: Taylor & Francis
DOI: 10.1080/10428194.2018.1564827

Dissection of CD20 regulation in lymphoma using RNAi

Autori: M Słabicki, K S Lee, A Jethwa, L Sellner, F Sacco, T Walther, J Hüllein, S Dietrich, B Wu, D B Lipka, C C Oakes, S Mamidi, B Pyrzyńska, M Winiarska, M Oleś, M Seifert, C Plass, M Kirschfink, M Boettcher, J Gołąb, W Huber, S Fröhling, T Zenz
Pubblicato in: Leukemia, Numero 30/12, 2016, Pagina/e 2409-2412, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.230

Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity

Autori: Ole-Jacob Norum, Ane Sofie Viset Fremstedal, Anette Weyergang, Jakub Golab, Kristian Berg
Pubblicato in: Journal of Controlled Release, Numero 268, 2017, Pagina/e 120-127, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2017.10.015

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice

Autori: Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W. Kilarski, Louis Boon, Tomasz J. Klaus, Jakub Golab
Pubblicato in: European Journal of Cancer, Numero 83, 2017, Pagina/e 19-27, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2017.06.004

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Autori: Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, Robert Koralewski, Wojciech Czestkowski, Anna Jedrzejczak, Jakub Golab, Karolina Dzwonek, Barbara Dymek, Piotr L. Sklepkiewicz, Agnieszka Zagozdzon, Tom Noonan, Keyvan Mahboubi, Bruce Conway, Ryan Sheeler, Paul Beckett, William M. Hungerford, Alberto Podjarny, Andre Mitschler, Alexandra Cousido-Siah, Firas Fadel, Adam Golebiowski
Pubblicato in: Journal of Medicinal Chemistry, Numero 61/3, 2018, Pagina/e 695-710, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01051

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

Autori: Luca Laurenti, Francesco Autore, Idanna Innocenti, Giovanni D’Arena, Marta Coscia, Patrizia Mondello, Patrizia Chiusolo, Silvia Bellesi, Dimitar G. Efremov, Simona Sica, Francesca Romana Mauro
Pubblicato in: Leukemia & Lymphoma, Numero 57/10, 2016, Pagina/e 2429-2431, ISSN 1042-8194
Editore: Taylor & Francis
DOI: 10.3109/10428194.2015.1137293

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

Autori: G Lohmann, E Vasyutina, J Bloehdorn, N Reinart, J I Schneider, V Babu, G Knittel, G Crispatzu, P Mayer, C Prinz, J K Muenzner, B Biersack, D G Efremov, L Chessa, C D Herling, S Stilgenbauer, M Hallek, R Schobert, H C Reinhardt, B Schumacher, M Herling
Pubblicato in: Leukemia, Numero 31/5, 2017, Pagina/e 1177-1186, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.294

B-cell receptor signaling in the pathogenesis of lymphoid malignancies

Autori: Kamil Bojarczuk, Malgorzata Bobrowicz, Michal Dwojak, Nina Miazek, Piotr Zapala, Anders Bunes, Marta Siernicka, Maria Rozanska, Magdalena Winiarska
Pubblicato in: Blood Cells, Molecules, and Diseases, Numero 55/3, 2015, Pagina/e 255-265, ISSN 1079-9796
Editore: Academic Press
DOI: 10.1016/j.bcmd.2015.06.016

SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress

Autori: Angelika Muchowicz, Małgorzata Firczuk, Małgorzata Wachowska, Marek Kujawa, Ewa Jankowska-Steifer, Magdalena Gabrysiak, Zofia Pilch, Szymon Kłossowski, Ryszard Ostaszewski, Jakub Golab
Pubblicato in: Biochemical Pharmacology, Numero 93/4, 2015, Pagina/e 418-427, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2014.12.019

Adenanthin targets proteins involved in the regulation of disulphide bonds

Autori: Angelika Muchowicz, Małgorzata Firczuk, Justyna Chlebowska, Dominika Nowis, Joanna Stachura, Joanna Barankiewicz, Anna Trzeciecka, Szymon Kłossowski, Ryszard Ostaszewski, Radosław Zagożdżon, Jian-Xin Pu, Han-Dong Sun, Jakub Golab
Pubblicato in: Biochemical Pharmacology, Numero 89/2, 2014, Pagina/e 210-216, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2014.02.022

Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy

Autori: Aleksandra Maria Dudek-Perić, Jakub Gołąb, Abhishek D Garg, Patrizia Agostinis
Pubblicato in: OncoImmunology, Numero 4/12, 2015, Pagina/e e1054600, ISSN 2162-402X
Editore: Taylor & Francis
DOI: 10.1080/2162402x.2015.1054600

Neurodevelopmental phenotype caused by a de novo PTPN4 single nucleotide variant disrupting protein localization in neuronal dendritic spines

Autori: Krzysztof Szczałuba, Joanna J. Chmielewska, Olga Sokolowska, Małgorzata Rydzanicz, Krystyna Szymańska, Wojciech Feleszko, Paweł Włodarski, Anna Biernacka, Victor Murcia Pienkowski, Anna Walczak, Elżbieta Bargeł, Katarzyna Królewczyk, Agata Nowacka, Piotr Stawiński, Dominika Nowis, Magdalena Dziembowska, Rafał Płoski
Pubblicato in: Clinical Genetics, Numero 94/6, 2018, Pagina/e 581-585, ISSN 0009-9163
Editore: Blackwell Publishing Inc.
DOI: 10.1111/cge.13450

Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment

Autori: Zofia Pilch, Katarzyna Tonecka, Agata Braniewska, Zuzanna Sas, Marcin Skorzynski, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Pubblicato in: Cancer Immunology Research, Numero 6/8, 2018, Pagina/e 930-940, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0454

Outcomes of Prolonged Treatment With Intravenous Immunoglobulin Infusions for Acute Antibody-mediated Rejection in Kidney Transplant Recipients

Autori: A. Bujnowska, M. Michon, P. Konopelski, E. Hryniewiecka, A. Jalbrzykowska, A. Perkowska-Ptasinska, T. Cieciura, R. Zagozdzon, L. Paczek, M. Ciszek
Pubblicato in: Transplantation Proceedings, Numero 50/6, 2018, Pagina/e 1720-1725, ISSN 0041-1345
Editore: Appleton & Lange
DOI: 10.1016/j.transproceed.2018.02.110

Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase

Autori: Marzena Mazur, Agnieszka Bartoszewicz, Barbara Dymek, Magdalena Salamon, Gleb Andryianau, Michał Kowalski, Sylwia Olejniczak, Krzysztof Matyszewski, Elżbieta Pluta, Bartłomiej Borek, Filip Stefaniak, Agnieszka Zagozdzon, Marcin Mazurkiewicz, Robert Koralewski, Wojciech Czestkowski, Michał Piotrowicz, Piotr Niedziejko, Mariusz M. Gruza, Karolina Dzwonek, Adam Golebiowski, Jakub Golab, Jacek Olc
Pubblicato in: Bioorganic & Medicinal Chemistry Letters, Numero 28/3, 2018, Pagina/e 310-314, ISSN 0960-894X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2017.12.047

Bortezomib-Induced Muscle Toxicity in Multiple Myeloma

Autori: Valeria Guglielmi, Dominika Nowis, Martina Tinelli, Manuela Malatesta, Laura Paoli, Matteo Marini, Paolo Manganotti, Radoslaw Sadowski, Grzegorz M. Wilczynski, Vittorio Meneghini, Giuliano Tomelleri, Gaetano Vattemi
Pubblicato in: Journal of Neuropathology & Experimental Neurology, Numero 76/7, 2017, Pagina/e 620-630, ISSN 0022-3069
Editore: American Association of Neuropathologists, Inc.
DOI: 10.1093/jnen/nlx043

The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development

Autori: Joanna Stachura, Malgorzata Wachowska, Witold W. Kilarski, Esra Güç, Jakub Golab, Angelika Muchowicz
Pubblicato in: OncoImmunology, Numero 5/7, 2016, Pagina/e e1182278, ISSN 2162-402X
Editore: Taylor&Francis
DOI: 10.1080/2162402X.2016.1182278

