Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils

Informacje na temat projektu

smartCC

Identyfikator umowy o grant: 705857

DOI

10.3030/705857

Projekt został zamknięty

Data podpisania przez KE 16 Marca 2016

Data rozpoczęcia 1 Czerwca 2017

Data zakończenia 15 Września 2019

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 159 460,80

Wkład UE

€ 159 460,80

Koordynowany przez

MAX-PLANCK-INSTITUT FUR NACHHALTIGE MATERIALIEN GMBH
Germany

Periodic Reporting for period 1 - smartCC (Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils)

Okres sprawozdawczy: 2017-06-01 do 2019-05-31

Podsumowanie kontekstu i ogólnych celów projektu

Smart interfaces, i.e. interfaces that change their properties on external triggers, such as temperature or electrode potential are a promising technology that can be applied in materials science, biotechnology or medicine. In this project a novel approach to realize such smart interfaces is investigated by applying a group of biologically abundant molecules, the coiled-coil peptides. The novel interface will allow for new applications that foster biotechnological research and technological progress.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

(I) The adsorption of coiled-coil peptides to hydropphilic-hydrophobic switchable germanium interfaces has been studied. The results indicate a completely different adsorption mechanism for the studied peptides. A manuscript for dissemination is in preparation.
(II) Coiled-coil binding to mixed SAMs has been studied. The studied systems show no switchable behaviour. For future work a different binding mechanism must be targeted. A manuscript for dissemination is in preparation.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

Smart interfaces based on coiled-coils open fascinating possibilities for applications. However, a realization is more difficult than anticipated. Difficulties arise from the interplay between peptide-peptide and peptide-interface interactions. During preparation these interactions affect significantly, the properties of the final interface. The project results provide an insight into these factors and their effects and build a base for further research in this direction.

Basic design and targeted working principle of a coiled-coil based smart interface.