Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils

Informations projet

smartCC

N° de convention de subvention: 705857

DOI

10.3030/705857

Projet clôturé

Date de signature de la CE 16 Mars 2016

Date de début 1 Juin 2017

Date de fin 15 Septembre 2019

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 159 460,80

Contribution de l’UE

€ 159 460,80

Coordonné par

MAX-PLANCK-INSTITUT FUR NACHHALTIGE MATERIALIEN GMBH
Germany

Periodic Reporting for period 1 - smartCC (Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils)

Période du rapport: 2017-06-01 au 2019-05-31

Résumé du contexte et des objectifs généraux du projet

Smart interfaces, i.e. interfaces that change their properties on external triggers, such as temperature or electrode potential are a promising technology that can be applied in materials science, biotechnology or medicine. In this project a novel approach to realize such smart interfaces is investigated by applying a group of biologically abundant molecules, the coiled-coil peptides. The novel interface will allow for new applications that foster biotechnological research and technological progress.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

(I) The adsorption of coiled-coil peptides to hydropphilic-hydrophobic switchable germanium interfaces has been studied. The results indicate a completely different adsorption mechanism for the studied peptides. A manuscript for dissemination is in preparation.
(II) Coiled-coil binding to mixed SAMs has been studied. The studied systems show no switchable behaviour. For future work a different binding mechanism must be targeted. A manuscript for dissemination is in preparation.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Smart interfaces based on coiled-coils open fascinating possibilities for applications. However, a realization is more difficult than anticipated. Difficulties arise from the interplay between peptide-peptide and peptide-interface interactions. During preparation these interactions affect significantly, the properties of the final interface. The project results provide an insight into these factors and their effects and build a base for further research in this direction.

Basic design and targeted working principle of a coiled-coil based smart interface.