The transcription-related DNA damage response

Project Information

TRANSDAM

Grant agreement ID: 693327

DOI 10.3030/693327

Project closed

EC signature date 27 June 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 988,00

EU contribution € 2 499 988,00

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (17)

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

Author(s): Marta Rodríguez-Martínez, Thierry Boissiére, Melvin Noe Gonzalez, Kevin Litchfield, Richard Mitter, Jane Walker, Svend Kjœr, Mohamed Ismail, Julian Downward, Charles Swanton, Jesper Q. Svejstrup
Published in: Cell, Issue 181/6, 2020, Page(s) 1395-1405.e11, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.04.014

The ASC-1 Complex Disassembles Collided Ribosomes

Author(s): Szymon Juszkiewicz, Shaun H. Speldewinde, Li Wan, Jesper Q. Svejstrup, Ramanujan S. Hegde
Published in: Molecular Cell, Issue 79/4, 2020, Page(s) 603-614.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.06.006

Translation stress and collided ribosomes are co-activators of cGAS

Author(s): Li Wan; Szymon Juszkiewicz; Daniel Blears; Prashanth Kumar Bajpe; Zhong Han; Zhong Han; Peter Faull; Richard Mitter; Aengus Stewart; Ambrosius P. Snijders; Ramanujan S. Hegde; Jesper Q. Svejstrup; Jesper Q. Svejstrup
Published in: Molecular Cell, Issue 2, 2021, ISSN 1097-4164
Publisher: Elsevier
DOI: 10.1016/j.molcel.2021.05.018

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

Author(s): Ana Tufegdžić Vidaković, Richard Mitter, Gavin P. Kelly, Michelle Neumann, Michelle Harreman, Marta Rodríguez-Martínez, Anna Herlihy, Juston C. Weems, Stefan Boeing, Vesela Encheva, Liam Gaul, Laura Milligan, David Tollervey, Ronald C. Conaway, Joan W. Conaway, Ambrosius P. Snijders, Aengus Stewart, Jesper Q. Svejstrup
Published in: Cell, Issue 180/6, 2020, Page(s) 1245-1261.e21, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.02.009

Multiplex Cell Fate Tracking by Flow Cytometry

Author(s): Marta Rodríguez-Martínez, Stephanie A. Hills, John F. X. Diffley, Jesper Q. Svejstrup
Published in: Methods and Protocols, Issue 3/3, 2020, Page(s) 50, ISSN 2409-9279
Publisher: MDPI
DOI: 10.3390/mps3030050

Transcription-coupled repair and the transcriptional response to UV-Irradiation.

Author(s): Liam Gaul; Jesper Q. Svejstrup
Published in: DNA Repair, Issue 4, 2021, ISSN 1568-7864
Publisher: Elsevier BV
DOI: 10.1016/j.dnarep.2021.103208

Annotation matters: validating the discovery of cancer drivers

Author(s): Marta Rodríguez-Martínez, Jesper Q. Svejstrup
Published in: Molecular & Cellular Oncology, Issue 7/6, 2020, Page(s) 1806679, ISSN 2372-3556
Publisher: Taylor and Francis
DOI: 10.1080/23723556.2020.1806679

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Author(s): Zheng Fan, Jennifer R. Devlin, Simon J. Hogg, Maria A. Doyle, Paul F. Harrison, Izabela Todorovski, Leonie A. Cluse, Deborah A. Knight, Jarrod J. Sandow, Gareth Gregory, Andrew Fox, Traude H. Beilharz, Nicholas Kwiatkowski, Nichollas E. Scott, Ana Tufegdzic Vidakovic, Gavin P. Kelly, Jesper Q. Svejstrup, Matthias Geyer, Nathanael S. Gray, Stephin J. Vervoort, Ricky W. Johnstone
Published in: Science Advances, Issue 6/18, 2020, Page(s) eaaz5041, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaz5041

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage

Author(s): Juston C. Weems, Brian D. Slaughter, Jay R. Unruh, Stefan Boeing, Shawn M. Hall, Merry B. McLaird, Takashi Yasukawa, Teijiro Aso, Jesper Q. Svejstrup, Joan W. Conaway, Ronald C. Conaway
Published in: Journal of Biological Chemistry, Issue 292/16, 2017, Page(s) 6431-6437, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.C117.777946

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene

Author(s): Laura Williamson, Marco Saponaro, Stefan Boeing, Philip East, Richard Mitter, Theodoros Kantidakis, Gavin P. Kelly, Anna Lobley, Jane Walker, Bradley Spencer-Dene, Michael Howell, Aengus Stewart, Jesper Q. Svejstrup
Published in: Cell, Issue 168/5, 2017, Page(s) 843-855.e13, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.01.019

The Cellular Response to Transcription-Blocking DNA Damage

Author(s): Lea H. Gregersen, Jesper Q. Svejstrup
Published in: Trends in Biochemical Sciences, Issue 43/5, 2018, Page(s) 327-341, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2018.02.010

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

Author(s): Michael Lim, Joseph A. Newman, Hannah L. Williams, Laura Masino, Hazel Aitkenhead, Angeline E. Gravard, Opher Gileadi, Jesper Q. Svejstrup
Published in: Structure, Issue 27/8, 2019, Page(s) 1316-1325.e6, ISSN 2352-0124
Publisher: Elsevier Limited

Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes

Author(s): Aylin Cakiroglu, Cedric R. Clapier, Andreas H. Ehrensberger, Elodie Darbo, Bradley R. Cairns, Nicholas M. Luscombe, Jesper Q. Svejstrup
Published in: Genome Research, Issue 29/6, 2019, Page(s) 988-998, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.243139.118

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

Author(s): Lea H. Gregersen, Richard Mitter, Alejandro P. Ugalde, Takayuki Nojima, Nicholas J. Proudfoot, Reuven Agami, Aengus Stewart, Jesper Q. Svejstrup
Published in: Cell, Issue 177/7, 2019, Page(s) 1797-1813.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.04.038

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Author(s): Diana Zatreanu, Zhong Han, Richard Mitter, Emanuela Tumini, Hannah Williams, Lea Gregersen, A. Barbara Dirac-Svejstrup, Stefania Roma, Aengus Stewart, Andres Aguilera, Jesper Q. Svejstrup
Published in: Molecular Cell, Issue 76/1, 2019, Page(s) 57-69.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.07.037

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

Author(s): Ana Tufegdzic Vidakovic, Michelle Harreman, A. Barbara Dirac-Svejstrup, Stefan Boeing, Anindya Roy, Vesela Encheva, Michelle Neumann, Marcus Wilson, Ambrosius P. Snijders, Jesper Q. Svejstrup
Published in: Methods, Issue 159-160, 2019, Page(s) 146-156, ISSN 1046-2023
Publisher: Academic Press
DOI: 10.1016/j.ymeth.2019.02.005

DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1

Author(s): A. Barbara Dirac-Svejstrup, Jane Walker, Peter Faull, Vesela Encheva, Vyacheslav Akimov, Michele Puglia, David Perkins, Sandra Kümper, Suchete S. Hunjan, Blagoy Blagoev, Ambrosius P. Snijders, David J. Powell, Jesper Q. Svejstrup
Published in: Molecular Cell, Issue 79/2, 2020, Page(s) 332-341.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.05.035