Objetivo As the world’s population is aging, the prevalence of Alzheimer’s disease (AD) is estimated to triple by 2050. Even though AD was identified more than 100 years ago, research has gained momentum only the last 30 years. To date, studies have mainly focused on the accumulation of two proteins, amyloid-beta and tau to understand the pathophysiology of this disease. In this project, I will take a new approach, by investigating the interaction between these two pathological hallmarks of AD and neuronal activity as a potential causal model for AD. The underlying hypothesis is that regional levels of neuronal activity determine the interaction between amyloid and tau pathology, and lead to AD symptomatology. To that end, I aim to combine novel molecular and state-of-the-art magnetic neuroimaging techniques with higher statistical modeling techniques. The group of Prof. Johnson at Massachusetts General Hospital (MGH) is currently the leading group pushing these techniques forward. The expertise within the lab of Prof. Johnson, his extensive network, the skills that I will acquire throughout this fellowship (scientifically and management-wise), combined with my existing level of expertise in MRI and my participation in diverse European networks will provide me with the competences to lead my own research group and establish a functional international multidisciplinary AD research network. Delaying or even treating this disease will require a multifactorial, multidisciplinary approach in which researchers combine resources, data and results in a coordinated manner worldwide. The implementation of these techniques in Europe and the subsequent close collaborations between European and American networks will have the highest chances to improve detection, prevention and treatment of AD. Ámbito científico natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepathology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2015-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Convocatoria de propuestas H2020-MSCA-IF-2015 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-GF - Global Fellowships Coordinador UNIVERSITEIT MAASTRICHT Aportación neta de la UEn € 174 864,60 Dirección MINDERBROEDERSBERG 4 6200 MD Maastricht Países Bajos Ver en el mapa Región Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 174 864,60 Socios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo Socio Las organizaciones asociadas contribuyen a la aplicación de la acción, pero no firman el acuerdo de subvención. THE GENERAL HOSPITAL CORPORATION Estados Unidos Aportación neta de la UEn € 0,00 Dirección FRUIT STREET 55 02114 Boston Ma Ver en el mapa Tipo de actividad Other Enlaces Contactar con la organización Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 86 065,20
