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Multicellular regulation of insulin secretion from pancreatic islets

Publications

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

Author(s): Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen
Published in: Organic & Biomolecular Chemistry, Issue 13, 2022, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1ob02216d

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Author(s): Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J Hodson, Erin E Mulvihill, Sophie Petropoulos, Gareth E Lim
Published in: JCI Insight, Issue 7(8), 2022, Page(s) e156378, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.156378

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

Author(s): Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP
Published in: PLoS Biology, Issue 20(9), 2022, Page(s) e3001761, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001761

GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress

Author(s): Katrina Viloria; Daniela Nasteska; Julia Ast; Annie Hasib; Federica Cuozzo; Silke Heising; Linford J.B. Briant; Martin Hewison; David J. Hodson
Published in: Diabetes, Issue db220326, 2022, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db22-0326

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo

Author(s): Julia Ast; Alissa N. Novak; Tom Podewin; Nicholas H. F. Fine; Ben Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia K. Linnemann; David J. Hodson; Johannes Broichhagen
Published in: JACS Au, Issue 6, 2022, ISSN 2691-3704
Publisher: ACS
DOI: 10.1021/jacsau.2c00130

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion.

Author(s): Katrina Viloria; Katrina Viloria; Daniela Nasteska; Daniela Nasteska; Linford J.B. Briant; Silke Heising; Silke Heising; Dean Larner; Dean Larner; Nicholas H. F. Fine; Nicholas H. F. Fine; Fiona B. Ashford; Fiona B. Ashford; Gabriela da Silva Xavier; Gabriela da Silva Xavier; Maria Jiménez Ramos; Maria Jiménez Ramos; Annie Hasib; Annie Hasib; Federica Cuozzo; Federica Cuozzo; Jocelyn E. Manning
Published in: Cell Reports, Issue 11, 2020, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107761

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

Author(s): Daniela Nasteska; Daniela Nasteska; Federica Cuozzo; Federica Cuozzo; Alpesh Thakker; Alpesh Thakker; Rula Bany Bakar; Rebecca L. Westbrook; Rebecca L. Westbrook; Ildem Akerman; Ildem Akerman; James Cantley; James Cantley; Daniel A. Tennant; Daniel A. Tennant; David J. Hodson; David J. Hodson
Published in: JCI Insight, Issue 17, 2021, ISSN 2379-3708
Publisher: ASCI
DOI: 10.1101/2020.04.30.068106

Glucagon-like peptide-1 receptor regulates thromboxane-induced human platelet activation

Author(s): Katherine N. Cahill; Taneem Amin; Olivier Boutaud; Richard Printz; Dawn C. Newcomb; Dinah Foer; David J. Hodson; Johannes Broichhagen; Joshua A. Beckman; Chang Yu; Hui Nian; Mona Mashayekhi; Heidi J. Silver; James M. Luther; Nancy J. Brown; R. Stokes Peebles; Kevin Niswender
Published in: JACC Basic to translational science, Issue 3, 2022, ISSN 2452-302X
Publisher: JACC
DOI: 10.1016/j.jacbts.2022.04.004

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

Author(s): Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder
Published in: Chemical Science, Issue 8/6, 2017, Page(s) 4644-4653, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c6sc05044a

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Author(s): Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen
Published in: ChemistryOpen, Issue 6/4, 2017, Page(s) 501-505, ISSN 2191-1363
Publisher: Wiley
DOI: 10.1002/open.201700062

The role of beta cell heterogeneity in islet function and insulin release

Author(s): Daniela Nasteska, David J Hodson
Published in: Journal of Molecular Endocrinology, Issue 61/1, 2018, Page(s) R43-R60, ISSN 0952-5041
Publisher: Society for Endocrinology
DOI: 10.1530/JME-18-0011

Remote control of glucose homeostasis in vivo using photopharmacology

Author(s): Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-00397-0

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling

Author(s): Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom
Published in: Endocrinology, Issue 158/8, 2017, Page(s) 2680-2693, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/en.2016-1755

Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

Author(s): Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.32965

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice

Author(s): Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter
Published in: Journal of Biological Chemistry, Issue 292/21, 2017, Page(s) 8892-8906, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M117.784629

