Strategies towards Excellence in Immuno-Oncology

Livrables

Report on overall promotional activities I

Report will summarize the Promotional activities related to the project.

Report from the Steering Group Meeting I

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M36

Report on transfer of know-how and best practices to MUW as a result of twinning visits in collaborating institutions; will include the analysis of added value for potential increase of research capacity / quality of MUW and the analysis of STREAM funds exploitation; will be discussed during the annual Steering Group meetings.

"Report on organization of theoretical workshop - ""Adoptive immunotherapy for cancer"""

Report on organized workshop will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on know-how knowledge dissemination at MUW - M12

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on participation in international research/innovation conferences - M36

Report on the attendance of European and world-wide conferences, symposia and meetings will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits.

Specifications of training material used for the twinning visits

Deliverable D37 will include the list of training materials to be used to deliver high-quality training during the twinning visits.

Report on management activities III

Report will summarize the yearly Management activities.

Report from the Steering Group Meeting III

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on publications, patents and funding support resulting from twinning visits

Report on publications, patents and funding support, resulting from twinning visits.

Report from the Steering Group Meeting II

Report will be considered as milestone, since it will summarize the project activities, progress and financial resources exploitation.

Report on know-how transfer through twinning visits - M24

Report on overall promotional activities III

Report will summarize the Promotional activities related to the project.

Report on knowledge dissemination - M18

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during hands-on workshop

Report on the promotional activities undertaken before and during the workshop.

"Report on organization of international summer-school - ""Immuno-Oncology"""

Report on organized summer-school will include an agenda, a list of participants, presentations and conclusions. Each of the reports will be complemented by an evaluation on whether the concerned activities contribute to the Research Potential increase of the applicants and the necessary measures to be taken in order to preserve the sustainability of the implemented actions or benefits. Report will also include the summary of STREAM financial resources exploitation.

Report on participation in international research/innovation conferences - M18

Report on know-how transfer through twinning visits - M12

Report on promotional activities undertaken during theoretical workshop

Report on the promotional activities undertaken before and during the workshop.

Report on prior publications of the coordinator

A one-page statement that the information about prior publications of the coordinator has been provided.

Report on overall promotional activities II

Report will summarize the Promotional activities related to the project.

Report on know-how knowledge dissemination at MUW - M36

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Report on management activities II

Report will summarize the yearly Management activities.

Report on management activities I

Report will summarize the yearly Management activities.

Report on knowledge dissemination - M36

Report on dissemination of knowledge acquired during conferences, symposia and meetings.

Report on promotional activities undertaken during summer-school

Report on the promotional activities undertaken before and during the summer-school.

Report on STREAM webpage launching

Report on the STREAM webpage launching is considered a Milestone in project implementation since it will be the basis for communication and promotion of the project.

"Report on organization of hands-on workshop - ""Application of flow cytometry methods in Immuno-Oncology"""

Report on know-how knowledge dissemination at MUW - M24

Report on sharing and dissemination of know-how knowledge, executed by weekly seminars at the Department of Immunology at MUW.

Publications

MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Auteurs: Anna Polak, Przemysław Kiliszek, Tomasz Sewastianik, Maciej Szydłowski, Ewa Jabłońska, Emilia Białopiotrowicz, Patryk Górniak, Sergiusz Markowicz, Eliza Nowak, Monika A. Grygorowicz, Monika Prochorec-Sobieszek, Dominika Nowis, Jakub Gołąb, Sebastian Giebel, Ewa Lech-Marańda, Krzysztof Warzocha, Przemysław Juszczyński
Publié dans: PLOS ONE, Numéro 11/5, 2016, Page(s) e0155893, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0155893

HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Auteurs: Malgorzata Bobrowicz, Michal Dwojak, Beata Pyrzynska, Joanna Stachura, Angelika Muchowicz, Elise Berthel, Nicole Dalla Venezia, Mieszko Kozikowski, Marta Siernicka, Nina Miazek, Piotr Zapala, Antoni Domagala, Kamil Bojarczuk, Agata Malenda, Joanna Barankiewicz, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Magdalena Gabrysiak, Jean-Jacques Diaz, Marta Karp, Ewa Lech-Maranda, Malgorzata Firczuk,
Publié dans: Blood, Numéro 130(14):1628-1638, 2017, Page(s) blood-2016-08-736066, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2016-08-736066

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

Auteurs: Anna Trzeciecka, Szymon Klossowski, Malgorzata Bajor, Radoslaw Zagozdzon, Pawel Gaj, Angelika Muchowicz, Agata Malinowska, Anna Czerwoniec, Joanna Barankiewicz, Antoni Domagala, Justyna Chlebowska, Monika Prochorec-Sobieszek, Magdalena Winiarska, Ryszard Ostaszewski, Iwonna Gwizdalska, Jakub Golab, Dominika Nowis, Malgorzata Firczuk
Publié dans: Oncotarget, Numéro 7/2, 2016, Page(s) 1717-1731, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.6435

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo

Auteurs: MAGDALENA GABRYSIAK, MALGORZATA WACHOWSKA, JOANNA BARANKIEWICZ, ZOFIA PILCH, ANNA RATAJSKA, EWA SKRZYPEK, MAGDALENA WINIARSKA, ANTONI DOMAGALA, TOMASZ P. RYGIEL, ALICJA JOZKOWICZ, LOUIS BOON, JAKUB GOLAB, MALGORZATA FIRCZUK
Publié dans: Oncology Reports, Numéro 35/6, 2016, Page(s) 3151-3158, ISSN 1021-335X
Éditeur: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/or.2016.4723

The Anatomy of Caprine Female Urethra and Characteristics of Muscle and Bone Marrow Derived Caprine Cells for Autologous Cell Therapy Testing

Auteurs: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wisniewska, Agnieszka Kulesza, Radoslaw Zagozdzon, Zdzislaw Gajewski, Leszek Paczek
Publié dans: The Anatomical Record, Numéro 300/3, 2017, Page(s) 577-588, ISSN 1932-8486
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ar.23498

Iterative Sequencing and Variant Screening (ISVS) as a novel pathogenic mutations search strategy - application for TMPRSS3 mutations screen

