Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications

Project Information

ALERT

Grant agreement ID: 713482

DOI 10.3030/713482

Project closed

EC signature date 3 May 2016

Start date 1 May 2016

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 976 320,00

EU contribution € 1 988 160,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Publications

Peer reviewed articles (41)

Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light

Author(s): Mickel J. Hansen, Femke M. Feringa, Piermichele Kobauri, Wiktor Szymanski, René H. Medema, Ben L. Feringa
Published in: Journal of the American Chemical Society, Issue 140/41, 2018, Page(s) 13136-13141, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b04870

Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Author(s): Putri D. Utari, Jan Vogel, Wim J. Quax
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.01123

Impact of solid surface hydrophobicity and micrococcal nuclease production on Staphylococcus aureus Newman biofilms

Author(s): Abigail M. Forson, Henny C. van der Mei, Jelmer Sjollema
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69084-x

Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Author(s): Stephen D. Zoller, Howard Y. Park, Tove Olafsen, Charles Zamilpa, Zachary D.C. Burke, Gideon Blumstein, William L. Sheppard, Christopher D. Hamad, Kellyn R. Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T. Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa J.M. Raineri, Jeffery F. Miller, Lloyd S. Miller, Jan Maarten van Dijl, Kevin P. Francis, Nicholas M. Bernthal
Published in: JCI Insight, Issue 4/3, 2019, ISSN 2379-3708
Publisher: JCI Insight
DOI: 10.1172/jci.insight.124813

Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock

Author(s): Dušan Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben L. Feringa, Kenichiro Itami, Tsuyoshi Hirota
Published in: Journal of the American Chemical Society, Issue 143/4, 2021, Page(s) 2078-2087, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c12280

Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

Author(s): Anna I. Lauxen, Piermichele Kobauri, Michael Wegener, Mickel J. Hansen, Nicole S. Galenkamp, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa, Oscar P. Kuipers
Published in: Pharmaceuticals, Issue 14/5, 2021, Page(s) 392, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14050392

Photochemical control of bacterial gene expression based on trans encoded genetic switches

Author(s): Avishek Paul, Jingyi Huang, Yanxiao Han, Xintong Yang, Lela Vuković, Petr Král, Lifei Zheng, Andreas Herrmann
Published in: Chemical Science, Issue 12/7, 2021, Page(s) 2646-2654, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05479h

Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

Author(s): Elisa J.M. Raineri, Harita Yedavally, Anna Salvati, Jan Maarten van Dijl
Published in: Virulence, Issue 11/1, 2020, Page(s) 1623-1639, ISSN 2150-5594
Publisher: Landes Bioscience
DOI: 10.1080/21505594.2020.1844418

Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer

Author(s): Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymanski, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa
Published in: Chemical Science, Issue 12/26, 2021, Page(s) 9207-9220, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc02194j

Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization

Author(s): Riccardo Leinardi, Cristina Pavan, Harita Yedavally, Maura Tomatis, Anna Salvati, Francesco Turci
Published in: Archives of Toxicology, Issue 94/9, 2020, Page(s) 2981-2995, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-020-02819-x

Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter , Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains

Author(s): Patricia Arias-Orozco, Yunhai Yi, Oscar P. Kuipers
Published in: Microbiology Resource Announcements, Issue 10/19, 2021, ISSN 2576-098X
Publisher: ASM Microbiology Resource Announcements
DOI: 10.1128/mra.00116-21

Biaryl sulfonamides as cisoid azosteres for photopharmacology

Author(s): Piermichele Kobauri, Wiktor Szymanski, Fangyuan Cao, Sebastian Thallmair, Siewert J. Marrink, Martin D. Witte, Frank J. Dekker, Ben L. Feringa
Published in: Chemical Communications, Issue 57/34, 2021, Page(s) 4126-4129, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc00950h

Light-controlled inhibition of BRAFV600E kinase

Author(s): Mark W.H. Hoorens, Maria E. Ourailidou, Theo Rodat, Petra E. van der Wouden, Piermichele Kobauri, Malte Kriegs, Christian Peifer, Ben L. Feringa, Frank J. Dekker, Wiktor Szymanski
Published in: European Journal of Medicinal Chemistry, Issue 179, 2019, Page(s) 133-146, ISSN 0223-5234
Publisher: Elsevier BV
DOI: 10.1016/j.ejmech.2019.06.042

Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

Author(s): Valentina Vignali, Barbara S. Miranda, Irene Lodoso-Torrecilla, Cathelijn A. J. van Nisselroy, Bas-Jan Hoogenberg, Sybren Dantuma, Frank Hollmann, Jan Willem de Vries, Eliza M. Warszawik, Rainer Fischer, Ulrich Commandeur, Patrick van Rijn
Published in: Chemical Communications, Issue 55/1, 2019, Page(s) 51-54, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc08042a

Identification of a conserved N‐terminal domain in the first module of ACV synthetases

