Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils

Informazioni relative al progetto

smartCC

ID dell’accordo di sovvenzione: 705857

DOI

10.3030/705857

Progetto chiuso

Data della firma CE 16 Marzo 2016

Data di avvio 1 Giugno 2017

Data di completamento 15 Settembre 2019

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 159 460,80

Contributo UE

€ 159 460,80

Coordinato da

MAX-PLANCK-INSTITUT FUR NACHHALTIGE MATERIALIEN GMBH
Germany

Periodic Reporting for period 1 - smartCC (Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils)

Periodo di rendicontazione: 2017-06-01 al 2019-05-31

Sintesi del contesto e degli obiettivi generali del progetto

Smart interfaces, i.e. interfaces that change their properties on external triggers, such as temperature or electrode potential are a promising technology that can be applied in materials science, biotechnology or medicine. In this project a novel approach to realize such smart interfaces is investigated by applying a group of biologically abundant molecules, the coiled-coil peptides. The novel interface will allow for new applications that foster biotechnological research and technological progress.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

(I) The adsorption of coiled-coil peptides to hydropphilic-hydrophobic switchable germanium interfaces has been studied. The results indicate a completely different adsorption mechanism for the studied peptides. A manuscript for dissemination is in preparation.
(II) Coiled-coil binding to mixed SAMs has been studied. The studied systems show no switchable behaviour. For future work a different binding mechanism must be targeted. A manuscript for dissemination is in preparation.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

Smart interfaces based on coiled-coils open fascinating possibilities for applications. However, a realization is more difficult than anticipated. Difficulties arise from the interplay between peptide-peptide and peptide-interface interactions. During preparation these interactions affect significantly, the properties of the final interface. The project results provide an insight into these factors and their effects and build a base for further research in this direction.

Basic design and targeted working principle of a coiled-coil based smart interface.