Auteurs: Urszula Lechowicz, Tomasz Gambin, Agnieszka Pollak, Anna Podgorska, Piotr Stawinski, Andre Franke, Britt-Sabina Petersen, Malgorzata Firczuk, Monika Oldak, Henryk Skarzynski, Rafal Ploski
Publié dans: Scientific Reports, Numéro 7/1, 2017, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-017-02315-w

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

Auteurs: Beata Pyrzynska, Michal Dwojak, Abdessamad Zerrouqi, Giulia Morlino, Piotr Zapala, Nina Miazek, Agnieszka Zagozdzon, Kamil Bojarczuk, Malgorzata Bobrowicz, Marta Siernicka, Marcin M. Machnicki, Stefania Gobessi, Joanna Barankiewicz, Ewa Lech-Maranda, Dimitar G. Efremov, Przemyslaw Juszczynski, Dinis Calado, Jakub Golab, Magdalena Winiarska
Publié dans: OncoImmunology, Numéro 7/5, 2018, Page(s) e1423183, ISSN 2162-402X
Éditeur: Taylor & Francis
DOI: 10.1080/2162402X.2017.1423183

Application of Genome Editing Techniques in Immunology

Auteurs: Agata O. Zych, Malgorzata Bajor, Radoslaw Zagozdzon
Publié dans: Archivum Immunologiae et Therapiae Experimentalis, Numéro 66/4, 2018, Page(s) 289-298, ISSN 0004-069X
Éditeur: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0504-z

Selection of an optimal promoter for gene transfer in normal B cells

Auteurs: Magdalena Winiarska, Dominika Nowis, Malgorzata Firczuk, Agnieszka Zagozdzon, Magdalena Gabrysiak, Radoslaw Sadowski, Joanna Barankiewicz, Michal Dwojak, Jakub Golab
Publié dans: Molecular Medicine Reports, Numéro 16/3, 2017, Page(s) 3041-3048, ISSN 1791-2997
Éditeur: Spandidos Publications
DOI: 10.3892/mmr.2017.6974

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

Auteurs: Seweryn Mroczek, Justyna Chlebowska, Tomasz M. Kuliński, Olga Gewartowska, Jakub Gruchota, Dominik Cysewski, Vladyslava Liudkovska, Ewa Borsuk, Dominika Nowis, Andrzej Dziembowski
Publié dans: Nature Communications, Numéro 8/1, 2017, Page(s) 619, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-00578-5

In vivo imaging system for explants analysis—A new approach for assessment of cell transplantation effects in large animal models

Auteurs: Weronika Zarychta-Wiśniewska, Anna Burdzinska, Radosław Zagozdzon, Bartosz Dybowski, Marta Butrym, Zdzisław Gajewski, Leszek Paczek
Publié dans: PLOS ONE, Numéro 12/9, 2017, Page(s) e0184588, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0184588

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors

Auteurs: Vincent Yi Sheng Oei, Marta Siernicka, Agnieszka Graczyk-Jarzynka, Hanna Julie Hoel, Weiwen Yang, Daniel Palacios, Hilde Almåsbak, Malgorzata Bajor, Dennis Clement, Ludwig Brandt, Björn Önfelt, Jodie Goodridge, Magdalena Winiarska, Radoslaw Zagozdzon, Johanna Olweus, Jon-Amund Kyte, Karl-Johan Malmberg
Publié dans: Cancer Immunology Research, Numéro 6/4, 2018, Page(s) 467-480, ISSN 2326-6066
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.CIR-17-0207

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

Auteurs: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk
Publié dans: BMC Cancer, Numéro 18/1, 2018, Page(s) 210, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-018-4126-y

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Auteurs: Natalia Krata, Radosław Zagożdżon, Bartosz Foroncewicz, Krzysztof Mucha
Publié dans: Archivum Immunologiae et Therapiae Experimentalis, Numéro 66/3, 2018, Page(s) 211-220, ISSN 0004-069X
Éditeur: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0496-0

Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy

Auteurs: Antoni Domagala, Klaudyna Fidyt, Malgorzata Bobrowicz, Joanna Stachura, Kacper Szczygiel, Malgorzata Firczuk
Publié dans: International Journal of Molecular Sciences, Numéro 19/8, 2018, Page(s) 2256, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19082256

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis

Auteurs: Marcin Waligora, Malgorzata M. Bala, Magdalena Koperny, Mateusz T. Wasylewski, Karolina Strzebonska, Rafał R. Jaeschke, Agnieszka Wozniak, Jan Piasecki, Agnieszka Sliwka, Jerzy W. Mitus, Maciej Polak, Dominika Nowis, Dean Fergusson, Jonathan Kimmelman
Publié dans: PLOS Medicine, Numéro 15/2, 2018, Page(s) e1002505, ISSN 1549-1676
Éditeur: PLOS Medicine
DOI: 10.1371/journal.pmed.1002505

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

Auteurs: Justyna Chlebowska-Tuz, Olga Sokolowska, Pawel Gaj, Michal Lazniewski, Malgorzata Firczuk, Karolina Borowiec, Hanna Sas-Nowosielska, Malgorzata Bajor, Agata Malinowska, Angelika Muchowicz, Kavita Ramji, Piotr Stawinski, Mateusz Sobczak, Zofia Pilch, Anna Rodziewicz-Lurzynska, Malgorzata Zajac, Krzysztof Giannopoulos, Przemyslaw Juszczynski, Grzegorz W. Basak, Dariusz Plewczynski, Rafal Ploski, Jak
Publié dans: Haematologica, Numéro 103/11, 2018, Page(s) 1843-1852, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.190231

Intraurethral co-transplantation of bone marrow mesenchymal stem cells and muscle-derived cells improves the urethral closure

Auteurs: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski, Leszek Paczek
Publié dans: Stem Cell Research & Therapy, Numéro 9/1, 2018, Page(s) 239, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-018-0990-2

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Auteurs: Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publié dans: BMC Cancer, Numéro 18/1, 2018, Page(s) 965, ISSN 1471-2407
Éditeur: BioMed Central
DOI: 10.1186/s12885-018-4852-1