Author(s): Riccardo Iacovelli, László Mózsik, Roel A.L. Bovenberg, Arnold J.M. Driessen
Published in: MicrobiologyOpen, Issue 10/1, 2021, Page(s) e1145, ISSN 2045-8827
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/mbo3.1145

Antimicrobial Nanogels with Nanoinjection Capabilities for Delivery of the Hydrophobic Antibacterial Agent Triclosan

Author(s): Guangyue Zu, Magdalena Steinmüller, Damla Keskin, Henny C. van der Mei, Olga Mergel, Patrick van Rijn
Published in: ACS Applied Polymer Materials, Issue 2/12, 2020, Page(s) 5779-5789, ISSN 2637-6105
Publisher: ACS Applied Polymer Materials
DOI: 10.1021/acsapm.0c01031

Fighting Staphylococcus aureus infections with light and photoimmunoconjugates

Author(s): Mafalda Bispo, Andrea Anaya-Sanchez, Sabrina Suhani, Elisa J. M. Raineri, Marina López-Álvarez, Marjolein Heuker, Wiktor Szymański, Francisco Romero Pastrana, Girbe Buist, Alexander R. Horswill, Kevin P. Francis, Gooitzen M. van Dam, Marleen van Oosten, Jan Maarten van Dijl
Published in: JCI Insight, Issue 5/22, 2020, ISSN 2379-3708
Publisher: JCI insight
DOI: 10.1172/jci.insight.139512

A synthetic metabolic network for physicochemical homeostasis

Author(s): Tjeerd Pols, Hendrik R. Sikkema, Bauke F. Gaastra, Jacopo Frallicciardi, Wojciech M. Śmigiel, Shubham Singh, Bert Poolman
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12287-2

The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties

Author(s): Damla Keskin, Taraneh Mokabbar, Yutao Pei, Patrick van Rijn
Published in: Polymers, Issue 10/5, 2018, Page(s) 534, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym10050534

Staphylococcal trafficking and infection—from ‘nose to gut’ and back

Author(s): Elisa J M Raineri, Dania Altulea, Jan Maarten van Dijl
Published in: FEMS Microbiology Reviews, 2021, ISSN 1574-6976
Publisher: FEMS Microbiology Reviews
DOI: 10.1093/femsre/fuab041

Enhanced bacterial killing by vancomycin in staphylococcal biofilms disrupted by novel, DMMA-modified carbon dots depends on EPS production

Author(s): Yanyan Wu, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Published in: Colloids and Surfaces B: Biointerfaces, Issue 193, 2020, Page(s) 111114, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111114

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

Author(s): Chao Ma, Juanjuan Su, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann, Rudolph E. Tanzi, Kai Liu, Can Zhang
Published in: Angewandte Chemie International Edition, Issue 58/51, 2019, Page(s) 18703-18709, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201912399

Immobilized Acylase PvdQ Reduces Pseudomonas aeruginosa Biofilm Formation on PDMS Silicone

Author(s): Jan Vogel, Marijke Wakker-Havinga, Rita Setroikromo, Wim J. Quax
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
Publisher: Frontiers Media
DOI: 10.3389/fchem.2020.00054

Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Author(s): Damla Keskin, Lisa Tromp, Olga Mergel, Guangyue Zu, Eliza Warszawik, Henny C. van der Mei, Patrick van Rijn
Published in: ACS Applied Materials & Interfaces, Issue 12/52, 2020, Page(s) 57721-57731, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c18172

De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane

Author(s): Chao Ma, Jingjin Dong, Marco Viviani, Isotta Tulini, Nicola Pontillo, Sourav Maity, Yu Zhou, Wouter H. Roos, Kai Liu, Andreas Herrmann, Giuseppe Portale
Published in: Science Advances, Issue 6/29, 2020, Page(s) eabc0810, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abc0810

A Penicillium rubens platform strain for secondary metabolite production

Author(s): Carsten Pohl, Fabiola Polli, Tabea Schütze, Annarita Viggiano, László Mózsik, Sascha Jung, Maaike de Vries, Roel A. L. Bovenberg, Vera Meyer, Arnold J. M. Driessen
Published in: Scientific Reports, Issue 10/1, 2020, Page(s) 7360, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-64893-6

Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages

Author(s): da Cruz Campos, Cavallo, L. Andrade, van Dijl, Couto, Zrimec, Lo Ten Foe, P. Rosa, V. Damasco, Friedrich, Chlebowicz-Flissikowska, Rossen
Published in: Microorganisms, Issue 7/11, 2019, Page(s) 534, ISSN 2076-2607
Publisher: Microorganisms
DOI: 10.3390/microorganisms7110534

Inheritance of physico-chemical properties and ROS generation by carbon quantum dots derived from pyrolytically carbonized bacterial sources

