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Study of the therapeutic potential of an Akkermansia muciniphila-based products in subjects with an increased cardio-metabolic risk.

Ziel

Overweight and obesity have reached worldwide epidemic level. Both overweight and obesity are characterized by comorbidities such as cardio-metabolic risk factors (i.e. insulin resistance, type 2 diabetes, hypertension, dyslipidemia, low-grade inflammation) representing a major public health problem. Therefore, it is urgent to find a therapeutic solution to target all these metabolic disorders.

Among the environmental factors able to influence the individual susceptibility to gain weight and to develop metabolic disorders associated with obesity, we have contributed to the demonstration that gut bacteria (i.e gut microbiota) influence host metabolism.
We recently discovered a putative interesting microbial candidate, namely Akkermansia muciniphila. More exactly, we found that the administration of Akkermansia muciniphila reduced body weight gain, fat mass gain, glycemia, cholesterolemia and inflammatory markers in diet-induced obese mice. Moreover, in overweight/obese patients subjected to a calorie restriction diet, the higher abundance of Akkermansia muciniphila was associated with a better cardio-metabolic status. These observations suggested that the administration of Akkermansia muciniphila in overweight or obese people could be a very interesting therapeutic solution.
Currently, no human study have investigated the beneficial effects of Akkermansia muciniphila administration on obesity and metabolic disorders.

Thus, the main objective of this ERC POC project “Microbes4U” is to get the proof of concept in humans of the safety and efficacy of Akkermansia muciniphila administration in the treatment of overweight, obesity and metabolic disorders associated such as insulin resistance, type-2 diabetes and dyslipidemia.

Wissenschaftliches Gebiet

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

ERC-2015-PoC

Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-POC - Proof of Concept Grant

Gastgebende Einrichtung

UNIVERSITE CATHOLIQUE DE LOUVAIN
Netto-EU-Beitrag
€ 136 875,00
Adresse
PLACE DE L UNIVERSITE 1
1348 Louvain La Neuve
Belgien

Auf der Karte ansehen
Region
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 149 375,00

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Letzte Aktualisierung: 5 August 2022

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Permalink: https://cordis.europa.eu/project/id/713547/de

European Union, 2024