Publications Peer reviewed articles (37) Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins Author(s): Ramona Birke; Julia Ast; Dorien A. Roosen; Joon Lee; Kilian Roßmann; Christiane Huhn; Bettina Mathes; Michael Lisurek; David Bushiri; Han Sun; Ben Jones; Martin Lehmann; Joshua Levitz; Volker Haucke; David J. Hodson; Johannes Broichhagen Published in: Organic & Biomolecular Chemistry, Issue 13, 2022, ISSN 1477-0520 Publisher: Royal Society of Chemistry DOI: 10.1039/d1ob02216d 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells Author(s): Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J Hodson, Erin E Mulvihill, Sophie Petropoulos, Gareth E Lim Published in: JCI Insight, Issue 7(8), 2022, Page(s) e156378, ISSN 0021-9738 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci.insight.156378 Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response Author(s): Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP Published in: PLoS Biology, Issue 20(9), 2022, Page(s) e3001761, ISSN 1544-9173 Publisher: Public Library of Science DOI: 10.1371/journal.pbio.3001761 GC-globulin/vitamin D-binding protein is Required for Pancreatic α Cell Adaptation to Metabolic Stress Author(s): Katrina Viloria; Daniela Nasteska; Julia Ast; Annie Hasib; Federica Cuozzo; Silke Heising; Linford J.B. Briant; Martin Hewison; David J. Hodson Published in: Diabetes, Issue db220326, 2022, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/db22-0326 An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo Author(s): Julia Ast; Alissa N. Novak; Tom Podewin; Nicholas H. F. Fine; Ben Jones; Alejandra Tomas; Ramona Birke; Kilian Roßmann; Bettina Mathes; Jenny Eichhorst; Martin Lehmann; Amelia K. Linnemann; David J. Hodson; Johannes Broichhagen Published in: JACS Au, Issue 6, 2022, ISSN 2691-3704 Publisher: ACS DOI: 10.1021/jacsau.2c00130 Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Author(s): Katrina Viloria; Katrina Viloria; Daniela Nasteska; Daniela Nasteska; Linford J.B. Briant; Silke Heising; Silke Heising; Dean Larner; Dean Larner; Nicholas H. F. Fine; Nicholas H. F. Fine; Fiona B. Ashford; Fiona B. Ashford; Gabriela da Silva Xavier; Gabriela da Silva Xavier; Maria Jiménez Ramos; Maria Jiménez Ramos; Annie Hasib; Annie Hasib; Federica Cuozzo; Federica Cuozzo; Jocelyn E. Manning Published in: Cell Reports, Issue 11, 2020, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.107761 The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess Author(s): Daniela Nasteska; Daniela Nasteska; Federica Cuozzo; Federica Cuozzo; Alpesh Thakker; Alpesh Thakker; Rula Bany Bakar; Rebecca L. Westbrook; Rebecca L. Westbrook; Ildem Akerman; Ildem Akerman; James Cantley; James Cantley; Daniel A. Tennant; Daniel A. Tennant; David J. Hodson; David J. Hodson Published in: JCI Insight, Issue 17, 2021, ISSN 2379-3708 Publisher: ASCI DOI: 10.1101/2020.04.30.068106 Glucagon-like peptide-1 receptor regulates thromboxane-induced human platelet activation Author(s): Katherine N. Cahill; Taneem Amin; Olivier Boutaud; Richard Printz; Dawn C. Newcomb; Dinah Foer; David J. Hodson; Johannes Broichhagen; Joshua A. Beckman; Chang Yu; Hui Nian; Mona Mashayekhi; Heidi J. Silver; James M. Luther; Nancy J. Brown; R. Stokes Peebles; Kevin Niswender Published in: JACC Basic to translational science, Issue 3, 2022, ISSN 2452-302X Publisher: JACC DOI: 10.1016/j.jacbts.2022.04.004 Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone Author(s): Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner, Anja Hoffmann-Röder Published in: Chemical Science, Issue 8/6, 2017, Page(s) 4644-4653, ISSN 2041-6520 Publisher: Royal Society of Chemistry DOI: 10.1039/c6sc05044a Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor Author(s): Ben J. Jones, Rosario Scopelliti, Alejandra Tomas, Stephen R. Bloom, David J. Hodson, Johannes Broichhagen Published in: ChemistryOpen, Issue 6/4, 2017, Page(s) 501-505, ISSN 2191-1363 Publisher: Wiley DOI: 10.1002/open.201700062 The role of beta cell heterogeneity in islet function and insulin release Author(s): Daniela Nasteska, David J Hodson Published in: Journal of Molecular Endocrinology, Issue 61/1, 2018, Page(s) R43-R60, ISSN 0952-5041 Publisher: Society for Endocrinology DOI: 10.1530/JME-18-0011 Remote control of glucose homeostasis in vivo using photopharmacology Author(s): Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-017-00397-0 RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling Author(s): Jaimini Cegla, Ben J Jones, James