The Genetics and Physiology of Growth and Size Determination

Informazioni relative al progetto

VitruVius

ID dell’accordo di sovvenzione: 694677

DOI

10.3030/694677

Progetto chiuso

Data della firma CE 12 Dicembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 144,00

Contributo UE

€ 2 499 144,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Periodic Reporting for period 5 - VitruVius (The Genetics and Physiology of Growth and Size Determination)

Periodo di rendicontazione: 2023-07-01 al 2023-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Body size is an important property of living organisms that is intimately linked to the developmental program to produce fit individuals with proper proportions. We tackle here the important question of how final organ size is determined ad we use the drosophila model for our experimental program. This fundamental question in biology is of importance for the society, since a better understanding of normal physiological mechanisms controlling growth of tissues is key for a better understanding of the pathological situations, like cancer, regeneration, or metabolic diseases.
Our main objectives for this project are:
- to understand the link between organ growth and the program of development.
- to understand the coordination between the growth of different organs during normal development and in response to abnormal growth (injury, tumor).

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

- We have identified a new pathway using the Xrp1:Dilp8 axis that mediates inter-organ growth coordination in response to a perturbation of the growth program in one organ (Boulan et al. Dev Cell 2019)
- We have discovered a time-window during development which allows bilateral organs to adjust their size. (Blanco-Obregon et al. Nat Commun. 2022)
- We have identified a hormone sequestration mechanism linking tumor growth and host tissue wasting, similar to what is observed during cancer-induced cachexia (Santa-Barbara et al. Dev Cell 2021).
- We have studied the mechanisms selecting for perfect bilateral symmetry of organs in a population of individuals (Vijendravarma et al. PNAS 2022).
- We have studied the mechanisms of resource allocation during development allowing storing nutrients during feeding phases for later use during non-feeding ones (Valzania et al. Dev Cell 2024).

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

During the course of the project, we have made important discoveries on the mechanisms of organ growth coordination, the coupling of tumor growth and tissue wasting, the adjustment of bilateral organ size and sexual selection for symmetry, and the mechanisms of nutritional resource allocation during development.

mouche.jpg