Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications

Informazioni relative al progetto

ALERT

ID dell’accordo di sovvenzione: 713482

DOI

10.3030/713482

Progetto chiuso

Data della firma CE 3 Maggio 2016

Data di avvio 1 Maggio 2016

Data di completamento 30 Aprile 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 976 320,00

Contributo UE

€ 1 988 160,00

Coordinato da

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (41)

Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light

Autori: Mickel J. Hansen, Femke M. Feringa, Piermichele Kobauri, Wiktor Szymanski, René H. Medema, Ben L. Feringa
Pubblicato in: Journal of the American Chemical Society, Numero 140/41, 2018, Pagina/e 13136-13141, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b04870

Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Autori: Putri D. Utari, Jan Vogel, Wim J. Quax
Pubblicato in: Frontiers in Microbiology, Numero 8, 2017, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2017.01123

Impact of solid surface hydrophobicity and micrococcal nuclease production on Staphylococcus aureus Newman biofilms

Autori: Abigail M. Forson, Henny C. van der Mei, Jelmer Sjollema
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-69084-x

Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Autori: Stephen D. Zoller, Howard Y. Park, Tove Olafsen, Charles Zamilpa, Zachary D.C. Burke, Gideon Blumstein, William L. Sheppard, Christopher D. Hamad, Kellyn R. Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T. Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa J.M. Raineri, Jeffery F. Miller, Lloyd S. Miller, Jan Maarten van Dijl, Kevin P. Francis, Nicholas M. Bernthal
Pubblicato in: JCI Insight, Numero 4/3, 2019, ISSN 2379-3708
Editore: JCI Insight
DOI: 10.1172/jci.insight.124813

Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock

Autori: Dušan Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben L. Feringa, Kenichiro Itami, Tsuyoshi Hirota
Pubblicato in: Journal of the American Chemical Society, Numero 143/4, 2021, Pagina/e 2078-2087, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c12280

Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

Autori: Anna I. Lauxen, Piermichele Kobauri, Michael Wegener, Mickel J. Hansen, Nicole S. Galenkamp, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa, Oscar P. Kuipers
Pubblicato in: Pharmaceuticals, Numero 14/5, 2021, Pagina/e 392, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14050392

Photochemical control of bacterial gene expression based on trans encoded genetic switches

Autori: Avishek Paul, Jingyi Huang, Yanxiao Han, Xintong Yang, Lela Vuković, Petr Král, Lifei Zheng, Andreas Herrmann
Pubblicato in: Chemical Science, Numero 12/7, 2021, Pagina/e 2646-2654, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05479h

Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

Autori: Elisa J.M. Raineri, Harita Yedavally, Anna Salvati, Jan Maarten van Dijl
Pubblicato in: Virulence, Numero 11/1, 2020, Pagina/e 1623-1639, ISSN 2150-5594
Editore: Landes Bioscience
DOI: 10.1080/21505594.2020.1844418

Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer

Autori: Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymanski, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa
Pubblicato in: Chemical Science, Numero 12/26, 2021, Pagina/e 9207-9220, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc02194j

Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization

Autori: Riccardo Leinardi, Cristina Pavan, Harita Yedavally, Maura Tomatis, Anna Salvati, Francesco Turci
Pubblicato in: Archives of Toxicology, Numero 94/9, 2020, Pagina/e 2981-2995, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02819-x

Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter , Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains

Autori: Patricia Arias-Orozco, Yunhai Yi, Oscar P. Kuipers
Pubblicato in: Microbiology Resource Announcements, Numero 10/19, 2021, ISSN 2576-098X
Editore: ASM Microbiology Resource Announcements
DOI: 10.1128/mra.00116-21

Biaryl sulfonamides as cisoid azosteres for photopharmacology

Autori: Piermichele Kobauri, Wiktor Szymanski, Fangyuan Cao, Sebastian Thallmair, Siewert J. Marrink, Martin D. Witte, Frank J. Dekker, Ben L. Feringa
Pubblicato in: Chemical Communications, Numero 57/34, 2021, Pagina/e 4126-4129, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc00950h

Light-controlled inhibition of BRAFV600E kinase

Autori: Mark W.H. Hoorens, Maria E. Ourailidou, Theo Rodat, Petra E. van der Wouden, Piermichele Kobauri, Malte Kriegs, Christian Peifer, Ben L. Feringa, Frank J. Dekker, Wiktor Szymanski
Pubblicato in: European Journal of Medicinal Chemistry, Numero 179, 2019, Pagina/e 133-146, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2019.06.042

Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

Autori: Valentina Vignali, Barbara S. Miranda, Irene Lodoso-Torrecilla, Cathelijn A. J. van Nisselroy, Bas-Jan Hoogenberg, Sybren Dantuma, Frank Hollmann, Jan Willem de Vries, Eliza M. Warszawik, Rainer Fischer, Ulrich Commandeur, Patrick van Rijn
Pubblicato in: Chemical Communications, Numero 55/1, 2019, Pagina/e 51-54, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c8cc08042a

Identification of a conserved N‐terminal domain in the first module of ACV synthetases