V Gardiner, David J Hodson, Thomas Marjot, Emma R McGlone, Tricia M Tan, Stephen R Bloom Published in: Endocrinology, Issue 158/8, 2017, Page(s) 2680-2693, ISSN 0013-7227 Publisher: The Endocrine Society DOI: 10.1210/en.2016-1755 Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish Author(s): Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov Published in: eLife, Issue 7, 2018, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/eLife.32965 The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca 2+ dynamics in adult mice Author(s): Ryan K. Mitchell, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Rebecca M. Callingham, Timothy J. Pullen, Rebecca Cheung, Isabelle Leclerc, David J. Hodson, Guy A. Rutter Published in: Journal of Biological Chemistry, Issue 292/21, 2017, Page(s) 8892-8906, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M117.784629 Optical control of GPR40 signalling in pancreatic β-cells Author(s): James Allen Frank, Dmytro A. Yushchenko, Nicholas H. F. Fine, Margherita Duca, Mevlut Citir, Johannes Broichhagen, David J. Hodson, Carsten Schultz, Dirk Trauner Published in: Chem. Sci., Issue 8/11, 2017, Page(s) 7604-7610, ISSN 2041-6520 Publisher: Royal Society of Chemistry DOI: 10.1039/c7sc01475a Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis Author(s): Kate E.R. Hollinshead, Haydn Munford, Katherine L. Eales, Chiara Bardella, Chunjie Li, Cristina Escribano-Gonzalez, Alpesh Thakker, Yannic Nonnenmacher, Katarina Kluckova, Mark Jeeves, Robert Murren, Federica Cuozzo, Dan Ye, Giulio Laurenti, Wei Zhu, Karsten Hiller, David J. Hodson, Wei Hua, Ian P. Tomlinson, Christian Ludwig, Ying Mao, Daniel A. Tennant Published in: Cell Reports, Issue 22/12, 2018, Page(s) 3107-3114, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2018.02.084 Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology Author(s): Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson Published in: ACS Central Science, Issue 4/2, 2018, Page(s) 166-179, ISSN 2374-7943 Publisher: American Chemical Society DOI: 10.1021/acscentsci.7b00237 Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes Author(s): Guadalupe Navarro, Camille Allard, Jamie J. Morford, Weiwei Xu, Suhuan Liu, Adrien J.R. Molinas, Sierra M. Butcher, Nicholas H.F. Fine, Manuel Blandino-Rosano, Venkata N. Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A. Jacobson, Prasad V. Katakam, David J. Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis Published in: JCI Insight, Issue 3/12, 2018, ISSN 2379-3708 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci.insight.98607 Optical tools for understanding the complexity of β-cell signalling and insulin release Author(s): James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz, David J. Hodson Published in: Nature Reviews Endocrinology, Issue 14/12, 2018, Page(s) 721-737, ISSN 1759-5029 Publisher: Nature Publishing Group DOI: 10.1038/s41574-018-0105-2 The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis Author(s): Richard K. P. Benninger, Craig Dorrell, David J. Hodson, Guy A. Rutter Published in: Current Diabetes Reports, Issue 18/11, 2018, ISSN 1534-4827 Publisher: Current Science Inc. DOI: 10.1007/s11892-018-1085-2 New Understanding of β-Cell Heterogeneity and In Situ Islet Function Author(s): Richard K.P. Benninger, David J. Hodson Published in: Diabetes, Issue 67/4, 2018, Page(s) 537-547, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/dbi17-0040 Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes Author(s): Sophie R. Sayers, Rebecca L. Beavil, Nicholas H. F. Fine, Guo C. Huang, Pratik Choudhary, Kamila J. Pacholarz, Perdita E. Barran, Sam Butterworth, Charlotte E. Mills, J. Kennedy Cruickshank, Marta P. Silvestre, Sally D. Poppitt, Anne-Thea McGill, Gareth G. Lavery, David J. Hodson, Paul W. Caton Published in: Diabetologia, 2019, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-019-05029-y Informing β-cell regeneration strategies using studies of heterogeneity Author(s): Daniela Nasteska, Katrina Viloria, Lewis Everett, David J. Hodson Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S49-S59, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2019.06.004 Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons Author(s): Siew H. Yip, Nicola Romanò, Papillon Gustafson, David J. Hodson, Eloise J. Williams, Ilona C. Kokay, Agnes O. Martin, Patrice Mollard, David R. Grattan, Stephen J. Bunn Published in: Cell Reports, Issue 26/7, 2019, Page(s) 1787-1799.e5, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2019.01.067 Dimerization of the Sodium/Iodide Symporter Author(s): Rebecca J. Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M. Alshahrani, Jonathan W. Mueller, Nicholas H.F. Fine, David J. Hodson, Kristien Boelaert, Martin L. Read, Vicki E. Smith, Christopher J. McCabe Published in: Thyroid, Issue 29/10, 2019, Page(s) 1485-1498, ISSN 1050-7256 Publisher: Mary Ann Liebert Inc. DOI: 10.1089/thy.2019.0034 A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics Author(s): Michael W. O'Reilly, Connar S.J. Westgate, Catherine Hornby, Hannah Botfield, Angela E. Taylor, Keira Markey, James L. Mitchell, William J. Scotton, Susan P. Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C. Gilligan, Mark Sherlock, James Gibney, Jeremy W. Tomlinson, Gareth G. Lavery, David J. Hodson, Wiebke Arlt, Alexandra J. Sinclair Published in: JCI Insight, 2019, ISSN 2379-3708 Publisher: JCI DOI: 10.1172/jci.insight.125348 Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics Author(s): Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Po Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-14309-w Maternal hypothyroidism in mice influences glucose metabolism in adult offspring Author(s): Yasmine Kemkem, Daniela Nasteska, Anne de Bray, Paula Bargi-Souza, Rodrigo A. Peliciari-Garcia, Anne Guillou, Patrice Mollard, David J. Hodson, Marie Schaeffer Published in: Diabetologia, 2020, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05172-x The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis Author(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alp Published in: Molecular Metabolism, 2020, Page(s) 101015, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2020.101015 Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide Author(s): Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones Published in: British Journal of Pharmacology, 2020, ISSN 0007-1188 Publisher: Wiley-Blackwell DOI: 10.1111/bph.15134 The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists Author(s): Zijian Fang, Shiqian Chen, Philip Pickford, Johannes Broichhagen, David J. Hodson, Ivan R. Corrêa, Sunil Kumar, Frederik Görlitz, Chris Dunsby, Paul M. W. French, Guy A. Rutter, Tricia Tan, Stephen R. Bloom, Alejandra Tomas, Ben Jones Published in: ACS Pharmacology & Translational Science, Issue 3/2, 2020, Page(s) 345-360, ISSN 2575-9108 Publisher: ACS DOI: 10.1021/acsptsci.0c00022 A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets Author(s): David J. Hodson, Patrik Rorsman Published in: Diabetes, Issue 69/5, 2020, Page(s) 864-866, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/dbi19-0035 AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner Author(s): Alex P. Seabright, Nicholas H. F. Fine, Jonathan P. Barlow, Samuel O. Lord, Ibrahim Musa, Alexander Gray, Jack A. Bryant, Manuel Banzhaf, Gareth G. Lavery, D. Grahame Hardie, David J. Hodson, Andrew Philp, Yu‐Chiang Lai Published in: The FASEB Journal, Issue 34/5, 2020, Page(s) 6284-6301, ISSN 0892-6638 Publisher: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.201903051r Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates Author(s): Pascal Poc; Vanessa A. Gutzeit; Julia Ast; Joon Lee; Ben Jones; Elisa D’Este; Bettina Mathes; David J. Hodson; Joshua Levitz; Johannes Broichhagen Published in: Chemical Science, Issue 22, 2021, ISSN 2041-6539 Publisher: RSC DOI: 10.1101/2020.01.29.924829 PDX1LOW MAFALOW β-cells contribute to islet function and insulin release Author(s): Daniela Nasteska , Nicholas H F Fine, Fiona B Ashford, Federica Cuozzo, Katrina Viloria, Gabrielle Smith, Aisha Dahir, Peter W J Dawson, Yu-Chiang Lai, Aimée Bastidas-Ponce, Mostafa Bakhti, Guy A Rutter, Remi Fiancette, Rita Nano, Lorenzo Piemonti, Heiko Lickert, Qiao Zhou, Ildem Akerman, David J Hodson Published in: Nature Communications, Issue 12(1), 2021, Page(s) 674, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-20632-z GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition Author(s): Audrys G Pauza, Pratik Thakkar, Tatjana Tasic, Igor Felippe, Paul Bishop, Michael P Greenwood, Kristina Rysevaite-Kyguoliene, Julia Ast, Johannes Broichhagen, David J Hodson, Helio C Salgado, Dainius H Pauza, Nina Japundzic-Zigon, Julian F R Paton, David Murphy Published in: Circulation Research, Issue 130(5), 2022, Page(s) 694-707, ISSN 0009-7330 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/circresaha.121.319874 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available