Directed Evolution of Artificial Metalloenzymes for In Vivo Applications

Pubblicazioni

A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase.

Autori: Alina Stein; Dongping Chen; Nico V. Igareta; Yoann Cotelle; Johannes G. Rebelein; Thomas R. Ward
Pubblicato in: ACS Central Science, Numero 23747943, 2021, ISSN 2374-7943
Editore: American Chemical Society
DOI: 10.1021/acscentsci.1c00825

Bioorthogonal strategies for the in vivo synthesis or release of drugs

Autori: Boris Lozhkin, Thomas R.Ward
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 09680896, 2021, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116310

Functional and morphological adaptation in DNA protocells via signal processing prompted by artificial metalloenzymes

Autori: Avik Samanta, Valerio Sabatino, Thomas R. Ward, Andreas Walther
Pubblicato in: Nature Nanotechnology, Numero 15/11, 2020, Pagina/e 914-921, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-020-0761-y

Enantioselective Hydroxylation of Benzylic C(sp 3 )–H Bonds by an Artificial Iron Hydroxylase Based on the Biotin–Streptavidin Technology

Autori: Joan Serrano-Plana, Corentin Rumo, Johannes G. Rebelein, Ryan L. Peterson, Maxime Barnet, Thomas R. Ward
Pubblicato in: Journal of the American Chemical Society, Numero 142/24, 2020, Pagina/e 10617-10623, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c02788

Directed Evolution of a Surface-Displayed Artificial Allylic Deallylase Relying on a GFP Reporter Protein

Autori: Alain Baiyoumy; Jaicy Vallapurackal; Fabian Schwizer; Tillmann Heinisch; Tsvetan Kardashliev; Martin Held; Sven Panke; Thomas R. Ward
Pubblicato in: ACS Catalysis, Numero 21555435, 2021, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.3929/ethz-b-000506507

An Artificial Metalloenzyme Based on a Copper Heteroscorpionate Enables sp3 C–H Functionalization via Intramolecular Carbene Insertion

Autori: Corentin Rumo, Alina Stein, Juliane Klehr, Ryo Tachibana, Alessandro Prescimone, Daniel Häussinger, Thomas R. Ward
Pubblicato in: Journal of the American Chemical Society, Numero 00027863, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c03311

Engineering a Metathesis-Catalyzing Artificial Metalloenzyme Based on HaloTag

Autori: Sandro Fischer, Thomas R. Ward, and Alexandria D. Liang
Pubblicato in: ACS Catalysis, Numero 21555435, 2021, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.1c01470

Droplet Microfluidics and Directed Evolution of Enzymes: an Intertwined Journey

Autori: Ariane Stucki, Jaicy Vallapurackal, Thomas R. Ward, Petra S Dittrich
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016154

Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis

Autori: Fadri Christoffel, Nico V. Igareta, Michela M. Pellizzoni, Laura Tiessler-Sala, Boris Lozhkin, Daniel C. Spiess, Agustí Lledós, Jean-Didier Maréchal, Ryan L. Peterson, Thomas R. Ward
Pubblicato in: Nature Catalysis, Numero 25201158, 2021, ISSN 2520-1158
Editore: Nature Publishing Group
DOI: 10.1038/s41929-021-00651-9

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

Autori: Shuke Wu, Yi Zhou, Daniel Gerngross, Markus Jeschek, Thomas R. Ward
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-13071-y

Streptavidin-Enzyme Linked Aggregates for the One-Step Assembly and Purification of Enzyme Cascades

Autori: Hendrik Mallin, Thomas R. Ward
Pubblicato in: ChemCatChem, Numero 10, 2018, Pagina/e 2810 –2816, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201800162

Photo-Driven Hydrogen Evolution by an Artificial Hydrogenase Utilizing the Biotin-Streptavidin Technology

Autori: Sascha G. Keller, Benjamin Probst, Tillmann Heinisch, Roger Alberto, Thomas R. Ward
Pubblicato in: Helvetica Chimica Acta, Numero 101/4, 2018, Pagina/e e1800036, ISSN 0018-019X
Editore: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.201800036

Streptavidin as a Scaffold for Light-Induced Long-Lived Charge Separation

Autori: Sascha G. Keller, Andrea Pannwitz, Hendrik Mallin, Oliver S. Wenger, Thomas R. Ward
Pubblicato in: Chemistry - A European Journal, Numero 23/71, 2017, Pagina/e 18019-18024, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201703885

In vivo catalyzed new-to-nature reactions

Autori: Johannes G Rebelein, Thomas R Ward
Pubblicato in: Current Opinion in Biotechnology, Numero 53, 2018, Pagina/e 106-114, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2017.12.008

