The Genetics and Physiology of Growth and Size Determination

Projektinformationen

VitruVius

ID Finanzhilfevereinbarung: 694677

DOI

10.3030/694677

Projekt abgeschlossen

EK-Unterschriftsdatum 12 Dezember 2016

Startdatum 1 Januar 2017

Enddatum 31 Dezember 2023

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten

€ 2 499 144,00

EU-Beitrag

€ 2 499 144,00

Koordiniert durch

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Periodic Reporting for period 5 - VitruVius (The Genetics and Physiology of Growth and Size Determination)

Berichtszeitraum: 2023-07-01 bis 2023-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Body size is an important property of living organisms that is intimately linked to the developmental program to produce fit individuals with proper proportions. We tackle here the important question of how final organ size is determined ad we use the drosophila model for our experimental program. This fundamental question in biology is of importance for the society, since a better understanding of normal physiological mechanisms controlling growth of tissues is key for a better understanding of the pathological situations, like cancer, regeneration, or metabolic diseases.
Our main objectives for this project are:
- to understand the link between organ growth and the program of development.
- to understand the coordination between the growth of different organs during normal development and in response to abnormal growth (injury, tumor).

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

- We have identified a new pathway using the Xrp1:Dilp8 axis that mediates inter-organ growth coordination in response to a perturbation of the growth program in one organ (Boulan et al. Dev Cell 2019)
- We have discovered a time-window during development which allows bilateral organs to adjust their size. (Blanco-Obregon et al. Nat Commun. 2022)
- We have identified a hormone sequestration mechanism linking tumor growth and host tissue wasting, similar to what is observed during cancer-induced cachexia (Santa-Barbara et al. Dev Cell 2021).
- We have studied the mechanisms selecting for perfect bilateral symmetry of organs in a population of individuals (Vijendravarma et al. PNAS 2022).
- We have studied the mechanisms of resource allocation during development allowing storing nutrients during feeding phases for later use during non-feeding ones (Valzania et al. Dev Cell 2024).

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

During the course of the project, we have made important discoveries on the mechanisms of organ growth coordination, the coupling of tumor growth and tissue wasting, the adjustment of bilateral organ size and sexual selection for symmetry, and the mechanisms of nutritional resource allocation during development.

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