Obiettivo Glia far out number neurons in the brain and their defects are now known to be associated with many neurological diseases. Glial specification and physiological function are very well studied however, remarkably little is known about they way in which glia are positioned or shaped in order to perform their critical support functions. The goal of the present study is to broaden the field of glial development by using new techniques to ask previously unattainable questions. This central goal of this research project is carried out through an in-depth morphological, genetic and transcritpomic analyses of differentiating Müller Glia in the Zebrafish (Danio rerio) eye. Results from these studies will provide and the first extensive profiling of a differentiating glial population. Furthermore, the extensive data that will be generated in this proposal will provide a basis for many future studies on glial biology for both in the host laboratory and for the experienced researcher during his career development. Ultimately, these and future studies will provide a foundation for identifying the molecular networks that underlie glial patterning in the brain that will no doubt be informative in the study of glial related neurological disease. Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineophthalmologymedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicinepsychiatryschizophrenia Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2015 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution nette de l'UE € 195 454,80 Indirizzo TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Regno Unito Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 195 454,80