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

Auteurs: Anna A. Marusiak, Monika K. Prelowska, Dawid Mehlich, Michal Lazniewski, Klaudia Kaminska, Adam Gorczynski, Aleksandra Korwat, Olga Sokolowska, Hanna Kedzierska, Jakub Golab, Wojciech Biernat, Dariusz Plewczynski, John Brognard, Dominika Nowis
Publié dans: Oncogene, 2018, ISSN 0950-9232
Éditeur: Nature Publishing Group
DOI: 10.1038/s41388-018-0618-0

Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

Auteurs: Agnieszka Graczyk-Jarzynka, Agnieszka Goral, Angelika Muchowicz, Radoslaw Zagozdzon, Magdalena Winiarska, Malgorzata Bajor, Anna Trzeciecka, Klaudyna Fidyt, Joanna Alicja Krupka, Julia Cyran, Kacper Szczygiel, Dimitar G. Efremov, Stefania Gobessi, Adam Jagielski, Karolina Siudakowska, Malgorzata Bobrowicz, Marta Klopotowska, Joanna Barankiewicz, Agata Malenda, Ewa Lech-Maranda, Nina Miazek-Zapala,
Publié dans: Redox Biology, Numéro 21, 2019, Page(s) 101062, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2018.11.020

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

Auteurs: Malgorzata Bajor, Agata O. Zych, Agnieszka Graczyk-Jarzynka, Angelika Muchowicz, Malgorzata Firczuk, Lech Trzeciak, Pawel Gaj, Antoni Domagala, Marta Siernicka, Agnieszka Zagozdzon, Pawel Siedlecki, Monika Kniotek, Patrick C. O’Leary, Jakub Golab, Radoslaw Zagozdzon
Publié dans: British Journal of Cancer, Numéro 119/7, 2018, Page(s) 873-884, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/s41416-018-0263-y

STING Signaling in Cancer Cells: Important or Not?

Auteurs: Olga Sokolowska, Dominika Nowis
Publié dans: Archivum Immunologiae et Therapiae Experimentalis, Numéro 66/2, 2018, Page(s) 125-132, ISSN 0004-069X
Éditeur: Ossolineum Publishing House
DOI: 10.1007/s00005-017-0481-7

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy

Auteurs: Arkadiusz Urbanowicz, Radosław Zagożdżon, Michał Ciszek
Publié dans: Archivum Immunologiae et Therapiae Experimentalis, 2018, ISSN 0004-069X
Éditeur: Ossolineum Publishing House
DOI: 10.1007/s00005-018-0532-8

The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies

Auteurs: Zofia Pilch, Katarzyna Tonecka, Marcin Skorzynski, Zuzanna Sas, Agata Braniewska, Tomasz Kryczka, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Publié dans: PLOS ONE, Numéro 14/1, 2019, Page(s) e0210796, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0210796

Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome

Auteurs: Florian Anzengruber, Desislava Ignatova, Tanja Schlaepfer, Yun-Tsan Chang, Lars E. French, Steve Pascolo, Emmanuel Contassot, Malgorzata Bobrowicz, Wolfram Hoetzenecker, Emmanuella Guenova
Publié dans: Leukemia & Lymphoma, 2019, Page(s) 1-9, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.1080/10428194.2018.1564827

Dissection of CD20 regulation in lymphoma using RNAi

Auteurs: M Słabicki, K S Lee, A Jethwa, L Sellner, F Sacco, T Walther, J Hüllein, S Dietrich, B Wu, D B Lipka, C C Oakes, S Mamidi, B Pyrzyńska, M Winiarska, M Oleś, M Seifert, C Plass, M Kirschfink, M Boettcher, J Gołąb, W Huber, S Fröhling, T Zenz
Publié dans: Leukemia, Numéro 30/12, 2016, Page(s) 2409-2412, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2016.230

Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity

Auteurs: Ole-Jacob Norum, Ane Sofie Viset Fremstedal, Anette Weyergang, Jakub Golab, Kristian Berg
Publié dans: Journal of Controlled Release, Numéro 268, 2017, Page(s) 120-127, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2017.10.015

Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice

Auteurs: Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W. Kilarski, Louis Boon, Tomasz J. Klaus, Jakub Golab
Publié dans: European Journal of Cancer, Numéro 83, 2017, Page(s) 19-27, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2017.06.004

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Auteurs: Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, Robert Koralewski, Wojciech Czestkowski, Anna Jedrzejczak, Jakub Golab, Karolina Dzwonek, Barbara Dymek, Piotr L. Sklepkiewicz, Agnieszka Zagozdzon, Tom Noonan, Keyvan Mahboubi, Bruce Conway, Ryan Sheeler, Paul Beckett, William M. Hungerford, Alberto Podjarny, Andre Mitschler, Alexandra Cousido-Siah, Firas Fadel, Adam Golebiowski
Publié dans: Journal of Medicinal Chemistry, Numéro 61/3, 2018, Page(s) 695-710, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01051

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

Auteurs: Luca Laurenti, Francesco Autore, Idanna Innocenti, Giovanni D’Arena, Marta Coscia, Patrizia Mondello, Patrizia Chiusolo, Silvia Bellesi, Dimitar G. Efremov, Simona Sica, Francesca Romana Mauro
Publié dans: Leukemia & Lymphoma, Numéro 57/10, 2016, Page(s) 2429-2431, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2015.1137293

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

Auteurs: G Lohmann, E Vasyutina, J Bloehdorn, N Reinart, J I Schneider, V Babu, G Knittel, G Crispatzu, P Mayer, C Prinz, J K Muenzner, B Biersack, D G Efremov, L Chessa, C D Herling, S Stilgenbauer, M Hallek, R Schobert, H C Reinhardt, B Schumacher, M Herling
Publié dans: Leukemia, Numéro 31/5, 2017, Page(s) 1177-1186, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2016.294

B-cell receptor signaling in the pathogenesis of lymphoid malignancies

Auteurs: Kamil Bojarczuk, Malgorzata Bobrowicz, Michal Dwojak, Nina Miazek, Piotr Zapala, Anders Bunes, Marta Siernicka, Maria Rozanska, Magdalena Winiarska
Publié dans: Blood Cells, Molecules, and Diseases, Numéro 55/3, 2015, Page(s) 255-265, ISSN 1079-9796
Éditeur: Academic Press
DOI: 10.1016/j.bcmd.2015.06.016

SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress

Auteurs: Angelika Muchowicz, Małgorzata Firczuk, Małgorzata Wachowska, Marek Kujawa, Ewa Jankowska-Steifer, Magdalena Gabrysiak, Zofia Pilch, Szymon Kłossowski, Ryszard Ostaszewski, Jakub Golab
Publié dans: Biochemical Pharmacology, Numéro 93/4, 2015, Page(s) 418-427, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2014.12.019

Adenanthin targets proteins involved in the regulation of disulphide bonds

Auteurs: Angelika Muchowicz, Małgorzata Firczuk, Justyna Chlebowska, Dominika Nowis, Joanna Stachura, Joanna Barankiewicz, Anna Trzeciecka, Szymon Kłossowski, Ryszard Ostaszewski, Radosław Zagożdżon, Jian-Xin Pu, Han-Dong Sun, Jakub Golab
Publié dans: Biochemical Pharmacology, Numéro 89/2, 2014, Page(s) 210-216, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2014.02.022

Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy

Auteurs: Aleksandra Maria Dudek-Perić, Jakub Gołąb, Abhishek D Garg, Patrizia Agostinis
Publié dans: OncoImmunology, Numéro 4/12, 2015, Page(s) e1054600, ISSN 2162-402X
Éditeur: Taylor & Francis
DOI: 10.1080/2162402x.2015.1054600

Neurodevelopmental phenotype caused by a de novo PTPN4 single nucleotide variant disrupting protein localization in neuronal dendritic spines

Auteurs: Krzysztof Szczałuba, Joanna J. Chmielewska, Olga Sokolowska, Małgorzata Rydzanicz, Krystyna Szymańska, Wojciech Feleszko, Paweł Włodarski, Anna Biernacka, Victor Murcia Pienkowski, Anna Walczak, Elżbieta Bargeł, Katarzyna Królewczyk, Agata Nowacka, Piotr Stawiński, Dominika Nowis, Magdalena Dziembowska, Rafał Płoski
Publié dans: Clinical Genetics, Numéro 94/6, 2018, Page(s) 581-585, ISSN 0009-9163
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cge.13450

Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment

Auteurs: Zofia Pilch, Katarzyna Tonecka, Agata Braniewska, Zuzanna Sas, Marcin Skorzynski, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Publié dans: Cancer Immunology Research, Numéro 6/8, 2018, Page(s) 930-940, ISSN 2326-6066
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-17-0454

Outcomes of Prolonged Treatment With Intravenous Immunoglobulin Infusions for Acute Antibody-mediated Rejection in Kidney Transplant Recipients

Auteurs: A. Bujnowska, M. Michon, P. Konopelski, E. Hryniewiecka, A. Jalbrzykowska, A. Perkowska-Ptasinska, T. Cieciura, R. Zagozdzon, L. Paczek, M. Ciszek
Publié dans: Transplantation Proceedings, Numéro 50/6, 2018, Page(s) 1720-1725, ISSN 0041-1345
Éditeur: Appleton & Lange
DOI: 10.1016/j.transproceed.2018.02.110

Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase

Auteurs: Marzena Mazur, Agnieszka Bartoszewicz, Barbara Dymek, Magdalena Salamon, Gleb Andryianau, Michał Kowalski, Sylwia Olejniczak, Krzysztof Matyszewski, Elżbieta Pluta, Bartłomiej Borek, Filip Stefaniak, Agnieszka Zagozdzon, Marcin Mazurkiewicz, Robert Koralewski, Wojciech Czestkowski, Michał Piotrowicz, Piotr Niedziejko, Mariusz M. Gruza, Karolina Dzwonek, Adam Golebiowski, Jakub Golab, Jacek Olc
Publié dans: Bioorganic & Medicinal Chemistry Letters, Numéro 28/3, 2018, Page(s) 310-314, ISSN 0960-894X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2017.12.047

Bortezomib-Induced Muscle Toxicity in Multiple Myeloma

Auteurs: Valeria Guglielmi, Dominika Nowis, Martina Tinelli, Manuela Malatesta, Laura Paoli, Matteo Marini, Paolo Manganotti, Radoslaw Sadowski, Grzegorz M. Wilczynski, Vittorio Meneghini, Giuliano Tomelleri, Gaetano Vattemi
Publié dans: Journal of Neuropathology & Experimental Neurology, Numéro 76/7, 2017, Page(s) 620-630, ISSN 0022-3069
Éditeur: American Association of Neuropathologists, Inc.
DOI: 10.1093/jnen/nlx043

The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development

Auteurs: Joanna Stachura, Malgorzata Wachowska, Witold W. Kilarski, Esra Güç, Jakub Golab, Angelika Muchowicz
Publié dans: OncoImmunology, Numéro 5/7, 2016, Page(s) e1182278, ISSN 2162-402X
Éditeur: Taylor&Francis
DOI: 10.1080/2162402X.2016.1182278

New insights into redox homeostasis as a therapeutic target in B-cell malignancies

Auteurs: Agnieszka Graczyk-Jarzynka, Radoslaw Zagozdzon, Angelika Muchowicz, Marta Siernicka, Malgorzata Firczuk, Przemyslaw Juszczynski
Publié dans: Current Opinion in Hematology, Numéro 24/4, 2017, Page(s) 1, ISSN 1065-6251
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/MOH.0000000000000351

Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells

Auteurs: Elina Timosenko, Hemza Ghadbane, Jonathan D. Silk, Dawn Shepherd, Uzi Gileadi, Lauren J. Howson, Robert Laynes, Qi Zhao, Robert L. Strausberg, Lars R. Olsen, Stephen Taylor, Francesca M. Buffa, Richard Boyd, Vincenzo Cerundolo
Publié dans: Cancer Research, Numéro 76/21, 2016, Page(s) 6193-6204, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-3502

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199

Auteurs: K. Bojarczuk, B. K. Sasi, S. Gobessi, I. Innocenti, G. Pozzato, L. Laurenti, D. G. Efremov
Publié dans: Blood, Numéro 127/25, 2016, Page(s) 3192-3201, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2015-10-675009

