The problem addressed was how to predict which patient will respond to therapy, knowing that a cancer is a personal disease. The Renal cell Carcinoma (RCC) is the most common kidney cancer for which the RCC-TEST diagnostic tool is a solution to investigate the response of tumor cells to medical drugs in vitro. ICELLTIS has optimized the RCC-TEST with 3D spheroid tumor cell culture model for fast, and accurate therapeutic protocol selection for RCC. New protocols with combined immuno-and targeted therapies have shown highly promising results but have to be evaluated for each patient to apply the best protocol.
The RCC represents the 7th most common cancer in men, and the 9th in women. It is often asymptomatic and the majority of patients are diagnosed at late disease stages with about 25-30% of them already with metastatic disease.The RCC-TEST will enable rapid and cost-effective personalization of anti-cancer treatments, leading to improve overall patient survival and decrease healthcare expenses.
The objective is to provide oncologists with a new in vitro diagnostic test to use immediatly after surgical intervention, as complementary Tools for establishing, the real personalized protocol. It will be used in parallel with standard compulsory anatomo-pathological analysis. For the first time, the spheroids will be composed of own patients' tumor and immune cells. The possibility to co-culture both types of cells is determinant to investigate the response to medical drugs in vitro.
The specific objective was to optimize and scale-up the RCC-TEST to be ready for further multicentric european clinical trial.