New insights into redox homeostasis as a therapeutic target in B-cell malignancies

Autori: Agnieszka Graczyk-Jarzynka, Radoslaw Zagozdzon, Angelika Muchowicz, Marta Siernicka, Malgorzata Firczuk, Przemyslaw Juszczynski
Pubblicato in: Current Opinion in Hematology, Numero 24/4, 2017, Pagina/e 1, ISSN 1065-6251
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOH.0000000000000351

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

Autori: Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, Vincenzo Cerundolo
Pubblicato in: Cancer Research, Numero 76/21, 2016, Pagina/e 6193-6204, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-3502

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199

Autori: K. Bojarczuk, B. K. Sasi, S. Gobessi, I. Innocenti, G. Pozzato, L. Laurenti, D. G. Efremov
Pubblicato in: Blood, Numero 127/25, 2016, Pagina/e 3192-3201, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2015-10-675009

IL-4 regulates B-cell receptor signaling in CLL

Autori: D. G. Efremov
Pubblicato in: Blood, Numero 128/4, 2016, Pagina/e 468-469, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2016-06-719872

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Autori: Andreas T. Björklund, Trevor Clancy, Jodie P. Goodridge, Vivien Béziat, Marie Schaffer, Eivind Hovig, Hans-Gustaf Ljunggren, Per T. Ljungman, Karl-Johan Malmberg
Pubblicato in: The Journal of Immunology, Numero 196/3, 2016, Pagina/e 1400-1411, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1501434

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells

Autori: P. J. Brown, D. M. Gascoyne, L. Lyne, H. Spearman, S. L. Felce, N. McFadden, P. Chakravarty, S. Barrans, S. Lynham, D. P. Calado, M. Ward, A. H. Banham
Pubblicato in: Haematologica, Numero 101/7, 2016, Pagina/e 861-871, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142141

Modulation of cancer-specific immune responses by amino acid degrading enzymes

Autori: Elina Timosenko, Andreas V Hadjinicolaou, Vincenzo Cerundolo
Pubblicato in: Immunotherapy, Numero 9/1, 2017, Pagina/e 83-97, ISSN 1750-743X
Editore: Future Medicine Ltd.
DOI: 10.2217/imt-2016-0118

FOXO discriminates tonic from chronic in DLBCL

Autori: D. G. Efremov
Pubblicato in: Blood, Numero 127/6, 2016, Pagina/e 669-670, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2015-12-683441

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Autori: Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat
Pubblicato in: Cell Reports, Numero 15/5, 2016, Pagina/e 1088-1099, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.04.005

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA

Autori: Nadia Mensali, Fan Ying, Vincent Oei Yi Sheng, Weiwen Yang, Even Walseng, Shraddha Kumari, Lars-Egil Fallang, Arne Kolstad, Wolfgang Uckert, Karl Johan Malmberg, Sébastien Wälchli, Johanna Olweus
Pubblicato in: OncoImmunology, Numero 5/5, 2016, Pagina/e e1138199, ISSN 2162-402X
Editore: Taylor&Francis
DOI: 10.1080/2162402X.2016.1138199

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

Autori: Luca Laurenti, Idanna Innocenti, Francecso Autore, Simona Sica, Dimitar Efremov
Pubblicato in: OncoTargets and Therapy, 2016, Pagina/e 421, ISSN 1178-6930
Editore: Dove Medical Press Ltd
DOI: 10.2147/OTT.S72845

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

Autori: Maryaline Coffre, David Benhamou, David Rieß, Lili Blumenberg, Valentina Snetkova, Marcus J. Hines, Tirtha Chakraborty, Sofia Bajwa, Kari Jensen, Mark M.W. Chong, Lelise Getu, Gregg J. Silverman, Robert Blelloch, Dan R. Littman, Dinis Calado, Doron Melamed, Jane A. Skok, Klaus Rajewsky, Sergei B. Koralov
Pubblicato in: Cell Reports, Numero 17/9, 2016, Pagina/e 2271-2285, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.11.006