IL-4 regulates B-cell receptor signaling in CLL

Auteurs: D. G. Efremov
Publié dans: Blood, Numéro 128/4, 2016, Page(s) 468-469, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2016-06-719872

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Auteurs: Andreas T. Björklund, Trevor Clancy, Jodie P. Goodridge, Vivien Béziat, Marie Schaffer, Eivind Hovig, Hans-Gustaf Ljunggren, Per T. Ljungman, Karl-Johan Malmberg
Publié dans: The Journal of Immunology, Numéro 196/3, 2016, Page(s) 1400-1411, ISSN 0022-1767
Éditeur: American Association of Immunologists
DOI: 10.4049/jimmunol.1501434

N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells

Auteurs: P. J. Brown, D. M. Gascoyne, L. Lyne, H. Spearman, S. L. Felce, N. McFadden, P. Chakravarty, S. Barrans, S. Lynham, D. P. Calado, M. Ward, A. H. Banham
Publié dans: Haematologica, Numéro 101/7, 2016, Page(s) 861-871, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142141

Modulation of cancer-specific immune responses by amino acid degrading enzymes

Auteurs: Elina Timosenko, Andreas V Hadjinicolaou, Vincenzo Cerundolo
Publié dans: Immunotherapy, Numéro 9/1, 2017, Page(s) 83-97, ISSN 1750-743X
Éditeur: Future Medicine Ltd.
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FOXO discriminates tonic from chronic in DLBCL

Auteurs: D. G. Efremov
Publié dans: Blood, Numéro 127/6, 2016, Page(s) 669-670, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2015-12-683441

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Auteurs: Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat
Publié dans: Cell Reports, Numéro 15/5, 2016, Page(s) 1088-1099, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2016.04.005

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA

Auteurs: Nadia Mensali, Fan Ying, Vincent Oei Yi Sheng, Weiwen Yang, Even Walseng, Shraddha Kumari, Lars-Egil Fallang, Arne Kolstad, Wolfgang Uckert, Karl Johan Malmberg, Sébastien Wälchli, Johanna Olweus
Publié dans: OncoImmunology, Numéro 5/5, 2016, Page(s) e1138199, ISSN 2162-402X
Éditeur: Taylor&Francis
DOI: 10.1080/2162402X.2016.1138199

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

Auteurs: Luca Laurenti, Idanna Innocenti, Francecso Autore, Simona Sica, Dimitar Efremov
Publié dans: OncoTargets and Therapy, 2016, Page(s) 421, ISSN 1178-6930
Éditeur: Dove Medical Press Ltd
DOI: 10.2147/OTT.S72845

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

Auteurs: Maryaline Coffre, David Benhamou, David Rieß, Lili Blumenberg, Valentina Snetkova, Marcus J. Hines, Tirtha Chakraborty, Sofia Bajwa, Kari Jensen, Mark M.W. Chong, Lelise Getu, Gregg J. Silverman, Robert Blelloch, Dan R. Littman, Dinis Calado, Doron Melamed, Jane A. Skok, Klaus Rajewsky, Sergei B. Koralov
Publié dans: Cell Reports, Numéro 17/9, 2016, Page(s) 2271-2285, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2016.11.006

Cognate HLA absence in trans diminishes human NK cell education

Auteurs: Vanessa Landtwing, Ana Raykova, Gaetana Pezzino, Vivien Béziat, Emanuela Marcenaro, Claudine Graf, Alessandro Moretta, Riccarda Capaul, Andrea Zbinden, Guido Ferlazzo, Karl-Johan Malmberg, Obinna Chijioke, Christian Münz
Publié dans: Journal of Clinical Investigation, Numéro 126/10, 2016, Page(s) 3772-3782, ISSN 0021-9738
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/JCI86923

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Auteurs: Abhishek D. Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B. Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, An Coosemans, Pierre G. Coulie, Dirk De Ruysscher, Luciana Dini, Peter de Witte, Aleksandra M. Dudek-Peric, Alberto Faggioni, Jitka Fucikova, Udo S. Gaipl, Jakub Golab, Marie-Lise Gougeon, Michael R. Hamblin, Akseli Hemminki, Martin Herrmann, James W. Hodge, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, Walter G. Land, Frank Madeo, Angelo A. Manfredi, Stephen R. Mattarollo, Christian Maueroder, Nicolò Merendino, Gabriele Multhoff, Thomas Pabst, Jean-Ehrland Ricci, Chiara Riganti, Erminia Romano, Nicole Rufo, Mark J. Smyth, Jürgen Sonnemann, Radek Spisek, John Stagg, Erika Vacchelli, Peter Vandenabeele, Lien Vandenberk, Benoit J. Van den Eynde, Stefaan Van Gool, Francesca Velotti, Laurence Zitvogel, Patrizia Agostinis
Publié dans: Frontiers in Immunology, Numéro 16643224, 2015, Page(s) 588, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2015.00588

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity

Auteurs: Malgorzata Wachowska, Angelika Muchowicz, Jakub Golab
Publié dans: Frontiers in Oncology, Numéro 2234943X, 2015, Page(s) 176, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2015.00176

Review Cancer stem cells in haematological malignancies

Auteurs: Radoslaw Zagozdzon, Jakub Golab
Publié dans: Współczesna Onkologia, Numéro 14282526, 2015, Page(s) 1-6, ISSN 1428-2526
Éditeur: Termedia
DOI: 10.5114/wo.2014.47127

Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells

Auteurs: Marta Siernicka, Magdalena Winiarska, Malgorzata Bajor, Malgorzata Firczuk, Angelika Muchowicz, Malgorzata Bobrowicz, Cyril Fauriat, Jakub Golab, Daniel Olive, Radoslaw Zagozdzon
Publié dans: Immunology, Numéro 00192805, 2015, Page(s) 173-183, ISSN 0019-2805
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/imm.12494

Sorafenib improves rituximab and ofatumumab efficacy by decreasing the expression of complement regulatory proteins