Autori: Riccardo Iacovelli, László Mózsik, Roel A.L. Bovenberg, Arnold J.M. Driessen
Pubblicato in: MicrobiologyOpen, Numero 10/1, 2021, Pagina/e e1145, ISSN 2045-8827
Editore: John Wiley and Sons Inc.
DOI: 10.1002/mbo3.1145

Antimicrobial Nanogels with Nanoinjection Capabilities for Delivery of the Hydrophobic Antibacterial Agent Triclosan

Autori: Guangyue Zu, Magdalena Steinmüller, Damla Keskin, Henny C. van der Mei, Olga Mergel, Patrick van Rijn
Pubblicato in: ACS Applied Polymer Materials, Numero 2/12, 2020, Pagina/e 5779-5789, ISSN 2637-6105
Editore: ACS Applied Polymer Materials
DOI: 10.1021/acsapm.0c01031

Fighting Staphylococcus aureus infections with light and photoimmunoconjugates

Autori: Mafalda Bispo, Andrea Anaya-Sanchez, Sabrina Suhani, Elisa J. M. Raineri, Marina López-Álvarez, Marjolein Heuker, Wiktor Szymański, Francisco Romero Pastrana, Girbe Buist, Alexander R. Horswill, Kevin P. Francis, Gooitzen M. van Dam, Marleen van Oosten, Jan Maarten van Dijl
Pubblicato in: JCI Insight, Numero 5/22, 2020, ISSN 2379-3708
Editore: JCI insight
DOI: 10.1172/jci.insight.139512

A synthetic metabolic network for physicochemical homeostasis

Autori: Tjeerd Pols, Hendrik R. Sikkema, Bauke F. Gaastra, Jacopo Frallicciardi, Wojciech M. Śmigiel, Shubham Singh, Bert Poolman
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-12287-2

The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties

Autori: Damla Keskin, Taraneh Mokabbar, Yutao Pei, Patrick van Rijn
Pubblicato in: Polymers, Numero 10/5, 2018, Pagina/e 534, ISSN 2073-4360
Editore: MDPI
DOI: 10.3390/polym10050534

Staphylococcal trafficking and infection—from ‘nose to gut’ and back

Autori: Elisa J M Raineri, Dania Altulea, Jan Maarten van Dijl
Pubblicato in: FEMS Microbiology Reviews, 2021, ISSN 1574-6976
Editore: FEMS Microbiology Reviews
DOI: 10.1093/femsre/fuab041

Enhanced bacterial killing by vancomycin in staphylococcal biofilms disrupted by novel, DMMA-modified carbon dots depends on EPS production

Autori: Yanyan Wu, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Pubblicato in: Colloids and Surfaces B: Biointerfaces, Numero 193, 2020, Pagina/e 111114, ISSN 0927-7765
Editore: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111114

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

Autori: Chao Ma, Juanjuan Su, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann, Rudolph E. Tanzi, Kai Liu, Can Zhang
Pubblicato in: Angewandte Chemie International Edition, Numero 58/51, 2019, Pagina/e 18703-18709, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201912399

Immobilized Acylase PvdQ Reduces Pseudomonas aeruginosa Biofilm Formation on PDMS Silicone

Autori: Jan Vogel, Marijke Wakker-Havinga, Rita Setroikromo, Wim J. Quax
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, ISSN 2296-2646
Editore: Frontiers Media
DOI: 10.3389/fchem.2020.00054

Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Autori: Damla Keskin, Lisa Tromp, Olga Mergel, Guangyue Zu, Eliza Warszawik, Henny C. van der Mei, Patrick van Rijn
Pubblicato in: ACS Applied Materials & Interfaces, Numero 12/52, 2020, Pagina/e 57721-57731, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.0c18172

De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane

Autori: Chao Ma, Jingjin Dong, Marco Viviani, Isotta Tulini, Nicola Pontillo, Sourav Maity, Yu Zhou, Wouter H. Roos, Kai Liu, Andreas Herrmann, Giuseppe Portale
Pubblicato in: Science Advances, Numero 6/29, 2020, Pagina/e eabc0810, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abc0810

A Penicillium rubens platform strain for secondary metabolite production

Autori: Carsten Pohl, Fabiola Polli, Tabea Schütze, Annarita Viggiano, László Mózsik, Sascha Jung, Maaike de Vries, Roel A. L. Bovenberg, Vera Meyer, Arnold J. M. Driessen
Pubblicato in: Scientific Reports, Numero 10/1, 2020, Pagina/e 7360, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-64893-6

Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages

Autori: da Cruz Campos, Cavallo, L. Andrade, van Dijl, Couto, Zrimec, Lo Ten Foe, P. Rosa, V. Damasco, Friedrich, Chlebowicz-Flissikowska, Rossen
Pubblicato in: Microorganisms, Numero 7/11, 2019, Pagina/e 534, ISSN 2076-2607
Editore: Microorganisms
DOI: 10.3390/microorganisms7110534

Inheritance of physico-chemical properties and ROS generation by carbon quantum dots derived from pyrolytically carbonized bacterial sources