Optical control of GPR40 signalling in pancreatic β-cells

Author(s): James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner
Published in: Chem. Sci., Issue 8/11, 2017, Page(s) 7604-7610, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7sc01475a

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

Author(s): Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant
Published in: Cell Reports, Issue 22/12, 2018, Page(s) 3107-3114, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.02.084

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Author(s): Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson
Published in: ACS Central Science, Issue 4/2, 2018, Page(s) 166-179, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.7b00237

Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes

Author(s): Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Published in: JCI Insight, Issue 3/12, 2018, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.98607

Optical tools for understanding the complexity of β-cell signalling and insulin release

Author(s): James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson
Published in: Nature Reviews Endocrinology, Issue 14/12, 2018, Page(s) 721-737, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-018-0105-2

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis

Author(s): Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter
Published in: Current Diabetes Reports, Issue 18/11, 2018, ISSN 1534-4827
Publisher: Current Science Inc.
DOI: 10.1007/s11892-018-1085-2

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

Author(s): Richard K.P. Benninger, David J. Hodson
Published in: Diabetes, Issue 67/4, 2018, Page(s) 537-547, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi17-0040

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

Author(s): Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton
Published in: Diabetologia, 2019, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-019-05029-y

Informing β-cell regeneration strategies using studies of heterogeneity

Author(s): Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson
Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S49-S59, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.004

Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons

Author(s): Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn
Published in: Cell Reports, Issue 26/7, 2019, Page(s) 1787-1799.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.01.067

Dimerization of the Sodium/Iodide Symporter

Author(s): Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe
Published in: Thyroid, Issue 29/10, 2019, Page(s) 1485-1498, ISSN 1050-7256
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/thy.2019.0034

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

Author(s): Michael W. O'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair
Published in: JCI Insight, 2019, ISSN 2379-3708
Publisher: JCI
DOI: 10.1172/jci.insight.125348

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Author(s): Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Po
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14309-w

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

Author(s): Yasmine Kemkem, Daniela Nasteska, Anne de Bray, Paula Bargi-Souza, Rodrigo A. Peliciari-Garcia, Anne Guillou, Patrice Mollard, David J. Hodson, Marie Schaeffer
Published in: Diabetologia, 2020, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05172-x

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Author(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alp
Published in: Molecular Metabolism, 2020, Page(s) 101015, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101015

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

Author(s): Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published in: British Journal of Pharmacology, 2020, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.15134

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Author(s): Zijian Fang, Shiqian Chen, Philip Pickford, Johannes Broichhagen, David J. Hodson, Ivan R. Corrêa, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M. W. French, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published in: ACS Pharmacology & Translational Science, Issue 3/2, 2020, Page(s) 345-360, ISSN 2575-9108
Publisher: ACS
DOI: 10.1021/acsptsci.0c00022

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

Author(s): David J. Hodson, Patrik Rorsman
Published in: Diabetes, Issue 69/5, 2020, Page(s) 864-866, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi19-0035

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

Author(s): Alex P. Seabright, Nicholas H. F. Fine, Jonathan P. Barlow, Samuel O. Lord, Ibrahim Musa, Alexander Gray, Jack A. Bryant, Manuel Banzhaf, Gareth G. Lavery, D. Grahame Hardie, David J. Hodson, Andrew Philp, Yu‐Chiang Lai
Published in: The FASEB Journal, Issue 34/5, 2020, Page(s) 6284-6301, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201903051r

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

Author(s): Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen
Published in: Chemical Science, Issue 22, 2021, ISSN 2041-6539
Publisher: RSC
DOI: 10.1101/2020.01.29.924829

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

Author(s): Daniela Nasteska , Nicholas H F Fine, Fiona B Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W J Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J Hodson
Published in: Nature Communications, Issue 12(1), 2021, Page(s) 674, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20632-z

GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition

Author(s): Audrys G Pauza, Pratik Thakkar, Tatjana Tasic, Igor Felippe, Paul Bishop, Michael P Greenwood, Kristina Rysevaite-Kyguoliene, Julia Ast, Johannes Broichhagen, David J Hodson, Helio C Salgado, Dainius H Pauza, Nina Japundzic-Zigon, Julian F R Paton, David Murphy
Published in: Circulation Research, Issue 130(5), 2022, Page(s) 694-707, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.319874

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