Cognate HLA absence in trans diminishes human NK cell education

Autori: Vanessa Landtwing, Ana Raykova, Gaetana Pezzino, Vivien Béziat, Emanuela Marcenaro, Claudine Graf, Alessandro Moretta, Riccarda Capaul, Andrea Zbinden, Guido Ferlazzo, Karl-Johan Malmberg, Obinna Chijioke, Christian Münz
Pubblicato in: Journal of Clinical Investigation, Numero 126/10, 2016, Pagina/e 3772-3782, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI86923

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Autori: Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, Martin Herrmann, James W. Hodge, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, Walter G. Land, Frank Madeo, Angelo A. Manfredi, Stephen R. Mattarollo, Christian Maueroder, Nicolò Merendino, Gabriele Multhoff, Thomas Pabst, Jean-Ehrland Ricci, Chiara Riganti, Erminia Romano, Nicole Rufo, Mark J. Smyth, Jürgen Sonnemann, Radek Spisek, John Stagg, Erika Vacchelli, Peter Vandenabeele, Lien Vandenberk, Benoit J. Van den Eynde, Stefaan Van Gool, Francesca Velotti, Laurence Zitvogel, Patrizia Agostinis
Pubblicato in: Frontiers in Immunology, Numero 16643224, 2015, Pagina/e 588, ISSN 1664-3224
Editore: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00588

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity

Autori: Malgorzata Wachowska, Angelika Muchowicz, Jakub Golab
Pubblicato in: Frontiers in Oncology, Numero 2234943X, 2015, Pagina/e 176, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2015.00176

Review Cancer stem cells in haematological malignancies

Autori: Radoslaw Zagozdzon, Jakub Golab
Pubblicato in: Współczesna Onkologia, Numero 14282526, 2015, Pagina/e 1-6, ISSN 1428-2526
Editore: Termedia
DOI: 10.5114/wo.2014.47127

Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

Autori: Marta Siernicka, Magdalena Winiarska, Malgorzata Bajor, Malgorzata Firczuk, Angelika Muchowicz, Malgorzata Bobrowicz, Cyril Fauriat, Jakub Golab, Daniel Olive, Radoslaw Zagozdzon
Pubblicato in: Immunology, Numero 00192805, 2015, Pagina/e 173-183, ISSN 0019-2805
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imm.12494

Sorafenib improves rituximab and ofatumumab efficacy by decreasing the expression of complement regulatory proteins

Autori: M Dwojak, M Bobrowicz, J Bil, K Bojarczuk, B Pyrzynska, M Siernicka, A Malenda, E Lech-Maranda, W Tomczak, K Giannopoulos, J Golab, M Winiarska
Pubblicato in: Blood Cancer Journal, Numero 20445385, 2015, Pagina/e e300, ISSN 2044-5385
Editore: Nature Publishing Group
DOI: 10.1038/bcj.2015.27

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies

Autori: Magdalena Winiarska, Kamil Bojarczuk, Beata Pyrzynska, Jacek Bil, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Magdalena Krol, Aleksandra Syta, Paulina Podszywalow-Bartnicka, Zofia Pilch, Anna Dabrowska-Iwanicka, Przemyslaw Juszczynski, Dimitar G Efremov, Mikolaj Slabicki, Thorsten Zenz, Aude Le Roy, Daniel Olive, Tomasz P Rygiel, Jeanette HW Leusen, Jakub Golab
Pubblicato in: mAbs, Numero 19420870, 2014, Pagina/e 1300-1313, ISSN 1942-0870
Editore: Landes Bioscience
DOI: 10.4161/mabs.32106

Statins impair glucose uptake in human cells

Autori: D. Nowis, A. Malenda, K. Furs, B. Oleszczak, R. Sadowski, J. Chlebowska, M. Firczuk, J. M. Bujnicki, A. D. Staruch, R. Zagozdzon, E. Glodkowska-Mrowka, L. Szablewski, J. Golab
Pubblicato in: BMJ Open Diabetes Research & Care, Numero 20524897, 2014, Pagina/e e000017-e000017, ISSN 2052-4897
Editore: BMJ in partnership with the American Diabetes Association
DOI: 10.1136/bmjdrc-2014-000017

