Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies From Synthesis towards Clinical Applications

Publicaciones

Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light

Autores: Mickel J. Hansen, Femke M. Feringa, Piermichele Kobauri, Wiktor Szymanski, René H. Medema, Ben L. Feringa
Publicado en: Journal of the American Chemical Society, Edición 140/41, 2018, Página(s) 13136-13141, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.8b04870

Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Autores: Putri D. Utari, Jan Vogel, Wim J. Quax
Publicado en: Frontiers in Microbiology, Edición 8, 2017, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2017.01123

Impact of solid surface hydrophobicity and micrococcal nuclease production on Staphylococcus aureus Newman biofilms

Autores: Abigail M. Forson, Henny C. van der Mei, Jelmer Sjollema
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-69084-x

Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Autores: Stephen D. Zoller, Howard Y. Park, Tove Olafsen, Charles Zamilpa, Zachary D.C. Burke, Gideon Blumstein, William L. Sheppard, Christopher D. Hamad, Kellyn R. Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T. Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa J.M. Raineri, Jeffery F. Miller, Lloyd S. Miller, Jan Maarten van Dijl, Kevin P. Francis, Nicholas M. Bernthal
Publicado en: JCI Insight, Edición 4/3, 2019, ISSN 2379-3708
Editor: JCI Insight
DOI: 10.1172/jci.insight.124813

Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock

Autores: Dušan Kolarski, Simon Miller, Tsuyoshi Oshima, Yoshiko Nagai, Yugo Aoki, Piermichele Kobauri, Ashutosh Srivastava, Akiko Sugiyama, Kazuma Amaike, Ayato Sato, Florence Tama, Wiktor Szymanski, Ben L. Feringa, Kenichiro Itami, Tsuyoshi Hirota
Publicado en: Journal of the American Chemical Society, Edición 143/4, 2021, Página(s) 2078-2087, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c12280

Mechanism of Resistance Development in E. coli against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

Autores: Anna I. Lauxen, Piermichele Kobauri, Michael Wegener, Mickel J. Hansen, Nicole S. Galenkamp, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa, Oscar P. Kuipers
Publicado en: Pharmaceuticals, Edición 14/5, 2021, Página(s) 392, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14050392

Photochemical control of bacterial gene expression based on trans encoded genetic switches

Autores: Avishek Paul, Jingyi Huang, Yanxiao Han, Xintong Yang, Lela Vuković, Petr Král, Lifei Zheng, Andreas Herrmann
Publicado en: Chemical Science, Edición 12/7, 2021, Página(s) 2646-2654, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc05479h

Time-resolved analysis of Staphylococcus aureus invading the endothelial barrier

Autores: Elisa J.M. Raineri, Harita Yedavally, Anna Salvati, Jan Maarten van Dijl
Publicado en: Virulence, Edición 11/1, 2020, Página(s) 1623-1639, ISSN 2150-5594
Editor: Landes Bioscience
DOI: 10.1080/21505594.2020.1844418

Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer

Autores: Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymanski, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa
Publicado en: Chemical Science, Edición 12/26, 2021, Página(s) 9207-9220, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc02194j

Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization

Autores: Riccardo Leinardi, Cristina Pavan, Harita Yedavally, Maura Tomatis, Anna Salvati, Francesco Turci
Publicado en: Archives of Toxicology, Edición 94/9, 2020, Página(s) 2981-2995, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-020-02819-x

Draft Genome Sequences of Four Bacterial Strains of Heterotrophic Alteromonas macleodii and Marinobacter , Isolated from a Nonaxenic Culture of Two Marine Synechococcus Strains

Autores: Patricia Arias-Orozco, Yunhai Yi, Oscar P. Kuipers
Publicado en: Microbiology Resource Announcements, Edición 10/19, 2021, ISSN 2576-098X
Editor: ASM Microbiology Resource Announcements
DOI: 10.1128/mra.00116-21