Auteurs: M Dwojak, M Bobrowicz, J Bil, K Bojarczuk, B Pyrzynska, M Siernicka, A Malenda, E Lech-Maranda, W Tomczak, K Giannopoulos, J Golab, M Winiarska
Publié dans: Blood Cancer Journal, Numéro 20445385, 2015, Page(s) e300, ISSN 2044-5385
Éditeur: Nature Publishing Group
DOI: 10.1038/bcj.2015.27

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies

Auteurs: Magdalena Winiarska, Kamil Bojarczuk, Beata Pyrzynska, Jacek Bil, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Magdalena Krol, Aleksandra Syta, Paulina Podszywalow-Bartnicka, Zofia Pilch, Anna Dabrowska-Iwanicka, Przemyslaw Juszczynski, Dimitar G Efremov, Mikolaj Slabicki, Thorsten Zenz, Aude Le Roy, Daniel Olive, Tomasz P Rygiel, Jeanette HW Leusen, Jakub Golab
Publié dans: mAbs, Numéro 19420870, 2014, Page(s) 1300-1313, ISSN 1942-0870
Éditeur: Landes Bioscience
DOI: 10.4161/mabs.32106

Statins impair glucose uptake in human cells

Auteurs: D. Nowis, A. Malenda, K. Furs, B. Oleszczak, R. Sadowski, J. Chlebowska, M. Firczuk, J. M. Bujnicki, A. D. Staruch, R. Zagozdzon, E. Glodkowska-Mrowka, L. Szablewski, J. Golab
Publié dans: BMJ Open Diabetes Research & Care, Numéro 20524897, 2014, Page(s) e000017-e000017, ISSN 2052-4897
Éditeur: BMJ in partnership with the American Diabetes Association
DOI: 10.1136/bmjdrc-2014-000017

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Auteurs: Izabela Mlynarczuk-Bialy, Thorsten R. Doeppner, Jakub Golab, Dominika Nowis, Grzegorz M. Wilczynski, Kamil Parobczak, Moritz E. Wigand, Malgorzata Hajdamowicz, Łukasz P. Biały, Olga Aniolek, Petra Henklein, Mathias Bähr, Boris Schmidt, Ulrike Kuckelkorn, Peter-M. Kloetzel
Publié dans: Translational Oncology, Numéro 19365233, 2014, Page(s) 570-579, ISSN 1936-5233
Éditeur: Neoplasia Press
DOI: 10.1016/j.tranon.2014.07.002

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Auteurs: Maciej Serda, Danuta S. Kalinowski, Nathalie Rasko, Eliška Potůčková, Anna Mrozek-Wilczkiewicz, Robert Musiol, Jan G. Małecki, Mieczysław Sajewicz, Alicja Ratuszna, Angelika Muchowicz, Jakub Gołąb, Tomáš Šimůnek, Des R. Richardson, Jaroslaw Polanski
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e110291, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0110291

Iron Chelators in Photodynamic Therapy Revisited: Synergistic Effect by Novel Highly Active Thiosemicarbazones

Auteurs: Anna Mrozek-Wilczkiewicz, Maciej Serda, Robert Musiol, Grzegorz Malecki, Agnieszka Szurko, Angelika Muchowicz, Jakub Golab, Alicja Ratuszna, Jaroslaw Polanski
Publié dans: ACS Medicinal Chemistry Letters, Numéro 19485875, 2014, Page(s) 336-339, ISSN 1948-5875
Éditeur: American Chemical Society
DOI: 10.1021/ml400422a

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

Auteurs: K Bojarczuk, M Siernicka, M Dwojak, M Bobrowicz, B Pyrzynska, P Gaj, M Karp, K Giannopoulos, D G Efremov, C Fauriat, J Golab, M Winiarska
Publié dans: Leukemia, Numéro 08876924, 2014, Page(s) 1163-1167, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2014.12

Danger signalling during cancer cell death: origins, plasticity and regulation

Auteurs: A D Garg, S Martin, J Golab, P Agostinis
Publié dans: Cell Death and Differentiation, Numéro 13509047, 2013, Page(s) 26-38, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/cdd.2013.48

5-Aza-2′-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy

Auteurs: Malgorzata Wachowska, Magdalena Gabrysiak, Angelika Muchowicz, Weronika Bednarek, Joanna Barankiewicz, Tomasz Rygiel, Louis Boon, Pawel Mroz, Michael R Hamblin, Jakub Golab
Publié dans: European Journal of Cancer, Numéro 09598049, 2014, Page(s) 1370-1381, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2014.01.017

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Auteurs: Witold W. Kilarski, Angelika Muchowicz, Malgorzata Wachowska, Renata Mężyk-Kopeć, Jakub Golab, Melody A. Swartz, Patrycja Nowak-Sliwinska
Publié dans: Angiogenesis, Numéro 09696970, 2014, Page(s) 347-357, ISSN 0969-6970
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10456-013-9365-6

GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy

Auteurs: M Firczuk, M Gabrysiak, J Barankiewicz, A Domagala, D Nowis, M Kujawa, E Jankowska-Steifer, M Wachowska, E Glodkowska-Mrowka, B Korsak, M Winiarska, J Golab
Publié dans: Cell Death and Disease, Numéro 20414889, 2013, Page(s) e741, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/cddis.2013.265

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

Auteurs: Patrick C O’Leary, Marta Terrile, Malgorzata Bajor, Pawel Gaj, Bryan T Hennessy, Gordon B Mills, Agnieszka Zagozdzon, Darran P O’Connor, Donal J Brennan, Kate Connor, Jane Li, Ana Gonzalez-Angulo, Han-Dong Sun, Jian-Xin Pu, Fredrik Pontén, Mathias Uhlén, Karin Jirström, Dominika A Nowis, John P Crown, Radoslaw Zagozdzon, William M Gallagher
Publié dans: Breast Cancer Research, Numéro 14655411, 2014, Page(s) R79, ISSN 1465-5411
Éditeur: BioMed Central
DOI: 10.1186/bcr3691

Interleukin 12: still a promising candidate for tumor immunotherapy?

