Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils

Projektinformationen

smartCC

ID Finanzhilfevereinbarung: 705857

DOI

10.3030/705857

Projekt abgeschlossen

EK-Unterschriftsdatum 16 März 2016

Startdatum 1 Juni 2017

Enddatum 15 September 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten

€ 159 460,80

EU-Beitrag

€ 159 460,80

Koordiniert durch

MAX-PLANCK-INSTITUT FUR NACHHALTIGE MATERIALIEN GMBH
Germany

Periodic Reporting for period 1 - smartCC (Designing novel smart sensor interfaces based on a biologically abundant peptide motif: coiled-coils)

Berichtszeitraum: 2017-06-01 bis 2019-05-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Smart interfaces, i.e. interfaces that change their properties on external triggers, such as temperature or electrode potential are a promising technology that can be applied in materials science, biotechnology or medicine. In this project a novel approach to realize such smart interfaces is investigated by applying a group of biologically abundant molecules, the coiled-coil peptides. The novel interface will allow for new applications that foster biotechnological research and technological progress.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

(I) The adsorption of coiled-coil peptides to hydropphilic-hydrophobic switchable germanium interfaces has been studied. The results indicate a completely different adsorption mechanism for the studied peptides. A manuscript for dissemination is in preparation.
(II) Coiled-coil binding to mixed SAMs has been studied. The studied systems show no switchable behaviour. For future work a different binding mechanism must be targeted. A manuscript for dissemination is in preparation.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Smart interfaces based on coiled-coils open fascinating possibilities for applications. However, a realization is more difficult than anticipated. Difficulties arise from the interplay between peptide-peptide and peptide-interface interactions. During preparation these interactions affect significantly, the properties of the final interface. The project results provide an insight into these factors and their effects and build a base for further research in this direction.

Basic design and targeted working principle of a coiled-coil based smart interface.