The Genetics and Physiology of Growth and Size Determination

Información del proyecto

VitruVius

Identificador del acuerdo de subvención: 694677

DOI

10.3030/694677

Proyecto cerrado

Fecha de la firma de la CE 12 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Diciembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 144,00

Aportación de la UE

€ 2 499 144,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Periodic Reporting for period 5 - VitruVius (The Genetics and Physiology of Growth and Size Determination)

Período documentado: 2023-07-01 hasta 2023-12-31

Resumen del contexto y de los objetivos generales del proyecto

Body size is an important property of living organisms that is intimately linked to the developmental program to produce fit individuals with proper proportions. We tackle here the important question of how final organ size is determined ad we use the drosophila model for our experimental program. This fundamental question in biology is of importance for the society, since a better understanding of normal physiological mechanisms controlling growth of tissues is key for a better understanding of the pathological situations, like cancer, regeneration, or metabolic diseases.
Our main objectives for this project are:
- to understand the link between organ growth and the program of development.
- to understand the coordination between the growth of different organs during normal development and in response to abnormal growth (injury, tumor).

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

- We have identified a new pathway using the Xrp1:Dilp8 axis that mediates inter-organ growth coordination in response to a perturbation of the growth program in one organ (Boulan et al. Dev Cell 2019)
- We have discovered a time-window during development which allows bilateral organs to adjust their size. (Blanco-Obregon et al. Nat Commun. 2022)
- We have identified a hormone sequestration mechanism linking tumor growth and host tissue wasting, similar to what is observed during cancer-induced cachexia (Santa-Barbara et al. Dev Cell 2021).
- We have studied the mechanisms selecting for perfect bilateral symmetry of organs in a population of individuals (Vijendravarma et al. PNAS 2022).
- We have studied the mechanisms of resource allocation during development allowing storing nutrients during feeding phases for later use during non-feeding ones (Valzania et al. Dev Cell 2024).

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

During the course of the project, we have made important discoveries on the mechanisms of organ growth coordination, the coupling of tumor growth and tissue wasting, the adjustment of bilateral organ size and sexual selection for symmetry, and the mechanisms of nutritional resource allocation during development.

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