Auteurs: Witold Lasek, Radosław Zagożdżon, Marek Jakobisiak
Publié dans: Cancer Immunology, Immunotherapy, Numéro 03407004, 2014, Page(s) 419-435, ISSN 0340-7004
Éditeur: Springer Verlag
DOI: 10.1007/s00262-014-1523-1

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin

Auteurs: A. M. Dudek-Peri , G. B. Ferreira, A. Muchowicz, J. Wouters, N. Prada, S. Martin, S. Kiviluoto, M. Winiarska, L. Boon, C. Mathieu, J. van den Oord, M. Stas, M.-L. Gougeon, J. Golab, A. D. Garg, P. Agostinis
Publié dans: Cancer Research, Numéro 00085472, 2015, Page(s) 1603-1614, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-14-2089

In silico analysis of microRNA-510 as a potential oncomir in human breast cancer

Auteurs: Pawel Gaj, Radoslaw Zagozdzon
Publié dans: Breast Cancer Research, Numéro 14655411, 2014, Page(s) 403, ISSN 1465-5411
Éditeur: BioMed Central
DOI: 10.1186/bcr3624

Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses

Auteurs: Malgorzata Wachowska, Magdalena Gabrysiak, Jakub Golab
Publié dans: OncoImmunology, Numéro 2162402X, 2014, Page(s) e28837, ISSN 2162-402X
Éditeur: Landes Bioscience, Austin, TX
DOI: 10.4161/onci.28837

Abstract LB-242: PTEN regulates the CD20 antigen expression and affects rituximab-based therapy of lymphoma malignancies

Auteurs: Beata Pyrzynska, Kamil Bojarczuk, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Jakub Golab, Magdalena Winiarska
Publié dans: Cancer Research, Numéro 00085472, 2015, Page(s) LB-242-LB-242, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/1538-7445.AM2015-LB-242

Abstract P5-07-09: Adenanthin, a new peroxiredoxin inhibitor, induces a switch between estrogen receptor alpha-mediated and Src/Akt-driven signaling in breast cancer cells

Auteurs: Malgorzata Bajor, Agata O Zych, Patrick C O'Leary, Anna Czekalska, William M Gallagher, Jakub Golab, Radoslaw Zagozdzon
Publié dans: Cancer Research, Numéro 00085472, 2015, Page(s) P5-07-09-P5-07-09, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/1538-7445.SABCS14-P5-07-09

Abstract 3919: Targeting urease to human VEGFR2 elicits antitumor activity in triple-negative breast cancer models

Auteurs: Angelika Muchowicz, Anna Bujak, Beata Pyrzynska, Justyna Karolczak, Abdessamad Zerrouqi, Magdalena Ozga, Lukasz Szewczyk, Baomin Tian, Wah Wong, Marni Uger, Katarzyna Poplawska, Dorota Gierej, Pawel Wisniewski, Heman Chao, Magdalena Winiarska, Radoslaw Zagozdzon
Publié dans: Cancer Research, Numéro 78, Suppl 13, 2018, Page(s) 3919-3919
Éditeur: American Association for Cancer Research

Ovarian cancer cells release arginase-1-containing exosomes to suppress antitumor immune response

Auteurs: Malgorzata Czystowska, Marta Szajnik, Kavita Ramji, Slawomir Gruca, Artur Stefanowicz, Jakub Golab, Dominika Nowis
Publié dans: Cancer Research, Numéro 77, Suppl 13, 2017, Page(s) 3975-3975
Éditeur: American Association for Cancer Research

FOXO1 determines non-Hodgkin lymphomas response to anti-CD20-based therapy

Auteurs: Abdessamad Zerrouqi, Beata Pyrzynska, Michal Dwoyak, giulia Morlino, Piotr Zapala, Nina Miazek, Jakub Golab, Magdalena Winiarska
Publié dans: Cancer Research, Numéro 78/10, Suppl, 2018, Page(s) B51-B51
Éditeur: American Association for Cancer Research

Dasatinib Effect on NK Cells and Anti-Tumor Immunity

Auteurs: Mieszko Lachota, Marta Siernicka, Zofia Pilch, Agnieszka Graczyk-Jarzynka and Magdalena Winiarska
Publié dans: Blood, Numéro 132 (Suppl 1), 2018, Page(s) 3004
Éditeur: ASH

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Auteurs: Binu K Sasi, Sven Turkalj, Hilal Kalkan, Fabiola Porro, Engin Bojnik, Beata Pyrzynska, Abdessamad Zerrouqi, Malgorzata Bobrowicz, Magdalena Winiarska, Valdemar Priebe, Francesco Bertoni, Larry Mansouri, Richard Rosenquist and Dimitar G Efremov
Publié dans: Blood, Numéro 132 (Suppl 1), 2018, Page(s) 2860
Éditeur: ASH

Lysosomal Disruption Augments Obinutuzumab-Induced Direct Cell Death

Auteurs: Antoni Domagala, Malgorzata Bobrowicz, Joanna Stachura, Marta Siernicka, Piotr Mrowka, Michal Dwojak, Beata Pyrzynska, Malgorzata Firczuk and Magdalena Winiarska
Publié dans: Blood, Numéro 128/22, 2016, Page(s) 2766
Éditeur: ASH

HDAC6 Inhibition Increases Translation of CD20 mRNA and Potentiates the Efficacy of Anti-CD20 Immunotherapy

Auteurs: Malgorzata Bobrowicz, Joanna Stachura, Michal Dwojak, Antoni Domagala, Beata Pyrzynska, Elise Berthel, Nicole Dalla Venezia, Marta Siernicka, Malgorzata Firczuk and Magdalena Winiarska
Publié dans: Blood, Numéro 128/22, 2016, Page(s) 1586
Éditeur: ASH

NK cells cytotoxicity is affected by various BTK inhibitors

Auteurs: Siernicka, M.; Bojarczuk, K.; Bobrowicz, M.; et al.
Publié dans: HAEMATOLOGICA, 2015, Page(s) 549-550, Abstract: E1372
Éditeur: European-Hematology-Association

Ofatumumab overcomes CD59-dependent resistance to complement-dependent cytotoxicity in human B-cell lymphoma model

Auteurs: Dwojak, M.; Bobrowicz, M.; Siernicka, M.; et al.
Publié dans: HAEMATOLOGICA, 2015, Page(s) 552-552, Abstract: E1379
Éditeur: European-Hematology-Association