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Autori: Izabela Mlynarczuk-Bialy, Thorsten R. Doeppner, Jakub Golab, Dominika Nowis, Grzegorz M. Wilczynski, Kamil Parobczak, Moritz E. Wigand, Malgorzata Hajdamowicz, Łukasz P. Biały, Olga Aniolek, Petra Henklein, Mathias Bähr, Boris Schmidt, Ulrike Kuckelkorn, Peter-M. Kloetzel
Pubblicato in: Translational Oncology, Numero 19365233, 2014, Pagina/e 570-579, ISSN 1936-5233
Editore: Neoplasia Press
DOI: 10.1016/j.tranon.2014.07.002

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Autori: Maciej Serda, Danuta S. Kalinowski, Nathalie Rasko, Eliška Potůčková, Anna Mrozek-Wilczkiewicz, Robert Musiol, Jan G. Małecki, Mieczysław Sajewicz, Alicja Ratuszna, Angelika Muchowicz, Jakub Gołąb, Tomáš Šimůnek, Des R. Richardson, Jaroslaw Polanski
Pubblicato in: PLoS ONE, Numero 19326203, 2014, Pagina/e e110291, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0110291

Iron Chelators in Photodynamic Therapy Revisited: Synergistic Effect by Novel Highly Active Thiosemicarbazones

Autori: Anna Mrozek-Wilczkiewicz, Maciej Serda, Robert Musiol, Grzegorz Malecki, Agnieszka Szurko, Angelika Muchowicz, Jakub Golab, Alicja Ratuszna, Jaroslaw Polanski
Pubblicato in: ACS Medicinal Chemistry Letters, Numero 19485875, 2014, Pagina/e 336-339, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/ml400422a

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

Autori: K Bojarczuk, M Siernicka, M Dwojak, M Bobrowicz, B Pyrzynska, P Gaj, M Karp, K Giannopoulos, D G Efremov, C Fauriat, J Golab, M Winiarska
Pubblicato in: Leukemia, Numero 08876924, 2014, Pagina/e 1163-1167, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2014.12

Danger signalling during cancer cell death: origins, plasticity and regulation

Autori: A D Garg, S Martin, J Golab, P Agostinis
Pubblicato in: Cell Death and Differentiation, Numero 13509047, 2013, Pagina/e 26-38, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/cdd.2013.48

5-Aza-2′-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy

Autori: Malgorzata Wachowska, Magdalena Gabrysiak, Angelika Muchowicz, Weronika Bednarek, Joanna Barankiewicz, Tomasz Rygiel, Louis Boon, Pawel Mroz, Michael R Hamblin, Jakub Golab
Pubblicato in: European Journal of Cancer, Numero 09598049, 2014, Pagina/e 1370-1381, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2014.01.017

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Autori: Witold W. Kilarski, Angelika Muchowicz, Malgorzata Wachowska, Renata Mężyk-Kopeć, Jakub Golab, Melody A. Swartz, Patrycja Nowak-Sliwinska
Pubblicato in: Angiogenesis, Numero 09696970, 2014, Pagina/e 347-357, ISSN 0969-6970
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10456-013-9365-6

GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy

Autori: M Firczuk, M Gabrysiak, J Barankiewicz, A Domagala, D Nowis, M Kujawa, E Jankowska-Steifer, M Wachowska, E Glodkowska-Mrowka, B Korsak, M Winiarska, J Golab
Pubblicato in: Cell Death and Disease, Numero 20414889, 2013, Pagina/e e741, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/cddis.2013.265

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

Autori: Patrick C O’Leary, Marta Terrile, Malgorzata Bajor, Pawel Gaj, Bryan T Hennessy, Gordon B Mills, Agnieszka Zagozdzon, Darran P O’Connor, Donal J Brennan, Kate Connor, Jane Li, Ana Gonzalez-Angulo, Han-Dong Sun, Jian-Xin Pu, Fredrik Pontén, Mathias Uhlén, Karin Jirström, Dominika A Nowis, John P Crown, Radoslaw Zagozdzon, William M Gallagher
Pubblicato in: Breast Cancer Research, Numero 14655411, 2014, Pagina/e R79, ISSN 1465-5411
Editore: BioMed Central
DOI: 10.1186/bcr3691

Interleukin 12: still a promising candidate for tumor immunotherapy?