Biaryl sulfonamides as cisoid azosteres for photopharmacology

Autores: Piermichele Kobauri, Wiktor Szymanski, Fangyuan Cao, Sebastian Thallmair, Siewert J. Marrink, Martin D. Witte, Frank J. Dekker, Ben L. Feringa
Publicado en: Chemical Communications, Edición 57/34, 2021, Página(s) 4126-4129, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cc00950h

Light-controlled inhibition of BRAFV600E kinase

Autores: Mark W.H. Hoorens, Maria E. Ourailidou, Theo Rodat, Petra E. van der Wouden, Piermichele Kobauri, Malte Kriegs, Christian Peifer, Ben L. Feringa, Frank J. Dekker, Wiktor Szymanski
Publicado en: European Journal of Medicinal Chemistry, Edición 179, 2019, Página(s) 133-146, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2019.06.042

Biocatalytically induced surface modification of the tobacco mosaic virus and the bacteriophage M13

Autores: Valentina Vignali, Barbara S. Miranda, Irene Lodoso-Torrecilla, Cathelijn A. J. van Nisselroy, Bas-Jan Hoogenberg, Sybren Dantuma, Frank Hollmann, Jan Willem de Vries, Eliza M. Warszawik, Rainer Fischer, Ulrich Commandeur, Patrick van Rijn
Publicado en: Chemical Communications, Edición 55/1, 2019, Página(s) 51-54, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c8cc08042a

Identification of a conserved N‐terminal domain in the first module of ACV synthetases

Autores: Riccardo Iacovelli, László Mózsik, Roel A.L. Bovenberg, Arnold J.M. Driessen
Publicado en: MicrobiologyOpen, Edición 10/1, 2021, Página(s) e1145, ISSN 2045-8827
Editor: John Wiley and Sons Inc.
DOI: 10.1002/mbo3.1145

Antimicrobial Nanogels with Nanoinjection Capabilities for Delivery of the Hydrophobic Antibacterial Agent Triclosan

Autores: Guangyue Zu, Magdalena Steinmüller, Damla Keskin, Henny C. van der Mei, Olga Mergel, Patrick van Rijn
Publicado en: ACS Applied Polymer Materials, Edición 2/12, 2020, Página(s) 5779-5789, ISSN 2637-6105
Editor: ACS Applied Polymer Materials
DOI: 10.1021/acsapm.0c01031

Fighting Staphylococcus aureus infections with light and photoimmunoconjugates

Autores: Mafalda Bispo, Andrea Anaya-Sanchez, Sabrina Suhani, Elisa J. M. Raineri, Marina López-Álvarez, Marjolein Heuker, Wiktor Szymański, Francisco Romero Pastrana, Girbe Buist, Alexander R. Horswill, Kevin P. Francis, Gooitzen M. van Dam, Marleen van Oosten, Jan Maarten van Dijl
Publicado en: JCI Insight, Edición 5/22, 2020, ISSN 2379-3708
Editor: JCI insight
DOI: 10.1172/jci.insight.139512

A synthetic metabolic network for physicochemical homeostasis

Autores: Tjeerd Pols, Hendrik R. Sikkema, Bauke F. Gaastra, Jacopo Frallicciardi, Wojciech M. Śmigiel, Shubham Singh, Bert Poolman
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12287-2

The Relationship between Bulk Silicone and Benzophenone-Initiated Hydrogel Coating Properties

Autores: Damla Keskin, Taraneh Mokabbar, Yutao Pei, Patrick van Rijn
Publicado en: Polymers, Edición 10/5, 2018, Página(s) 534, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym10050534

Staphylococcal trafficking and infection—from ‘nose to gut’ and back

Autores: Elisa J M Raineri, Dania Altulea, Jan Maarten van Dijl
Publicado en: FEMS Microbiology Reviews, 2021, ISSN 1574-6976
Editor: FEMS Microbiology Reviews
DOI: 10.1093/femsre/fuab041

Enhanced bacterial killing by vancomycin in staphylococcal biofilms disrupted by novel, DMMA-modified carbon dots depends on EPS production

Autores: Yanyan Wu, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Publicado en: Colloids and Surfaces B: Biointerfaces, Edición 193, 2020, Página(s) 111114, ISSN 0927-7765
Editor: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111114