SRC inhibitors downregulate CD20 and modulate the activity of the CD20 promoter

Auteurs: Winiarska, M.; Bojarczuk, K.; Pyrzynska, B.; et al
Publié dans: HAEMATOLOGICA, 2014, Page(s) 45, Abstract: P211
Éditeur: European-Hematology-Association

MEK1 inhibitor selumetinib sensitizes B-cell Acute Lymphoblastic Leukemia (B-ALL) cells to dexamethasone by modulating autophagy

Auteurs: Polak, A.; Kiliszek, P.; Sewastianik, T.; Szydlowski, M.; Jablonska, E.; Prusisz, W.; Bialopiotrowicz, E.; Markowicz, S.; Nowak, E.; Grygorowicz, M.; Nowis, D.; Bojarczuk, K.; Golab, J.; Juszczynski, P.
Publié dans: HAEMATOLOGICA, 2014, Page(s) 272, Abstract: P751
Éditeur: European-Hematology-Association

SK053-an allosteric protein disulphide isomerase inhibitor induces differentiation of human acute myeloid leukemia cells

Auteurs: Golab, J.; Chlebowska, J.; Firczuk, M.; et al.
Publié dans: HAEMATOLOGICA, 2014, Page(s) 296, Abstract: P809
Éditeur: European-Hematology-Association

FoxO1 transcription factor mediates toxicity of SYK inhibition in DLBCL

Auteurs: Kiliszek, P.; Szydlowski, M.; Sewastianik, T.; Bialopiotrowicz, E.; Jablonska, E.; Polak, A.; Prusisz, W.; Markowicz, S.; Nowak, E.; Grygorowicz, MA.; Bojarczuk, K.; Winiarska, M.; Golab, J.; Juszczynski, P.
Publié dans: HAEMATOLOGICA, 2014, Page(s) 137, Abstract: P430
Éditeur: European-Hematology-Association

HDAC6 inhibition augments the efficacy of anti-CD20 monoclonal antibodies by up-regulating CD20 level in malignant B-cells

Auteurs: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Publié dans: HAEMATOLOGICA, 2014, Page(s) 437, Abstract: P1143
Éditeur: European-Hematology-Association

Protein disulphide inhibitors induce differentiation of human acute myeloid leukemia cells

Auteurs: Chlebowska, J.; Firczuk, M.; Furs, K.; et al.
Publié dans: HAEMATOLOGICA, 2014, Page(s) 558, Abstract: PB1430
Éditeur: European-Hematology-Association

HDAC Inhibitors As Potential New Agents Improving the Efficacy of Monoclonal Antibodies

Auteurs: Bobrowicz, Malgorzata; Dwojak, Michal; Malenda, Agata; et al.
Publié dans: BLOOD, 2014
Éditeur: American-Society-of-Hematology

Influence of Btk Inhibitors on Antitumor Activity of Natural Killer Cells

Auteurs: Siernicka, Marta; Bojarczuk, Kamil; Bobrowicz, Malgorzata; et al.
Publié dans: BLOOD, 2014
Éditeur: American-Society-of-Hematology

SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell

Auteurs: Chlebowska, Justyna; Gaj, Pawel; Stawinski, Piotr; et al.
Publié dans: BLOOD, 2014
Éditeur: American-Society-of-Hematology

Peroxiredoxins-1 and 2 Affect Proliferation and Survival of Lymphoma Cells

Auteurs: Firczuk, Malgorzata; Trzeciecka, Anna; Bajor, Malgorzata; et al.
Publié dans: BLOOD, 2014
Éditeur: American-Society-of-Hematology

Inhibitors of B-Cell Receptor Molecules Affect Surface CD20 and Impair Antitumor Activity of Anti-CD20 Monoclonal Antibodies

Auteurs: Bojarczuk, Kamil; Winiarska, Magdalena; Bobrowicz, Malgorzata; et al.
Publié dans: BLOOD, 2013, Page(s) Abstract: 4217
Éditeur: American-Society-of-Hematology

SK053 An Inhibitor of Enzymes Involved In Allosteric Disulfide Bonds Formation Induces Differentiation of Human AML Cells

Auteurs: Chlebowska, Justyna; Firczuk, Malgorzata; Furs, Karolina; et al.
Publié dans: BLOOD, 2013, Page(s) Abstract: 4215
Éditeur: American-Society-of-Hematology

Inhibitors of SRC family and AKT regulate the activity of CD20 promoter

Auteurs: Pyrzynska B., Bojarczuk K., Winiarska M. Bil J. Miazek N. Zapala P., Bobrowicz M., Dwojak M., Siernicka M., Golab J.
Publié dans: BLOOD, 2013, Page(s) Abstract: 1838
Éditeur: American-Society-of-Hematology

A novel pathway regulating CD20 level influence of the inhibition of HDAC6 on the efficacy of anti-CD20 antibodies

Auteurs: Bobrowicz, M.; Dwojak, M.; Bojarczuk, K.; et al.
Publié dans: FEBS JOURNAL, 2014, Page(s) 239-240, Abstract: SUN-509
Éditeur: FEBS; EMBO

Regulation of CD20 levels in B-cell tumors by SRC family kinases

Auteurs: Bojarczuk, K.; Winiarska, M.; Bil, J.; et al.
Publié dans: FEBS JOURNAL, 2013, Page(s) 474
Éditeur: Federat European Biochemical Soc

Thiol-Reactive Peptidomimetic SK053 Targets Dimeric Peroxiredoxins in Human Lymphoma Cell Lines. Oral presentation.

Auteurs: Firczuk, M; Trzeciecka, A; Klosowski, S; et al.
Publié dans: Journal of International Society of Antioxidants in Health & Nutrition, 2015, Page(s) 43
Éditeur: International Society of Antioxidants

Influence of BCR inhibitors on CD20 regulation in tumor cells

Auteurs: Kamil Bojarczuk; Supervisor 1: Dominika Nowis, MD, PhD; Supervisor 2: Magdalena Winiarska, PhD
Publié dans: 2015
Éditeur: Medical University of Warsaw, I Faculty of Medicine, Warsaw

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