Autori: Witold Lasek, Radosław Zagożdżon, Marek Jakobisiak
Pubblicato in: Cancer Immunology, Immunotherapy, Numero 03407004, 2014, Pagina/e 419-435, ISSN 0340-7004
Editore: Springer Verlag
DOI: 10.1007/s00262-014-1523-1

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

Autori: A. M. Dudek-Peri , G. B. Ferreira, A. Muchowicz, J. Wouters, N. Prada, S. Martin, S. Kiviluoto, M. Winiarska, L. Boon, C. Mathieu, J. van den Oord, M. Stas, M.-L. Gougeon, J. Golab, A. D. Garg, P. Agostinis
Pubblicato in: Cancer Research, Numero 00085472, 2015, Pagina/e 1603-1614, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-2089

In silico analysis of microRNA-510 as a potential oncomir in human breast cancer

Autori: Pawel Gaj, Radoslaw Zagozdzon
Pubblicato in: Breast Cancer Research, Numero 14655411, 2014, Pagina/e 403, ISSN 1465-5411
Editore: BioMed Central
DOI: 10.1186/bcr3624

Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses

Autori: Malgorzata Wachowska, Magdalena Gabrysiak, Jakub Golab
Pubblicato in: OncoImmunology, Numero 2162402X, 2014, Pagina/e e28837, ISSN 2162-402X
Editore: Landes Bioscience, Austin, TX
DOI: 10.4161/onci.28837

Abstract LB-242: PTEN regulates the CD20 antigen expression and affects rituximab-based therapy of lymphoma malignancies

Autori: Beata Pyrzynska, Kamil Bojarczuk, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Jakub Golab, Magdalena Winiarska
Pubblicato in: Cancer Research, Numero 00085472, 2015, Pagina/e LB-242-LB-242, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/1538-7445.AM2015-LB-242

Abstract P5-07-09: Adenanthin, a new peroxiredoxin inhibitor, induces a switch between estrogen receptor alpha-mediated and Src/Akt-driven signaling in breast cancer cells

Autori: Malgorzata Bajor, Agata O Zych, Patrick C O'Leary, Anna Czekalska, William M Gallagher, Jakub Golab, Radoslaw Zagozdzon
Pubblicato in: Cancer Research, Numero 00085472, 2015, Pagina/e P5-07-09-P5-07-09, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/1538-7445.SABCS14-P5-07-09

Abstract 3919: Targeting urease to human VEGFR2 elicits antitumor activity in triple-negative breast cancer models

Autori: Angelika Muchowicz, Anna Bujak, Beata Pyrzynska, Justyna Karolczak, Abdessamad Zerrouqi, Magdalena Ozga, Lukasz Szewczyk, Baomin Tian, Wah Wong, Marni Uger, Katarzyna Poplawska, Dorota Gierej, Pawel Wisniewski, Heman Chao, Magdalena Winiarska, Radoslaw Zagozdzon
Pubblicato in: Cancer Research, Numero 78, Suppl 13, 2018, Pagina/e 3919-3919
Editore: American Association for Cancer Research

Ovarian cancer cells release arginase-1-containing exosomes to suppress antitumor immune response

Autori: Malgorzata Czystowska, Marta Szajnik, Kavita Ramji, Slawomir Gruca, Artur Stefanowicz, Jakub Golab, Dominika Nowis
Pubblicato in: Cancer Research, Numero 77, Suppl 13, 2017, Pagina/e 3975-3975
Editore: American Association for Cancer Research

FOXO1 determines non-Hodgkin lymphomas response to anti-CD20-based therapy

Autori: Abdessamad Zerrouqi, Beata Pyrzynska, Michal Dwoyak, giulia Morlino, Piotr Zapala, Nina Miazek, Jakub Golab, Magdalena Winiarska
Pubblicato in: Cancer Research, Numero 78/10, Suppl, 2018, Pagina/e B51-B51
Editore: American Association for Cancer Research