Autori: Y. Wu, H. Wei, H.C. van der Mei, J. de Vries, H.J. Busscher, Y. Ren
Pubblicato in: Materials Today Bio, Numero 12, 2021, Pagina/e 100151, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/j.mtbio.2021.100151

Synthetic control devices for gene regulation in Penicillium chrysogenum

Autori: László Mózsik, Zsófia Büttel, Roel A. L. Bovenberg, Arnold J. M. Driessen, Yvonne Nygård
Pubblicato in: Microbial Cell Factories, Numero 18/1, 2019, Pagina/e 203, ISSN 1475-2859
Editore: BioMed Central
DOI: 10.1186/s12934-019-1253-3

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

Autori: Yanyan Wu, Cong Li, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Pubblicato in: Antibiotics, Numero 10/6, 2021, Pagina/e 623, ISSN 2079-6382
Editore: MDPI
DOI: 10.3390/antibiotics10060623

Stereoselective Protection-Free Modification of 3-Keto-saccharides

Autori: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard
Pubblicato in: Organic Letters, Numero 22/14, 2020, Pagina/e 5622-5626, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.0c01986

Inhibiting Bacterial Adhesion by Mechanically Modulated Microgel Coatings

Autori: Damla Keskin, Olga Mergel, Henny C. van der Mei, Henk J. Busscher, Patrick van Rijn
Pubblicato in: Biomacromolecules, Numero 20/1, 2019, Pagina/e 243-253, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.8b01378

Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized Staphylococcus aureus as a Driver for Infection*

Autori: Laura M. Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa J.M. Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A. Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl, Uwe Völker
Pubblicato in: Molecular & Cellular Proteomics, Numero 18/5, 2019, Pagina/e 892-908, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra118.001138

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre‐Clinical Evaluation of 18 F‐Labeled PSMA‐Tracers for Prostate Cancer Imaging

Autori: Verena I. Böhmer, Wiktor Szymanski, Keimpe‐Oeds Berg, Chantal Mulder, Piermichele Kobauri, Hugo Helbert, Dion Born, Friederike Reeβing, Anja Huizing, Marten Klopstra, Douwe F. Samplonius, Ines F. Antunes, Jürgen W. A. Sijbesma, Gert Luurtsema, Wijnand Helfrich, Ton J. Visser, Ben L. Feringa, Philip H. Elsinga
Pubblicato in: Chemistry – A European Journal, Numero 26/47, 2020, Pagina/e 10871-10881, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001795

Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies

Autori: Patricia Arias-Orozco, Maartje Inklaar, Judith Lanooij, Rubén Cebrián, Oscar P. Kuipers
Pubblicato in: ACS Synthetic Biology, Numero 10/10, 2021, Pagina/e 2579-2591, ISSN 2161-5063
Editore: American Chemical Society
DOI: 10.1021/acssynbio.1c00224

CRISPR-based transcriptional activation tool for silent genes in filamentous fungi

Autori: László Mózsik, Mirthe Hoekzema, Niels A. W. de Kok, Roel A. L. Bovenberg, Yvonne Nygård, Arnold J. M. Driessen
Pubblicato in: Scientific Reports, Numero 11/1, 2021, Pagina/e 20129, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-80864-3

Bdellovibrio bacteriovorus : a potential ‘living antibiotic’ to control bacterial pathogens

Autori: Francis M. Cavallo, Lorea Jordana, Alexander W. Friedrich, Corinna Glasner, Jan Maarten van Dijl
Pubblicato in: Critical Reviews in Microbiology, Numero 47/5, 2021, Pagina/e 630-646, ISSN 1040-841X
Editore: Taylor & Francis
DOI: 10.1080/1040841x.2021.1908956

Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier

Autori: Laís Ribovski, Edwin de Jong, Olga Mergel, Guangyue Zu, Damla Keskin, Patrick van Rijn, Inge S. Zuhorn
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 34, 2021, Pagina/e 102377, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2021.102377

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Autori: Damla Keskin, Guangyue Zu, Abigail M. Forson, Lisa Tromp, Jelmer Sjollema, Patrick van Rijn
Pubblicato in: Bioactive Materials, Numero 6/10, 2021, Pagina/e 3634-3657, ISSN 2452-199X
Editore: Bioactive Materials
DOI: 10.1016/j.bioactmat.2021.03.004

Mechanochemical bond scission for the activation of drugs

Autori: Shuaidong Huo, Pengkun Zhao, Zhiyuan Shi, Miancheng Zou, Xintong Yang, Eliza Warszawik, Mark Loznik, Robert Göstl, Andreas Herrmann
Pubblicato in: Nature Chemistry, Numero 13/2, 2021, Pagina/e 131-139, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-020-00624-8

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane

Autori: Matteo Gabba, Jacopo Frallicciardi, Joury van ’t Klooster, Ryan Henderson, Łukasz Syga, Robert Mans, Antonius J.A. van Maris, Bert Poolman
Pubblicato in: Biophysical Journal, Numero 118/2, 2020, Pagina/e 422-434, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2019.11.3384