Significant Upregulation of Alzheimer's β‐Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

Autores: Chao Ma, Juanjuan Su, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann, Rudolph E. Tanzi, Kai Liu, Can Zhang
Publicado en: Angewandte Chemie International Edition, Edición 58/51, 2019, Página(s) 18703-18709, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201912399

Immobilized Acylase PvdQ Reduces Pseudomonas aeruginosa Biofilm Formation on PDMS Silicone

Autores: Jan Vogel, Marijke Wakker-Havinga, Rita Setroikromo, Wim J. Quax
Publicado en: Frontiers in Chemistry, Edición 8, 2020, ISSN 2296-2646
Editor: Frontiers Media
DOI: 10.3389/fchem.2020.00054

Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Autores: Damla Keskin, Lisa Tromp, Olga Mergel, Guangyue Zu, Eliza Warszawik, Henny C. van der Mei, Patrick van Rijn
Publicado en: ACS Applied Materials & Interfaces, Edición 12/52, 2020, Página(s) 57721-57731, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.0c18172

De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane

Autores: Chao Ma, Jingjin Dong, Marco Viviani, Isotta Tulini, Nicola Pontillo, Sourav Maity, Yu Zhou, Wouter H. Roos, Kai Liu, Andreas Herrmann, Giuseppe Portale
Publicado en: Science Advances, Edición 6/29, 2020, Página(s) eabc0810, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abc0810

A Penicillium rubens platform strain for secondary metabolite production

Autores: Carsten Pohl, Fabiola Polli, Tabea Schütze, Annarita Viggiano, László Mózsik, Sascha Jung, Maaike de Vries, Roel A. L. Bovenberg, Vera Meyer, Arnold J. M. Driessen
Publicado en: Scientific Reports, Edición 10/1, 2020, Página(s) 7360, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-64893-6

Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages

Autores: da Cruz Campos, Cavallo, L. Andrade, van Dijl, Couto, Zrimec, Lo Ten Foe, P. Rosa, V. Damasco, Friedrich, Chlebowicz-Flissikowska, Rossen
Publicado en: Microorganisms, Edición 7/11, 2019, Página(s) 534, ISSN 2076-2607
Editor: Microorganisms
DOI: 10.3390/microorganisms7110534

Inheritance of physico-chemical properties and ROS generation by carbon quantum dots derived from pyrolytically carbonized bacterial sources

Autores: Y. Wu, H. Wei, H.C. van der Mei, J. de Vries, H.J. Busscher, Y. Ren
Publicado en: Materials Today Bio, Edición 12, 2021, Página(s) 100151, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/j.mtbio.2021.100151

Synthetic control devices for gene regulation in Penicillium chrysogenum

Autores: László Mózsik, Zsófia Büttel, Roel A. L. Bovenberg, Arnold J. M. Driessen, Yvonne Nygård
Publicado en: Microbial Cell Factories, Edición 18/1, 2019, Página(s) 203, ISSN 1475-2859
Editor: BioMed Central
DOI: 10.1186/s12934-019-1253-3

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

Autores: Yanyan Wu, Cong Li, Henny C. van der Mei, Henk J. Busscher, Yijin Ren
Publicado en: Antibiotics, Edición 10/6, 2021, Página(s) 623, ISSN 2079-6382
Editor: MDPI
DOI: 10.3390/antibiotics10060623

Stereoselective Protection-Free Modification of 3-Keto-saccharides

Autores: Nittert Marinus, Nabil Tahiri, Margherita Duca, L. M. C. Marc Mouthaan, Simona Bianca, Marco van den Noort, Bert Poolman, Martin D. Witte, Adriaan J. Minnaard
Publicado en: Organic Letters, Edición 22/14, 2020, Página(s) 5622-5626, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.0c01986

Inhibiting Bacterial Adhesion by Mechanically Modulated Microgel Coatings

Autores: Damla Keskin, Olga Mergel, Henny C. van der Mei, Henk J. Busscher, Patrick van Rijn
Publicado en: Biomacromolecules, Edición 20/1, 2019, Página(s) 243-253, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.8b01378

Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized Staphylococcus aureus as a Driver for Infection*

Autores: Laura M. Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa J.M. Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A. Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl, Uwe Völker
Publicado en: Molecular & Cellular Proteomics, Edición 18/5, 2019, Página(s) 892-908, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra118.001138

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre‐Clinical Evaluation of 18 F‐Labeled PSMA‐Tracers for Prostate Cancer Imaging

Autores: Verena I. Böhmer, Wiktor Szymanski, Keimpe‐Oeds Berg, Chantal Mulder, Piermichele Kobauri, Hugo Helbert, Dion Born, Friederike Reeβing, Anja Huizing, Marten Klopstra, Douwe F. Samplonius, Ines F. Antunes, Jürgen W. A. Sijbesma, Gert Luurtsema, Wijnand Helfrich, Ton J. Visser, Ben L. Feringa, Philip H. Elsinga
Publicado en: Chemistry – A European Journal, Edición 26/47, 2020, Página(s) 10871-10881, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001795

Functional Expression and Characterization of the Highly Promiscuous Lanthipeptide Synthetase SyncM, Enabling the Production of Lanthipeptides with a Broad Range of Ring Topologies

Autores: Patricia Arias-Orozco, Maartje Inklaar, Judith Lanooij, Rubén Cebrián, Oscar P. Kuipers
Publicado en: ACS Synthetic Biology, Edición 10/10, 2021, Página(s) 2579-2591, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.1c00224

CRISPR-based transcriptional activation tool for silent genes in filamentous fungi

Autores: László Mózsik, Mirthe Hoekzema, Niels A. W. de Kok, Roel A. L. Bovenberg, Yvonne Nygård, Arnold J. M. Driessen
Publicado en: Scientific Reports, Edición 11/1, 2021, Página(s) 20129, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-80864-3

Bdellovibrio bacteriovorus : a potential ‘living antibiotic’ to control bacterial pathogens

Autores: Francis M. Cavallo, Lorea Jordana, Alexander W. Friedrich, Corinna Glasner, Jan Maarten van Dijl
Publicado en: Critical Reviews in Microbiology, Edición 47/5, 2021, Página(s) 630-646, ISSN 1040-841X
Editor: Taylor & Francis
DOI: 10.1080/1040841x.2021.1908956

Low nanogel stiffness favors nanogel transcytosis across an in vitro blood–brain barrier

Autores: Laís Ribovski, Edwin de Jong, Olga Mergel, Guangyue Zu, Damla Keskin, Patrick van Rijn, Inge S. Zuhorn
Publicado en: Nanomedicine: Nanotechnology, Biology and Medicine, Edición 34, 2021, Página(s) 102377, ISSN 1549-9634
Editor: Elsevier BV
DOI: 10.1016/j.nano.2021.102377

Nanogels: A novel approach in antimicrobial delivery systems and antimicrobial coatings

Autores: Damla Keskin, Guangyue Zu, Abigail M. Forson, Lisa Tromp, Jelmer Sjollema, Patrick van Rijn
Publicado en: Bioactive Materials, Edición 6/10, 2021, Página(s) 3634-3657, ISSN 2452-199X
Editor: Bioactive Materials
DOI: 10.1016/j.bioactmat.2021.03.004

Mechanochemical bond scission for the activation of drugs

Autores: Shuaidong Huo, Pengkun Zhao, Zhiyuan Shi, Miancheng Zou, Xintong Yang, Eliza Warszawik, Mark Loznik, Robert Göstl, Andreas Herrmann
Publicado en: Nature Chemistry, Edición 13/2, 2021, Página(s) 131-139, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-020-00624-8

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane

Autores: Matteo Gabba, Jacopo Frallicciardi, Joury van ’t Klooster, Ryan Henderson, Łukasz Syga, Robert Mans, Antonius J.A. van Maris, Bert Poolman
Publicado en: Biophysical Journal, Edición 118/2, 2020, Página(s) 422-434, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2019.11.3384

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