Dasatinib Effect on NK Cells and Anti-Tumor Immunity

Autori: Mieszko Lachota, Marta Siernicka, Zofia Pilch, Agnieszka Graczyk-Jarzynka and Magdalena Winiarska
Pubblicato in: Blood, Numero 132 (Suppl 1), 2018, Pagina/e 3004
Editore: ASH

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Autori: Binu K Sasi, Sven Turkalj, Hilal Kalkan, Fabiola Porro, Engin Bojnik, Beata Pyrzynska, Abdessamad Zerrouqi, Malgorzata Bobrowicz, Magdalena Winiarska, Valdemar Priebe, Francesco Bertoni, Larry Mansouri, Richard Rosenquist and Dimitar G Efremov
Pubblicato in: Blood, Numero 132 (Suppl 1), 2018, Pagina/e 2860
Editore: ASH

Lysosomal Disruption Augments Obinutuzumab-Induced Direct Cell Death

Autori: Antoni Domagala, Malgorzata Bobrowicz, Joanna Stachura, Marta Siernicka, Piotr Mrowka, Michal Dwojak, Beata Pyrzynska, Malgorzata Firczuk and Magdalena Winiarska
Pubblicato in: Blood, Numero 128/22, 2016, Pagina/e 2766
Editore: ASH

HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy

Autori: Malgorzata Bobrowicz, Joanna Stachura, Michal Dwojak, Antoni Domagala, Beata Pyrzynska, Elise Berthel, Nicole Dalla Venezia, Marta Siernicka, Malgorzata Firczuk and Magdalena Winiarska
Pubblicato in: Blood, Numero 128/22, 2016, Pagina/e 1586
Editore: ASH

NK cells cytotoxicity is affected by various BTK inhibitors

Autori: Siernicka, M.; Bojarczuk, K.; Bobrowicz, M.; et al.
Pubblicato in: HAEMATOLOGICA, 2015, Pagina/e 549-550, Abstract: E1372
Editore: European-Hematology-Association

Ofatumumab overcomes CD59-dependent resistance to complement-dependent cytotoxicity in human B-cell lymphoma model

Autori: Dwojak, M.; Bobrowicz, M.; Siernicka, M.; et al.
Pubblicato in: HAEMATOLOGICA, 2015, Pagina/e 552-552, Abstract: E1379
Editore: European-Hematology-Association

SRC inhibitors downregulate CD20 and modulate the activity of the CD20 promoter

Autori: Winiarska, M.; Bojarczuk, K.; Pyrzynska, B.; et al
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 45, Abstract: P211
Editore: European-Hematology-Association

MEK1 inhibitor selumetinib sensitizes B-cell Acute Lymphoblastic Leukemia (B-ALL) cells to dexamethasone by modulating autophagy

Autori: Polak, A.; Kiliszek, P.; Sewastianik, T.; Szydlowski, M.; Jablonska, E.; Prusisz, W.; Bialopiotrowicz, E.; Markowicz, S.; Nowak, E.; Grygorowicz, M.; Nowis, D.; Bojarczuk, K.; Golab, J.; Juszczynski, P.
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 272, Abstract: P751
Editore: European-Hematology-Association

SK053-an allosteric protein disulphide isomerase inhibitor induces differentiation of human acute myeloid leukemia cells

Autori: Golab, J.; Chlebowska, J.; Firczuk, M.; et al.
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 296, Abstract: P809
Editore: European-Hematology-Association

FoxO1 transcription factor mediates toxicity of SYK inhibition in DLBCL

Autori: Kiliszek, P.; Szydlowski, M.; Sewastianik, T.; Bialopiotrowicz, E.; Jablonska, E.; Polak, A.; Prusisz, W.; Markowicz, S.; Nowak, E.; Grygorowicz, MA.; Bojarczuk, K.; Winiarska, M.; Golab, J.; Juszczynski, P.
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 137, Abstract: P430
Editore: European-Hematology-Association