Author(s): Y. Wu, H. Wei, H.C. van der Mei, J. de Vries, H.J. Busscher, Y. Ren
Published in: Materials Today Bio, Issue 12, 2021, Page(s) 100151, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/j.mtbio.2021.100151

Synthetic control devices for gene regulation in Penicillium chrysogenum

Author(s): László Mózsik, Zsófia Büttel, Roel A. L. Bovenberg, Arnold J. M. Driessen, Yvonne Nygård
Published in: Microbial Cell Factories, Issue 18/1, 2019, Page(s) 203, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-019-1253-3

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

Author(s): Yanyan Wu, Cong Li, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Published in: Antibiotics, Issue 10/6, 2021, Page(s) 623, ISSN 2079-6382
Publisher: MDPI
DOI: 10.3390/antibiotics10060623

Stereoselective Protection-Free Modification of 3-Keto-saccharides

Author(s): Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard
Published in: Organic Letters, Issue 22/14, 2020, Page(s) 5622-5626, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.0c01986

Inhibiting Bacterial Adhesion by Mechanically Modulated Microgel Coatings

Author(s): Damla Keskin, Olga Mergel, Henny C. van der Mei, Henk J. Busscher, Patrick van Rijn
Published in: Biomacromolecules, Issue 20/1, 2019, Page(s) 243-253, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b01378

Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized Staphylococcus aureus as a Driver for Infection*

Author(s): Laura M. Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa J.M. Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A. Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl, Uwe Völker
Published in: Molecular & Cellular Proteomics, Issue 18/5, 2019, Page(s) 892-908, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra118.001138

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre‐Clinical Evaluation of 18 F‐Labeled PSMA‐Tracers for Prostate Cancer Imaging

Author(s): Verena I. Böhmer, Wiktor Szymanski, Keimpe‐Oeds Berg, Chantal Mulder, Piermichele Kobauri, Hugo Helbert, Dion Born, Friederike Reeβing, Anja Huizing, Marten Klopstra, Douwe F. Samplonius, Ines F. Antunes, Jürgen W. A. Sijbesma, Gert Luurtsema, Wijnand Helfrich, Ton J. Visser, Ben L. Feringa, Philip H. Elsinga
Published in: Chemistry – A European Journal, Issue 26/47, 2020, Page(s) 10871-10881, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001795

Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies

Author(s): Patricia Arias-Orozco, Maartje Inklaar, Judith Lanooij, Rubén Cebrián, Oscar P. Kuipers
Published in: ACS Synthetic Biology, Issue 10/10, 2021, Page(s) 2579-2591, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.1c00224

CRISPR-based transcriptional activation tool for silent genes in filamentous fungi

Author(s): László Mózsik, Mirthe Hoekzema, Niels A. W. de Kok, Roel A. L. Bovenberg, Yvonne Nygård, Arnold J. M. Driessen
Published in: Scientific Reports, Issue 11/1, 2021, Page(s) 20129, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-80864-3

Bdellovibrio bacteriovorus : a potential ‘living antibiotic’ to control bacterial pathogens

Author(s): Francis M. Cavallo, Lorea Jordana, Alexander W. Friedrich, Corinna Glasner, Jan Maarten van Dijl
Published in: Critical Reviews in Microbiology, Issue 47/5, 2021, Page(s) 630-646, ISSN 1040-841X
Publisher: Taylor & Francis
DOI: 10.1080/1040841x.2021.1908956

Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier

Author(s): Laís Ribovski, Edwin de Jong, Olga Mergel, Guangyue Zu, Damla Keskin, Patrick van Rijn, Inge S. Zuhorn
Published in: Nanomedicine: Nanotechnology, Biology and Medicine, Issue 34, 2021, Page(s) 102377, ISSN 1549-9634
Publisher: Elsevier BV
DOI: 10.1016/j.nano.2021.102377

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Author(s): Damla Keskin, Guangyue Zu, Abigail M. Forson, Lisa Tromp, Jelmer Sjollema, Patrick van Rijn
Published in: Bioactive Materials, Issue 6/10, 2021, Page(s) 3634-3657, ISSN 2452-199X
Publisher: Bioactive Materials
DOI: 10.1016/j.bioactmat.2021.03.004

Mechanochemical bond scission for the activation of drugs

Author(s): Shuaidong Huo, Pengkun Zhao, Zhiyuan Shi, Miancheng Zou, Xintong Yang, Eliza Warszawik, Mark Loznik, Robert Göstl, Andreas Herrmann
Published in: Nature Chemistry, Issue 13/2, 2021, Page(s) 131-139, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-00624-8

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane

Author(s): Matteo Gabba, Jacopo Frallicciardi, Joury van ’t Klooster, Ryan Henderson, Łukasz Syga, Robert Mans, Antonius J.A. van Maris, Bert Poolman
Published in: Biophysical Journal, Issue 118/2, 2020, Page(s) 422-434, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2019.11.3384