Directed Evolution of an Artificial Imine Reductase

Autori: Martina Hestericová, Tillman Heinisch, Lur Alonso-Cotchico, Jean-Didier Maréchal, Pietro Vidossich, Thomas R. Ward
Pubblicato in: Angewandte Chemie International Edition, Numero 57/7, 2018, Pagina/e 1863-1868, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201711016

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

Autori: Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer, Eline Bartolami, Tillmann Heinisch, Stefan Matile, Martin Fussenegger, Thomas R. Ward
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04440-0

An artificial metalloenzyme for carbene transfer based on a biotinylated dirhodium anchored within streptavidin

Autori: Jingming Zhao, Daniel G. Bachmann, Markus Lenz, Dennis G. Gillingham, Thomas R. Ward
Pubblicato in: Catalysis Science & Technology, Numero 8/9, 2018, Pagina/e 2294-2298, ISSN 2044-4753
Editore: Royal Society of Chemistry
DOI: 10.1039/C8CY00646F

Cross-Regulation of an Artificial Metalloenzyme

Autori: Yasunori Okamoto, Thomas R. Ward
Pubblicato in: Angewandte Chemie International Edition, Numero 56/34, 2017, Pagina/e 10156-10160, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201702181

Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase

Autori: Martina Hestericová, Tillmann Heinisch, Markus Lenz, Thomas R. Ward
Pubblicato in: Dalton Transactions, Numero 47/32, 2018, Pagina/e 10837-10841, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/c8dt02224k

Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli’ s Periplasm

Autori: Jingming Zhao, Johannes G. Rebelein, Hendrik Mallin, Christian Trindler, Michela M. Pellizzoni, Thomas R. Ward
Pubblicato in: Journal of the American Chemical Society, Numero 140/41, 2018, Pagina/e 13171-13175, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b07189

Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein

Autori: Johannes G. Rebelein, Yoann Cotelle, Brett Garabedian, Thomas R. Ward
Pubblicato in: ACS Catalysis, Numero 9/5, 2019, Pagina/e 4173-4178, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.9b01006

Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Enzymatic Cascades and Directed Evolution

Autori: Alexandria Deliz Liang, Joan Serrano-Plana, Ryan L. Peterson, Thomas R. Ward
Pubblicato in: Accounts of Chemical Research, Numero 52/3, 2019, Pagina/e 585-595, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.8b00618

E. coli surface display of streptavidin for directed evolution of an allylic deallylase

Autori: Tillmann Heinisch, Fabian Schwizer, Brett Garabedian, Eszter Csibra, Markus Jeschek, Jaicy Vallapurackal, Vitor B. Pinheiro, Philippe Marlière, Sven Panke, Thomas R. Ward
Pubblicato in: Chemical Science, Numero 9/24, 2018, Pagina/e 5383-5388, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sc00484f

Artificial Metalloenzymes: Challenges and Opportunities

Autori: Holly J. Davis, Thomas R. Ward
Pubblicato in: ACS Central Science, Numero 5/7, 2019, Pagina/e 1120-1136, ISSN 2374-7943
Editore: American Chemical Society
DOI: 10.1021/acscentsci.9b00397

“Close-to-Release”: Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis

Autori: Valerio Sabatino, Johannes G. Rebelein, Thomas R. Ward
Pubblicato in: Journal of the American Chemical Society, Numero 141/43, 2019, Pagina/e 17048-17052, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b07193

Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes

Autori: Shuke Wu, Yi Zhou, Johannes G. Rebelein, Miriam Kuhn, Hendrik Mallin, Jingming Zhao, Nico V. Igareta, Thomas R. Ward
Pubblicato in: Journal of the American Chemical Society, Numero 141/40, 2019, Pagina/e 15869-15878, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b06923

Incorporation of metal-chelating unnatural amino acids into halotag for allylic deamination

Autori: Alina Stein, Alexandria Deliz Liang, Reyhan Sahin, Thomas R.Ward
Pubblicato in: Journal of Organometallic Chemistry, Numero 0022328X, 2022, ISSN 0022-328X
Editore: Elsevier BV
DOI: 10.1016/j.jorganchem.2022.122272

Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis

Autori: Valerio Sabatino, Dario Staub, Thomas R. Ward
Pubblicato in: Catalysis Letters, Numero 151/1, 2021, Pagina/e 1-7, ISSN 1011-372X
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10562-020-03271-3

Ultrahigh-Throughput Screening of an Artificial Metalloenzyme using Double Emulsions

Autori: Jaicy Vallapurackal, Ariane Stucki, Alexandria Deliz Liang, Juliane Klehr, Petra S. Dittrich, Thomas R. Ward
Pubblicato in: Angewandte Chemie International Edition, Numero 14337851, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207328

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