HDAC6 inhibition augments the efficacy of anti-CD20 monoclonal antibodies by up-regulating CD20 level in malignant B-cells

Autori: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 437, Abstract: P1143
Editore: European-Hematology-Association

Protein disulphide inhibitors induce differentiation of human acute myeloid leukemia cells

Autori: Chlebowska, J.; Firczuk, M.; Furs, K.; et al.
Pubblicato in: HAEMATOLOGICA, 2014, Pagina/e 558, Abstract: PB1430
Editore: European-Hematology-Association

HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies

Autori: Bobrowicz, Malgorzata; Dwojak, Michal; Malenda, Agata; et al.
Pubblicato in: BLOOD, 2014
Editore: American-Society-of-Hematology

Influence of Btk Inhibitors on Antitumor Activity of Natural Killer Cells

Autori: Siernicka, Marta; Bojarczuk, Kamil; Bobrowicz, Malgorzata; et al.
Pubblicato in: BLOOD, 2014
Editore: American-Society-of-Hematology

SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell

Autori: Chlebowska, Justyna; Gaj, Pawel; Stawinski, Piotr; et al.
Pubblicato in: BLOOD, 2014
Editore: American-Society-of-Hematology

Peroxiredoxins-1 and 2 Affect Proliferation and Survival of Lymphoma Cells

Autori: Firczuk, Malgorzata; Trzeciecka, Anna; Bajor, Malgorzata; et al.
Pubblicato in: BLOOD, 2014
Editore: American-Society-of-Hematology

Inhibitors of B-Cell Receptor Molecules Affect Surface CD20 and Impair Antitumor Activity of Anti-CD20 Monoclonal Antibodies

Autori: Bojarczuk, Kamil; Winiarska, Magdalena; Bobrowicz, Malgorzata; et al.
Pubblicato in: BLOOD, 2013, Pagina/e Abstract: 4217
Editore: American-Society-of-Hematology

SK053 An Inhibitor of Enzymes Involved In Allosteric Disulfide Bonds Formation Induces Differentiation of Human AML Cells

Autori: Chlebowska, Justyna; Firczuk, Malgorzata; Furs, Karolina; et al.
Pubblicato in: BLOOD, 2013, Pagina/e Abstract: 4215
Editore: American-Society-of-Hematology

Inhibitors of SRC family and AKT regulate the activity of CD20 promoter

Autori: Pyrzynska B., Bojarczuk K., Winiarska M. Bil J. Miazek N. Zapala P., Bobrowicz M., Dwojak M., Siernicka M., Golab J.
Pubblicato in: BLOOD, 2013, Pagina/e Abstract: 1838
Editore: American-Society-of-Hematology

A novel pathway regulating CD20 level influence of the inhibition of HDAC6 on the efficacy of anti-CD20 antibodies

Autori: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Pubblicato in: FEBS JOURNAL, 2014, Pagina/e 239-240, Abstract: SUN-509
Editore: FEBS; EMBO

Regulation of CD20 levels in B-cell tumors by SRC family kinases

Autori: Bojarczuk, K.; Winiarska, M.; Bil, J.; et al.
Pubblicato in: FEBS JOURNAL, 2013, Pagina/e 474
Editore: Federat European Biochemical Soc

Thiol-Reactive Peptidomimetic SK053 Targets Dimeric Peroxiredoxins in Human Lymphoma Cell Lines. Oral presentation.

Autori: Firczuk, M; Trzeciecka, A; Klosowski, S; et al.
Pubblicato in: Journal of International Society of Antioxidants in Health & Nutrition, 2015, Pagina/e 43
Editore: International Society of Antioxidants

Influence of BCR inhibitors on CD20 regulation in tumor cells

Autori: Kamil Bojarczuk; Supervisor 1: Dominika Nowis, MD, PhD; Supervisor 2: Magdalena Winiarska, PhD
Pubblicato in: 2015
Editore: Medical University of Warsaw, I Faculty of Medicine, Warsaw

È in corso la ricerca di dati su OpenAIRE...

Risultati finali

Pubblicazioni

Condividi questa pagina

Scarica